Journal of Gastroenterology and Hepatology, ISSN 0815-9319, 02/2019, Volume 34, Issue 2, pp. 346 - 354
Diabetes of the exocrine pancreas (DEP) is a form of diabetes that occurs due to pancreatic disease. It is far more common than has been previously considered,...
adenocarcinoma | diabetes mellitus | pancreatitis | cystic fibrosis | hemachromatosis | RISK | PREVALENCE | CANCER | INSULIN | MELLITUS SECONDARY | DISEASES | GLUCOSE-METABOLISM | CYSTIC-FIBROSIS | MUTATIONS | GASTROENTEROLOGY & HEPATOLOGY | Diabetes Mellitus - blood | Hypoglycemic Agents - therapeutic use | Predictive Value of Tests | Diagnosis, Differential | Humans | Pancreatic Diseases - diagnosis | Risk Factors | Diabetes Mellitus - drug therapy | Treatment Outcome | Biomarkers - blood | Insulin - blood | Pancreas, Exocrine - drug effects | Glucagon - blood | Pancreatic Diseases - epidemiology | Blood Glucose - drug effects | Animals | Pancreatic Polypeptide - blood | Diabetes Mellitus - epidemiology | Pancreas, Exocrine - metabolism | Diabetes Mellitus - diagnosis | Blood Glucose - metabolism | Insulin - therapeutic use | Type 2 diabetes | Hyperglycemia | Glucagon | Pancreatic cancer | Pancreatitis | Cystic fibrosis | Glucose | Dextrose | Hemochromatosis | Polypeptides | Secretion | Diabetes mellitus | Insulin | Patients | Pancreatic carcinoma | Pancreatic diseases | Ketoacidosis | Diabetes | Metformin | Islets of Langerhans | Pancreas | Diabetes mellitus (non-insulin dependent)
adenocarcinoma | diabetes mellitus | pancreatitis | cystic fibrosis | hemachromatosis | RISK | PREVALENCE | CANCER | INSULIN | MELLITUS SECONDARY | DISEASES | GLUCOSE-METABOLISM | CYSTIC-FIBROSIS | MUTATIONS | GASTROENTEROLOGY & HEPATOLOGY | Diabetes Mellitus - blood | Hypoglycemic Agents - therapeutic use | Predictive Value of Tests | Diagnosis, Differential | Humans | Pancreatic Diseases - diagnosis | Risk Factors | Diabetes Mellitus - drug therapy | Treatment Outcome | Biomarkers - blood | Insulin - blood | Pancreas, Exocrine - drug effects | Glucagon - blood | Pancreatic Diseases - epidemiology | Blood Glucose - drug effects | Animals | Pancreatic Polypeptide - blood | Diabetes Mellitus - epidemiology | Pancreas, Exocrine - metabolism | Diabetes Mellitus - diagnosis | Blood Glucose - metabolism | Insulin - therapeutic use | Type 2 diabetes | Hyperglycemia | Glucagon | Pancreatic cancer | Pancreatitis | Cystic fibrosis | Glucose | Dextrose | Hemochromatosis | Polypeptides | Secretion | Diabetes mellitus | Insulin | Patients | Pancreatic carcinoma | Pancreatic diseases | Ketoacidosis | Diabetes | Metformin | Islets of Langerhans | Pancreas | Diabetes mellitus (non-insulin dependent)
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 135, Issue 2, pp. 621 - 631.e8
Although both endocrine and the exocrine pancreas display a significant capacity for tissue regeneration and renewal, the existence of progenitor cells in the...
