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Nature neuroscience, ISSN 1546-1726, 01/2013, Volume 16, Issue 2, pp. 183 - 192
A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates. We found that... 
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Brain-Derived Neurotrophic Factor - genetics | Biophysical Phenomena - drug effects | Motor Activity - drug effects | Male | Ribosome Inactivating Proteins, Type 1 - pharmacology | Touch | CD11b Antigen - genetics | Microglia - physiology | Time Factors | Chlorides - metabolism | Pain Threshold - drug effects | Biophysical Phenomena - genetics | Vocalization, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Homeostasis - drug effects | Protein Synthesis Inhibitors - pharmacology | Spinal Cord - cytology | Neurons - drug effects | Membrane Potentials - drug effects | Hot Temperature - adverse effects | Microglia - drug effects | Mice, Inbred C57BL | Rats | Mice, Transgenic | Signal Transduction - genetics | Down-Regulation - drug effects | Rats, Sprague-Dawley | Symporters - metabolism | Gene Expression Regulation - drug effects | Narcotics - administration & dosage | Patch-Clamp Techniques | Rotarod Performance Test | Animals | Hyperalgesia - drug therapy | Signal Transduction - drug effects | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Mice | CD11b Antigen - metabolism | Receptors, Purinergic P2X4 - metabolism | Morphine - administration & dosage | Receptors, Purinergic P2X4 - genetics | Ion Channel Gating - drug effects | Index Medicus
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 05/2011, Volume 70, Issue 3, pp. 482 - 494
Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca 2+-permeable nonselective cation channel. Previous work has demonstrated robust... 
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Hyperalgesia - chemically induced | Telemetry - methods | Calcium - metabolism | Capsaicin - pharmacology | Humans | Ganglia, Spinal - cytology | Transient Receptor Potential Channels - deficiency | Inflammation - metabolism | Time Factors | Behavior, Animal - drug effects | Sensory Receptor Cells - metabolism | Disease Models, Animal | Membrane Potentials - drug effects | Plant Oils - pharmacology | Trigeminal Ganglion - cytology | Mice, Knockout | Blood Glucose - drug effects | Patch-Clamp Techniques | Hyperalgesia - genetics | Transient Receptor Potential Channels - genetics | Gene Expression Regulation - radiation effects | TRPM Cation Channels - genetics | Blood Glucose - genetics | Mice | Inflammation - chemically induced | Mustard Plant | Pain Threshold - physiology | TRPM Cation Channels - deficiency | Membrane Potentials - genetics | Pregnenolone - adverse effects | Dose-Response Relationship, Drug | Transfection - methods | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Freund's Adjuvant - adverse effects | Pain Threshold - drug effects | Nifedipine - pharmacology | Hot Temperature - adverse effects | Hyperalgesia - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Pain Measurement - drug effects | Calcium Channel Blockers - pharmacology | Pain Measurement - methods | Animals | Sensory Receptor Cells - drug effects | TRPM Cation Channels - antagonists & inhibitors | Hyperalgesia - drug therapy | TRPA1 Cation Channel | Inflammation - genetics | Acrylamides - therapeutic use | TRPM Cation Channels - metabolism | Cell Line, Transformed | Chemotherapy | Progesterone | Sulfates | Cancer | Heat | Behavior | Cold | Neurons | Rodents | Index Medicus
Journal Article
Neuroscience, ISSN 0306-4522, 2016, Volume 339, pp. 622 - 633
Journal Article
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 04/2016, Volume 150, Issue 4, pp. 875 - 887.e9
Abstract Background & Aims Histamine sensitizes the nociceptor TRPV1 and has been shown to contribute to visceral hypersensitivity in animals. We investigated... 
