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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2018, Volume 115, Issue 48, pp. 12265 - 12270
Parainfluenza virus types 1-4 (PIV1-4) are highly infectious human pathogens, of which PIV3 is most commonly responsible for severe respiratory illness in... 
Virus | Vaccine design | Structure | Antibody | Conformational change | antibody | TRIMER | PROTEIN | MULTIDISCIPLINARY SCIENCES | vaccine design | INFECTION | conformational change | CLEAVAGE | virus | structure | PNEUMONIA REQUIRING HOSPITALIZATION | Viral Fusion Proteins - administration & dosage | Viral Fusion Proteins - genetics | Humans | Viral Vaccines - genetics | Male | Macaca mulatta | Respirovirus Infections - virology | Viral Fusion Proteins - immunology | Parainfluenza Virus 4, Human - immunology | Parainfluenza Virus 3, Human - genetics | Antibodies, Neutralizing - immunology | Parainfluenza Virus 2, Human - immunology | Viral Fusion Proteins - chemistry | Female | Parainfluenza Virus 4, Human - chemistry | Respirovirus Infections - immunology | Parainfluenza Virus 2, Human - chemistry | Parainfluenza Virus 1, Human - chemistry | Parainfluenza Virus 3, Human - chemistry | Parainfluenza Virus 1, Human - genetics | Parainfluenza Virus 4, Human - genetics | Parainfluenza Virus 3, Human - immunology | Respirovirus Infections - prevention & control | Respiratory Syncytial Virus Infections | Viral Vaccines - administration & dosage | Cryoelectron Microscopy | Animals | Viral Vaccines - chemistry | Antibodies, Viral - immunology | Parainfluenza Virus 1, Human - immunology | Parainfluenza Virus 2, Human - genetics | Mice | Viral Vaccines - immunology | Elderly people | Neonates | Immunoglobulins | Immunization | Glycoprotein | Antibodies | Viruses | Glycoproteins | Trimers | Vaccines | Microscopy | Influenza | Human performance | Neutralizing | Primates | Adults | Mutation | Parainfluenza | Elderly | Geriatrics | Neutralization | Conformation | Biological Sciences
Journal Article
Journal Article
Virology, ISSN 0042-6822, 2012, Volume 433, Issue 2, pp. 320 - 328
Abstract Human parainfluenza viruses (PIVs) cause acute respiratory illness in children, the elderly, and immunocompromised patients. PIV3 is a common cause of... 
Infectious Disease | Human parainfluenza virus | Human airway epithelium | Interferon | Cytokines | Pathogenesis | Chemokines | NONHUMAN-PRIMATES | IMMUNE-RESPONSE | WILD-TYPE | CHEMOKINE RESPONSES | CELL TRANSPLANTATION | COMPLETE NUCLEOTIDE-SEQUENCE | VACCINE CANDIDATES | VIROLOGY | HEMAGGLUTININ-NEURAMINIDASE | INTERFERON-PRODUCTION | RESPIRATORY SYNCYTIAL VIRUS | Parainfluenza Virus 2, Human - classification | Bronchi - virology | Parainfluenza Virus 3, Human - pathogenicity | Species Specificity | Humans | Parainfluenza Virus 1, Human - pathogenicity | Respiratory Mucosa - virology | Bronchi - immunology | Parainfluenza Virus 1, Human - physiology | Parainfluenza Virus 2, Human - physiology | Trachea - virology | Host-Pathogen Interactions - immunology | Parainfluenza Virus 1, Human - classification | Parainfluenza Virus 2, Human - immunology | Respiratory Mucosa - immunology | Cytokines - genetics | Serotyping | Chemokines - biosynthesis | Interleukin-6 - genetics | Parainfluenza Virus 3, Human - physiology | Cells, Cultured | Parainfluenza Virus 3, Human - immunology | Parainfluenza Virus 2, Human - pathogenicity | Trachea - immunology | Parainfluenza Virus 3, Human - classification | Host-Pathogen Interactions - genetics | Virus Replication | Interleukin-6 - biosynthesis | Parainfluenza Virus 1, Human - immunology | Polymorphism, Single Nucleotide | Kinetics | Cytokines - biosynthesis | Virus diseases | Pneumonia | Bacterial pneumonia | Cystic fibrosis | Biological response modifiers | T cells | Epithelium | Chemotactic factors | Cell culture | Bronchopneumonia | Lymphocytes T | Epidemiology | Infection | Interleukin 6 | Respiratory tract | Donors | CXCL10 protein | Serotypes | Replication | CXCL11 protein | Children | Immunocompromised hosts | Parainfluenza | Croup | Geriatrics | pathogenesis | cytokines | chemokines | interferon
Journal Article
Applied Microbiology and Biotechnology, ISSN 0175-7598, 4/2017, Volume 101, Issue 7, pp. 2991 - 3004
The aim of this study was to produce human parainfluenza virus type 4 (HPIV4) nucleocapsid (N) protein in yeast Saccharomyces cerevisiae expression system, to... 
