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Journal of Biological Chemistry, ISSN 0021-9258, 07/2014, Volume 289, Issue 30, pp. 21082 - 21097
Journal Article
Neuroscience, ISSN 0306-4522, 2011, Volume 193, pp. 440 - 451
Abstract Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested the hypothesis that... 
Neurology | mast cell tryptase | paclitaxel-induced pain | TRPV1 | TRPA1 | proteinase-activated receptor 2 | TRPV4 | Proteinase-activated receptor 2 | Mast cell tryptase | Paclitaxel-induced pain | NEUROSCIENCES | SENSORY NEURONS | CAPSAICIN RECEPTOR | MECHANICAL HYPERALGESIA | IN-VIVO | KINASE-C-EPSILON | ION-CHANNEL | PERIPHERAL NEUROPATHY | INFLAMMATORY PAIN | PROTEASE-ACTIVATED-RECEPTOR-2 SENSITIZES | IRRITABLE-BOWEL-SYNDROME | Tryptases - metabolism | Central Nervous System - metabolism | Capsaicin - pharmacology | Receptor, PAR-2 - metabolism | Type C Phospholipases - metabolism | Male | Neuralgia - pathology | Dose-Response Relationship, Drug | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Drug Interactions | Paclitaxel - toxicity | Time Factors | Protein Kinase C - metabolism | TRPV Cation Channels - antagonists & inhibitors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Neuralgia - chemically induced | Neuralgia - physiopathology | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mice, Inbred ICR | Hyperalgesia - physiopathology | Antineoplastic Agents, Phytogenic - toxicity | Gene Expression Regulation - drug effects | Pain Measurement - methods | Pyrroles - pharmacology | Animals | Analysis of Variance | Ankyrins - antagonists & inhibitors | Anilides - pharmacology | Ankyrins - metabolism | Central Nervous System - drug effects | Mice | Physical Stimulation - adverse effects | Carbazoles - pharmacology | Oligopeptides - pharmacology | Protein Kinase C - pharmacology | Enzymes | Care and treatment | Neurosciences | Paclitaxel | Phospholipases | Protein kinases | Cancer | Index Medicus
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 05/2004, Volume 96, Issue 10, pp. 739 - 749
Background. Trastuzumab, a humanized anti-HER2 antibody, increases the clinical benefit of first-line chemotherapy in patients with metastatic breast cancers... 
TUMOR-CELL LINES | GROWTH-FACTOR RECEPTOR | PHASE-II TRIAL | IN-VITRO | PACLITAXEL TAXOL(R) | ONCOLOGY | 1ST-LINE CHEMOTHERAPY | RANDOMIZED-TRIAL | MONOCLONAL-ANTIBODY | CLINICAL PHARMACOKINETICS | DOCETAXEL TAXOTERE(R) | Up-Regulation | Cyclophosphamide - analogs & derivatives | Paclitaxel - pharmacology | Taxoids - pharmacology | Neoplastic Stem Cells - drug effects | Humans | Receptor, ErbB-2 - metabolism | Deoxycytidine - pharmacology | Transplantation, Heterologous | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Breast Neoplasms - metabolism | Antibodies, Monoclonal, Humanized | Vinblastine - analogs & derivatives | Female | Gene Expression Regulation, Neoplastic - drug effects | Receptor, ErbB-2 - drug effects | Disease Models, Animal | Floxuridine - pharmacology | Cell Survival - drug effects | Tumor Stem Cell Assay | Proto-Oncogene Proteins - drug effects | Enzyme-Linked Immunosorbent Assay | Antibodies, Monoclonal - pharmacology | Docetaxel | Breast Neoplasms - drug therapy | DNA, Neoplasm - drug effects | Guanine Nucleotide Exchange Factors | Drug Synergism | Animals | Mice, Nude | Cyclophosphamide - pharmacology | Cell Line, Tumor | Mice | Vinblastine - pharmacology | Carboplatin - pharmacology | Deoxycytidine - analogs & derivatives | Doxorubicin - pharmacology | Trastuzumab | Vinorelbine | Epirubicin - pharmacology | Chemotherapy | Care and treatment | Breast cancer | Research | Health aspects | Drug therapy | Medical treatment | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2008, Volume 14, Issue 20, pp. 6456 - 6468
Purpose: It was the aim of our study to establish an extensive panel of non-small cell lung cancer (NSCLC) xenograft models useful for the testing of novel... 