Gastroenterology and Hepatology | ACINAR-CELL | AXOLOTL TAIL REGENERATION | GROWTH-FACTOR-ALPHA | MOUSE | STEM-CELL | BETA-CELL | PROLIFERATION | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | CANCER | TRANSDIFFERENTIATION | Nestin | Cell Proliferation | Epithelial Cells - metabolism | Receptors, G-Protein-Coupled - metabolism | Epithelial Cells - drug effects | Pancreatic Ducts - drug effects | Pancreas, Exocrine - pathology | Hedgehog Proteins - metabolism | Pancreatic Ducts - pathology | Pancreas, Exocrine - drug effects | Stem Cells - metabolism | Pancreatic Ducts - metabolism | Time Factors | Smoothened Receptor | Veratrum Alkaloids - pharmacology | Cell Differentiation | Genes, Reporter | Disease Models, Animal | Mice, Inbred C57BL | Epithelial Cells - pathology | Mice, Transgenic | Pancreatic Elastase - metabolism | Pancreatitis - chemically induced | Cell Transformation, Neoplastic - metabolism | Nerve Tissue Proteins - metabolism | Metaplasia | Regeneration - drug effects | Animals | Signal Transduction - drug effects | Stem Cells - drug effects | Stem Cells - pathology | Pancreatitis - pathology | Mice | Pancreas, Exocrine - metabolism | Receptors, G-Protein-Coupled - genetics | Pancreatitis - metabolism | Ceruletide | Intermediate Filament Proteins - metabolism | Research | Pancreatic cancer | Analysis | Oncology, Experimental | Cancer | Index Medicus | Abridged Index Medicus
Gastroenterology and Hepatology | ACINAR-CELL | AXOLOTL TAIL REGENERATION | GROWTH-FACTOR-ALPHA | MOUSE | STEM-CELL | BETA-CELL | PROLIFERATION | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | CANCER | TRANSDIFFERENTIATION | Nestin | Cell Proliferation | Epithelial Cells - metabolism | Receptors, G-Protein-Coupled - metabolism | Epithelial Cells - drug effects | Pancreatic Ducts - drug effects | Pancreas, Exocrine - pathology | Hedgehog Proteins - metabolism | Pancreatic Ducts - pathology | Pancreas, Exocrine - drug effects | Stem Cells - metabolism | Pancreatic Ducts - metabolism | Time Factors | Smoothened Receptor | Veratrum Alkaloids - pharmacology | Cell Differentiation | Genes, Reporter | Disease Models, Animal | Mice, Inbred C57BL | Epithelial Cells - pathology | Mice, Transgenic | Pancreatic Elastase - metabolism | Pancreatitis - chemically induced | Cell Transformation, Neoplastic - metabolism | Nerve Tissue Proteins - metabolism | Metaplasia | Regeneration - drug effects | Animals | Signal Transduction - drug effects | Stem Cells - drug effects | Stem Cells - pathology | Pancreatitis - pathology | Mice | Pancreas, Exocrine - metabolism | Receptors, G-Protein-Coupled - genetics | Pancreatitis - metabolism | Ceruletide | Intermediate Filament Proteins - metabolism | Research | Pancreatic cancer | Analysis | Oncology, Experimental | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 12/2015, Volume 64, Issue 12, pp. 4123 - 4134
The exocrine pancreas can give rise to endocrine insulin-producing cells upon ectopic expression of key transcription factors. However, the need for genetic...
PROGENITOR CELLS | INSULIN | IN-VITRO | EMBRYONIC STEM-CELLS | MOUSE | ENDOCRINOLOGY & METABOLISM | OSTEOGENIC PROTEIN-1 | MESENCHYMAL TRANSITION | IDENTIFICATION | BETA-LIKE CELLS | EXPRESSION | C-Peptide - blood | Bone Morphogenetic Protein 7 - genetics | Homeodomain Proteins - metabolism | Humans | Pancreas, Exocrine - pathology | Male | Transplantation, Heterologous | Pancreas, Exocrine - drug effects | Diabetes Mellitus, Experimental - therapy | Kidney | Diabetes Mellitus, Experimental - blood | Insulin-Secreting Cells - metabolism | Cell Transdifferentiation - drug effects | Diabetes Mellitus, Experimental - metabolism | C-Peptide - metabolism | Insulin Secretion | Biomarkers - metabolism | Recombinant Proteins - metabolism | Cells, Cultured | Transplantation, Heterotopic | Recombinant Proteins - pharmacology | Cell Lineage | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Mice, Nude | Bone Morphogenetic Protein 7 - metabolism | Fluorescent Antibody Technique | Diabetes Mellitus, Experimental - pathology | Trans-Activators - metabolism | Pancreas, Exocrine - metabolism | Insulin-Secreting Cells - pathology | Bone Morphogenetic Protein 7 - pharmacology | Insulin-Secreting Cells - transplantation | Care and treatment | Analysis | Aging | Insulin resistance | Cystic fibrosis | Influence | Diabetes | Research | Islet Studies
PROGENITOR CELLS | INSULIN | IN-VITRO | EMBRYONIC STEM-CELLS | MOUSE | ENDOCRINOLOGY & METABOLISM | OSTEOGENIC PROTEIN-1 | MESENCHYMAL TRANSITION | IDENTIFICATION | BETA-LIKE CELLS | EXPRESSION | C-Peptide - blood | Bone Morphogenetic Protein 7 - genetics | Homeodomain Proteins - metabolism | Humans | Pancreas, Exocrine - pathology | Male | Transplantation, Heterologous | Pancreas, Exocrine - drug effects | Diabetes Mellitus, Experimental - therapy | Kidney | Diabetes Mellitus, Experimental - blood | Insulin-Secreting Cells - metabolism | Cell Transdifferentiation - drug effects | Diabetes Mellitus, Experimental - metabolism | C-Peptide - metabolism | Insulin Secretion | Biomarkers - metabolism | Recombinant Proteins - metabolism | Cells, Cultured | Transplantation, Heterotopic | Recombinant Proteins - pharmacology | Cell Lineage | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Mice, Nude | Bone Morphogenetic Protein 7 - metabolism | Fluorescent Antibody Technique | Diabetes Mellitus, Experimental - pathology | Trans-Activators - metabolism | Pancreas, Exocrine - metabolism | Insulin-Secreting Cells - pathology | Bone Morphogenetic Protein 7 - pharmacology | Insulin-Secreting Cells - transplantation | Care and treatment | Analysis | Aging | Insulin resistance | Cystic fibrosis | Influence | Diabetes | Research | Islet Studies
Journal Article
Diabetes, ISSN 0012-1797, 08/2013, Volume 62, Issue 8, pp. 2821 - 2833
Because of the lack of tissue available for islet transplantation, new sources of beta-cells have been sought for the treatment of type 1 diabetes. The aim of...
TRANSCRIPTION FACTORS | DIABETES-MELLITUS | EMBRYONIC STEM-CELLS | ISLET-LIKE CLUSTERS | ENDOCRINOLOGY & METABOLISM | GENERATION | DIFFERENTIATION | LINEAGE TRACING EVIDENCE | SECRETING CELLS | PRECURSOR CELLS | EXPANDED IN-VITRO | Epithelial-Mesenchymal Transition - physiology | Humans | Cells, Cultured | Glucose - pharmacology | Mice, SCID | Pancreas, Exocrine - drug effects | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | rho-Associated Kinases - metabolism | Mice, Inbred NOD | Mice | Pancreas, Exocrine - metabolism | Diabetes Mellitus, Experimental - metabolism | Cell Differentiation - physiology | Insulin Secretion | Original Research
TRANSCRIPTION FACTORS | DIABETES-MELLITUS | EMBRYONIC STEM-CELLS | ISLET-LIKE CLUSTERS | ENDOCRINOLOGY & METABOLISM | GENERATION | DIFFERENTIATION | LINEAGE TRACING EVIDENCE | SECRETING CELLS | PRECURSOR CELLS | EXPANDED IN-VITRO | Epithelial-Mesenchymal Transition - physiology | Humans | Cells, Cultured | Glucose - pharmacology | Mice, SCID | Pancreas, Exocrine - drug effects | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | rho-Associated Kinases - metabolism | Mice, Inbred NOD | Mice | Pancreas, Exocrine - metabolism | Diabetes Mellitus, Experimental - metabolism | Cell Differentiation - physiology | Insulin Secretion | Original Research
Journal Article
Diabetologia, ISSN 0012-186X, 11/2015, Volume 58, Issue 11, pp. 2582 - 2591
Lineage conversion of non-beta cells into insulin-producing cells has been proposed as a therapy for the cure of diabetes. Glucagon-like peptide-1 (GLP-1) and...
