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1. Full Text Angiogenesis in Synchronous and Metachronous Colorectal Liver Metastases The Liver as a Permissive Soil
by van der Wal, Gesiena E and Gouw, Annette S. H and Kamps, Jan A. A. M and Moorlag, Henk E and Bulthuis, Marian L. C and Molema, Grietje and de Jong, Koert P
Annals of surgery, ISSN 0003-4932, 01/2012, Volume 255, Issue 1, pp. 86 - 94
CELLS | CANCER-PATIENTS | BILIARY TREE | TRANSENDOTHELIAL MIGRATION | PREMETASTATIC NICHE | E-SELECTIN | TUMOR DORMANCY | HUMAN HEPATOCELLULAR-CARCINOMA | EXPRESSION | UMCG Approved | ENDOTHELIAL GROWTH-FACTOR | Life Sciences & Biomedicine | Surgery | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | General aspects | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Biological and medical sciences | Medical sciences | Tumors | Neoplasms, Multiple Primary - surgery | Colorectal Neoplasms - surgery | Liver - pathology | Cell Proliferation | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Prognosis | Humans | Middle Aged | Apoptosis - genetics | Male | Neoplasms, Second Primary - surgery | Vascular Endothelial Growth Factor A - genetics | Neovascularization, Pathologic - pathology | Vascular Endothelial Growth Factor Receptor-2 - genetics | Adult | Female | Neoplasms, Second Primary - genetics | Liver Neoplasms - secondary | Real-Time Polymerase Chain Reaction | Gene Expression Regulation, Neoplastic - genetics | Neoplasms, Second Primary - blood supply | Neoplasms, Multiple Primary - genetics | Colorectal Neoplasms - blood supply | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Membrane Proteins - genetics | Ribonuclease, Pancreatic - genetics | Liver Neoplasms - surgery | Neoplasms, Multiple Primary - secondary | Neoplasms, Multiple Primary - pathology | Disease Progression | Neoplasms, Second Primary - secondary | Liver - blood supply | Liver Neoplasms - blood supply | Neovascularization, Pathologic - genetics | Aged | Neoplasms, Multiple Primary - blood supply | Colorectal Neoplasms - pathology | Neoplasms, Second Primary - pathology | Index Medicus | Abridged Index Medicus
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2. Full Text Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling
by Allen, Elizabeth and Miéville, Pascal and Warren, Carmen M and Saghafinia, Sadegh and Li, Leanne and Peng, Mei-Wen and Hanahan, Douglas
Cell reports (Cambridge), ISSN 2211-1247, 05/2016, Volume 15, Issue 6, pp. 1144 - 1160
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Pancreatic Neoplasms - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Pancreatic Neoplasms - blood supply | Glutamine - metabolism | Stomach Neoplasms - metabolism | Glycolysis - drug effects | Stomach Neoplasms - blood supply | Pancreatic Neoplasms - drug therapy | Angiogenesis Inhibitors - therapeutic use | Indoles - pharmacology | Membrane Transport Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Imidazoles - therapeutic use | Pyrroles - therapeutic use | Neuroendocrine Tumors - metabolism | Intestinal Neoplasms - metabolism | Lactic Acid - metabolism | Angiogenesis Inhibitors - pharmacology | Imidazoles - pharmacology | Stomach Neoplasms - drug therapy | Sirolimus - pharmacology | Indazoles - pharmacology | Up-Regulation - drug effects | Pyrroles - pharmacology | Animals | Signal Transduction - drug effects | Models, Biological | Cell Line, Tumor | Glucose - metabolism | Neuroendocrine Tumors - drug therapy | Indoles - therapeutic use | Mice | Intestinal Neoplasms - drug therapy | Indazoles - therapeutic use | Neuroendocrine Tumors - blood supply | Drug Resistance, Neoplasm - drug effects | Intestinal Neoplasms - blood supply | Index Medicus