Life Sciences | Biotechnology | Microbiology | Human parainfluenza virus 2 | Microbial Genetics and Genomics | Yeast-produced N protein | Serology | Human parainfluenza virus 4 | Nucleocapsid-like particles | ELISA | DIAGNOSIS | INFECTIONS | TYPE-4 | HIGH-LEVEL EXPRESSION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | NUCLEOPROTEIN | COMMON | GENERATION | MONOCLONAL-ANTIBODIES | PROTEINS | Prospective Studies | Immunoglobulin G - blood | Saccharomyces cerevisiae - genetics | Humans | Middle Aged | Rubulavirus Infections - immunology | Child, Preschool | Infant | Male | Seroepidemiologic Studies | Nucleocapsid Proteins - blood | Antibodies, Viral - blood | Parainfluenza Virus 4, Human - immunology | Saccharomyces cerevisiae - metabolism | Young Adult | Parainfluenza Virus 2, Human - immunology | Adult | Female | Parainfluenza Virus 4, Human - chemistry | Respiratory Tract Infections - virology | Child | Antibodies, Monoclonal - immunology | Infant, Newborn | Parainfluenza Virus 2, Human - chemistry | Enzyme-Linked Immunosorbent Assay | Parainfluenza Virus 4, Human - genetics | Nucleocapsid | Cross Reactions | Antigens, Viral - immunology | Nucleocapsid Proteins - genetics | Recombinant Proteins - immunology | Adolescent | Respiratory Tract Infections - immunology | Nucleocapsid Proteins - immunology | Parainfluenza Virus 2, Human - genetics | Aged | Proteins | Immunoglobulin G | Monoclonal antibodies | Respiratory tract diseases | Health aspects | Viral antigens | Enzyme-linked immunosorbent assay | Studies | Yeast | Protein synthesis | Influenza | Analysis | Viruses | Genetic recombination
Journal Article
Vaccine, ISSN 0264-410X, 2009, Volume 27, Issue 12, pp. 1848 - 1857
Abstract The human parainfluenza viruses (hPIVs) and respiratory syncytial viruses (RSVs) are the leading causes of hospitalizations due to respiratory viral... 
Allergy and Immunology | Protective immunity | Parainfluenza virus | Respiratory syncytial virus | MEDICINE, RESEARCH & EXPERIMENTAL | AFRICAN-GREEN MONKEYS | COTTON RATS | VACCINIA VIRUS | SUBGROUP-B | IMMUNOLOGY | HUMAN PARAINFLUENZA | B-CELL | HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEINS | TYPE-3 PIV3 | RESPIRATORY-SYNCYTIAL-VIRUS | MUCOSAL IMMUNIZATION | Enzyme-Linked Immunosorbent Assay | Humans | Neutralization Tests | Parainfluenza Virus 3, Human - immunology | Vaccines, Synthetic - immunology | Respiratory Syncytial Virus Infections - immunology | Sendai virus - genetics | Paramyxoviridae Infections - immunology | Sigmodontinae | Animals | Parainfluenza Virus 2, Human - immunology | Respiratory Syncytial Virus, Human - immunology | Respiratory Syncytial Virus Infections - prevention & control | Female | Parainfluenza Vaccines - therapeutic use | Parainfluenza Virus 1, Human - immunology | Paramyxoviridae Infections - prevention & control | Genetic Vectors | Viral antibodies | Virus diseases | Virus diseases in children | Vaccination | Analysis | Antibodies | Infants | Children | Health aspects | Diseases | Medical research | Pediatrics | Laboratories | Cloning | Mortality | Clinical trials | Viruses | Infections | Vaccines | RNA polymerase | Cotton | Proteins | Studies | Plasmids | Rodents | Population | Evacuations & rescues | Animal models | parainfluenza virus | respiratory syncytial virus | protective immunity
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e66614
Atopic dermatitis (AD) is a refractory and recurrent inflammatory skin disease. Various factors including heredity, environmental agent, innate and acquired... 