GLP-1 | Medicine & Public Health | Human Physiology | Beta cell neogenesis | GLP-1 receptor | Metabolic Diseases | Gastrin | Internal Medicine | DIABETIC NOD MICE | ISLET DIFFERENTIATION | MOUSE PANCREAS | COMBINATION THERAPY | INSULIN GENE-TRANSCRIPTION | GLP-1-BASED THERAPIES | GLUCAGON-LIKE PEPTIDE-1 | EPIDERMAL-GROWTH-FACTOR | ENDOCRINOLOGY & METABOLISM | RESTORES NORMOGLYCEMIA | AR42J CELLS | Glucagon-Like Peptide 1 - metabolism | Gastrins - metabolism | Pancreas, Exocrine - drug effects | Peptides - pharmacology | Cellular Reprogramming - drug effects | Glucagon-Like Peptide-1 Receptor - metabolism | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | Pancreas, Exocrine - cytology | Signal Transduction - drug effects | Signal Transduction - physiology | Insulin-Secreting Cells - cytology | Mice | Pancreas, Exocrine - metabolism | Venoms - pharmacology | Cellular Reprogramming - physiology | Dysplasia | Pancreatic beta cells | Sarcoma | Analysis | Pancreatitis | Cell differentiation
GLP-1 | Medicine & Public Health | Human Physiology | Beta cell neogenesis | GLP-1 receptor | Metabolic Diseases | Gastrin | Internal Medicine | DIABETIC NOD MICE | ISLET DIFFERENTIATION | MOUSE PANCREAS | COMBINATION THERAPY | INSULIN GENE-TRANSCRIPTION | GLP-1-BASED THERAPIES | GLUCAGON-LIKE PEPTIDE-1 | EPIDERMAL-GROWTH-FACTOR | ENDOCRINOLOGY & METABOLISM | RESTORES NORMOGLYCEMIA | AR42J CELLS | Glucagon-Like Peptide 1 - metabolism | Gastrins - metabolism | Pancreas, Exocrine - drug effects | Peptides - pharmacology | Cellular Reprogramming - drug effects | Glucagon-Like Peptide-1 Receptor - metabolism | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | Pancreas, Exocrine - cytology | Signal Transduction - drug effects | Signal Transduction - physiology | Insulin-Secreting Cells - cytology | Mice | Pancreas, Exocrine - metabolism | Venoms - pharmacology | Cellular Reprogramming - physiology | Dysplasia | Pancreatic beta cells | Sarcoma | Analysis | Pancreatitis | Cell differentiation
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 10/2008, Volume 28, Issue 20, pp. 6373 - 6383
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
MORPHOGENESIS | CHROMATIN-STRUCTURE | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CELLS | TRANSCRIPTION | VALPROIC ACID | GENERATION | ALPHA-CELL | DIFFERENTIATION | TRICHOSTATIN-A | CELL BIOLOGY | Islets of Langerhans - drug effects | Rats, Wistar | Apoptosis - drug effects | Pancreas - cytology | Pancreatic Ducts - drug effects | Stem Cells - cytology | Pancreas, Exocrine - drug effects | Cell Lineage - drug effects | Valproic Acid - pharmacology | Pancreatic Polypeptide-Secreting Cells - cytology | Pancreatic Ducts - enzymology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Pancreas, Exocrine - cytology | Islets of Langerhans - cytology | Female | Hydroxamic Acids - pharmacology | Pancreas - enzymology | Pancreatic Ducts - cytology | Islets of Langerhans - enzymology | Pancreatic Polypeptide-Secreting Cells - enzymology | Enzyme Inhibitors - pharmacology | Pancreas - drug effects | Rats | Pancreatic Polypeptide-Secreting Cells - drug effects | Down-Regulation - drug effects | Pancreas - embryology | Pancreas, Exocrine - enzymology | Nerve Tissue Proteins - metabolism | Animals | Cell Differentiation - drug effects | Stem Cells - drug effects | Cell Proliferation - drug effects | Histone Deacetylase Inhibitors
MORPHOGENESIS | CHROMATIN-STRUCTURE | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CELLS | TRANSCRIPTION | VALPROIC ACID | GENERATION | ALPHA-CELL | DIFFERENTIATION | TRICHOSTATIN-A | CELL BIOLOGY | Islets of Langerhans - drug effects | Rats, Wistar | Apoptosis - drug effects | Pancreas - cytology | Pancreatic Ducts - drug effects | Stem Cells - cytology | Pancreas, Exocrine - drug effects | Cell Lineage - drug effects | Valproic Acid - pharmacology | Pancreatic Polypeptide-Secreting Cells - cytology | Pancreatic Ducts - enzymology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Pancreas, Exocrine - cytology | Islets of Langerhans - cytology | Female | Hydroxamic Acids - pharmacology | Pancreas - enzymology | Pancreatic Ducts - cytology | Islets of Langerhans - enzymology | Pancreatic Polypeptide-Secreting Cells - enzymology | Enzyme Inhibitors - pharmacology | Pancreas - drug effects | Rats | Pancreatic Polypeptide-Secreting Cells - drug effects | Down-Regulation - drug effects | Pancreas - embryology | Pancreas, Exocrine - enzymology | Nerve Tissue Proteins - metabolism | Animals | Cell Differentiation - drug effects | Stem Cells - drug effects | Cell Proliferation - drug effects | Histone Deacetylase Inhibitors
Journal Article
Genes and Development, ISSN 0890-9369, 08/2011, Volume 25, Issue 16, pp. 1674 - 1679
We have determined the cistrome and transcriptome for the nuclear receptor liver receptor homolog-1 (LRH-1) in exocrine pancreas. Chromatin immunoprecipitation...
