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Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2516 - 2516
Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial... 
INTERSTITIAL FLUID PRESSURE | BREAST-CANCER | GROWTH-FACTOR-BETA | PANCREATIC STELLATE CELLS | TGF-BETA | AORTIC-ANEURYSM | SOLID STRESS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | GENE-EXPRESSION | II TYPE-2 RECEPTOR | Index Medicus
Journal Article
Cell Reports, ISSN 2211-1247, 05/2016, Volume 15, Issue 6, pp. 1144 - 1160
Journal Article
Science, ISSN 0036-8075, 6/2009, Volume 324, Issue 5933, pp. 1457 - 1461
Pancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers in part because it is insensitive to many chemotherapeutic drugs. Studying a... 
Patent ductus arteriosus | Half lives | Perfusion | Antineoplastics | Ultrasonography | Blood vessels | Reports | Tissue transplantation | Pancreatic neoplasms | Tumors | Apoptosis | SURVIVAL | TRIAL | DIAGNOSIS | METASTASIS | THERAPY | DUCTAL ADENOCARCINOMA | SONIC HEDGEHOG | MULTIDISCIPLINARY SCIENCES | GROWTH | TUMORS | GEMCITABINE | Veratrum Alkaloids - administration & dosage | Neoplasm Transplantation | Pancreatic Neoplasms - metabolism | Receptors, G-Protein-Coupled - metabolism | Apoptosis - drug effects | Stromal Cells - pathology | Veratrum Alkaloids - pharmacokinetics | Humans | Pancreatic Neoplasms - blood supply | Carcinoma, Pancreatic Ductal - metabolism | Neovascularization, Pathologic | Hedgehog Proteins - metabolism | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - metabolism | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Deoxycytidine - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Stromal Cells - drug effects | Disease Models, Animal | Veratrum Alkaloids - therapeutic use | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - pathology | Antineoplastic Combined Chemotherapy Protocols | Hedgehog Proteins - antagonists & inhibitors | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Signal Transduction - drug effects | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Zinc Finger Protein GLI1 | Carcinoma, Pancreatic Ductal - blood supply | Deoxycytidine - analogs & derivatives | Care and treatment | Chemotherapy | Pancreatic cancer | Physiological aspects | Cellular signal transduction | Health aspects | Cancer | Proteins | Signal transduction | Cellular biology | Rodents | Index Medicus
Journal Article
Gut, ISSN 0017-5749, 01/2013, Volume 62, Issue 1, pp. 112 - 120
Objective Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This... 
INTERSTITIAL FLUID PRESSURE | CELLS | THERAPY | SOLID TUMORS | MICROENVIRONMENT | PERMEABILITY | DUCTAL ADENOCARCINOMA | GASTROENTEROLOGY & HEPATOLOGY | GEMCITABINE | CHEMOTHERAPY | ENDOTHELIAL GROWTH-FACTOR | Immunohistochemistry | Cell Adhesion Molecules - administration & dosage | Tissue Array Analysis | Pancreatic Neoplasms - blood supply | Antineoplastic Agents - administration & dosage | Hyaluronic Acid - physiology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Drug Delivery Systems | Pancreatic Neoplasms - drug therapy | Hyaluronoglucosaminidase - administration & dosage | Carcinoma, Pancreatic Ductal - mortality | Cell Adhesion Molecules - pharmacology | Pancreatic Neoplasms - mortality | Doxorubicin - administration & dosage | Deoxycytidine - administration & dosage | Kaplan-Meier Estimate | Mice, Transgenic | Treatment Outcome | Biomarkers, Tumor - physiology | Recombinant Proteins - pharmacology | Recombinant Proteins - administration & dosage | Hyaluronoglucosaminidase - pharmacology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Carcinoma, Pancreatic Ductal - physiopathology | Mice | Carcinoma, Pancreatic Ductal - blood supply | Pancreatic Neoplasms - physiopathology | Drug Resistance, Neoplasm - physiology | Deoxycytidine - analogs & derivatives | Drug Resistance, Neoplasm - drug effects | Care and treatment | Blood-vessels | Pancreatic cancer | Patient outcomes | Physiological aspects | Models | Research | Hyaluronic acid | Tumors | Studies | Angiogenesis | Medical research | Medical prognosis | Cytotoxicity | Extracellular matrix | Permeability | Kinases | Vascular endothelial growth factor | Index Medicus | Abridged Index Medicus | stem cells | cell death | cancer vaccines | hyaluronan | epithelial cell growth | cancer immunobiology | drug delivery | matrix | epithelial cell adhesion | cancer genetics | carcinogenesis | pancreatic fibrosis | pharmacology | pharmacokinetics | tumour microenvironment | cancer | fibrosis | pancreatic disease | Original | 1506 | pancreatic tumours | extracellular matrix | oxidative stress
Journal Article
Cancer Cell, ISSN 1535-6108, 11/2013, Volume 24, Issue 5, pp. 589 - 602
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2012, Volume 122, Issue 5, pp. 1832 - 1848
Cancer development, progression, and metastasis are highly dependent on angiogenesis. The use of antiangiogenic drugs has been proposed as a novel strategy to... 
