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Science, ISSN 0036-8075, 10/2010, Volume 330, Issue 6000, pp. 70 - 74
Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew tree. Currently, cost-efficient production of Taxol and its... 
Enzymes | Cellular metabolism | Terpenoids | Chemical engineering | Bioreactors | Plasmids | REPORTS | Operons | Biosynthesis | Indoles | Streams | YEAST | CYTOCHROME-P450 | TAXADIENE | CELLS | MULTIDISCIPLINARY SCIENCES | CONSTRUCTION | BIOSYNTHETIC GENES | STEP | OXYGENASES | LYCOPENE PRODUCTION | TERPENOIDS | Metabolomics | NADPH-Ferrihemoprotein Reductase - genetics | Erythritol - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Taxoids - metabolism | Organophosphorus Compounds - metabolism | Recombinant Fusion Proteins - metabolism | Farnesyltranstransferase - metabolism | Escherichia coli K12 - metabolism | Hemiterpenes - metabolism | Indoles - metabolism | Terpenes - metabolism | Erythritol - metabolism | Isomerases - genetics | Diterpenes - metabolism | NADPH-Ferrihemoprotein Reductase - metabolism | Paclitaxel - biosynthesis | Oxidation-Reduction | Fermentation | Taxus - enzymology | Metabolic Networks and Pathways - genetics | Genetic Engineering | Sugar Phosphates - metabolism | Farnesyltranstransferase - genetics | Cytochrome P-450 Enzyme System - genetics | Isomerases - metabolism | Escherichia coli K12 - genetics | Alkenes - metabolism | Escherichia coli K12 - enzymology | Physiological aspects | Research | Health aspects | Escherichia coli | Biological transport | Biochemistry | Pharmacology | E coli
Journal Article
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2012, Volume 57, Issue 3, pp. 628 - 636
Journal Article
Cancer Letters, ISSN 0304-3835, 2010, Volume 295, Issue 1, pp. 110 - 123
Abstract It has been shown that IL-6 is elevated in the serum and ascites of ovarian cancer patients, and increased IL-6 concentration correlates with poor... 
Hematology, Oncology and Palliative Medicine | Interleukin-6 (IL-6) | Multidrug resistance-related genes | Apoptosis inhibitory proteins | Chemoresistance | Ovarian cancer | CARCINOMA-CELLS | X-LINKED INHIBITOR | DRUG-RESISTANCE | APOPTOSIS PROTEIN | IN-VITRO | INCREASES EFFICACY | ONCOLOGY | GENE-EXPRESSION | REGULATED PROTEIN-KINASE | MULTIDRUG-RESISTANCE | UP-REGULATION | Paclitaxel - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Gene Expression Regulation, Neoplastic | bcl-X Protein - genetics | ras Proteins - metabolism | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | raf Kinases - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Female | Antineoplastic Agents - pharmacology | Ovarian Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Ovarian Neoplasms - drug therapy | Glutathione S-Transferase pi - genetics | Glutathione S-Transferase pi - metabolism | Cytokine Receptor gp130 - metabolism | Cisplatin - pharmacology | X-Linked Inhibitor of Apoptosis Protein - genetics | Interleukin-6 - pharmacology | Signal Transduction - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinases - metabolism | Receptors, Interleukin-6 - metabolism | Medical research | Chemotherapy | Kinases
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 04/2010, Volume 5, Issue 4, pp. 436 - 441
The dichotomization of non-small cell carcinoma (NSCLC) subtype into squamous (SQCC) and adenocarcinoma (ADC) has become important in recent years and is... 
Immunohistochemistry | Adenocarcinoma | Squamous cell carcinoma | Lung | Cytology | Non-small cell carcinoma | EGFR | Cancer | Transbronchial needle aspirate | CARBOPLATIN | MARKER | PHASE-II | COMBINATION | PACLITAXEL | PULMONARY ADENOCARCINOMAS | FINE-NEEDLE-ASPIRATION | ONCOLOGY | RESPIRATORY SYSTEM | TRANSCRIPTION FACTOR-I | EXPRESSION | Receptor, Epidermal Growth Factor - genetics | Thyroid Nuclear Factor 1 | Prognosis | Prospective Studies | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - diagnosis | Cytodiagnosis - methods | Immunoenzyme Techniques | Carcinoma, Squamous Cell - diagnosis | Small Cell Lung Carcinoma - metabolism | Adenocarcinoma - metabolism | DNA Mutational Analysis | Sensitivity and Specificity | Mucins - metabolism | Polymerase Chain Reaction | Biomarkers, Tumor - metabolism | Adenocarcinoma - genetics | Retrospective Studies | Lung Neoplasms - genetics | Diagnosis, Differential | Tumor Suppressor Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Genotype | Nuclear Proteins - metabolism | Survival Rate | Small Cell Lung Carcinoma - genetics | Mutation - genetics | Transcription Factors - metabolism | Biopsy, Fine-Needle | Adenocarcinoma - diagnosis | Keratin-5 - metabolism | Small Cell Lung Carcinoma - diagnosis | Trans-Activators - metabolism | Biomarkers, Tumor - genetics | Keratin-6 - metabolism | DNA, Neoplasm - genetics | Lung Neoplasms - diagnosis | Neoplasm Staging
Journal Article
The EMBO Journal, ISSN 0261-4189, 06/2003, Volume 22, Issue 12, pp. 2934 - 2947
Genetic evidence is mounting that survivin plays a crucial role in mitosis, but its exact role in human cell division remains elusive. We show that mammalian... 
