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pyrrole-imidazole polyamides (211) 211
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biochemistry & molecular biology (110) 110
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hairpin polyamides (38) 38
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polyamide (33) 33
solid-phase synthesis (33) 33
models, molecular (32) 32
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dna minor-groove (28) 28
imidazoles - pharmacology (28) 28
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deoxyribonucleic acid--dna (21) 21
distamycin (21) 21
gene expression (21) 21
polymerase-ii transcription (20) 20
transcription factors - metabolism (20) 20
cancer (19) 19
transcription factors (19) 19
dna footprinting (18) 18
analysis (17) 17
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design (17) 17
dna recognition (17) 17
sequence specificity (17) 17
small molecules (17) 17
cell line (16) 16
cell line, tumor (16) 16
crystal-structure (16) 16
nf-kappa-b (16) 16
specificity (16) 16
surface plasmon resonance (16) 16
beta-alanine (15) 15
biophysics (15) 15
distamycin-a (15) 15
expression (15) 15
hairpin polyamide (15) 15
imidazoles - metabolism (15) 15
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pyrrole–imidazole polyamide (15) 15
complex (14) 14
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base pairing (12) 12
base-pair sequences (12) 12
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minor groove binder (12) 12
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Organic and Biomolecular Chemistry, ISSN 1477-0520, 2017, Volume 15, Issue 46, pp. 9880 - 9888
Minor-groove binding hairpin polyamides (PAs) bind specific DNA sequences. Synthetic modifications can improve PA-DNA binding affinity and include flexible... 
COMPLEX | BASE-PAIRS | SMALL MOLECULES | SPECIFICITY | HAIRPIN POLYAMIDES | DISTAMYCIN | CHEMISTRY, ORGANIC | PYRROLE-IMIDAZOLE POLYAMIDES | TRANSCRIPTION FACTOR | SEQUENCE-SPECIFIC RECOGNITION | MINOR-GROOVE
Journal Article
Organic & Biomolecular Chemistry, ISSN 1477-0520, 01/2017, Volume 15, Issue 46, pp. 9880 - 9888
Minor-groove binding hairpin polyamides (PAs) bind specific DNA sequences. Synthetic modifications can improve PA–DNA binding affinity and include flexible... 
Binding | Chromatin | Alanine | Nucleotide sequence | Polyamides | Pyrroles | Steric hindrance | Electrostatic properties | Circular dichroism | Gene sequencing | Polyamide resins | PU.1 protein | Imidazole | Dichroism | Affinity | Inserts | Surface plasmon resonance | Cations | Kinetics | Biosensors | Deoxyribonucleic acid--DNA
Journal Article
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 05/2017, Volume 1860, Issue 5, pp. 617 - 629
Journal Article
Advanced drug delivery reviews, ISSN 0169-409X, 02/2019, Volume 147, pp. 66 - 85
Recent innovations in cutting-edge sequencing platforms have allowed the rapid identification of genes associated with communicable, noncommunicable and rare... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 5, pp. 2057 - 2066
Journal Article
International Journal of Oncology, ISSN 1019-6439, 07/2015, Volume 47, Issue 1, pp. 115 - 121
KvDMR (an intronic CpG island within the KCNQI gene) is one of the imprinting control regions on human chromosome 11p15.5. Since KvDMR exists within the... 
KvDMR | Wilms' tumor | Pyrrole-imidazole polyamides | KCNQ1OT1 | DOWN-REGULATION | CANCER | P57(KIP2) | NONCODING RNA | HEPATOCELLULAR-CARCINOMA | CDK INHIBITORS | BECKWITH-WIEDEMANN-SYNDROME | ONCOLOGY | KCNQIOT1 | GROWTH | ANNEXIN-V | HUMAN-CHROMOSOME 11P15.5
Journal Article
Cancer Science, ISSN 1347-9032, 04/2015, Volume 106, Issue 4, pp. 421 - 429
The MYC transcription factor plays a crucial role in the regulation of cell cycle progression, apoptosis, angiogenesis, and cellular transformation. Due to its... 
E‐Box | transcription therapy | MYC | pyrrole‐imidazole polyamide | Cell cycle | E-Box | Pyrrole-imidazole polyamide | Transcription therapy | TRANSFORMATION | MAX | C-MYC | CHLORAMBUCIL CONJUGATE | TRANSLATION | SUPPRESSION | pyrrole-imidazole polyamide | GENOMIC TARGETS | ONCOLOGY | GENE-EXPRESSION | TRANSCRIPTION FACTOR | PROGRESSION | Promoter Regions, Genetic | E-Box Elements - drug effects | Apoptosis - drug effects | Cyclin-Dependent Kinase 4 - genetics | Humans | Imidazoles - chemistry | Nylons - chemistry | Nylons - chemical synthesis | E-Box Elements - genetics | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Cyclin D1 - genetics | Protein Binding - drug effects | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Burkitt Lymphoma - genetics | Cell Line, Tumor | Pyrroles - chemistry | Cell Proliferation - drug effects | Eukaryotic Initiation Factor-4G - genetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Binding Sites - drug effects | DNA-Binding Proteins | DNA microarrays | RNA | Analysis | Polyamides | Leukemia | Thiophene | Gene expression | Cell proliferation | Transformation | Transcription factors | Toxicity | Myc protein | Cyclin-dependent kinase 4 | Proteins | Angiogenesis | Conserved sequence | Cell growth | Imidazole | Xenografts | Localization | Bioinformatics | Growth factors | Deoxyribonucleic acid--DNA | Medical research | Phenotypes | Nucleotide sequence | Myeloid leukemia | Chronic myeloid leukemia | Promoters | Burkitt's lymphoma | Studies | Laboratory animals | Binding sites | Cancer | Apoptosis | Index Medicus | Original
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 02/2019, Volume 25, Issue 11, pp. 2646 - 2646
DNA‐binding polyamides are molecules that hold great promise as regulators of gene expression. One of the challenges in their therapeutic development is... 
minor groove binder | pyrrole-imidazole polyamide | binding kinetics | NMR characterisation | allosterism
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2019, Volume 29, Issue 18, pp. 2622 - 2625
Journal Article
Chemistry – An Asian Journal, ISSN 1861-4728, 09/2014, Volume 9, Issue 9, pp. 2527 - 2533
Journal Article