ChIP-seq | Digestive enzymes | LRH-1 | RNA-seq | PTF1-L | Exocrine pancreas | SUPPRESSOR | HOMEOSTASIS | COMPLEX | DEVELOPMENTAL BIOLOGY | IDENTIFICATION | NUCLEAR RECEPTOR | CELL BIOLOGY | LIVER RECEPTOR HOMOLOG-1 | GENE | DNA | GENETICS & HEREDITY | exocrine pancreas | RBP-L | EXPRESSION | digestive enzymes | Peptide Hydrolases - genetics | Humans | Molecular Sequence Data | Male | Gene Expression Profiling | Gene Regulatory Networks | Pancreas, Exocrine - drug effects | Chromatin Immunoprecipitation | Base Sequence | Female | Peptide Hydrolases - metabolism | Antineoplastic Agents, Hormonal - pharmacology | Mice, Transgenic | Receptors, Cytoplasmic and Nuclear - genetics | Lipase - metabolism | Transcription Factors - genetics | Down-Regulation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Sequence Homology, Amino Acid | Transcription Factors - metabolism | Animals | Tamoxifen - pharmacology | Mice | Pancreas, Exocrine - metabolism | Lipase - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Transcription factors | Chromatin | Usage | Analysis | Research | Chemical properties | Nucleotide sequencing | Gene expression | Structure | Research Communication
ChIP-seq | Digestive enzymes | LRH-1 | RNA-seq | PTF1-L | Exocrine pancreas | SUPPRESSOR | HOMEOSTASIS | COMPLEX | DEVELOPMENTAL BIOLOGY | IDENTIFICATION | NUCLEAR RECEPTOR | CELL BIOLOGY | LIVER RECEPTOR HOMOLOG-1 | GENE | DNA | GENETICS & HEREDITY | exocrine pancreas | RBP-L | EXPRESSION | digestive enzymes | Peptide Hydrolases - genetics | Humans | Molecular Sequence Data | Male | Gene Expression Profiling | Gene Regulatory Networks | Pancreas, Exocrine - drug effects | Chromatin Immunoprecipitation | Base Sequence | Female | Peptide Hydrolases - metabolism | Antineoplastic Agents, Hormonal - pharmacology | Mice, Transgenic | Receptors, Cytoplasmic and Nuclear - genetics | Lipase - metabolism | Transcription Factors - genetics | Down-Regulation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Sequence Homology, Amino Acid | Transcription Factors - metabolism | Animals | Tamoxifen - pharmacology | Mice | Pancreas, Exocrine - metabolism | Lipase - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Transcription factors | Chromatin | Usage | Analysis | Research | Chemical properties | Nucleotide sequencing | Gene expression | Structure | Research Communication
Journal Article
Diabetologia, ISSN 0012-186X, 1/2010, Volume 53, Issue 1, pp. 1 - 6
Type 2 diabetes | Glucagon-like peptide-1 | GLP-1 | Medicine & Public Health | Human Physiology | Pancreatic cancer | Metabolic Diseases | Pancreatitis | Internal Medicine | METFORMIN | DRUG SAFETY | HEREDITARY PANCREATITIS | EXENATIDE | SITAGLIPTIN | RISK | MECHANISMS | GENE | ENDOCRINOLOGY & METABOLISM | MUTATIONS | EXPRESSION | United States | Humans | Pancreatic Ducts - drug effects | Rats | Pancreatic Ducts - pathology | Pancreatitis, Chronic - physiopathology | Pancreatitis - drug therapy | Pancreas, Exocrine - drug effects | Animals | Pancreatitis, Chronic - drug therapy | Hyperplasia - drug therapy | United States Food and Drug Administration | Disease Models, Animal | Glucagon-Like Peptide 1 - therapeutic use | Research | Peptides | Oncology, Experimental | Cancer
Journal Article
HPB, ISSN 1365-182X, 2016, Volume 18, Issue 4, pp. 360 - 366
Abstract Background Long-term incidence of endocrine and exocrine insufficiency after pancreatectomy is poorly described. We analyze the long-term risks of...