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3. Full Text Vascular and pharmacokinetic effects of EndoTAG-1 in patients with advanced cancer and liver metastasis
by Fasol, U and Frost, A and Büchert, M and Arends, J and Fiedler, U and Scharr, D and Scheuenpflug, J and Mross, K
Annals of oncology, ISSN 0923-7534, 04/2012, Volume 23, Issue 4, pp. 1030 - 1036
EndoTAG-1 | contrast-enhanced ultrasound (CEUS) | liver metastasis | pharmacokinetic profile | DCE-MRI | angiogenesis | Angiogenesis | Contrast-enhanced ultrasound (CEUS) | Pharmacokinetic profile | Liver metastasis | Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | Paclitaxel - pharmacology | Area Under Curve | Humans | Middle Aged | Angiotensin II - blood | Magnetic Resonance Imaging - methods | Male | Paclitaxel - pharmacokinetics | Pancreatic Neoplasms - drug therapy | Colorectal Neoplasms - drug therapy | Ultrasonography | Angiogenesis Inhibitors - therapeutic use | Adult | Female | Liver Neoplasms - secondary | Pancreatic Neoplasms - blood | Colorectal Neoplasms - blood supply | Interleukins - blood | Pancreatic Neoplasms - pathology | Liver Neoplasms - drug therapy | Vascular Endothelial Growth Factor A - blood | Angiogenesis Inhibitors - pharmacology | Angiogenesis Inhibitors - pharmacokinetics | Breast Neoplasms - drug therapy | Liver Neoplasms - diagnostic imaging | Paclitaxel - therapeutic use | Endothelin-1 - blood | Contrast Media | Liver Neoplasms - blood supply | Breast Neoplasms - pathology | Breast Neoplasms - blood | Aged | Liposomes | Colorectal Neoplasms - pathology | Index Medicus
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4. FIRST EXPERIENCE OF APPLICATION OF TECHNOLOGY OF A TWO-STREAM LOW-FREQUENCY ULTRASOUND TECHNOLOGY IN ABDOMINAL SURGERY
by Lifshits, Yu Z and Babayev, E and Afremov, M and Valetskiy, V L and Grigoruk, A V and Omelchenko, A N
Klinična hìrurgìâ (Kiïv), ISSN 0023-2130, 09/2015, Issue 9, p. 29
Adrenal Gland Neoplasms - surgery | Blood Vessels - pathology | Humans | Pancreatic Neoplasms - blood supply | Abdominal Cavity - pathology | Ultrasonic Surgical Procedures - methods | Blood Vessels - radiation effects | Kidney Neoplasms - surgery | Neoplasm Metastasis | Pelvic Neoplasms - blood supply | Liver Neoplasms - pathology | Abdominal Cavity - blood supply | Adrenal Gland Neoplasms - pathology | Pelvic Neoplasms - pathology | Splenic Neoplasms - blood supply | Intestinal Neoplasms - surgery | Ultrasonic Surgical Procedures - instrumentation | Pelvic Neoplasms - surgery | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - surgery | Pseudomonas aeruginosa - radiation effects | Liver Neoplasms - surgery | Ultrasonic Therapy - methods | Intestinal Neoplasms - pathology | Splenic Neoplasms - surgery | Splenic Neoplasms - pathology | Liver Neoplasms - blood supply | Microcirculation - radiation effects | Adrenal Gland Neoplasms - blood supply | Kidney Neoplasms - pathology | Abdominal Cavity - surgery | Ultrasonic Therapy - instrumentation | Pseudomonas aeruginosa - ultrastructure | Kidney Neoplasms - blood supply | Intestinal Neoplasms - blood supply
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5. Full Text Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
by Chauhan, Vikash P and Martin, John D and Liu, Hao and Lacorre, Delphine A and Jain, Saloni R and Kozin, Sergey V and Stylianopoulos, Triantafyllos and Mousa, Ahmed S and Han, Xiaoxing and Adstamongkonkul, Pichet and Popović, Zoran and Huang, Peigen and Bawendi, Moungi G and Boucher, Yves and Jain, Rakesh K
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2516 - 2516
