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Journal of clinical oncology, ISSN 1527-7755, 2015, Volume 33, Issue 3, pp. 244 - 250
Journal Article
JNCI : Journal of the National Cancer Institute, ISSN 0027-8874, 01/2018, Volume 110, Issue 1, pp. 109 - 120
Background: Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as... 
CELL LUNG-CANCER | PHASE-II TRIAL | OXIDATIVE STRESS | ONCOLOGY | NAB-PACLITAXEL | ACTIVATION PROTEIN | DEPENDENT INVASION | PANCREATIC-CANCER | MONOCLONAL-ANTIBODY | DIFFERENTIATION | STROMAL CELLS | Lung Neoplasms - drug therapy | Up-Regulation | Pyrazoles - therapeutic use | Reactive Oxygen Species - metabolism | Cell Count | Humans | Middle Aged | Male | Oropharyngeal Neoplasms - pathology | Head and Neck Neoplasms - chemistry | RNA Interference | Cancer-Associated Fibroblasts - chemistry | Aged, 80 and over | NADPH Oxidases - genetics | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Lung Neoplasms - chemistry | NADPH Oxidases - antagonists & inhibitors | Head and Neck Neoplasms - drug therapy | Carcinoma, Squamous Cell - chemistry | Survival Rate | Adenocarcinoma - drug therapy | Disease Progression | Phenotype | Carcinoma, Squamous Cell - drug therapy | Head and Neck Neoplasms - genetics | Mice | Neoplasm Transplantation | Carcinoma, Non-Small-Cell Lung - chemistry | Carcinoma, Squamous Cell - genetics | Colorectal Neoplasms - chemistry | Cell Transdifferentiation - genetics | Myofibroblasts - chemistry | Actins - analysis | Cell Transdifferentiation - drug effects | Adult | Female | Adenocarcinoma - genetics | Cancer-Associated Fibroblasts - physiology | Pyridines - therapeutic use | Lung Neoplasms - genetics | Myofibroblasts - pathology | Carcinoma, Non-Small-Cell Lung - genetics | NADPH Oxidases - analysis | Mouth Neoplasms - chemistry | NADPH Oxidase 4 | Cancer-Associated Fibroblasts - pathology | Animals | Esophageal Neoplasms - genetics | Mouth Neoplasms - pathology | Oropharyngeal Neoplasms - chemistry | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Colorectal Neoplasms - pathology | Esophageal Neoplasms - drug therapy
Journal Article
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2012, Volume 366, Issue 26, pp. 2455 - 2465
Antibodies to PD-1 protein and to one of its ligands, PD-L1, have shown antitumor activity. Unleashing T cells from inhibitory signals may be a strategy to... 
MEDICINE, GENERAL & INTERNAL | IMMUNOTHERAPY | GUIDELINES | B7 FAMILY | B7-H1 | CTLA-4 | LIGAND | BLOCKADE | CLINICAL ACTIVITY | PHASE-I | PD-1 | Neoplasms - metabolism | Humans | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Antineoplastic Agents - adverse effects | Colorectal Neoplasms - drug therapy | Adult | Female | Carcinoma, Renal Cell - drug therapy | Ovarian Neoplasms - drug therapy | Programmed Cell Death 1 Receptor - metabolism | Stomach Neoplasms - drug therapy | Breast Neoplasms - drug therapy | Neoplasms - drug therapy | Antibodies, Monoclonal - administration & dosage | Melanoma - drug therapy | Nivolumab | Carcinoma, Non-Small-Cell Lung - drug therapy | Programmed Cell Death 1 Receptor - immunology | Intravenous administration | Kidneys | Immune response | Disease | PD-1 protein | Tumor cells | Colorectal carcinoma | Body weight | Melanoma | Lymphocytes T | Breast cancer | Stomach cancer | Patients | Ovarian cancer | Lungs | Pancreatic cancer | PD-L1 protein | Antitumor activity | Ligands | Autoimmune diseases | Gastric cancer | Clear cell-type renal cell carcinoma | Apoptosis | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Cell stem cell, ISSN 1934-5909, 2010, Volume 6, Issue 6, pp. 603 - 615
Recent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However,... 
STEMCELL | CELLCYCLE | BREAST-CANCER | INITIATING CELLS | DIPEPTIDYL-PEPTIDASE-IV | CARCINOMA CELLS | EXTRACELLULAR-MATRIX | ACUTE MYELOID-LEUKEMIA | E-CADHERIN | IDENTIFICATION | TUMOR-GROWTH | HUMAN PANCREATIC-CANCER | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Neoplasm Transplantation | RNA, Small Interfering - genetics | Prognosis | Follow-Up Studies | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Colorectal Neoplasms - genetics | Humans | Apoptosis - genetics | Gene Expression Profiling | Colorectal Neoplasms - diagnosis | Organoplatinum Compounds - pharmacology | Neoplastic Stem Cells - metabolism | Cell Transformation, Neoplastic - genetics | Colorectal Neoplasms - drug therapy | Liver Neoplasms - physiopathology | Neoplastic Stem Cells - pathology | Tumor Burden - genetics | Tumor Cells, Cultured | Liver Neoplasms - secondary | Colorectal Neoplasms - metabolism | Carcinoma - secondary | Carcinoma - drug therapy | Liver Neoplasms - genetics | Dipeptidyl Peptidase 4 - biosynthesis | Liver Neoplasms - drug therapy | Carcinoma - diagnosis | Dipeptidyl Peptidase 4 - genetics | Mice, SCID | Carcinoma - physiopathology | Disease Progression | Colorectal Neoplasms - physiopathology | Drug Resistance, Neoplasm - genetics | Animals | Liver Neoplasms - diagnosis | Tumor Burden - drug effects | Liver Neoplasms - metabolism | Carcinoma - genetics | Biomarkers, Tumor - genetics | Fluorouracil - pharmacology | Mice | Carcinoma - metabolism | Colorectal Neoplasms - pathology | Neoplasm Invasiveness - genetics | Cell Migration Assays | Biomarkers, Tumor - biosynthesis
Journal Article
Nature medicine, ISSN 1546-170X, 2017, Volume 23, Issue 6, pp. 664 - 673
Neuroendocrine (NE) cancers are a diverse group of neoplasms typically diagnosed and treated on the basis of their site of origin... 
