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Gastroenterology, ISSN 0016-5085, 2011, Volume 141, Issue 4, pp. 1486 - 1497.e14
Background & Aims Patients with pancreatic ductal adenocarcinoma are deficient in vitamin A, resulting in activation of pancreatic stellate cells (PSCs). We... 
Gastroenterology and Hepatology | 9RA | Therapy | Secreted Frizzled-Related Protein 4 | 13RA | Mouse Model | ACTIVATION | CANCER CELLS | TRANSCRIPTOME | ADENOCARCINOMA | STABILIZATION | MODEL | CULTURE | IN-VITRO | GASTROENTEROLOGY & HEPATOLOGY | IMMORTALIZATION | EXPRESSION | Transcription, Genetic - drug effects | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Pancreatic Stellate Cells - drug effects | Carcinoma, Pancreatic Ductal - metabolism | Cellular Senescence - drug effects | Wnt Proteins - metabolism | Carcinoma, Pancreatic Ductal - genetics | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | RNA Interference | Time Factors | Mice, Mutant Strains | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Pancreatic Stellate Cells - pathology | Disease Models, Animal | Tretinoin - pharmacology | Proto-Oncogene Proteins - metabolism | Isotretinoin - pharmacology | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - pathology | beta Catenin - metabolism | Disease Progression | Carcinoma, Pancreatic Ductal - drug therapy | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Paracrine Communication - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Pancreatic Stellate Cells - metabolism
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3390 - 18
Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier... 
ASSEMBLED GOLD NANOPARTICLES | HSP47 SIRNA | IN-VITRO | RETINOIC ACID | COLLAGEN-SPECIFIC CHAPERONE | DUCTAL ADENOCARCINOMA | A-COUPLED LIPOSOMES | MULTIDISCIPLINARY SCIENCES | EXTRACELLULAR-MATRIX | SIRNA DELIVERY | CANCER MODEL | Gene Silencing - drug effects | Stromal Cells - pathology | Humans | Pancreatic Stellate Cells - drug effects | Spheroids, Cellular - pathology | Extracellular Matrix - metabolism | Homeostasis | Polyethylene Glycols - chemistry | Polyethyleneimine - chemistry | Stromal Cells - drug effects | Female | Spheroids, Cellular - drug effects | Tretinoin - pharmacokinetics | Pancreatic Stellate Cells - pathology | Metal Nanoparticles - ultrastructure | Tretinoin - pharmacology | Gold - chemistry | Tumor Microenvironment - drug effects | Tissue Distribution - drug effects | Endocytosis - drug effects | Extracellular Matrix - drug effects | Metal Nanoparticles - chemistry | Pancreatic Neoplasms - pathology | Spheroids, Cellular - metabolism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Mice, Inbred BALB C | Cell Cycle - drug effects | Hydrogen-Ion Concentration | Pancreatic Stellate Cells - metabolism | RNA, Small Interfering - metabolism | Adenocarcinoma | Polyethyleneimine | Gold | Stellate cells | Drug delivery systems | Hyperplasia | Heat shock proteins | Recovery of function | siRNA | Drug delivery | Cobalt | Anticancer properties | Nanoparticles | Proteins | Chemotherapy | Stromal cells | Collagen | Extracellular matrix | Pancreas | Retinoic acid | Tumors | Heat shock
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 7, pp. 2345 - 2356
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2015, Volume 212, Issue 12, pp. 2077 - 2094
Journal Article
International Journal of Cancer, ISSN 0020-7136, 12/2016, Volume 139, Issue 11, pp. 2540 - 2552
The ATP‐gated receptor P2X7 (P2X7R) is involved in regulation of cell survival and has been of interest in cancer field. Pancreatic ductal adenocarcinoma... 
stellate cells | fibrosis | PDAC | P2X7 | AZ10606120 | Stellate cells | Fibrosis | EXTRACELLULAR ATP | ACTIVATION | DUCTAL ADENOCARCINOMA | INVASIVENESS | ONCOLOGY | P2X RECEPTOR | DISEASE | PURINERGIC RECEPTORS | MICE | EXPRESSION | CARCINOMA | Adamantane - pharmacology | Pancreatic Neoplasms - metabolism | Cell Growth Processes - drug effects | Humans | Pancreatic Neoplasms - pathology | Pancreatic Stellate Cells - drug effects | Carcinoma, Pancreatic Ductal - metabolism | Male | Luminescent Measurements | Molecular Targeted Therapy | Carcinoma, Pancreatic Ductal - pathology | Pancreatic Neoplasms - drug therapy | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Heterografts | Cell Line, Tumor | Receptors, Purinergic P2X7 - metabolism | Receptors, Purinergic P2X7 - biosynthesis | Mice | Mice, Inbred BALB C | Pancreatic Stellate Cells - pathology | Aminoquinolines - pharmacology | Adamantane - analogs & derivatives | Pancreatic Stellate Cells - metabolism | Collagen | Pancreatic cancer | Luciferase | Cell growth | Bioluminescence | Rodents | Cell proliferation | Adenocarcinoma | Cell survival | Therapeutic applications | Xenotransplantation | Survival | Proteins | Allosteric properties | Xenografts | In vivo methods and tests | ATP | Cell migration | Adenosine triphosphate | Tumors | Cancer | Molecular Cancer Biology
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 2506 - 12
Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive malignancy characterised by the presence of extensive desmoplasia, thought to be responsible for the... 
CARCINOMA-CELLS | FIBROSIS | MIGRATION | STARRING ROLE | MATRIX STIFFNESS | CANCER CELLS | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | DESMOPLASTIC REACTION | FOCAL ADHESIONS | FIBROBLAST DUROTAXIS | Laminin - pharmacology |