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1. Full Text Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
by Parayil Kumaran Ajikumar and Wen-Hai Xiao and Keith E. J. Tyo and Yong Wang and Fritz Simeon and Effendi Leonard and Oliver Mucha and Too Heng Phon and Blaine Pfeifer and Gregory Stephanopoulos
Science, ISSN 0036-8075, 10/2010, Volume 330, Issue 6000, pp. 70 - 74
Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew tree. Currently, cost-efficient production of Taxol and its... 
Enzymes | Cellular metabolism | Terpenoids | Chemical engineering | Bioreactors | Plasmids | REPORTS | Operons | Biosynthesis | Indoles | Streams | YEAST | CYTOCHROME-P450 | TAXADIENE | CELLS | MULTIDISCIPLINARY SCIENCES | CONSTRUCTION | BIOSYNTHETIC GENES | STEP | OXYGENASES | LYCOPENE PRODUCTION | TERPENOIDS | Metabolomics | NADPH-Ferrihemoprotein Reductase - genetics | Erythritol - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Taxoids - metabolism | Organophosphorus Compounds - metabolism | Recombinant Fusion Proteins - metabolism | Farnesyltranstransferase - metabolism | Escherichia coli K12 - metabolism | Hemiterpenes - metabolism | Indoles - metabolism | Terpenes - metabolism | Erythritol - metabolism | Isomerases - genetics | Diterpenes - metabolism | NADPH-Ferrihemoprotein Reductase - metabolism | Paclitaxel - biosynthesis | Oxidation-Reduction | Fermentation | Taxus - enzymology | Metabolic Networks and Pathways - genetics | Genetic Engineering | Sugar Phosphates - metabolism | Farnesyltranstransferase - genetics | Cytochrome P-450 Enzyme System - genetics | Isomerases - metabolism | Escherichia coli K12 - genetics | Alkenes - metabolism | Escherichia coli K12 - enzymology | Physiological aspects | Research | Health aspects | Escherichia coli | Biological transport | Biochemistry | Pharmacology | E coli
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2. Full Text Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma
by Bishop, Justin A., MD and Sharma, Rajni, PhD and Illei, Peter B., MD
Human Pathology, ISSN 0046-8177, 2010, Volume 41, Issue 1, pp. 20 - 25
Summary Recent advances in the treatment of pulmonary adenocarcinoma have increased the need for accurate typing of non–small cell carcinomas.... 
Pathology | Napsin A | Thyroid transcription factor-1 (TTF-1) | Lung carcinoma | PULMONARY SURFACTANT | BEVACIZUMAB | ADENOCARCINOMA | TISSUE | TA02 | PLUS CARBOPLATIN | PATHOLOGY | TTF-1 | ASPARTIC PROTEINASE | CANCER | PACLITAXEL | Immunohistochemistry | Neoplasms - metabolism | Thyroid Nuclear Factor 1 | Pancreatic Neoplasms - metabolism | Tissue Array Analysis | Humans | Lung Neoplasms - metabolism | Nuclear Proteins - metabolism | Kidney Neoplasms - metabolism | Mesothelioma - diagnosis | Colonic Neoplasms - metabolism | Breast Neoplasms - metabolism | Transcription Factors - metabolism | Adenocarcinoma - diagnosis | Adenocarcinoma - metabolism | Mesothelioma - metabolism | Aspartic Acid Endopeptidases - metabolism | Biomarkers, Tumor - metabolism | Female | Lung Neoplasms - diagnosis | Thyroid Neoplasms - metabolism | Squamous cell carcinoma | Thyroid diseases | Respiratory agents | Breast cancer | Metastasis | Aspartic proteinases | Proteins | Thyroid cancer | Colon | Pancreas | Surfactants | Tumors | Skin cancer
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3. Full Text Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction
by Takayama, Kazuo and Inamura, Mitsuru and Kawabata, Kenji and Sugawara, Michiko and Kikuchi, Kiyomi and Higuchi, Maiko and Nagamoto, Yasuhito and Watanabe, Hitoshi and Tashiro, Katsuhisa and Sakurai, Fuminori and Hayakawa, Takao and Furue, Miho Kusuda and Mizuguchi, Hiroyuki
Journal of Hepatology, ISSN 0168-8278, 2012, Volume 57, Issue 3, pp. 628 - 636
Background & Aims Hepatocyte-like cells differentiated from human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) can be utilized as a... 