Gastroenterology and Hepatology | Islets of Langerhans - drug effects | Humans | Middle Aged | Pancreas, Exocrine - pathology | Male | Islets of Langerhans - surgery | Exocrine Pancreatic Insufficiency - diagnosis | Pancreas, Exocrine - surgery | Pancreas, Exocrine - drug effects | Pancreaticoduodenectomy - adverse effects | Young Adult | Exocrine Pancreatic Insufficiency - physiopathology | Time Factors | Chemotherapy, Adjuvant - adverse effects | Radiotherapy, Adjuvant - adverse effects | Aged, 80 and over | Islets of Langerhans - physiopathology | Adult | Female | Retrospective Studies | Databases, Factual | Hypoglycemic Agents - therapeutic use | Pancreatectomy - adverse effects | Islets of Langerhans - pathology | Exocrine Pancreatic Insufficiency - drug therapy | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - surgery | Risk Factors | Treatment Outcome | Exocrine Pancreatic Insufficiency - etiology | Aged | Pancreas, Exocrine - physiopathology | Original
Gastroenterology and Hepatology | Islets of Langerhans - drug effects | Humans | Middle Aged | Pancreas, Exocrine - pathology | Male | Islets of Langerhans - surgery | Exocrine Pancreatic Insufficiency - diagnosis | Pancreas, Exocrine - surgery | Pancreas, Exocrine - drug effects | Pancreaticoduodenectomy - adverse effects | Young Adult | Exocrine Pancreatic Insufficiency - physiopathology | Time Factors | Chemotherapy, Adjuvant - adverse effects | Radiotherapy, Adjuvant - adverse effects | Aged, 80 and over | Islets of Langerhans - physiopathology | Adult | Female | Retrospective Studies | Databases, Factual | Hypoglycemic Agents - therapeutic use | Pancreatectomy - adverse effects | Islets of Langerhans - pathology | Exocrine Pancreatic Insufficiency - drug therapy | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - surgery | Risk Factors | Treatment Outcome | Exocrine Pancreatic Insufficiency - etiology | Aged | Pancreas, Exocrine - physiopathology | Original
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 2015, Volume 118, Issue 3, pp. 535 - 539
Abstract Background and purpose The pancreas is located almost entirely within the treatment area for radiotherapy of gastric cancer. The aim of this study was...
Hematology, Oncology and Palliative Medicine | Hypoamylasemia | Hypolipasemia | Radiation induced pancreas injury | Pancreas | Radiotherapy | Gastric cancer | ABDOMINAL RADIOTHERAPY | VOLUME | INTRAOPERATIVE IRRADIATION | RISK | ADJUVANT | DIABETES-MELLITUS | RESERVE | ONCOLOGY | SURVIVORS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Stomach Neoplasms - radiotherapy | Chemoradiotherapy - adverse effects | Exocrine Pancreatic Insufficiency - chemically induced | Radiation Injuries - chemically induced | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Pancreas, Exocrine - radiation effects | Male | Stomach Neoplasms - drug therapy | Pancreas, Exocrine - drug effects | Radiation Injuries - etiology | Fluorouracil - administration & dosage | Exocrine Pancreatic Insufficiency - etiology | Fluorouracil - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adult | Female | Aged | Care and treatment | Stomach cancer | Pancreatic cancer | Analysis | Radiation | Cancer
Hematology, Oncology and Palliative Medicine | Hypoamylasemia | Hypolipasemia | Radiation induced pancreas injury | Pancreas | Radiotherapy | Gastric cancer | ABDOMINAL RADIOTHERAPY | VOLUME | INTRAOPERATIVE IRRADIATION | RISK | ADJUVANT | DIABETES-MELLITUS | RESERVE | ONCOLOGY | SURVIVORS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Stomach Neoplasms - radiotherapy | Chemoradiotherapy - adverse effects | Exocrine Pancreatic Insufficiency - chemically induced | Radiation Injuries - chemically induced | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Pancreas, Exocrine - radiation effects | Male | Stomach Neoplasms - drug therapy | Pancreas, Exocrine - drug effects | Radiation Injuries - etiology | Fluorouracil - administration & dosage | Exocrine Pancreatic Insufficiency - etiology | Fluorouracil - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adult | Female | Aged | Care and treatment | Stomach cancer | Pancreatic cancer | Analysis | Radiation | Cancer
Journal Article
Gastroenterology, ISSN 0016-5085, 2010, Volume 138, Issue 5, pp. 1988 - 1996.e3
Background & Aims Corticosteroids are now widely accepted as a treatment for autoimmune pancreatitis (AIP). However, the molecular mechanism by which steroid...
