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1. Full Text Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
by Parayil Kumaran Ajikumar and Wen-Hai Xiao and Keith E. J. Tyo and Yong Wang and Fritz Simeon and Effendi Leonard and Oliver Mucha and Too Heng Phon and Blaine Pfeifer and Gregory Stephanopoulos
Science (American Association for the Advancement of Science), ISSN 0036-8075, 10/2010, Volume 330, Issue 6000, pp. 70 - 74
Enzymes | Cellular metabolism | Terpenoids | Chemical engineering | Bioreactors | Plasmids | REPORTS | Operons | Biosynthesis | Indoles | Streams | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Metabolomics | NADPH-Ferrihemoprotein Reductase - genetics | Erythritol - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Taxoids - metabolism | Organophosphorus Compounds - metabolism | Recombinant Fusion Proteins - metabolism | Farnesyltranstransferase - metabolism | Escherichia coli K12 - metabolism | Hemiterpenes - metabolism | Indoles - metabolism | Terpenes - metabolism | Erythritol - metabolism | Isomerases - genetics | Diterpenes - metabolism | NADPH-Ferrihemoprotein Reductase - metabolism | Paclitaxel - biosynthesis | Oxidation-Reduction | Fermentation | Taxus - enzymology | Metabolic Networks and Pathways - genetics | Genetic Engineering | Sugar Phosphates - metabolism | Farnesyltranstransferase - genetics | Cytochrome P-450 Enzyme System - genetics | Isomerases - metabolism | Escherichia coli K12 - genetics | Alkenes - metabolism | Escherichia coli K12 - enzymology | Physiological aspects | Research | Health aspects | Escherichia coli | Biological transport | Biochemistry | Pharmacology | E coli | Drugs | Pathways | Searching | Taxol | Modules | Modular | Pacific yew | Optimization | Index Medicus
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2. Full Text Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction
by Takayama, Kazuo and Inamura, Mitsuru and Kawabata, Kenji and Sugawara, Michiko and Kikuchi, Kiyomi and Higuchi, Maiko and Nagamoto, Yasuhito and Watanabe, Hitoshi and Tashiro, Katsuhisa and Sakurai, Fuminori and Hayakawa, Takao and Furue, Miho Kusuda and Mizuguchi, Hiroyuki
Journal of hepatology, ISSN 0168-8278, 2012, Volume 57, Issue 3, pp. 628 - 636
Gastroenterology and Hepatology | hiPSCs | Hepatocytes | Adenovirus | Drug metabolism | HNF1α | Drug screening | hESCs | FOXA2 | HESCs | HiPSCs | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Medical sciences | Bupropion - metabolism | Hepatocyte Nuclear Factor 3-beta - metabolism | Paclitaxel - metabolism | Cell Line | Embryonic Stem Cells - metabolism | Gene Transfer Techniques | Embryonic Stem Cells - cytology | Transduction, Genetic | Hepatocyte Nuclear Factor 1-alpha - genetics | Hepatocyte Nuclear Factor 3-beta - genetics | Humans | Hepatocytes - metabolism | Hepatocyte Nuclear Factor 1-alpha - metabolism | Testosterone - metabolism | Hepatocytes - cytology | Ethanolamines - metabolism | Midazolam - metabolism | Phenacetin - metabolism | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Hepatocytes - enzymology | Induced Pluripotent Stem Cells - metabolism | Tolbutamide - metabolism | Index Medicus
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3. Full Text Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells
by Wang, Yue and Niu, Xiu Long and Qu, Ye and Wu, Jian and Zhu, Ya Qin and Sun, Wei Jia and Li, Ling Zhi
Cancer letters, ISSN 0304-3835, 2010, Volume 295, Issue 1, pp. 110 - 123
Hematology, Oncology and Palliative Medicine | Interleukin-6 (IL-6) | Multidrug resistance-related genes | Apoptosis inhibitory proteins | Chemoresistance | Ovarian cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Paclitaxel - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Gene Expression Regulation, Neoplastic | bcl-X Protein - genetics | ras Proteins - metabolism | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | raf Kinases - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Female | Antineoplastic Agents - pharmacology | Ovarian Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Ovarian Neoplasms - drug therapy | Glutathione S-Transferase pi - genetics | Glutathione S-Transferase pi - metabolism | Cytokine Receptor gp130 - metabolism | Cisplatin - pharmacology | X-Linked Inhibitor of Apoptosis Protein - genetics | Interleukin-6 - pharmacology | Signal Transduction - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinases - metabolism | Receptors, Interleukin-6 - metabolism | Index Medicus
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4. Full Text Engineering of Secondary Metabolism