Gastroenterology and Hepatology | hiPSCs | Hepatocytes | Adenovirus | Drug metabolism | HNF1α | Drug screening | hESCs | FOXA2 | HESCs | HiPSCs | HNF1 alpha | TRANSCRIPTION | MOUSE | GENE | LIVER | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Bupropion - metabolism | Hepatocyte Nuclear Factor 3-beta - metabolism | Paclitaxel - metabolism | Cell Line | Embryonic Stem Cells - metabolism | Gene Transfer Techniques | Embryonic Stem Cells - cytology | Transduction, Genetic | Hepatocyte Nuclear Factor 1-alpha - genetics | Hepatocyte Nuclear Factor 3-beta - genetics | Humans | Hepatocytes - metabolism | Hepatocyte Nuclear Factor 1-alpha - metabolism | Testosterone - metabolism | Hepatocytes - cytology | Ethanolamines - metabolism | Midazolam - metabolism | Phenacetin - metabolism | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Hepatocytes - enzymology | Induced Pluripotent Stem Cells - metabolism | Tolbutamide - metabolism | Index Medicus
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4. Full Text Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells
by Wang, Yue and Niu, Xiu Long and Qu, Ye and Wu, Jian and Zhu, Ya Qin and Sun, Wei Jia and Li, Ling Zhi
Cancer Letters, ISSN 0304-3835, 2010, Volume 295, Issue 1, pp. 110 - 123
Abstract It has been shown that IL-6 is elevated in the serum and ascites of ovarian cancer patients, and increased IL-6 concentration correlates with poor... 
Hematology, Oncology and Palliative Medicine | Interleukin-6 (IL-6) | Multidrug resistance-related genes | Apoptosis inhibitory proteins | Chemoresistance | Ovarian cancer | CARCINOMA-CELLS | X-LINKED INHIBITOR | DRUG-RESISTANCE | APOPTOSIS PROTEIN | IN-VITRO | INCREASES EFFICACY | ONCOLOGY | GENE-EXPRESSION | REGULATED PROTEIN-KINASE | MULTIDRUG-RESISTANCE | UP-REGULATION | Paclitaxel - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Gene Expression Regulation, Neoplastic | bcl-X Protein - genetics | ras Proteins - metabolism | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | raf Kinases - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Female | Antineoplastic Agents - pharmacology | Ovarian Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Ovarian Neoplasms - drug therapy | Glutathione S-Transferase pi - genetics | Glutathione S-Transferase pi - metabolism | Cytokine Receptor gp130 - metabolism | Cisplatin - pharmacology | X-Linked Inhibitor of Apoptosis Protein - genetics | Interleukin-6 - pharmacology | Signal Transduction - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinases - metabolism | Receptors, Interleukin-6 - metabolism | Medical research | Chemotherapy | Kinases
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5. Full Text Refining the Diagnosis and EGFR Status of Non-small Cell Lung Carcinoma in Biopsy and Cytologic Material, Using a Panel of Mucin Staining, TTF-1, Cytokeratin 5/6, and P63, and EGFR Mutation Analysis
by Nicholson, Andrew G and Gonzalez, David and Shah, Pallav and Pynegar, Matthew J and Deshmukh, Manjiri and Rice, Alexandra and Popat, Sanjay
Journal of Thoracic Oncology, ISSN 1556-0864, 04/2010, Volume 5, Issue 4, pp. 436 - 441
The dichotomization of non-small cell carcinoma (NSCLC) subtype into squamous (SQCC) and adenocarcinoma (ADC) has become important in recent years and is... 
