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dna damage footprints; dna damage repair; epigenetic silencing; integrative statistical analysis; mutational signatures; protein structure analysis; somatic copy-number alterations; somatic mutations; the cancer genome atlas pancanatlas project (1) 1
dna damage footprints; dna damage repair; the cancer genome atlas pancanatlas project; epigenetic silencing; integrative statistical analysis; mutational signatures; protein structure analysis; somatic copy-number alterations; somatic mutations (1) 1
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by Knijnenburg, Theo and Knijnenburg, Theo A and Wang, Chen and Wang, Linghua and Wang, Jing and Wang, Jioajiao and Wang, Min and Wang, Zhining and Wang, Timothy and Zimmermann, Michael T and Chambwe, Nyasha and Gao, Jianjiong and Gao, Galen F and Cherniack, Andrew D and Fan, Huihui and Fan, Cheng and Shen, Yang and Shen, Hui and Way, Gregory P and Greene, Casey S and Liu, Wenbin and Liu, Jianfang and Liu, Jia and Liu, Yuexin and Liu, Xiuping and Akbani, Rehan and Feng, Bin and Donehower, Lawrence A and Miller, Christopher A and Miller, Chase and Miller, Judy and Miller, Michael and Karimi, Mostafa and Chen, Haoran and Chen, Amy and Chen, Chu and Kim, Jaegil and Kim, Pora and Jia, Peilin and Shinbrot, Eve and Zhang, Hongxin and Zhang, Wei and Zhang, Hailei and Zhang, Jiashan (Julia) and Zhang, Lizhi and Zhang, Jiexin and Zhang, Shaojun and Zhang, Hongzheng and Hu, Jianhong and Hu, Hai and Bailey, Matthew H and Bailey, Matthew and Yau, Christina and Wolf, Denise and Wolf, Gregory and Zhao, Fengmei and Zhao, Zhongming and Weinstein, John N and Li, Lei and Li, Jun and Li, Wei and Ding, Li and Mills, Gordon B and Laird, Peter W and Wheeler, David A and Shmulevich, Ilya and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Yang, Ian and Yang, Ju Dong and Yang, Hannah and Yang, Liming and Zenklusen, Jean C and Chudamani, Sudha and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Sun, Yichao and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and Heiman, David I and Lawrence, Michael S and Lin, Pei and Meier, Sam and Noble, Michael S and Saksena, Gordon and Voet, Doug and Bernard, Brady and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 1, pp. 239 - 254.e6
Journal Article
by Sanchez-Vega, Francisco and Mina, Marco and Armenia, Joshua and Chatila, Walid K and Luna, Augustin and La, Konnor and La, Konnor C and Dimitriadoy, Sofia and Liu, Jia and Liu, Yuexin and Liu, David L and Liu, Wenbin and Liu, Xiuping and Kantheti, Havish S and Saghafinia, Sadegh and Chakravarty, Debyani and Daian, Foysal and Gao, Qingsong and Gao, Galen F and Gao, Jianjiong and Bailey, Matthew H and Bailey, Matthew and Liang, Wen-Wei and Liang, Han and Foltz, Steven M and Shmulevich, Ilya and Ding, Li and Heins, Zachary and Heins, Zachary J and Ochoa, Angelica and Gross, Benjamin E and Gross, Benjamin and Zhang, Wei and Zhang, Hongzheng and Zhang, Hailei and Zhang, Hongxin and Zhang, Jiexin and Zhang, Jiashan (Julia) and Zhang, Lizhi and Kundra, Ritika and Kandoth, Cyriac and Bahceci, Istemi and Dervishi, Leonard and Dogrusoz, Ugur and Zhou, Wanding and Shen, Hui and Laird, Peter W and Way, Gregory P and Greene, Casey S and Xiao, Yonghong and Wang, Timothy and Wang, Jioajiao and Wang, Chen and Wang, Zhining and Wang, Linghua and Wang, Jing and Wang, Min and Iavarone, Antonio and Berger, Ashton C and Berger, Alice H and Bivona, Trever G and Lazar, Alexander J and Hammer, Gary D and Giordano, Thomas and Kwong, Lawrence N and McArthur, Grant and Huang, Chenfei and Tward, Aaron D and Frederick, Mitchell J and McCormick, Frank and Meyerson, Matthew and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Yang, Hannah and Yang, Ian and Yang, Ju Dong and Yang, Liming and Zenklusen, Jean C and Chudamani, Sudha and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Yichao and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and Heiman, David I and Kim, Jaegil and Lawrence, Michael S and ... and Cancer Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cell, ISSN 0092-8674, 04/2018, Volume 173, Issue 2, pp. 321 - 337.e10
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent,... 