Gastroenterology and Hepatology | Aquaporin Water Channel | Exocrine Function Test | CFTR | CD133 | ADENOCARCINOMAS | EXOCRINE FUNCTION | TRANSMEMBRANE CONDUCTANCE REGULATOR | DEPENDENT HCO3-TRANSPORT | STEROID-THERAPY | MUTATIONS | DIAGNOSTIC-CRITERIA | GASTROENTEROLOGY & HEPATOLOGY | IDIOPATHIC CHRONIC-PANCREATITIS | EXPRESSION | CYSTIC-FIBROSIS GENE | Humans | Middle Aged | Pancreatic Ducts - drug effects | Glycoproteins - metabolism | Male | Pancreatic Ducts - immunology | Pancreatitis - drug therapy | Adrenal Cortex Hormones - therapeutic use | Pancreas, Exocrine - drug effects | Aquaporin 1 - metabolism | Pancreatic Ducts - metabolism | Antigens, CD - metabolism | Plasma Cells - drug effects | Peptides - metabolism | Time Factors | Pancreatitis - immunology | Adult | Female | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Pancreas, Exocrine - immunology | Pancreatic Juice - enzymology | Autoimmune Diseases - immunology | Treatment Outcome | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | AC133 Antigen | Protein Transport | Regeneration - drug effects | Fibrosis | Bicarbonates - metabolism | Aged | Pancreas, Exocrine - metabolism | Pancreatitis - metabolism | Immunoglobulin G - metabolism | Plasma Cells - immunology | Cell research | Corticosteroids | Aquaporins | Pancreatitis | Cystic fibrosis | Universities and colleges | Histochemistry
Gastroenterology and Hepatology | Aquaporin Water Channel | Exocrine Function Test | CFTR | CD133 | ADENOCARCINOMAS | EXOCRINE FUNCTION | TRANSMEMBRANE CONDUCTANCE REGULATOR | DEPENDENT HCO3-TRANSPORT | STEROID-THERAPY | MUTATIONS | DIAGNOSTIC-CRITERIA | GASTROENTEROLOGY & HEPATOLOGY | IDIOPATHIC CHRONIC-PANCREATITIS | EXPRESSION | CYSTIC-FIBROSIS GENE | Humans | Middle Aged | Pancreatic Ducts - drug effects | Glycoproteins - metabolism | Male | Pancreatic Ducts - immunology | Pancreatitis - drug therapy | Adrenal Cortex Hormones - therapeutic use | Pancreas, Exocrine - drug effects | Aquaporin 1 - metabolism | Pancreatic Ducts - metabolism | Antigens, CD - metabolism | Plasma Cells - drug effects | Peptides - metabolism | Time Factors | Pancreatitis - immunology | Adult | Female | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Pancreas, Exocrine - immunology | Pancreatic Juice - enzymology | Autoimmune Diseases - immunology | Treatment Outcome | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | AC133 Antigen | Protein Transport | Regeneration - drug effects | Fibrosis | Bicarbonates - metabolism | Aged | Pancreas, Exocrine - metabolism | Pancreatitis - metabolism | Immunoglobulin G - metabolism | Plasma Cells - immunology | Cell research | Corticosteroids | Aquaporins | Pancreatitis | Cystic fibrosis | Universities and colleges | Histochemistry
Journal Article
Experimental Cell Research, ISSN 0014-4827, 12/2015, Volume 339, Issue 2, pp. 397 - 406
Exocrine pancreas acinar cells have a highly developed endoplasmic reticulum (ER), accommodating their high protein production rate. Overload of dietary fat...
