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British Journal of Dermatology, ISSN 0007-0963, 06/2019, Volume 180, Issue 6, pp. e261 - e261
化脓性汗腺炎(HS)是一种炎性皮肤病, 在全世界约有1%HS患者。HS可使患者生活质量严重下降, 使腋窝和臀部等有毛发的部位出现慢性疼痛病变 (小块受累区域)。本次研究由土耳其和德国的科学家进行, 旨在分析 MEFV 基因在HS 中的作用, 研究使用了 119名HS患者。研究者确认了一些与多发性HS(例如,... 
Pyrin protein
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 08/2017, Volume 196, Issue 3, pp. 283 - 297
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 12/2016, Volume 41, Issue 12, pp. 1012 - 1021
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2016, Volume 113, Issue 50, pp. 14384 - 14389
Journal Article
Rheumatology, ISSN 1462-0324, 01/2018, Volume 57, Issue 1, pp. 100 - 111
Abstract Objectives FMF is the most frequent autoinflammatory disease and is associated in most patients with bi-allelic MEFV mutations. MEFV encodes Pyrin, an... 
Autoinflammation | IL-18 | Familial mediterranean fever | NLRP3 | Inflammasome | NLRC4 | IL-1β | MEFV | Pyrin | PROTEIN | INTERLEUKIN-1-BETA | TRIGGERS | KINASE | autoinflammation | IL-1 beta | RHEUMATOLOGY | IL-1-ALPHA | GENE | inflammasome | familial mediterranean fever | AUTOINFLAMMATORY DISEASES | IL-1-BETA | SECRETION | Interleukin-18 - immunology | Humans | Middle Aged | Child, Preschool | Pyrin - genetics | Male | Monocytes - immunology | Healthy Volunteers | Salmonella typhimurium | Case-Control Studies | Adenosine Triphosphate - pharmacology | Calcium-Binding Proteins - immunology | Pyrin - immunology | Cell Death | Adult | Female | Child | Ionophores - pharmacology | CARD Signaling Adaptor Proteins - immunology | Familial Mediterranean Fever - genetics | Interleukin-1beta - immunology | Antigens, Bacterial - pharmacology | Familial Mediterranean Fever - immunology | Inflammasomes - genetics | Monocytes - drug effects | Bacterial Proteins - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Bacterial Toxins - pharmacology | Adolescent | Nigericin - pharmacology | Mutation | rho GTP-Binding Proteins | Gene dosage | Cryopyrin | Toxin b | Hypersensitivity | Fever | Interleukin 18 | Monocytes | Cell activation | Pyrin protein | Cell death | Familial Mediterranean fever | Sensors | Apoptosis | Life Sciences | Microbiology and Parasitology | Immunology | Bacteriology | Virology
Journal Article
Journal of the American Heart Association, ISSN 2047-9980, 09/2017, Volume 6, Issue 9, p. n/a
Background Trimethylamine‐N‐oxide (TMAO) has recently been identified as a novel and independent risk factor for promoting atherosclerosis through inducing... 
atherosclerosis | trimethylamine‐N‐oxide | vascular inflammation | NOD‐like receptor family pyrin domain containing 3 inflammasome | sirtuin 3 | Sirtuin 3 | Vascular inflammation | NOD-like receptor family pyrin domain containing 3 inflammasome | Atherosclerosis | Trimethylamine-Noxide | ATHEROSCLEROTIC LESIONS | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | MICROBIOTA METABOLISM | SIRT3 | trimethylamine-N-oxide | CHOLESTEROL CRYSTALS | TRANSPORT | ENDOTHELIAL-CELLS | CARDIOVASCULAR-DISEASE | DYSFUNCTION | PHOSPHATIDYLCHOLINE | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Sirtuin 3 - metabolism | Atherosclerosis - genetics | Humans | Sirtuin 3 - deficiency | Mice, 129 Strain | Dose-Response Relationship, Drug | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Atherosclerosis - enzymology | Vasculitis - genetics | Transfection | RNA Interference | Time Factors | Inflammation Mediators - metabolism | Female | Vasculitis - chemically induced | Superoxide Dismutase - metabolism | Disease Models, Animal | Genetic Predisposition to Disease | Sirtuin 3 - genetics | Human Umbilical Vein Endothelial Cells - drug effects | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Atherosclerosis - chemically induced | Inflammasomes - agonists | Cells, Cultured | Mitochondria - metabolism | Antioxidants - pharmacology | Mice, Knockout, ApoE | Mitochondria - drug effects | Inflammasomes - genetics | Apoptosis Regulatory Proteins - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - agonists | Phenotype | Animals | Human Umbilical Vein Endothelial Cells - enzymology | Signal Transduction - drug effects | Vasculitis - enzymology | Methylamines - toxicity
Journal Article
Redox Biology, ISSN 2213-2317, 04/2015, Volume 4, Issue C, pp. 296 - 307
Journal Article
Journal Article
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