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Nature Neuroscience, ISSN 1097-6256, 02/2013, Volume 16, Issue 2, pp. 183 - 192
A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates. We found that... 
LAMINA-I NEURONS | NEUROTROPHIC FACTOR | P2X RECEPTORS | DOWN-REGULATION | OPIOID-RECEPTOR GENE | SPINAL-CORD-INJURY | UNDERLYING NEUROPATHIC PAIN | ALTERED CHLORIDE HOMEOSTASIS | NERVE INJURY | NEUROSCIENCES | INDUCED ABNORMAL PAIN | Brain-Derived Neurotrophic Factor - genetics | Biophysical Phenomena - drug effects | Motor Activity - drug effects | Male | Ribosome Inactivating Proteins, Type 1 - pharmacology | Touch | CD11b Antigen - genetics | Microglia - physiology | Time Factors | Chlorides - metabolism | Pain Threshold - drug effects | Biophysical Phenomena - genetics | Vocalization, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Homeostasis - drug effects | Protein Synthesis Inhibitors - pharmacology | Spinal Cord - cytology | Neurons - drug effects | Membrane Potentials - drug effects | Hot Temperature - adverse effects | Microglia - drug effects | Mice, Inbred C57BL | Rats | Mice, Transgenic | Signal Transduction - genetics | Down-Regulation - drug effects | Rats, Sprague-Dawley | Symporters - metabolism | Gene Expression Regulation - drug effects | Narcotics - administration & dosage | Patch-Clamp Techniques | Rotarod Performance Test | Animals | Hyperalgesia - drug therapy | Signal Transduction - drug effects | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Mice | CD11b Antigen - metabolism | Receptors, Purinergic P2X4 - metabolism | Morphine - administration & dosage | Receptors, Purinergic P2X4 - genetics | Ion Channel Gating - drug effects
Journal Article
Neuron, ISSN 0896-6273, 2011, Volume 70, Issue 3, pp. 482 - 494
Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca -permeable nonselective cation channel. Previous work has demonstrated robust... 
TEMPERATURE | TRPV4 | CATION CHANNEL | ION-CHANNEL | PREGNENOLONE SULFATE | VANILLOID RECEPTOR-1 | COLD | CAPSAICIN-RECEPTOR | NEUROSCIENCES | MICE LACKING | EVOKED ACTIVATION | Hyperalgesia - chemically induced | Telemetry - methods | Calcium - metabolism | Capsaicin - pharmacology | Humans | Ganglia, Spinal - cytology | Transient Receptor Potential Channels - deficiency | Inflammation - metabolism | Time Factors | Behavior, Animal - drug effects | Sensory Receptor Cells - metabolism | Disease Models, Animal | Membrane Potentials - drug effects | Plant Oils - pharmacology | Trigeminal Ganglion - cytology | Mice, Knockout | Blood Glucose - drug effects | Patch-Clamp Techniques | Hyperalgesia - genetics | Transient Receptor Potential Channels - genetics | Gene Expression Regulation - radiation effects | TRPM Cation Channels - genetics | Blood Glucose - genetics | Mice | Inflammation - chemically induced | Mustard Plant | Pain Threshold - physiology | TRPM Cation Channels - deficiency | Membrane Potentials - genetics | Pregnenolone - adverse effects | Dose-Response Relationship, Drug | Transfection - methods | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Freund's Adjuvant - adverse effects | Pain Threshold - drug effects | Nifedipine - pharmacology | Hot Temperature - adverse effects | Hyperalgesia - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Pain Measurement - drug effects | Calcium Channel Blockers - pharmacology | Pain Measurement - methods | Animals | Sensory Receptor Cells - drug effects | TRPM Cation Channels - antagonists & inhibitors | Hyperalgesia - drug therapy | TRPA1 Cation Channel | Inflammation - genetics | Acrylamides - therapeutic use | TRPM Cation Channels - metabolism | Cell Line, Transformed | Chemotherapy | Progesterone | Sulfates | Cancer | Heat | Behavior | Cold | Neurons | Rodents
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2012, Volume 32, Issue 33, pp. 11187 - 11200
Journal Article
Annals of Neurology, ISSN 0364-5134, 09/2008, Volume 64, Issue 3, pp. 274 - 283
Objective Botulinum toxin type A (BTX‐A) has been reported to have analgesic effects independent of its action on muscle tone, possibly by acting on neurogenic... 