MYCOBACTERIUM-TUBERCULOSIS | IMMUNITY | PROTEIN | MULTIDISCIPLINARY SCIENCES | SEQUENCE | REGULATORY T-CELLS | CDNA | TH1 | EXPRESSION | CULTURE | REGION | T-Lymphocytes, Regulatory - metabolism | Vaccines, DNA - genetics | Skin - metabolism | Humans | Antigens, Bacterial - immunology | Vaccines, DNA - immunology | Male | Antigens, Bacterial - genetics | Vaccines, DNA - administration & dosage | Immunoglobulin E - blood | T-Lymphocytes, Regulatory - immunology | Oxazolone - immunology | Dermatitis, Atopic - chemically induced | Immunoglobulin E - immunology | Parainfluenza Virus 2, Human - immunology | Dermatitis, Atopic - immunology | Oxazolone - adverse effects | Cytokines - genetics | Skin - pathology | Disease Models, Animal | Skin - immunology | Cell Line | Gene Expression | Genetic Vectors - immunology | RNA, Messenger - genetics | Dermatitis, Atopic - pathology | Genetic Vectors - genetics | Animals | Parainfluenza Virus 2, Human - genetics | Mice | Antigens | Advertising executives | Wildlife conservation | RNA | Cytokines | Genetic vectors | Atopic dermatitis | Vaccination | Immunoglobulin E | Skin | Vaccines | Health aspects | Oxazolone | Antigen 85B | Pathogenesis | Cytotoxicity | Viruses | Lymphocytes T | Genomes | mRNA | Dermatitis | Immunity | Respiratory tract | Proteins | Interleukin 4 | Replicating | Immunology | Skin diseases | Parainfluenza | Deoxyribonucleic acid--DNA | Recombinant | Dermatology | Heredity | Tumor necrosis factor-α | Epithelium | Virology | Medicine | Influenza | γ-Interferon | Interleukin 10 | Ear | In vivo methods and tests | Interferon | Croup | Deoxyribonucleic acid | DNA
Journal Article
Pediatric Infectious Disease Journal, ISSN 0891-3668, 2010, Volume 29, Issue 4, pp. e26 - e31
To describe the clinical manifestations of parainfluenza virus (PIV) infection and to characterize biochemical markers of PIV disease severity. We reviewed the... 
Innate immunity | Parainfluenza virus | Respiratory viral infection | Laryngitis - physiopathology | Tracheitis - physiopathology | Parainfluenza Virus 3, Human - pathogenicity | Bronchitis - virology | Humans | Child, Preschool | Parainfluenza Virus 1, Human - pathogenicity | Infant | Laryngitis - virology | Parainfluenza Virus 4, Human - immunology | Paramyxoviridae Infections - physiopathology | Parainfluenza Virus 2, Human - immunology | Paramyxoviridae Infections - virology | Laryngitis - immunology | Inflammation Mediators - metabolism | Interleukin-8 - metabolism | Respiratory Tract Infections - virology | Bronchitis - immunology | Respiratory Tract Infections - physiopathology | Child | Infant, Newborn | Parainfluenza Virus 4, Human - pathogenicity | Severity of Illness Index | Parainfluenza Virus 3, Human - immunology | Bronchitis - physiopathology | Parainfluenza Virus 2, Human - pathogenicity | Paramyxoviridae Infections - immunology | Tracheitis - virology | Respiratory Tract Infections - immunology | Nasal Lavage Fluid - immunology | Parainfluenza Virus 1, Human - immunology | Tracheitis - immunology | UNITED-STATES | BRONCHIOLITIS | INFECTIOUS DISEASES | respiratory viral infection | NEBULIZED BUDESONIDE | IMMUNOLOGY | innate immunity | INFANTS | DISEASE | PEDIATRICS | INFLUENZA-VIRUS | parainfluenza virus | ORAL DEXAMETHASONE | HELPER TYPE-2 CYTOKINES | RESPIRATORY SYNCYTIAL VIRUS | YOUNG-CHILDREN
Journal Article