Immunohistochemistry | Adenocarcinoma | Squamous cell carcinoma | Lung | Cytology | Non-small cell carcinoma | EGFR | Cancer | Transbronchial needle aspirate | CARBOPLATIN | MARKER | PHASE-II | COMBINATION | PACLITAXEL | PULMONARY ADENOCARCINOMAS | FINE-NEEDLE-ASPIRATION | ONCOLOGY | RESPIRATORY SYSTEM | TRANSCRIPTION FACTOR-I | EXPRESSION | Receptor, Epidermal Growth Factor - genetics | Thyroid Nuclear Factor 1 | Prognosis | Prospective Studies | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - diagnosis | Cytodiagnosis - methods | Immunoenzyme Techniques | Carcinoma, Squamous Cell - diagnosis | Small Cell Lung Carcinoma - metabolism | Adenocarcinoma - metabolism | DNA Mutational Analysis | Sensitivity and Specificity | Mucins - metabolism | Polymerase Chain Reaction | Biomarkers, Tumor - metabolism | Adenocarcinoma - genetics | Retrospective Studies | Lung Neoplasms - genetics | Diagnosis, Differential | Tumor Suppressor Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Genotype | Nuclear Proteins - metabolism | Survival Rate | Small Cell Lung Carcinoma - genetics | Mutation - genetics | Transcription Factors - metabolism | Biopsy, Fine-Needle | Adenocarcinoma - diagnosis | Keratin-5 - metabolism | Small Cell Lung Carcinoma - diagnosis | Trans-Activators - metabolism | Biomarkers, Tumor - genetics | Keratin-6 - metabolism | DNA, Neoplasm - genetics | Lung Neoplasms - diagnosis | Neoplasm Staging
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6. Full Text Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension
by Kauw, Jos and Wolthuis, Rob M.F and Klompmaker, Rob and Brummelkamp, Thijn and Medema, René H and Lens, Susanne M.A and Agami, Reuven and Kops, Geert
The EMBO Journal, ISSN 0261-4189, 06/2003, Volume 22, Issue 12, pp. 2934 - 2947
Genetic evidence is mounting that survivin plays a crucial role in mitosis, but its exact role in human cell division remains elusive. We show that mammalian... 
checkpoint | mitosis | survivin | Mitosis | Checkpoint | Survivin | KINASE-ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN-CELLS | KINETOCHORE LOCALIZATION | SMALL-MOLECULE INHIBITOR | CELL BIOLOGY | APOPTOSIS FAMILY | CELL-DIVISION | SISTER CHROMATIDS | MITOTIC SPINDLE | CHROMOSOME SEGREGATION | AURORA-B | Paclitaxel - metabolism | Protein Kinases - metabolism | Protein Kinases - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Repressor Proteins | Cysteine Proteinase Inhibitors - metabolism | Stress, Mechanical | Thiones - metabolism | Recombinant Fusion Proteins - metabolism | Pyrimidines - metabolism | Aurora Kinase B | Spindle Apparatus - metabolism | Neoplasm Proteins | Cell Cycle Proteins - genetics | Spectrin - genetics | Antineoplastic Agents, Phytogenic - metabolism | Mad2 Proteins | Spectrin - metabolism | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism | Calcium-Binding Proteins - metabolism | Cell Line | Inhibitor of Apoptosis Proteins | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Aurora Kinases | Chromosomes, Human - metabolism | Animals | Mitosis - physiology | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Mice | Chromosomes, Mammalian - metabolism | Calcium-Binding Proteins - genetics
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7. Full Text CD133+ Cancer Stem Cell–like Cells Derived from Uterine Carcinosarcoma (Malignant Mixed Müllerian Tumor)
by Choijamts, Batsuren and Jimi, Shiro and Kondo, Toru and Naganuma, Yasuko and Matsumoto, Taichi and Kuroki, Masahide and Iwasaki, Hiroshi and Emoto, Makoto
STEM CELLS, ISSN 1066-5099, 10/2011, Volume 29, Issue 10, pp. 1485 - 1495
Cancer stem cells (CSCs) that display tumor‐initiating properties have recently been identified. CD133, a surface glycoprotein linked to organ‐specific stem... 