MEDICINE, RESEARCH & EXPERIMENTAL | VASCULAR NORMALIZATION | INDUCIBLE FACTOR-1-ALPHA | SQUAMOUS CARCINOGENESIS | PANCREATIC NEUROENDOCRINE TUMORS | MOUSE MODEL | ANTI-ANGIOGENIC THERAPY | GROWTH-FACTOR | K14-HPV16 TRANSGENIC MICE | NF-KAPPA-B | MALIGNANT PROGRESSION | Proto-Oncogene Proteins c-met - metabolism | Genetic Therapy | Pancreatic Neoplasms - metabolism | Uterine Cervical Neoplasms - blood supply | Pancreatic Neoplasms - blood supply | Drug Resistance, Neoplasm | NF-kappa B - metabolism | Uterine Cervical Neoplasms - pathology | Recombinant Proteins - biosynthesis | Semaphorin-3A - biosynthesis | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Pericytes - pathology | Epithelial-Mesenchymal Transition | Angiogenesis Inhibitors - therapeutic use | Female | Indoles - pharmacology | Liver Neoplasms - secondary | Pyrroles - therapeutic use | Uterine Cervical Neoplasms - therapy | Semaphorin-3A - genetics | Neuroendocrine Tumors - pathology | Cell Hypoxia - drug effects | Neoplasm Invasiveness | Neuroendocrine Tumors - metabolism | Pancreatic Neoplasms - pathology | Angiogenesis Inhibitors - pharmacology | Mice, Transgenic | Combined Modality Therapy | Lymphatic Metastasis | Recombinant Proteins - genetics | Tumor Burden | Pyrroles - pharmacology | Animals | Uterine Cervical Neoplasms - virology | Indoles - therapeutic use | Mice | Neuroendocrine Tumors - therapy | Neovascularization, Physiologic | Neuroendocrine Tumors - blood supply | Pancreatic Neoplasms - therapy | Research | Angiogenesis inhibitors | Semaphorins | Cancer cells | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 12/2010, Volume 70, Issue 24, pp. 10288 - 10298
Journal Article
Cancer Cell, ISSN 1535-6108, 03/2012, Volume 21, Issue 3, pp. 418 - 429
Pancreatic ductal adenocarcinomas (PDAs) are characterized by a robust fibroinflammatory response. We show here that this desmoplastic reaction generates... 
INTERSTITIAL FLUID PRESSURE | SOLID TUMORS | ONCOLOGY | COMPARING STANDARD PANCREATICODUODENECTOMY | HUMAN OSTEOSARCOMA XENOGRAFTS | RANDOMIZED-TRIAL | HEAD ADENOCARCINOMA | TUMOR VASCULATURE | EXTENDED LYMPHADENECTOMY | CANCER | BLOOD-PRESSURE | CELL BIOLOGY | Adenocarcinoma - pathology | Cell Adhesion Molecules - administration & dosage | Stromal Cells - pathology | Pancreatic Neoplasms - blood supply | Deoxycytidine - pharmacology | Hyaluronic Acid - physiology | Polyethylene Glycols - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Stromal Cells - drug effects | Hyaluronoglucosaminidase - administration & dosage | Drug Evaluation, Preclinical | Hyaluronoglucosaminidase - therapeutic use | Tumor Microenvironment - drug effects | Animals, Genetically Modified | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - pathology | Microvessels - drug effects | Adenocarcinoma - drug therapy | Carcinoma, Pancreatic Ductal - pathology | Extracellular Fluid - drug effects | Polyethylene Glycols - administration & dosage | Adenocarcinoma - blood supply | Hyaluronoglucosaminidase - pharmacology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Hyaluronic Acid - metabolism | Mice | Carcinoma, Pancreatic Ductal - blood supply | Cell Adhesion Molecules - therapeutic use | Deoxycytidine - analogs & derivatives | Enzymes | Medical colleges | Care and treatment | Glycosaminoglycans | Oncology, Experimental | Research | Chemotherapy | Universities and colleges | Drug therapy | Hyaluronic acid | Public health | Tumors | Cancer | Index Medicus
Journal Article
Annals of Surgery, ISSN 0003-4932, 01/2012, Volume 255, Issue 1, pp. 86 - 94
Objective: Resection of a primary colorectal carcinoma (CRC) can be accompanied by rapid outgrowth of liver metastases, suggesting a role for angiogenesis. The... 
SURGERY | CELLS | CANCER-PATIENTS | BILIARY TREE | TRANSENDOTHELIAL MIGRATION | PREMETASTATIC NICHE | E-SELECTIN | TUMOR DORMANCY | HUMAN HEPATOCELLULAR-CARCINOMA | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Neoplasms, Multiple Primary - surgery | Colorectal Neoplasms - surgery | Liver - pathology | Cell Proliferation | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Prognosis | Humans | Middle Aged | Apoptosis - genetics | Male | Neoplasms, Second Primary - surgery | Vascular Endothelial Growth Factor A - genetics | Neovascularization, Pathologic - pathology | Vascular Endothelial Growth Factor Receptor-2 - genetics | Adult | Female | Neoplasms, Second Primary - genetics | Liver Neoplasms - secondary | Real-Time Polymerase Chain Reaction | Gene Expression Regulation, Neoplastic - genetics | Neoplasms, Second Primary - blood supply | Neoplasms, Multiple Primary - genetics | Colorectal Neoplasms - blood supply | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Membrane Proteins - genetics | Ribonuclease, Pancreatic - genetics | Liver Neoplasms - surgery | Neoplasms, Multiple Primary - secondary | Neoplasms, Multiple Primary - pathology | Disease Progression | Neoplasms, Second Primary - secondary | Liver - blood supply | Liver Neoplasms - blood supply | Neovascularization, Pathologic - genetics | Aged | Neoplasms, Multiple Primary - blood supply | Colorectal Neoplasms - pathology | Neoplasms, Second Primary - pathology | Index Medicus | Abridged Index Medicus
Journal Article
Annals of Oncology, ISSN 0923-7534, 04/2012, Volume 23, Issue 4, pp. 1030 - 1036
Journal Article
Journal Article