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PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e61473
Background: The E7 protein of the Human Papillomavirus (HPV) type 16, being involved in malignant cellular transformation, represents a key antigen for... 
TRANSFORMATION | ANTICANCER ACTIVITY | PLANT | ONCOPROTEIN | PROTEIN | MULTIDISCIPLINARY SCIENCES | PURIFICATION | CHLOROPLAST | CERVICAL-CANCER | REINHARDTII | EXPRESSION | Recombinant Fusion Proteins - immunology | Papillomavirus Vaccines - genetics | Humans | Papillomavirus E7 Proteins - immunology | Human papillomavirus 16 - immunology | Antibodies, Viral - blood | Papillomavirus E7 Proteins - genetics | Chlamydomonas reinhardtii - genetics | Papillomavirus Infections - immunology | Female | 3' Untranslated Regions | Papillomavirus Vaccines - administration & dosage | Chloroplasts - genetics | Recombinant Fusion Proteins - administration & dosage | Uterine Cervical Neoplasms - mortality | Antibodies, Viral - biosynthesis | Vaccines, Subunit | Mice, Inbred C57BL | Uterine Cervical Neoplasms - prevention & control | Uterine Cervical Neoplasms - immunology | Papillomavirus Infections - mortality | Animals | Papillomavirus E7 Proteins - administration & dosage | 5' Untranslated Regions | Papillomavirus Infections - prevention & control | Survival Analysis | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Antibodies, Viral - immunology | Papillomavirus Vaccines - immunology | Mice | Human papillomavirus 16 - genetics | Antigens | Vaccination | Genomics | Development and progression | Biological products industry | T cells | Cancer vaccines | Proteins | Papillomaviruses | Analysis | Health aspects | Papillomavirus infections | Tumors | Cell proliferation | Transformation | Animal models | Protein purification | Homologous recombination | Clinical trials | Cytotoxicity | Homology | Genomes | Lymphocytes T | Vaccines | E7 protein | Human papillomavirus | Chloroplasts | Chlamydomonas reinhardtii | Lesions | Recombinant | Good Manufacturing Practice | Algae | Plant protection | Regression analysis | Gene expression | Economic development | Virology | Immunogenicity | 3' Untranslated regions | Affinity | Cervical cancer
Journal Article
IUBMB Life, ISSN 1521-6543, 06/2016, Volume 68, Issue 6, pp. 459 - 467
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 04/2015, Volume 203, pp. 16 - 22
The aim of the current study was to develop a cancer vaccine formulation for treatment of human papillomavirus (HPV)-induced malignancies. Synthetic long... 
Nanoparticles | pLHMGA | Synthetic long peptide (SLP) | Incomplete Freund's adjuvant (IFA) | Therapeutic cancer vaccine | Human papillomavirus (HPV) | Poly IC | TLR3 ligand | Incomplete | Freund's djuvant (IFA) | IMMUNE-RESPONSE | CERVICAL-CANCER | HUMAN-PAPILLOMAVIRUS | INDUCTION | TUMORS | CHEMISTRY, MULTIDISCIPLINARY | FUNCTIONALIZED POLY(ALPHA-HYDROXY ACID)S | FREUNDS-ADJUVANT | VULVAR INTRAEPITHELIAL NEOPLASIA | PHARMACOLOGY & PHARMACY | T-LYMPHOCYTE RESPONSES | CELL-ACTIVATION | Adjuvants, Immunologic - administration & dosage | Nanoparticles - chemistry | Poly I-C - administration & dosage | Humans | Vaccination | Papillomavirus E7 Proteins - immunology | Molecular Sequence Data | Human papillomavirus 16 - immunology | Cancer Vaccines - chemistry | Freund's Adjuvant - immunology | Papillomavirus Infections - therapy | Freund's Adjuvant - therapeutic use | Cancer Vaccines - therapeutic use | Papillomavirus E7 Proteins - therapeutic use | Papillomavirus Infections - immunology | Female | Poly I-C - immunology | Interferon Inducers - immunology | Poly I-C - therapeutic use | Adjuvants, Immunologic - therapeutic use | Uterine Cervical Neoplasms - therapy | Amino Acid Sequence | Cervix Uteri - virology | Cancer Vaccines - administration & dosage | Mice, Inbred C57BL | Uterine Cervical Neoplasms - immunology | Interferon Inducers - therapeutic use | Cancer Vaccines - immunology | Polyesters - chemistry | Freund's Adjuvant - administration & dosage | Animals | Papillomavirus E7 Proteins - administration & dosage | Cell Line, Tumor | Papillomavirus E7 Proteins - chemistry | CD8-Positive T-Lymphocytes - immunology | Interferon Inducers - administration & dosage | Cancer vaccines | Integrated circuits | Antigens | Peptides | Development and progression | Health aspects | Papillomavirus infections | Semiconductor chips | Medical research | Petroleum products | Medicine, Experimental | T cells
Journal Article
International Immunopharmacology, ISSN 1567-5769, 09/2018, Volume 62, pp. 170 - 180
The high risk human papillomavirus (HPV) types 16 and 18 are globally linked to >50% and 20% of all cervical cancers, respectively. The HPV E7 oncoprotein was... 
Human papillomavirus | Cell penetrating peptide | E7 protein | Therapeutic vaccine | Cervical cancer | EFFICIENT DELIVERY | GENE DELIVERY | NUCLEIC-ACID | SUPERCHARGED PROTEINS | STRATEGY | NANOPARTICLE | VACCINATION | IMMUNOLOGY | MAMMALIAN-CELLS | VECTOR | IMMUNOTHERAPY | PHARMACOLOGY & PHARMACY | Adjuvants, Immunologic - administration & dosage | Antigens, Viral - administration & dosage | Humans | Papillomavirus E7 Proteins - immunology | Human papillomavirus 16 - immunology | Th1 Cells - immunology | Antibodies, Viral - blood | Drug Delivery Systems | HEK293 Cells | Papillomavirus Infections - immunology | Female | Papillomavirus Vaccines - administration & dosage | Cell-Penetrating Peptides - chemistry | Cell-Penetrating Peptides - genetics | Th1 Cells - drug effects | Granzymes | Uterine Cervical Neoplasms - prevention & control | Uterine Cervical Neoplasms - immunology | Xenograft Model Antitumor Assays | Antigens, Viral - immunology | Immunity, Cellular - immunology | Animals | Papillomavirus E7 Proteins - administration & dosage | Papillomavirus Infections - prevention & control | Papillomavirus Vaccines - immunology | Mice | Proteins | Antigens | Vaccination | Development and progression | Vaccines | Nucleic acids | Comparative analysis | T cells | Health aspects | Papillomavirus infections | High performance liquid chromatography
Journal Article
Journal Article
Vaccine, ISSN 0264-410X, 2017, Volume 35, Issue 11, pp. 1509 - 1516
Highlights • GTL001 is a bivalent CyaA-HPV16 E7/CyaA-HPV18 E7 therapeutic vaccine. • GTL001-induced effector and prophylactic memory T-cell responses eradicate... 