Cancer stem cell | Uterine carcinosarcoma | Müllerian duct | Malignant mixed Müllerian tumor | CD133 | PROGNOSIS | UTERUS | STAGE | SELF-RENEWAL | PLURIPOTENCY | Malignant mixed Mullerian tumor | CELL & TISSUE ENGINEERING | CELL BIOLOGY | SIDE-POPULATION | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MYC | Mullerian duct | STEM/PROGENITOR CELLS | NANOG | HEMATOLOGY | EXPRESSION | Immunohistochemistry | Neoplastic Stem Cells - cytology | Wnt4 Protein - metabolism | PAX2 Transcription Factor - metabolism | Paclitaxel - pharmacology | Neoplastic Stem Cells - drug effects | Uterine Neoplasms - pathology | Vimentin - metabolism | Homeodomain Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Glycoproteins - metabolism | Drug Resistance, Neoplasm | Antigens, CD - metabolism | Epithelial Cell Adhesion Molecule | SOXB1 Transcription Factors - metabolism | Estrogen Receptor beta - metabolism | Mesenchymal Stromal Cells - cytology | Flow Cytometry | Peptides - metabolism | Antigens, Neoplasm - metabolism | Neoplastic Stem Cells - pathology | Female | Cell Differentiation | Mixed Tumor, Mullerian - metabolism | Carcinosarcoma - pathology | Uterine Neoplasms - genetics | Uterine Neoplasms - metabolism | Carcinosarcoma - metabolism | Nanog Homeobox Protein | Mesenchymal Stromal Cells - metabolism | Cell Separation - methods | Cisplatin - pharmacology | AC133 Antigen | Cell Adhesion Molecules - metabolism | Cell Transformation, Neoplastic - metabolism | Mixed Tumor, Mullerian - pathology | Animals | Mice, Nude | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Carcinosarcoma - genetics | Mice | Mice, Inbred BALB C | Cell Transformation, Neoplastic - pathology
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8. Full Text Non-specific binding and steric hindrance thresholds for penetration of particulate drug carriers within tumor tissue
by Dancy, Jimena G and Wadajkar, Aniket S and Schneider, Craig S and Mauban, Joseph R.H and Goloubeva, Olga G and Woodworth, Graeme F and Winkles, Jeffrey A and Kim, Anthony J
Journal of Controlled Release, ISSN 0168-3659, 09/2016, Volume 238, pp. 139 - 148
Therapeutic nanoparticles (NPs) approved for clinical use in solid tumor therapy provide only modest improvements in patient survival, in part due to... 
Nanoparticles | Intravital microscopy | Multiple particle tracking (MPT) | PEG density | Surface plasmon resonance (SPR) | Tumor tissue penetration | SOLID TUMORS | DEEP PENETRATION | CHEMISTRY, MULTIDISCIPLINARY | PHASE-III TRIAL | BREAST-CANCER | DELIVERY-SYSTEM | IN-VIVO | PHARMACOLOGY & PHARMACY | EXTRACELLULAR-MATRIX | HUMAN MUCUS | Neoplasms - metabolism | Nanoparticles - analysis | Humans | Polyethylene Glycols - analysis | Drug Carriers - analysis | Albumin-Bound Paclitaxel - administration & dosage | Antineoplastic Agents - administration & dosage | Polyglycolic Acid - analysis | Breast - metabolism | Breast Neoplasms - metabolism | Antineoplastic Agents - metabolism | Nanoparticles - metabolism | Surface Properties | Doxorubicin - analogs & derivatives | Female | Doxorubicin - metabolism | Polyglycolic Acid - metabolism | Diffusion | Lactic Acid - analysis | Doxorubicin - administration & dosage | Albumin-Bound Paclitaxel - metabolism | Polyethylene Glycols - metabolism | Drug Carriers - metabolism | Lactic Acid - metabolism | Proteoglycans - metabolism | Breast Neoplasms - drug therapy | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Particle Size | Collagen - metabolism | Animals | Breast - drug effects | Mice, Nude | Cell Line, Tumor | Mice | Laminin - metabolism | Drug Combinations | Drugs | Ethylene glycol | Drug delivery systems | Drug therapy | Drug approval | Tumors | Vehicles | Medical colleges | Cancer | multiple particle tracking (MPT) | tumor tissue penetration | surface plasmon resonance (SPR) | nanoparticles | intravital microscopy
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9. Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites
by Buey, Rubén M and Calvo, Enrique and Barasoain, Isabel and Pineda, Oriol and Edler, Michael C and Matesanz, Ruth and Cerezo, Gemma and Vanderwal, Christopher D and Day, Billy W and Sorensen, Erik J and López, Juan Antonio and Andreu, José Manuel and Hamel, Ernest and Díaz, J. Fernando
Nature Chemical Biology, ISSN 1552-4450, 2007, Volume 3, Issue 2, pp. 117 - 125
Cyclostreptin ( 1), a natural product from Streptomyces sp. 9885, irreversibly stabilizes cellular microtubules, causes cell cycle arrest, evades drug... 