Gastroenterology and Hepatology | Sensory Neurons | Drug | Transient Receptor Potential Cation Channel Subfamily V Member 1 | Treatment | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Abdominal Pain - prevention & control | Humans | Middle Aged | Male | Young Adult | Receptors, Histamine H1 - drug effects | TRPV Cation Channels - metabolism | Receptors, Histamine H1 - metabolism | Time Factors | Irritable Bowel Syndrome - diagnosis | Rectum - innervation | Pain Threshold - drug effects | Adult | Female | Surveys and Questionnaires | Neurons - metabolism | Neurons - drug effects | Analgesics - adverse effects | Analgesics - therapeutic use | Irritable Bowel Syndrome - metabolism | Butyrophenones - therapeutic use | Double-Blind Method | Abdominal Pain - physiopathology | Irritable Bowel Syndrome - drug therapy | Treatment Outcome | Abdominal Pain - metabolism | Irritable Bowel Syndrome - physiopathology | Remission Induction | Butyrophenones - adverse effects | Histamine H1 Antagonists - adverse effects | Belgium | Histamine H1 Antagonists - therapeutic use | Biopsy | Calcium Signaling - drug effects | Piperidines - therapeutic use | Piperidines - adverse effects | Adolescent | Gastrointestinal Agents - therapeutic use | Quality of Life | Aged | Gastrointestinal Agents - adverse effects | Pain Measurement | Receptor Cross-Talk - drug effects | Drugs | Histamine | Care and treatment | Drug delivery systems | Gastrointestinal diseases | Irritable bowel syndrome | Research institutes | Vehicles | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of neuroscience, ISSN 0270-6474, 12/2010, Volume 30, Issue 49, pp. 16459 - 16468
delta-Opioid receptors are G-protein-coupled receptors that regulate nociceptive and emotional responses. It has been well established that distinct agonists... 
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Analgesics - pharmacology | Calcium - metabolism | Drug Tolerance - genetics | Male | Ganglia, Spinal - cytology | Green Fluorescent Proteins - genetics | Drug Interactions | Piperidines - pharmacology | Time Factors | Protein Binding - drug effects | Brain - ultrastructure | Statistics, Nonparametric | Pain - etiology | Cell Membrane - drug effects | Disease Models, Animal | Locomotion - drug effects | Membrane Potentials - drug effects | Mice, Transgenic | Piperazines - therapeutic use | Piperazines - pharmacology | Protein Transport - genetics | Ligands | Mice | Receptors, Opioid, delta - agonists | Inflammation - chemically induced | Receptors, Opioid, delta - metabolism | Pain Threshold - physiology | Locomotion - genetics | Drug Tolerance - physiology | Protein Transport - physiology | Cell Membrane - genetics | Spinal Cord - ultrastructure | Patch-Clamp Techniques - methods | Inflammation - complications | Benzamides - therapeutic use | Pain - drug therapy | Receptors, Opioid, delta - genetics | Pain Threshold - drug effects | Female | Benzamides - pharmacology | Analgesics - therapeutic use | Mice, Inbred C57BL | Sulfur Isotopes - metabolism | Maze Learning - drug effects | Freund's Adjuvant | Hyperalgesia - physiopathology | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Sensory Receptor Cells - drug effects | Hyperalgesia - drug therapy | Piperidines - therapeutic use | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, pp. e0139394 - e0139394
...) cancer and 21 healthy control subjects underwent assessment of neuropathy using the neuropathy disability score, quantitative sensory testing for vibration perception threshold, warm and cold... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Capecitabine - administration & dosage | Hyperalgesia - chemically induced | Pain Threshold - physiology | Humans | Middle Aged | Erythromelalgia - chemically induced | Male | Epirubicin - administration & dosage | Stomach Neoplasms - physiopathology | Cisplatin - administration & dosage | Organoplatinum Compounds - administration & dosage | Nerve Fibers - physiology | Liver Neoplasms - physiopathology | Pain Threshold - drug effects | Female | Liver Neoplasms - secondary | Vibration - adverse effects | Hot Temperature - adverse effects | Nerve Fibers - drug effects | Neural Conduction | Trastuzumab - administration & dosage | Nerve Regeneration | Stomach Neoplasms - drug therapy | Microscopy, Confocal - methods | Cold Temperature - adverse effects | Hyperalgesia - physiopathology | Erythromelalgia - pathology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cisplatin - adverse effects | Esophageal Neoplasms - physiopathology | Cornea - innervation | Aged | Nerve Fibers - ultrastructure | Antineoplastic Agents, Alkylating - adverse effects | Esophageal Neoplasms - drug therapy | Organoplatinum Compounds - adverse effects | Complications and side effects | Cancer patients | Care and treatment | Polyneuropathies | Gastrointestinal cancer | Development and progression | Genetic aspects | Research | Risk factors | Cornea | Confocal microscopy | Diabetic neuropathy | Metastasis | Peripheral neuropathy | Cancer therapies | Lymph nodes