xenograft | NSCLC | erlotinib | mutational analysis | anti-EGFR therapy | cetuximab | biomarker | TARGETED THERAPY | KRAS MUTATIONS | GROWTH-FACTOR RECEPTOR | NUDE-MICE | TUMOR XENOGRAFTS | GEFITINIB | ONCOLOGY | GENE-EXPRESSION | TYROSINE KINASE INHIBITOR | EGFR MUTATIONS | ANTITUMOR-ACTIVITY | Carcinoma, Large Cell - drug therapy | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Adenocarcinoma - pathology | Oligonucleotide Array Sequence Analysis | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Middle Aged | Drug Resistance, Neoplasm | Immunoblotting | Male | Gene Expression Profiling | Adenocarcinoma - metabolism | Biomarkers, Tumor - metabolism | Cetuximab | Disease Models, Animal | Genes, ras - genetics | Antibodies, Monoclonal - pharmacology | Carcinoma, Non-Small-Cell Lung - metabolism | Etoposide - pharmacology | Mutation - genetics | Adenocarcinoma - drug therapy | Small Cell Lung Carcinoma - pathology | Carcinoma, Squamous Cell - drug therapy | Mice, Nude | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Mice | Carboplatin - pharmacology | Quinazolines - pharmacology | Deoxycytidine - analogs & derivatives | Erlotinib Hydrochloride | Paclitaxel - pharmacology | Prognosis | Carcinoma, Squamous Cell - metabolism | Deoxycytidine - pharmacology | Lung Neoplasms - pathology | Small Cell Lung Carcinoma - drug therapy | Tumor Suppressor Protein p53 - genetics | Small Cell Lung Carcinoma - metabolism | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | Vinblastine - analogs & derivatives | Polymerase Chain Reaction | Adult | Female | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - pathology | Carcinoma, Large Cell - metabolism | Radiation-Sensitizing Agents - pharmacology | Tumor Suppressor Protein p53 - metabolism | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Protein Kinase Inhibitors - pharmacology | Vinblastine - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Antineoplastic Agents, Phytogenic - pharmacology | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 04/1999, Volume 18, Issue 13, pp. 2241 - 2251
Previous studies have demonstrated a synergistic interaction between rhuMAb HER2 and the cytotoxic drug cisplatin in human breast and ovarian cancer cells. To... 
Chemotherapy | Breast cancer | Synergy | Multiple drug effects analysis | HER-2/neu (c-erbB-2) | HER2/NEU-OVEREXPRESSING METASTATIC BREAST | synergy | GROWTH-FACTOR-RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTINEOPLASTIC AGENTS | breast cancer | MONOCLONAL-ANTIBODY | OVARIAN-CANCER | SALIVARY-GLAND | chemotherapy | ENDOMETRIAL CANCER | CELL BIOLOGY | C-ERBB-2 PROTEIN | ONCOLOGY | multiple drug effects analysis | TUMOR NECROSIS FACTOR | GENETICS & HEREDITY | GENE-PRODUCT | Recombinant Proteins - therapeutic use | Doxorubicin - therapeutic use | Adenocarcinoma - pathology | Receptor, ErbB-2 - genetics | Humans | Neoplasm Proteins - immunology | Antibodies, Monoclonal - therapeutic use | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Vinblastine - therapeutic use | Topoisomerase II Inhibitors | Antimetabolites, Antineoplastic - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Receptor, ErbB-2 - biosynthesis | Antibodies, Monoclonal - pharmacology | Etoposide - pharmacology | Combined Modality Therapy | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Drug Synergism | Antimetabolites, Antineoplastic - therapeutic use | Adenocarcinoma - therapy | Antibiotics, Antineoplastic - therapeutic use | Mice, Nude | Cyclophosphamide - pharmacology | Immunization, Passive | Fluorouracil - pharmacology | Mice | Cell Cycle - drug effects | Trastuzumab | Neoplasm Transplantation | Paclitaxel - pharmacology | Antibiotics, Antineoplastic - pharmacology | Antineoplastic Agents, Alkylating - pharmacology | Transplantation, Heterologous | Fluorouracil - antagonists & inhibitors | Cyclophosphamide - therapeutic use | Breast Neoplasms - therapy | Antibodies, Monoclonal, Humanized | Fluorouracil - therapeutic use | Protein Processing, Post-Translational - drug effects | Female | Antineoplastic Agents - pharmacology | Thiotepa - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - biosynthesis | Etoposide - therapeutic use | Treatment Outcome | Cisplatin - pharmacology | Recombinant Proteins - pharmacology | Paclitaxel - therapeutic use | Neoplasms, Hormone-Dependent - therapy | Animals | Breast Neoplasms - pathology | Neoplasms, Hormone-Dependent - pathology | Vinblastine - pharmacology | Neoplasms, Hormone-Dependent - drug therapy | Doxorubicin - pharmacology | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
1995, Pharmacochemistry library, ISBN 0444817719, Volume 22, 350
Taxol®, a naturally occurring diterpenoid is one of the most exciting antitumor drugs available today. Its current indications (refractory ovarian and... 