Allergy and Immunology | Tumour-associated antigen | Tumour model | Human papillomavirus | Therapeutic vaccine | Cervical cancer | Memory T-cell response | MEDICINE, RESEARCH & EXPERIMENTAL | METAANALYSIS | DENDRITIC CELLS | ADENYLATE-CYCLASE TOXIN | IMMUNOLOGY | CUTTING EDGE | IMIQUIMOD | IMMUNIZATION | IMMUNE-SYSTEM | E7 ONCOPROTEIN | BORDETELLA-PERTUSSIS | ESTABLISHED TUMORS | Oncogene Proteins, Viral - administration & dosage | Adjuvants, Immunologic - administration & dosage | Neoplasm Proteins - administration & dosage | Ovalbumin - immunology | Papillomavirus Vaccines - genetics | Neoplasm Proteins - immunology | Papillomavirus E7 Proteins - immunology | Drug Carriers - administration & dosage | Vaccines, Synthetic - immunology | Adenylate Cyclase Toxin - genetics | Papillomavirus E7 Proteins - genetics | Antigens, Neoplasm - administration & dosage | Cancer Vaccines - genetics | Melanoma - prevention & control | DNA-Binding Proteins - administration & dosage | Female | Oncogene Proteins, Viral - genetics | Neoplasm Proteins - genetics | Papillomavirus Vaccines - administration & dosage | Disease Models, Animal | Injections, Intradermal | Ovalbumin - genetics | Antigens, Neoplasm - genetics | Papillomavirus Infections - complications | DNA-Binding Proteins - immunology | Ovarian Neoplasms - prevention & control | Antigens, Neoplasm - immunology | Cancer Vaccines - administration & dosage | Mice, Inbred C57BL | Vaccines, Synthetic - genetics | Uterine Cervical Neoplasms - prevention & control | Treatment Outcome | Adenylate Cyclase Toxin - administration & dosage | DNA-Binding Proteins - genetics | Cancer Vaccines - immunology | Animals | Ovalbumin - administration & dosage | Papillomavirus E7 Proteins - administration & dosage | Immunologic Memory | Papillomavirus Vaccines - immunology | T-Lymphocytes - immunology | Oncogene Proteins, Viral - immunology | Vaccines, Synthetic - administration & dosage | Antigens | Care and treatment | Vaccines | T cells | Health aspects | Papillomavirus infections | Tumors | Cancer | Peptides | Stock options | Dendritic cells | Cloning | Melanoma | Amino acids | Employees | T cell receptors | Infections | Experiments | Proteins | Cellular biology
Journal Article
Journal of translational medicine, ISSN 1479-5876, 2014, Volume 12, Issue 1, pp. 353 - 353
Journal Article
Biotechnology Letters, ISSN 0141-5492, 2/2014, Volume 36, Issue 2, pp. 349 - 356
Journal Article
European Journal of Immunology, ISSN 0014-2980, 10/2011, Volume 41, Issue 10, pp. 2977 - 2986
Programmed death‐1 receptor (PD‐1) is expressed on T cells following TCR activation. Binding of this receptor to its cognate ligands, programmed death ligand... 
Programmed death‐1 receptor | Cancer immunotherapy | Vaccine | Programmed death-1 receptor | CARCINOMA PATIENTS | PROGNOSTIC-FACTORS | INCREASED POPULATIONS | FACILITATED ADOPTIVE IMMUNOTHERAPY | PANCREATIC-CANCER | PERIPHERAL-BLOOD | IMMUNOLOGY | TUMOR-INFILTRATING LYMPHOCYTES | REGULATORY T-CELLS | IMMUNOLOGICAL SELF-TOLERANCE | CLINICAL-SIGNIFICANCE | T-Lymphocytes, Regulatory - metabolism | Cyclophosphamide - administration & dosage | Papillomavirus E7 Proteins - immunology | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Receptors, Antigen, T-Cell | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Neoplasms, Experimental - immunology | Female | Antibodies, Monoclonal - immunology | Lymphocyte Activation | Mice, Inbred C57BL | Neoplasms, Experimental - therapy | B7-H1 Antigen - immunology | Apoptosis Regulatory Proteins - metabolism | Programmed Cell Death 1 Ligand 2 Protein - immunology | Cancer Vaccines - immunology | B7-H1 Antigen - metabolism | T-Lymphocytes, Regulatory - drug effects | Animals | Papillomavirus E7 Proteins - administration & dosage | Antibodies, Monoclonal - administration & dosage | CD8-Positive T-Lymphocytes - drug effects | Cyclophosphamide - pharmacology | Mice | CD8-Positive T-Lymphocytes - immunology | Apoptosis | Medical research | T cell receptors | Vaccines | Immune system
Journal Article
IUBMB Life, ISSN 1521-6543, 10/2018, Volume 70, Issue 10, pp. 1002 - 1011
Therapeutic human papillomaviruse (HPV) vaccines have the potential to inhibit the tumor growth by targeting HPV E6 and E7 oncoproteins. Among different... 