by O'Connor, Sarah E
Annual review of genetics, ISSN 0066-4197, 11/2015, Volume 49, Issue 1, pp. 71 - 94
synthetic biology | combinatorial biosynthesis | compartmentalization | natural product | secondary metabolite | Compartmentalization | Combinatorial biosynthesis | Natural product | Synthetic biology | Secondary metabolite | Paclitaxel - metabolism | Bacteria - metabolism | Metabolic Engineering - methods | Protein Engineering - methods | Streptomyces - genetics | Erythromycin - metabolism | Fungi - metabolism | Bacteria - genetics | Fungi - genetics | Streptomyces - metabolism | Plants - metabolism | Metabolic Networks and Pathways | Plants - genetics | Escherichia coli - genetics | Enzymes - genetics | Escherichia coli - metabolism | Secondary Metabolism - physiology | Artemisinins - metabolism | Enzymes - metabolism | Genetic aspects | Biosynthesis | Metabolism | Observations | Gene expression | Bioengineering | Genotype & phenotype | Molecules | Metabolites | Index Medicus
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5. Full Text Non-specific binding and steric hindrance thresholds for penetration of particulate drug carriers within tumor tissue
by Dancy, Jimena G and Wadajkar, Aniket S and Schneider, Craig S and Mauban, Joseph R.H and Goloubeva, Olga G and Woodworth, Graeme F and Winkles, Jeffrey A and Kim, Anthony J
Journal of controlled release, ISSN 0168-3659, 09/2016, Volume 238, pp. 139 - 148
Nanoparticles | Intravital microscopy | Multiple particle tracking (MPT) | PEG density | Surface plasmon resonance (SPR) | Tumor tissue penetration | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Neoplasms - metabolism | Nanoparticles - analysis | Humans | Polyethylene Glycols - analysis | Drug Carriers - analysis | Albumin-Bound Paclitaxel - administration & dosage | Antineoplastic Agents - administration & dosage | Polyglycolic Acid - analysis | Breast - metabolism | Breast Neoplasms - metabolism | Antineoplastic Agents - metabolism | Nanoparticles - metabolism | Surface Properties | Doxorubicin - analogs & derivatives | Female | Doxorubicin - metabolism | Polyglycolic Acid - metabolism | Diffusion | Lactic Acid - analysis | Doxorubicin - administration & dosage | Albumin-Bound Paclitaxel - metabolism | Polyethylene Glycols - metabolism | Drug Carriers - metabolism | Lactic Acid - metabolism | Proteoglycans - metabolism | Breast Neoplasms - drug therapy | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Particle Size | Collagen - metabolism | Animals | Breast - drug effects | Mice, Nude | Cell Line, Tumor | Mice | Laminin - metabolism | Drug Combinations | Drugs | Ethylene glycol | Drug delivery systems | Drug therapy | Drug approval | Tumors | Vehicles | Medical colleges | Cancer | Index Medicus | multiple particle tracking (MPT) | tumor tissue penetration | surface plasmon resonance (SPR) | nanoparticles | intravital microscopy
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6. Full Text Activation of NLRP3 inflammasome in peripheral nerve contributes to paclitaxel-induced neuropathic pain
by Jia, Min and Wu, Caihua and Gao, Fang and Xiang, Hongchun and Sun, Ning and Peng, Ping and Li, Jingjing and Yuan, Xiaocui and Li, Hongping and Meng, Xianfang and Tian, Bo and Shi, Jing and Li, Man
Molecular pain, ISSN 1744-8069, 7/2017, Volume 13, pp. 1744806917719804 - 1744806917719804
paclitaxel | allodynia | Nod-like receptor protein 3 inflammasome | reactive oxygen species | Neuropathic pain | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Neuralgia - metabolism | Caspase 1 - metabolism | Male | Sciatic Nerve - ultrastructure | Interleukin-1beta - genetics | Neuralgia - pathology | Peripheral Nerves - drug effects | RNA, Messenger - metabolism | Mitochondria - ultrastructure | Hyperalgesia - pathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Cyclic N-Oxides - therapeutic use | Sciatic Nerve - metabolism | Cyclic N-Oxides - pharmacology | Interleukin-1beta - metabolism | Neuralgia - chemically induced | Peripheral Nerves - metabolism | Cell Line | Macrophages - ultrastructure | Hyperalgesia - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Sciatic Nerve - pathology | RNA, Messenger - genetics | Paclitaxel - adverse effects | Mitochondria - metabolism | Peripheral Nerves - pathology | Rats, Sprague-Dawley | Macrophages - metabolism | Animals | Hyperalgesia - drug therapy | Caspase 1 - genetics | Ganglia, Spinal - pathology | Ganglia, Spinal - metabolism | Index Medicus
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