ER stress | Fatty acids | Exocrine pancreas | CELLS | CHOLESTEROL | INDUCED APOPTOSIS | DEATH | ENDOPLASMIC-RETICULUM STRESS | PALMITATE | BETA | CELL BIOLOGY | UNFOLDED PROTEIN RESPONSE | ONCOLOGY | SIGNALING PATHWAY | BINDING | Fatty Acids - chemistry | Endoplasmic Reticulum Stress - drug effects | Pancreas, Exocrine - pathology | Endoplasmic Reticulum - metabolism | Rats | Structure-Activity Relationship | Pancreas, Exocrine - drug effects | Dose-Response Relationship, Drug | Animals | Endoplasmic Reticulum - drug effects | Pancreas, Exocrine - metabolism | Tumor Cells, Cultured | Fatty Acids - pharmacology | Monounsaturated fatty acids | Pancreatic cancer | Pancreatitis | Dietary fat | Stress (Physiology) | Triglycerides | Transforming growth factors | Saturated fatty acids | Protein binding | Oxidative stress | Diet | Cellular biology | Pancreas | TRANSLOCATION | NEOPLASMS | ECOLOGICAL CONCENTRATION | BUILDUP | PANCREAS | TRIGLYCERIDES | HEXADECANOIC ACID | 60 APPLIED LIFE SCIENCES | CELL NUCLEI | CONCENTRATION RATIO | DIGESTIVE SYSTEM DISEASES | ABUNDANCE | SPLICING | ENDOPLASMIC RETICULUM | OLEIC ACID | DOSES | ACUTE EXPOSURE | FATS | METABOLIC DISEASES | PROTEINS | TIME DEPENDENCE | HAZARDS
ER stress | Fatty acids | Exocrine pancreas | CELLS | CHOLESTEROL | INDUCED APOPTOSIS | DEATH | ENDOPLASMIC-RETICULUM STRESS | PALMITATE | BETA | CELL BIOLOGY | UNFOLDED PROTEIN RESPONSE | ONCOLOGY | SIGNALING PATHWAY | BINDING | Fatty Acids - chemistry | Endoplasmic Reticulum Stress - drug effects | Pancreas, Exocrine - pathology | Endoplasmic Reticulum - metabolism | Rats | Structure-Activity Relationship | Pancreas, Exocrine - drug effects | Dose-Response Relationship, Drug | Animals | Endoplasmic Reticulum - drug effects | Pancreas, Exocrine - metabolism | Tumor Cells, Cultured | Fatty Acids - pharmacology | Monounsaturated fatty acids | Pancreatic cancer | Pancreatitis | Dietary fat | Stress (Physiology) | Triglycerides | Transforming growth factors | Saturated fatty acids | Protein binding | Oxidative stress | Diet | Cellular biology | Pancreas | TRANSLOCATION | NEOPLASMS | ECOLOGICAL CONCENTRATION | BUILDUP | PANCREAS | TRIGLYCERIDES | HEXADECANOIC ACID | 60 APPLIED LIFE SCIENCES | CELL NUCLEI | CONCENTRATION RATIO | DIGESTIVE SYSTEM DISEASES | ABUNDANCE | SPLICING | ENDOPLASMIC RETICULUM | OLEIC ACID | DOSES | ACUTE EXPOSURE | FATS | METABOLIC DISEASES | PROTEINS | TIME DEPENDENCE | HAZARDS
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 11/2012, Volume 53, Issue 11, pp. 1755 - 1763
Determination of the residual β-cell mass using noninvasive tools might help to follow up the efficacy of new treatments in both type 1 (insulin-dependent) and...
Beta cells | C]HTP | Serotonin pathway | PET imaging | Exocrine pancreas | Binding, Competitive | Radioactive Tracers | Humans | Pancreas, Exocrine - diagnostic imaging | Enzyme Inhibitors - pharmacology | Rats | Male | 5-Hydroxytryptophan - pharmacokinetics | Positron-Emission Tomography | Pancreas, Exocrine - drug effects | Insulin-Secreting Cells - diagnostic imaging | Autoradiography | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | Cell Line, Tumor | Biological Transport - drug effects | Pancreas, Exocrine - metabolism | 5-Hydroxytryptophan - metabolism | Carbon Radioisotopes
Beta cells | C]HTP | Serotonin pathway | PET imaging | Exocrine pancreas | Binding, Competitive | Radioactive Tracers | Humans | Pancreas, Exocrine - diagnostic imaging | Enzyme Inhibitors - pharmacology | Rats | Male | 5-Hydroxytryptophan - pharmacokinetics | Positron-Emission Tomography | Pancreas, Exocrine - drug effects | Insulin-Secreting Cells - diagnostic imaging | Autoradiography | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | Cell Line, Tumor | Biological Transport - drug effects | Pancreas, Exocrine - metabolism | 5-Hydroxytryptophan - metabolism | Carbon Radioisotopes
Journal Article
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Full Text
Metformin improves immunosuppressant induced hyperglycemia and exocrine apoptosis in rats
Transplantation, ISSN 0041-1337, 01/2013, Volume 95, Issue 2, pp. 280 - 284
Background. Immunosuppressants are an important cause of posttransplantation diabetes mellitus. We have shown that tacrolimus and sirolimus induce...
Immunosuppression |
Immunosuppression |