therapeutic vaccine | heat shock protein | adjuvant | cell penetrating peptide | HPV | EFFICIENT DELIVERY | IMMUNITY | FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PENETRATING PEPTIDES | CERVICAL-CANCER | STRATEGIES | VECTOR | CELL BIOLOGY | OVEREXPRESSION | HPV16E7 | CARCINOMA | Adjuvants, Immunologic - administration & dosage | Neoplasm Proteins - administration & dosage | Papillomavirus Vaccines - genetics | Humans | Antigens, Viral - genetics | HSP20 Heat-Shock Proteins - genetics | Heat-Shock Proteins - genetics | Granzymes - administration & dosage | T-Lymphocytes - drug effects | DNA-Binding Proteins - administration & dosage | Female | Neoplasm Proteins - genetics | Papillomavirus Vaccines - administration & dosage | Heat-Shock Proteins - administration & dosage | Uterine Cervical Neoplasms - prevention & control | Uterine Cervical Neoplasms - immunology | Uterine Cervical Neoplasms - genetics | Antigens, Viral - immunology | Papillomavirus E7 Proteins - administration & dosage | Cell Line, Tumor | Uterine Cervical Neoplasms - virology | Antibodies, Viral - immunology | Papillomavirus Vaccines - immunology | T-Lymphocytes - immunology | Cell-Penetrating Peptides - administration & dosage | Antibodies, Viral - genetics | Proteins | Antigens | Medical research | Analysis | Medicine, Experimental | Heat shock proteins | Vaccines | T cells | Health aspects | Papillomavirus infections | Enzyme-linked immunosorbent assay
Journal Article
Viral Immunology, ISSN 0882-8245, 11/2014, Volume 27, Issue 9, pp. 463 - 467
Journal Article
Gene Therapy, ISSN 0969-7128, 07/2015, Volume 22, Issue 7, pp. 560 - 567
Cellular immunity against cancer can be achieved with viral vector-and DNA-based immunizations. In preclinical studies, cancer vaccines are very potent, but in... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CD4(+) T-CELLS | CERVICAL-CANCER | TYPE-16 | INTRAEPITHELIAL NEOPLASIA | RESPONSES | DNA VACCINES | PARTICLE VACCINE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CD4+T-CELL IMMUNITY | GENETICS & HEREDITY | ENDOPLASMIC-RETICULUM | Oncogene Proteins, Viral - administration & dosage | Papillomavirus Vaccines - genetics | Antigens, Viral - administration & dosage | Humans | Papillomavirus E7 Proteins - immunology | Vaccines, DNA - immunology | Antigens, Viral - genetics | Vaccines, DNA - administration & dosage | Papillomavirus E7 Proteins - genetics | Papillomavirus Vaccines - metabolism | Female | Oncogene Proteins, Viral - genetics | Oncogene Proteins, Viral - metabolism | T-Lymphocytes, Cytotoxic - immunology | Cricetinae | Cancer Vaccines - administration & dosage | Mice, Inbred C57BL | Uterine Cervical Neoplasms - prevention & control | Kidney - cytology | Epitopes, T-Lymphocyte - chemistry | Antigens, Viral - immunology | Cancer Vaccines - immunology | Papillomavirus E7 Proteins - metabolism | Animals | Papillomavirus E7 Proteins - administration & dosage | Semliki forest virus - genetics | T-Lymphocytes, Cytotoxic - metabolism | Papillomavirus Vaccines - immunology | Oncogene Proteins, Viral - immunology | Complications and side effects | Care and treatment | Usage | Clinical trials | Research | Papillomavirus infections | Antigenic determinants | Antigens | Human papillomavirus | Vaccines | Gene therapy | Endoplasmic reticulum | Cancer
Journal Article