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British Journal of Cancer, ISSN 0007-0920, 10/2008, Volume 99, Issue 9, pp. 1476 - 1483
Vimentin, nuclear factor-kappa B (NF-kappa B) p105, fascin, E-cadherin, TGF-beta, Par6 and atypical PKC are molecular markers that play an important role in... 
Par6 | Vimentin | Stromal | NSCLC | Disease-specific survival | Epithelial | par6 | stromal | METASTASIS | TUMOR PROGRESSION | epithelial | KERATINOCYTES | vimentin | MESENCHYMAL TRANSITION | HORMONE RECEPTORS | BETA | OVEREXPRESSION | disease-specific survival | ONCOLOGY | POLARITY PROTEIN PAR6 | DIFFERENTIATION | CARCINOMA | Molecular Diagnostics
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2018, Volume 495, Issue 1, pp. 1476 - 1481
Par6α (partitioning defective 6 homologue alpha), a component of the Par3/Par6/aPKC complex, was recently shown to be essential for axon specification during... 
Par6 | Neuronal differentiation | MSCs | Neuronal polarity | Axon differentiation | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | CDC42 | BIOPHYSICS | POLARITY PROTEIN PAR6 | NEUROGENESIS | RHO-GTPASES | POLARIZATION | Index Medicus
Journal Article
JOURNAL OF CELL SCIENCE, ISSN 0021-9533, 04/2019, Volume 132, Issue 8
The elaboration of polarity is central to organismal development and to the maintenance of functional epithelia. Among the controls determining polarity are... 
PAR6 | PROTEIN-KINASE-C | Atypical protein kinase C | RAC | NUCLEOTIDE EXCHANGE FACTOR | LINKS | FARP | Polarity | Cdc42 | CELL BIOLOGY
Journal Article
DEVELOPMENT, ISSN 0950-1991, 08/2019, Volume 146, Issue 15
Cdc42 regulates epithelial morphogenesis together with the Par complex (Baz/Par3-Par6-aPKC), Crumbs (Crb/CRB3) and Stardust (Sdt/PALS1). However, how these... 
CELL-POLARITY | PHOTORECEPTOR MORPHOGENESIS | COMPLEX | Par complex | Crumbs | aPKC | DEVELOPMENTAL BIOLOGY | Par6 | DROSOPHILA STARDUST | Par3 | PAR PROTEINS | ADHERENS JUNCTIONS | Bazooka | EFFICIENT | BINDING | Epithelial polarity | Cdc42 | Index Medicus
Journal Article
FASEB Journal, ISSN 0892-6638, 10/2018, Volume 32, Issue 10, pp. 5577 - 5586
The human rhomboid family (RHBDF)1 gene is highly expressed in breast cancer under clinical conditions but not in normal mammary gland tissues. Silencing the... 
Par6 | RHBDF1 | Protein complex | Acinus | CELL-POLARITY | CANCER-CELLS | APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | protein complex | acinus | CELL BIOLOGY | MORPHOGENESIS | GTPASES | PAR3 | BIOLOGY | COMMON TARGETS | PROTEINS | EXPRESSION | Index Medicus
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 02/2006, Volume 66, Issue 3, pp. 1767 - 1774
We recently showed that atypical protein kinase C iota (PKC iota) is required for transformed growth of human non-small-cell lung cancer (NSCLC) cells by... 
PAR6 | GREEN FLUORESCENT PROTEIN | KAPPA-B ACTIVATION | DOMAIN | POLARITY | ONCOLOGY | PATHWAY | PLAYS | ATYPICAL PKC | COMPLEXES | GOLD COMPOUNDS
Journal Article
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, ISSN 1046-6673, 04/2009, Volume 20, Issue 4, pp. 798 - 806
Atypical protein kinase C (aPKC) is a central component of the evolutionarily conserved Par3-Par6- aPKC complex, one of the fundamental regulators of cell... 
CELL-POLARITY | PAR6 | PROTEIN-KINASE-C | COMPLEX | CYTOSKELETON | EPITHELIA | NEPHRIN | UROLOGY & NEPHROLOGY | DIFFERENTIATION | EXPRESSION | TRANSGENIC MICE
Journal Article
Cellular Signalling, ISSN 0898-6568, 2012, Volume 24, Issue 2, pp. 539 - 548
Coronary vessel development requires transfer of mesothelial cells to the heart surface to form the epicardium where some cells subsequently undergo... 
Par6 | Smurf1 | Epicardial cell | Transforming growth factor beta | Rhoa | Epithelial mesenchymal transformation | III RECEPTOR | TRANSFORMATION | BREAST-CANCER PROGRESSION | CORONARY VESSEL DEVELOPMENT | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | GROWTH-FACTOR-BETA | POLARITY PROTEIN PAR6 | DIFFERENTIATION | EXPRESSION | Bone Morphogenetic Protein 2 - pharmacology | RNA, Small Interfering - genetics | Receptors, Transforming Growth Factor beta - genetics | Adenoviridae | Epithelial Cells - metabolism | Gene Expression - drug effects | Epithelial Cells - drug effects | Epithelial-Mesenchymal Transition - drug effects | rhoA GTP-Binding Protein - metabolism | Pericardium - metabolism | rhoA GTP-Binding Protein - genetics | Coronary Vessels - metabolism | Proteoglycans - deficiency | Transfection | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Cell Differentiation | Epithelial Cells - cytology | Cell Line | Coronary Vessels - drug effects | Pericardium - drug effects | Ubiquitin-Protein Ligases - metabolism | Cell Communication | Pericardium - cytology | Mice, Knockout | Transforming Growth Factor beta2 - pharmacology | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Coronary Vessels - cytology | Adaptor Proteins, Signal Transducing - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Proteoglycans - genetics | RNA, Small Interfering - metabolism | Receptors, Transforming Growth Factor beta - deficiency | Index Medicus
Journal Article
by Yin, J and Liu, ZP and Li, HX and Sun, JY and Chang, XZ and Liu, J and He, SS and Li, BH
PLOS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3
The protein kinase C (PKC) family has been functionally linked to cancer. It has been suggested that atypical PKCs contribute to cell proliferation and cancer... 
INHIBITS MIGRATION | CELL-POLARITY | PAR6 | PROTEIN-KINASE-C | ACTIVATION | COMPLEX | METASTASIS | CHEMOTAXIS | INTERACTS | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION
Journal Article
by Li, P and Wang, Y and Mao, X and Jiang, Y and Liu, J and Li, J and Wang, J and Wang, R and She, J and Zhang, J and Yang, J and Liu, Y and Liu, P
Oncogenesis, ISSN 2157-9024, 2017, Volume 6, Issue 4, pp. e322 - e322
The cancer stem cell (CSC) theory depicts a special population within the cancer mass that self-renew and sustain the cancer, even if the other cells were... 
PAR6 | TRANSITION | MORPHOGENESIS | INVASION | EPITHELIAL-CELLS | POLARITY | ONCOLOGY | PATHWAY | CRUMBS | TUMOR-SUPPRESSOR | ENDOCYTOSIS | Original
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 33, pp. 14028 - 14033
The role of polarity signaling in cancer metastasis is ill defined. Using two three-dimensional culture models of mammary epithelial cells and an orthotopic... 
Receptors | Lungs | Epithelial cells | Cadherins | Cultured cells |