checkpoint | mitosis | survivin | Mitosis | Checkpoint | Survivin | KINASE-ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN-CELLS | KINETOCHORE LOCALIZATION | SMALL-MOLECULE INHIBITOR | CELL BIOLOGY | APOPTOSIS FAMILY | CELL-DIVISION | SISTER CHROMATIDS | MITOTIC SPINDLE | CHROMOSOME SEGREGATION | AURORA-B | Paclitaxel - metabolism | Protein Kinases - metabolism | Protein Kinases - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Repressor Proteins | Cysteine Proteinase Inhibitors - metabolism | Stress, Mechanical | Thiones - metabolism | Recombinant Fusion Proteins - metabolism | Pyrimidines - metabolism | Aurora Kinase B | Spindle Apparatus - metabolism | Neoplasm Proteins | Cell Cycle Proteins - genetics | Spectrin - genetics | Antineoplastic Agents, Phytogenic - metabolism | Mad2 Proteins | Spectrin - metabolism | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism | Calcium-Binding Proteins - metabolism | Cell Line | Inhibitor of Apoptosis Proteins | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Aurora Kinases | Chromosomes, Human - metabolism | Animals | Mitosis - physiology | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Mice | Chromosomes, Mammalian - metabolism | Calcium-Binding Proteins - genetics
Journal Article
STEM CELLS, ISSN 1066-5099, 10/2011, Volume 29, Issue 10, pp. 1485 - 1495
Cancer stem cells (CSCs) that display tumor‐initiating properties have recently been identified. CD133, a surface glycoprotein linked to organ‐specific stem... 
Cancer stem cell | Uterine carcinosarcoma | Müllerian duct | Malignant mixed Müllerian tumor | CD133 | PROGNOSIS | UTERUS | STAGE | SELF-RENEWAL | PLURIPOTENCY | Malignant mixed Mullerian tumor | CELL & TISSUE ENGINEERING | CELL BIOLOGY | SIDE-POPULATION | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MYC | Mullerian duct | STEM/PROGENITOR CELLS | NANOG | HEMATOLOGY | EXPRESSION | Immunohistochemistry | Neoplastic Stem Cells - cytology | Wnt4 Protein - metabolism | PAX2 Transcription Factor - metabolism | Paclitaxel - pharmacology | Neoplastic Stem Cells - drug effects | Uterine Neoplasms - pathology | Vimentin - metabolism | Homeodomain Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Glycoproteins - metabolism | Drug Resistance, Neoplasm | Antigens, CD - metabolism | Epithelial Cell Adhesion Molecule | SOXB1 Transcription Factors - metabolism | Estrogen Receptor beta - metabolism | Mesenchymal Stromal Cells - cytology | Flow Cytometry | Peptides - metabolism | Antigens, Neoplasm - metabolism | Neoplastic Stem Cells - pathology | Female | Cell Differentiation | Mixed Tumor, Mullerian - metabolism | Carcinosarcoma - pathology | Uterine Neoplasms - genetics | Uterine Neoplasms - metabolism | Carcinosarcoma - metabolism | Nanog Homeobox Protein | Mesenchymal Stromal Cells - metabolism | Cell Separation - methods | Cisplatin - pharmacology | AC133 Antigen | Cell Adhesion Molecules - metabolism | Cell Transformation, Neoplastic - metabolism | Mixed Tumor, Mullerian - pathology | Animals | Mice, Nude | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Carcinosarcoma - genetics | Mice | Mice, Inbred BALB C | Cell Transformation, Neoplastic - pathology
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 09/2016, Volume 238, pp. 139 - 148
Therapeutic nanoparticles (NPs) approved for clinical use in solid tumor therapy provide only modest improvements in patient survival, in part due to... 
Nanoparticles | Intravital microscopy | Multiple particle tracking (MPT) | PEG density | Surface plasmon resonance (SPR) | Tumor tissue penetration | SOLID TUMORS | DEEP PENETRATION | CHEMISTRY, MULTIDISCIPLINARY | PHASE-III TRIAL | BREAST-CANCER | DELIVERY-SYSTEM | IN-VIVO | PHARMACOLOGY & PHARMACY | EXTRACELLULAR-MATRIX | HUMAN MUCUS | Neoplasms - metabolism | Nanoparticles - analysis | Humans | Polyethylene Glycols - analysis | Drug Carriers - analysis | Albumin-Bound Paclitaxel - administration & dosage | Antineoplastic Agents - administration & dosage | Polyglycolic Acid - analysis | Breast - metabolism | Breast Neoplasms - metabolism | Antineoplastic Agents - metabolism | Nanoparticles - metabolism | Surface Properties | Doxorubicin - analogs & derivatives | Female | Doxorubicin - metabolism | Polyglycolic Acid - metabolism | Diffusion | Lactic Acid - analysis | Doxorubicin - administration & dosage | Albumin-Bound Paclitaxel - metabolism | Polyethylene Glycols - metabolism | Drug Carriers - metabolism | Lactic Acid - metabolism | Proteoglycans - metabolism | Breast Neoplasms - drug therapy | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Particle Size | Collagen - metabolism | Animals | Breast - drug effects | Mice, Nude | Cell Line, Tumor | Mice | Laminin - metabolism | Drug Combinations | Drugs | Ethylene glycol | Drug delivery systems | Drug therapy | Drug approval | Tumors | Vehicles | Medical colleges | Cancer | multiple particle tracking (MPT) | tumor tissue penetration | surface plasmon resonance (SPR) | nanoparticles | intravital microscopy
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2007, Volume 3, Issue 2, pp. 117 - 125
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2013, Volume 202, Issue 5, pp. 779 - 792
Journal Article