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Stromal Cells - pathology | Humans | Pancreatic Neoplasms - blood supply | Transforming Growth Factor beta1 - metabolism | Gene Expression Regulation, Neoplastic | Stress, Mechanical | Angiotensin II Type 1 Receptor Blockers - pharmacology | Cell Hypoxia | Pancreatic Neoplasms - drug therapy | Receptor, Angiotensin, Type 1 - genetics | Mammary Neoplasms, Experimental - pathology | Stromal Cells - drug effects | Angiotensins - metabolism | Female | Mammary Neoplasms, Experimental - blood supply | Antineoplastic Agents - pharmacology | Mammary Neoplasms, Experimental - drug therapy | Angiotensins - antagonists & inhibitors | Endothelin-1 - genetics | Endothelin-1 - metabolism | Pancreatic Neoplasms - pathology | Stromal Cells - metabolism | Losartan - pharmacology | Transforming Growth Factor beta1 - genetics | Drug Repositioning | Drug Synergism | Collagen - metabolism | Mechanotransduction, Cellular | Animals | Hyaluronic Acid - metabolism | Receptor, Angiotensin, Type 1 - metabolism | Connective Tissue Growth Factor - genetics | Fluorouracil - pharmacology | Mice | Connective Tissue Growth Factor - metabolism | Index Medicus
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6. Full Text Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice
by Maione, Federica and Capano, Stefania and Regano, Donatella and Zentilin, Lorena and Giacca, Mauro and Casanovas, Oriol and Bussolino, Federico and Serini, Guido and Giraudo, Enrico
The Journal of clinical investigation, ISSN 0021-9738, 05/2012, Volume 122, Issue 5, pp. 1832 - 1848
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Proto-Oncogene Proteins c-met - metabolism | Genetic Therapy | Pancreatic Neoplasms - metabolism | Uterine Cervical Neoplasms - blood supply | Pancreatic Neoplasms - blood supply | Drug Resistance, Neoplasm | NF-kappa B - metabolism | Uterine Cervical Neoplasms - pathology | Recombinant Proteins - biosynthesis | Semaphorin-3A - biosynthesis | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Pericytes - pathology | Epithelial-Mesenchymal Transition | Angiogenesis Inhibitors - therapeutic use | Female | Indoles - pharmacology | Liver Neoplasms - secondary | Pyrroles - therapeutic use | Uterine Cervical Neoplasms - therapy | Semaphorin-3A - genetics | Neuroendocrine Tumors - pathology | Cell Hypoxia - drug effects | Neoplasm Invasiveness | Neuroendocrine Tumors - metabolism | Pancreatic Neoplasms - pathology | Angiogenesis Inhibitors - pharmacology | Mice, Transgenic | Combined Modality Therapy | Lymphatic Metastasis | Recombinant Proteins - genetics | Tumor Burden | Pyrroles - pharmacology | Animals | Uterine Cervical Neoplasms - virology | Indoles - therapeutic use | Mice | Neuroendocrine Tumors - therapy | Neovascularization, Physiologic | Neuroendocrine Tumors - blood supply | Pancreatic Neoplasms - therapy | Research | Angiogenesis inhibitors | Semaphorins | Cancer cells | Index Medicus | Abridged Index Medicus
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7. Full Text Tumor angiogenic marker expression levels during tumor growth: Longitudinal assessment with molecularly targeted microbubbles and US imaging
by Deshpande, Nirupama and Ren, Ying and Foygel, Kira and Rosenberg, Jarrett and Willmann, Jürgen K
Radiology, ISSN 0033-8419, 03/2011, Volume 258, Issue 3, pp. 804 - 811
Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Ultrasonic investigative techniques | Biological and medical sciences | Investigative techniques, diagnostic techniques (general aspects) | Medical sciences | Miscellaneous. Technology | Pancreatic Neoplasms - metabolism | Humans | Pancreatic Neoplasms - blood supply | Intracellular Signaling Peptides and Proteins - metabolism | Mammary Neoplasms, Experimental - metabolism | Integrins - metabolism | Neovascularization, Pathologic - diagnostic imaging | Ovarian Neoplasms - diagnostic imaging | Endoglin | Flow Cytometry | Statistics, Nonparametric | Ultrasonography | Biomarkers, Tumor - metabolism | Microbubbles | Female | Mammary Neoplasms, Experimental - blood supply | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - blood supply | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mammary Neoplasms, Experimental - diagnostic imaging | Animals | Image Processing, Computer-Assisted | Contrast Media - metabolism | Mice | Pancreatic Neoplasms - diagnostic imaging | Index Medicus | Abridged Index Medicus | Original Research | 31
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8. Full Text Vascularity and Tumor Size are Significant Predictors for Recurrence after Resection of a Pancreatic Neuroendocrine Tumor
by Yamamoto, Yusuke and Okamura, Yukiyasu and Uemura, Sunao and Sugiura, Teiichi and Ito, Takaaki and Ashida, Ryo and Kato, Yoshiyasu and Ohgi, Katsuhisa and Yamada, Mihoko and Sasaki, Keiko and Aramaki, Takeshi and Uesaka, Katsuhiko
Annals of surgical oncology, ISSN 1068-9265, 08/2017, Volume 24, Issue 8, pp. 2363 - 2370
Oncology | Life Sciences & Biomedicine | Surgery | Science & Technology | Prognosis | Follow-Up Studies | Humans | Pancreatic Neoplasms - blood supply | Tomography, X-Ray Computed - methods | Male | Neoplasm Recurrence, Local - pathology | Neoplasm Recurrence, Local - diagnostic imaging | Neuroendocrine Tumors - diagnostic imaging | Female | Liver Neoplasms - secondary | Neuroendocrine Tumors - pathology | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - surgery | Pancreatectomy | Liver Neoplasms - surgery | Survival Rate | Lymphatic Metastasis | Liver Neoplasms - diagnostic imaging | Liver Neoplasms - blood supply | Neuroendocrine Tumors - surgery | Aged | Neuroendocrine Tumors - blood supply | Pancreatic Neoplasms - diagnostic imaging | Development and progression | Analysis | Tumors | Index Medicus
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9. Full Text Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
by Kenneth P. Olive and Michael A. Jacobetz and Christian J. Davidson and Aarthi Gopinathan and Dominick McIntyre and Davina Honess and Basetti Madhu and Mae A. Goldgraben and Meredith E. Caldwell and David Allard and Kristopher K. Frese and Gina DeNicola and Christine Feig and Chelsea Combs and Stephen P. Winter and Heather Ireland-Zecchini and Stefanie Reichelt and William J. Howat and Alex Chang and Mousumi Dhara and Lifu Wang and Felix Rückert and Robert Grützmann and Christian Pilarsky and Kamel Izeradjene and Sunil R. Hingorani and Pearl Huang and Susan E. Davies and William Plunkett and Merrill Egorin and Ralph H. Hruban and Nigel Whitebread and Karen McGovern and Julian Adams and Christine Iacobuzio-Donahue and John Griffiths and David A. Tuveson
Science (American Association for the Advancement of Science), ISSN 0036-8075, 6/2009, Volume 324, Issue 5933, pp. 1457 - 1461
Patent ductus arteriosus | Half lives | Perfusion | Antineoplastics | Ultrasonography | Blood vessels | Reports | Tissue transplantation | Pancreatic neoplasms | Tumors | Apoptosis | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Chemotherapy | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Animal tumors. Experimental tumors | Experimental tumors, general aspects | Antineoplastic agents | Veratrum Alkaloids - administration & dosage | Neoplasm Transplantation | Pancreatic Neoplasms - metabolism | Receptors, G-Protein-Coupled - metabolism | Apoptosis - drug effects | Stromal Cells - pathology | Veratrum Alkaloids - pharmacokinetics | Humans | Pancreatic Neoplasms - blood supply | Carcinoma, Pancreatic Ductal - metabolism | Neovascularization, Pathologic | Hedgehog Proteins - metabolism | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - metabolism | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Deoxycytidine - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Stromal Cells - drug effects | Disease Models, Animal | Veratrum Alkaloids - therapeutic use | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - pathology | Antineoplastic Combined Chemotherapy Protocols | Hedgehog Proteins - antagonists & inhibitors | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Signal Transduction - drug effects | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Zinc Finger Protein GLI1 | Carcinoma, Pancreatic Ductal - blood supply | Deoxycytidine - analogs & derivatives | Care and treatment | Pancreatic cancer | Physiological aspects | Cellular signal transduction | Health aspects | Cancer | Proteins | Signal transduction | Cellular biology | Rodents | Index Medicus
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10. Full Text A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts
by Nobis, Max and Herrmann, David and Warren, Sean C and Kadir, Shereen and Leung, Wilfred and Killen, Monica and Magenau, Astrid and Stevenson, David and Lucas, Morghan C and Reischmann, Nadine and Vennin, Claire and Conway, James R.W and Boulghourjian, Alice and Zaratzian, Anaiis and Law, Andrew M and Gallego-Ortega, David and Ormandy, Christopher J and Walters, Stacey N and Grey, Shane T and Bailey, Jacqueline and Chtanova, Tatyana and Quinn, Julian M.W and Baldock, Paul A and Croucher, Peter I and Schwarz, Juliane P and Mrowinska, Agata and Zhang, Lei and Herzog, Herbert and Masedunskas, Andrius and Hardeman, Edna C and Gunning, Peter W and del Monte-Nieto, Gonzalo and Harvey, Richard P and Samuel, Michael S and Pajic, Marina and McGhee, Ewan J and Johnsson, Anna-Karin E and Sansom, Owen J and Welch, Heidi C.E and Morton, Jennifer P and Strathdee, Douglas and Anderson, Kurt I and Timpson, Paul
Cell reports (Cambridge), ISSN 2211-1247, 10/2017, Volume 21, Issue 1, pp. 274 - 288
pancreatic cancer | actin | development | cell biology | FLIM-FRET | breast cancer | small GTPase RhoA | biosensors | intravital imaging | immunology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Intestine, Small - ultrastructure | Mammary Neoplasms, Experimental - ultrastructure | Fluorescence Resonance Energy Transfer - instrumentation | Pancreatic Neoplasms - blood supply | Neutrophils - ultrastructure | Intravital Microscopy - methods | Mammary Glands, Animal - blood supply | Mammary Neoplasms, Experimental - genetics | Osteocytes - ultrastructure | Pancreatic Neoplasms - drug therapy | Time-Lapse Imaging - instrumentation | Bone and Bones - metabolism | Intravital Microscopy - instrumentation | Female | Mammary Neoplasms, Experimental - blood supply | Time-Lapse Imaging - methods | Antineoplastic Agents - pharmacology | Neutrophils - metabolism | Bone and Bones - cytology | Mammary Neoplasms, Experimental - drug therapy | Osteocytes - metabolism | rho GTP-Binding Proteins - genetics | Gene Expression Regulation | Pancreatic Neoplasms - ultrastructure | Mice, Transgenic | Pancreatic Neoplasms - genetics | Mammary Glands, Animal - drug effects | Dasatinib - pharmacology | Cell Movement - drug effects | Mammary Glands, Animal - ultrastructure | Mechanotransduction, Cellular | Animals | Erlotinib Hydrochloride - pharmacology | rho GTP-Binding Proteins - metabolism | Biosensing Techniques | Fluorescence Resonance Energy Transfer - methods | Mice | Intestine, Small - metabolism | Index Medicus
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