HUMAN SKIN | POSTHERPETIC NEURALGIA | CAPSAICIN-EVOKED PAIN | FORMALIN-INDUCED PAIN | DOUBLE-BLIND | AXILLARY HYPERHIDROSIS | HYPERALGESIA | ALLODYNIA | QUALITY-OF-LIFE | MODEL | NEUROSCIENCES | CLINICAL NEUROLOGY | Pain Threshold - physiology | Humans | Middle Aged | Neuralgia - metabolism | Nociceptors - physiology | Male | Peripheral Nervous System Diseases - physiopathology | Peripheral Nerves - drug effects | Botulinum Toxins, Type A - administration & dosage | Neuromuscular Agents - administration & dosage | Pain Threshold - drug effects | Placebos | Adult | Female | Quality of Life - psychology | Neuralgia - physiopathology | Chronic Disease - drug therapy | Injections, Intradermal | Double-Blind Method | Hyperalgesia - metabolism | Analgesics - administration & dosage | Treatment Outcome | Neuralgia - drug therapy | Hyperalgesia - physiopathology | Peripheral Nerves - physiopathology | Peripheral Nervous System Diseases - metabolism | Hyperalgesia - drug therapy | Aged | Pain Measurement | Nociceptors - drug effects | Peripheral Nervous System Diseases - drug therapy | Index Medicus | Neuromuscular Agents | Peripheral Nerves | Neurons and Cognition | Hyperalgesia | Tissues and Organs | Life Sciences | Analgesics | Botulinum Toxin Type A | Human health and pathology | Peripheral Nervous System Diseases | Nociceptors | Quality of Life | Pain Threshold | Neuralgia | Chronic Disease
Journal Article
Gastroenterology, ISSN 0016-5085, 2015, Volume 150, Issue 4, pp. 875 - 887.e9
Abstract Background & Aims Histamine sensitizes the nociceptor TRPV1 and has been shown to contribute to visceral hypersensitivity in animals. We investigated... 
Gastroenterology and Hepatology | Sensory Neurons | Drug | Transient Receptor Potential Cation Channel Subfamily V Member 1 | Treatment | PROTEIN-KINASE-C | LINACLOTIDE | COLONIC HYPERSENSITIVITY | DISORDERS | MUTATIONAL ANALYSIS | POTENTIAL VANILLOID 1 | CLINICAL-TRIALS | BINDING-SITE | PLACEBO-CONTROLLED TRIAL | ION CHANNELS | GASTROENTEROLOGY & HEPATOLOGY | Abdominal Pain - prevention & control | Humans | Middle Aged | Male | Young Adult | Receptors, Histamine H1 - drug effects | TRPV Cation Channels - metabolism | Receptors, Histamine H1 - metabolism | Time Factors | Irritable Bowel Syndrome - diagnosis | Rectum - innervation | Pain Threshold - drug effects | Adult | Female | Surveys and Questionnaires | Neurons - metabolism | Neurons - drug effects | Analgesics - adverse effects | Analgesics - therapeutic use | Irritable Bowel Syndrome - metabolism | Butyrophenones - therapeutic use | Double-Blind Method | Abdominal Pain - physiopathology | Irritable Bowel Syndrome - drug therapy | Treatment Outcome | Abdominal Pain - metabolism | Irritable Bowel Syndrome - physiopathology | Remission Induction | Butyrophenones - adverse effects | Histamine H1 Antagonists - adverse effects | Belgium | Histamine H1 Antagonists - therapeutic use | Biopsy | Calcium Signaling - drug effects | Piperidines - therapeutic use | Piperidines - adverse effects | Adolescent | Gastrointestinal Agents - therapeutic use | Quality of Life | Aged | Gastrointestinal Agents - adverse effects | Pain Measurement | Receptor Cross-Talk - drug effects | Drugs | Histamine | Care and treatment | Drug delivery systems | Gastrointestinal diseases | Irritable bowel syndrome | Research institutes | Vehicles
Journal Article
Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 1/2015, Volume 55, Issue 1, pp. 533 - 552
Migraine is a neurological disorder that manifests as a debilitating headache associated with altered sensory perception. The neuropeptide calcitonin... 
neuromodulation | sensitization | trigeminovasculature | photophobia | neuropeptide | Sensitization | Trigeminovasculature | Neuromodulation | Neuropeptide | Photophobia | TRIGEMINAL GANGLION | TRIGEMINOVASCULAR SYSTEM | CORTICAL SPREADING DEPRESSION | MENINGEAL NOCICEPTORS | RANDOMIZED CONTROLLED-TRIAL | INTERNATIONAL UNION | RECEPTOR ANTAGONIST BIBN4096BS | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | TOXICOLOGY | SUBSTANCE-P | ACTIVITY-MODIFYING PROTEIN-1 | Neural Pathways - drug effects | Humans | Epistasis, Genetic - drug effects | Antibodies, Monoclonal - therapeutic use | Receptors, Calcitonin Gene-Related Peptide - metabolism | Migraine Disorders - metabolism | Pain Perception - drug effects | Calcitonin Gene-Related Peptide - antagonists & inhibitors | Drug Design | Migraine Disorders - physiopathology | Pain Threshold - drug effects | Epigenesis, Genetic - drug effects | Neural Pathways - physiopathology | Calcitonin Gene-Related Peptide - metabolism | Molecular Targeted Therapy - methods | Analgesics - therapeutic use | Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors | Calcitonin Gene-Related Peptide - genetics | Migraine Disorders - drug therapy | Animals | Migraine Disorders - genetics | Signal Transduction - drug effects | Receptors, Calcitonin Gene-Related Peptide - immunology | Neural Pathways - metabolism | Calcitonin Gene-Related Peptide - immunology | Receptors, Calcitonin Gene-Related Peptide - genetics | Index Medicus
Journal Article