BETA-TUBULIN | CANCER-CELLS | EPOTHILONE | FR182877 | ANTIMITOTIC SUBSTANCE | THERMODYNAMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | GDP-TUBULIN | INHIBITOR | CYTOTOXICITY | Paclitaxel - metabolism | Paclitaxel - pharmacology | Taxoids - pharmacology | Models, Chemical | Tubulin Modulators - pharmacology | Humans | Molecular Sequence Data | Taxoids - metabolism | Threonine - metabolism | Carbamates - metabolism | Alkanes - metabolism | Microtubules - metabolism | Tubulin - metabolism | Microtubules - drug effects | Epothilones - metabolism | Mass Spectrometry | Inhibitory Concentration 50 | Microtubules - chemistry | Tubulin Modulators - metabolism | Tubulin - chemistry | Binding Sites | Polycyclic Compounds - metabolism | Binding, Competitive | Amino Acid Sequence | Polycyclic Compounds - chemistry | Tubulin Modulators - chemistry | Models, Molecular | Lactones - metabolism | Polycyclic Compounds - pharmacology | Asparagine - metabolism | Cell Line, Tumor | Protein Binding | Cell Proliferation - drug effects | Pyrones - metabolism | Cell Cycle - drug effects | Chemistry | Biology | Drug resistance | Binding sites | Cell cycle
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10. Full Text RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulation
by Wu, Yuping and Sukowati, Erike W and Sheng, Guojun and Nakaya, Yukiko
Nature Cell Biology, ISSN 1465-7392, 07/2008, Volume 10, Issue 7, pp. 765 - 775
Molecular and cellular mechanisms of epithelial-mesenchymal transition (EMT), crucial in development and pathogenesis, are still poorly understood. Here we... 
ACTIVE RHOA | MORPHOGENESIS | ACTIVATION | FAMILY GTPASES | TGF-BETA | NUCLEOTIDE EXCHANGE FACTOR | EPITHELIAL-MESENCHYMAL TRANSITIONS | E-CADHERIN | MOUSE GASTRULATION | EPITHELIOMESENCHYMAL TRANSFORMATION | CELL BIOLOGY | Biomarkers - metabolism | Paclitaxel - metabolism | Humans | Oncogene Proteins - metabolism | rhoA GTP-Binding Protein - metabolism | Mesoderm - cytology | Basement Membrane - metabolism | Chick Embryo | Nocodazole - metabolism | Gastrulation - physiology | Microtubules - metabolism | Animals | Mesoderm - physiology | Tubulin Modulators - metabolism | Cell Membrane - metabolism | Epithelium - physiology | Laminin - metabolism | Physiological aspects | Cell interaction | Membrane, Basement | Genetic aspects | Research | Guanosine triphosphatase
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11. Full Text Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage
by Yi, Jason and Wu, Xufeng and Chung, Andrew H and Chen, James K and Kapoor, Tarun M and Hammer, John A
Journal of Cell Biology, ISSN 0021-9525, 2013, Volume 202, Issue 5, pp. 779 - 792
T cells rapidly reposition their centrosome to the center of the immunological synapse (IS) to drive polarized secretion in the direction of the bound target... 
ORGANIZING CENTER | CYTOPLASMIC DYNEIN | PULLING FORCES | ACTIVATION | IMMUNE SYNAPSE | DYNAMICS | CYTOSKELETAL POLARIZATION | CORTICAL DYNEIN | IMMUNOLOGICAL SYNAPSE | PROTEINS | CELL BIOLOGY | Paclitaxel - pharmacology | Antigen-Presenting Cells - cytology | Calcium - metabolism | Humans | Nocodazole - pharmacology | Centrosome - drug effects | Lymphocyte Function-Associated Antigen-1 - metabolism | Microtubule-Organizing Center - drug effects | Immunological Synapses - metabolism | Polymerization - drug effects | Microtubules - metabolism | T-Lymphocytes - metabolism | Microtubules - drug effects | T-Lymphocytes - drug effects | Cell Membrane - metabolism | Cell Polarity - drug effects | Optical Tweezers | Cell Membrane - drug effects | Dyneins - metabolism | Microtubule-Organizing Center - metabolism | Antigen-Presenting Cells - metabolism | Receptors, Antigen, T-Cell - metabolism | Jurkat Cells | Antigen-Presenting Cells - drug effects | Centrosome - metabolism | Immunological Synapses - drug effects | Signal Transduction - drug effects | Dyneins - antagonists & inhibitors | Physiological aspects | Immunology | Research | T cells | Dynein | Centrosomes
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