cancer genome atlas | precision oncology | therapeutics | pan-cancer | signaling pathways | PanCanAtlas | combination therapy | cancer genomics | whole exome sequencing | TCGA | SIGNATURES | COMPREHENSIVE MOLECULAR CHARACTERIZATION | LANDSCAPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | MUTATIONS | EXPRESSION | CELL BIOLOGY
Journal Article
by Ricketts, Christopher J and De Cubas, Aguirre A and Fan, Cheng and Fan, Huihui and Smith, Christof C and Smith, Jennifer and Lang, James and Lang, Martin and Reznik, Ed and Bowlby, Reanne and Gibb, Ewan A and Akbani, Rehan and Beroukhim, Rameen and Bottaro, Donald P and Choueiri, Toni K and Gibbs, Richard A and Godwin, Andrew K and Godwin, Eryn M and Haake, Scott and Hakimi, A. Ari and Henske, Elizabeth P and Hsieh, James J and Ho, Thai and Ho, Thai H and Kanchi, Rupa S and Krishnan, Bhavani and Kwiatkowski, David J and Lui, Wembin and Merino, Maria J and Mills, Gordon B and Myers, Jerome and Nickerson, Michael L and Reuter, Victor E and Reuter, Victor and Schmidt, Laura S and Schmidt, Heather K and Shelley, C. Simon and Shelley, Carl Simon and Shen, Hui and Shuch, Brian and Signoretti, Sabina and Srinivasan, Ramaprasad and Tamboli, Pheroze and Thomas, George and Vincent, Benjamin G and Vocke, Cathy D and Wheeler, David A and Yang, Lixing and Yang, Ian and Yang, Ju Dong and Yang, Hannah and Yang, Liming and Kim, Jaegil and Kim, William Y and Robertson, A. Gordon and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Timothy and Wang, Linghua and Wang, Jioajiao and Wang, Min and Wang, Zhining and Wang, Jing and Zenklusen, Jean C and Zhang, Hailei and Zhang, Jiashan (Julia) and Zhang, Wei and Zhang, Hongxin and Zhang, Lizhi and Zhang, Jiexin and Zhang, Hongzheng and Chudamani, Sudha and Liu, Wenbin and Liu, Jia and Liu, Yuexin and Liu, Xiuping and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Sun, Yichao and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and Heiman, David I and Lawrence, Michael S and Lin, Pei and Meier, Sam and Noble, Michael S and Saksena, Gordon and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 1, pp. 313 - 326.e5
Journal Article
Cell Reports, ISSN 2211-1247, 07/2019, Volume 28, Issue 5, pp. 1370 - 1384.e5
The tumor suppressor gene is frequently mutated in human cancers. An analysis of five data platforms in 10,225 patient samples from 32 cancers reported by The... 
p53 signature | p53 signaling pathway | PanCanAtlas | chromosomal instability | p53 targets | TP53 | TP53 mutation | TCGA | p53 | The Cancer Genome Atlas | P53 MUTATIONS | TARGET | INSTABILITY | DATABASE | MUTANT P53 | TUMOR-SUPPRESSOR | CELL-CYCLE ARREST | NUMBER-NEUTRAL LOSS | HETEROZYGOSITY | EXPRESSION | CELL BIOLOGY | Life Sciences | Biochemistry, Molecular Biology | Genomics | Cancer
Journal Article