Paclitaxel | Derivatives | Other branches of medicine
eBook
Cancer Letters, ISSN 0304-3835, 2012, Volume 320, Issue 1, pp. 104 - 110
Abstract Molecularly targeted therapies have emerged as the leading theme in cancer therapeutics. Multi-cytotoxic drug regimens have been highly successful,... 
Hematology, Oncology and Palliative Medicine | Combination index | Dasatinib | Molecular targeted therapy | Rapamycin | ACTIVATION | SRC | BCR-ABL | TUMOR | MECHANISMS | SIMULATION | CHEMOTHERAPY | ONCOLOGY | RESISTANCE | SYSTEMS | KINASES | Niacinamide - analogs & derivatives | Paclitaxel - pharmacology | Nitriles - pharmacology | Humans | Epothilones - pharmacology | Thiazoles - administration & dosage | Chromones - administration & dosage | Phenylurea Compounds | Benzenesulfonates - administration & dosage | Tamoxifen - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Nitriles - administration & dosage | Benzenesulfonates - pharmacology | Female | Chromones - pharmacology | Paclitaxel - administration & dosage | Butadienes - pharmacology | Pyridines - administration & dosage | Pyrimidines - administration & dosage | Morpholines - administration & dosage | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Pyrimidines - pharmacology | Breast Neoplasms - drug therapy | Sirolimus - pharmacology | Drug Synergism | Sirolimus - administration & dosage | Signal Transduction - drug effects | Butadienes - administration & dosage | Epothilones - administration & dosage | Tamoxifen - pharmacology | Cell Line, Tumor | Pyridines - pharmacology | Thiazoles - pharmacology | Care and treatment | Oncology, Experimental | Genes | Breast cancer | Research | Tamoxifen | Cancer | Cell culture | Values | Cell division | Cytotoxicity | Regression analysis | Kinases | Cancer therapies | Cell growth | Cell cycle | Software | Mutation | Drug dosages | Methods | Tumors | Apoptosis | Index Medicus
Journal Article
Journal Article
Biomaterials, ISSN 0142-9612, 2014, Volume 35, Issue 21, pp. 5591 - 5604
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2008, Volume 105, Issue 49, pp. 19306 - 19311
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2013, Volume 12, Issue 9, pp. 1874 - 1885
Journal Article
Neuropharmacology, ISSN 0028-3908, 10/2018, Volume 141, pp. 201 - 213
Given our recent evidence for the role of high mobility group box 1 (HMGB1) in chemotherapy-induced peripheral neuropathy (CIPN) in rats, we examined the... 
Chemotherapy-induced peripheral neuropathy | Paclitaxel | Reactive oxygen species (ROS) | High mobility group box 1 (HMGB1) | Macrophage | CELLS | OXIDATIVE STRESS | SOLUBLE THROMBOMODULIN | RAT | ROOT GANGLION NEURONS | ALLODYNIA | NEUROSCIENCES | CHEMOTHERAPY | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | EXPRESSION | HYPERSENSITIVITY | Hyperalgesia - chemically induced | Peripheral Nervous System Diseases - chemically induced | Pyruvates - pharmacology | Reactive Oxygen Species - metabolism | Clodronic Acid - pharmacology | Minocycline - pharmacology | Coculture Techniques | Male | Phosphoproteins - metabolism | Paclitaxel - antagonists & inhibitors | Thrombomodulin - metabolism | Thiocarbamates - pharmacology | HMGB1 Protein - metabolism | Proline - pharmacology | Membrane Proteins - metabolism | Neurons - metabolism | Sciatic Nerve - drug effects | Phosphorylation - drug effects | Peripheral Nervous System Diseases - complications | Peripheral Nervous System Diseases - immunology | Recombinant Proteins - metabolism | Proline - analogs & derivatives | Hyperalgesia - complications | Receptor for Advanced Glycation End Products - metabolism | Cells, Cultured | Hyperalgesia - prevention & control | Paclitaxel - adverse effects | Imidazoles - pharmacology | Antibodies - pharmacology | Up-Regulation - drug effects | p300-CBP Transcription Factors - metabolism | Macrophages - metabolism | Animals | Acetylcysteine - pharmacology | Macrophages - drug effects | Mice | Pyridines - pharmacology | Receptors, CXCR4 | Ganglia, Spinal - metabolism | Chemotherapy | Cysteine | Chromosomal proteins | Macrophages | Cancer | Cystine | Index Medicus
Journal Article