MOLECULAR CHARACTERIZATION | MEDICINE, RESEARCH & EXPERIMENTAL | PANCREATIC ENDOCRINE NEOPLASMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GASTROINTESTINAL-TRACT | AUTOCHTHONOUS PROSTATE-CANCER | T-ANTIGEN | CELL BIOLOGY | CELL LUNG-CANCER | TRANSGENIC ADENOCARCINOMA | MOUSE MODEL | N-MYC | MUTATIONAL LANDSCAPE | Lung Neoplasms - drug therapy | Colonic Neoplasms - genetics | Carcinoma, Small Cell - genetics | Colonic Neoplasms - drug therapy | Epigenesis, Genetic | Humans | Male | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Tumor Suppressor Protein p53 - genetics | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | Prostatic Neoplasms - genetics | Urinary Bladder Neoplasms - genetics | Female | Cell Differentiation | Retinoblastoma Binding Proteins - genetics | Ovarian Neoplasms - drug therapy | Prostatic Neoplasms - drug therapy | Triazoles - therapeutic use | Lung Neoplasms - genetics | Antibodies, Monoclonal, Humanized - therapeutic use | Carcinoma, Neuroendocrine - drug therapy | Carcinoma, Small Cell - drug therapy | Carcinogenesis - genetics | Head and Neck Neoplasms - drug therapy | Carcinoma, Neuroendocrine - genetics | Uterine Cervical Neoplasms - drug therapy | Urinary Bladder Neoplasms - drug therapy | Uterine Cervical Neoplasms - genetics | Disease Progression | Azepines - therapeutic use | Neuroendocrine Tumors - genetics | Proto-Oncogene Proteins c-met - genetics | Cell Lineage | Cell Plasticity - genetics | Esophageal Neoplasms - genetics | Pyrimidines - therapeutic use | Neuroendocrine Tumors - drug therapy | Head and Neck Neoplasms - genetics | Proto-Oncogene Proteins c-myc - genetics | Ubiquitin-Protein Ligases - genetics | Benzodiazepines - therapeutic use | Esophageal Neoplasms - drug therapy | Proteins | Research | Health aspects | Carcinogenesis | Gastrin
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2016, Volume 68, pp. 1 - 10
.... Results Forty-one patients with advanced solid tumours refractory to standard therapies and with adequate organ function were recruited in eight cohorts up to doses of 150... 
Hematology, Oncology and Palliative Medicine | Pharmacodynamics | MEK inhibitor | Phase I | Optimal biological dose | Pharmacokinetics | BRAF-MUTATED MELANOMA | MULTICENTER | SELUMETINIB PLUS DOCETAXEL | SAFETY | TRAMETINIB | CELL LUNG-CANCER | TRIAL | DOSE-ESCALATION | ONCOLOGY | DOUBLE-BLIND | AZD6244 ARRY-142886 | Lung Neoplasms - drug therapy | Pancreatic Neoplasms - metabolism | Nausea - chemically induced | Allosteric Regulation | Humans | Lung Neoplasms - metabolism | Middle Aged | Male | Fatigue - chemically induced | Ribosomal Protein S6 Kinases, 70-kDa - drug effects | Protein Kinase Inhibitors - adverse effects | Colorectal Neoplasms - drug therapy | Chromatography, Liquid | Proto-Oncogene Proteins c-akt - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Bile Duct Neoplasms - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Administration, Oral | Carcinoma, Non-Small-Cell Lung - metabolism | Neoplasms - drug therapy | Maximum Tolerated Dose | Mesothelioma - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Anorexia - chemically induced | Glycogen Synthase Kinase 3 beta - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Neoplasms - metabolism | Phosphoproteins - drug effects | Mitogen-Activated Protein Kinase 1 - drug effects | Cholangiocarcinoma - metabolism | Chromatography, High Pressure Liquid | Diarrhea - chemically induced | Mitogen-Activated Protein Kinase 3 - drug effects | Pancreatic Neoplasms - drug therapy | Tandem Mass Spectrometry | Uterine Cervical Neoplasms - metabolism | Esophageal Neoplasms - metabolism | Adult | Female | Colorectal Neoplasms - metabolism | Bile Duct Neoplasms - drug therapy | Drug Eruptions - etiology | Abdominal Pain - chemically induced | Uterine Cervical Neoplasms - drug therapy | Glycogen Synthase Kinase 3 beta - metabolism | Mesothelioma - drug therapy | Cholangiocarcinoma - drug therapy | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Aged | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Esophageal Neoplasms - drug therapy | Proto-Oncogene Proteins c-akt - drug effects | Care and treatment | Protein kinases | Mitogens | Cells | Tumors
Journal Article
Journal Article
Cancer letters, ISSN 0304-3835, 2017, Volume 406, pp. 22 - 26
Journal Article