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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2006, Volume 103, Issue 35, pp. 13220 - 13225
Journal Article
Environmental Science and Pollution Research, ISSN 0944-1344, 11/2015, Volume 22, Issue 21, pp. 16329 - 16339
Journal Article
Journal Article
Journal Article
Human & Experimental Toxicology, ISSN 0960-3271, 04/2007, Volume 26, Issue 4, pp. 333 - 338
Risk assessment of neurotoxicity is mainly based on in vivo exposure, followed by tests on behaviour, physiology and pathology. In this study, an attempt to... 
LOED | SH-SY5Y | Neurotoxicity | In vitro | PBBK modelling | SYSTEMIC TOXICITY | DIAZEPAM | RATS | PREDICTION | LD50 | neurotoxicity | LINDANE | in vitro | ACRYLAMIDE | TOXICOLOGY | CULTURES | Phenytoin - toxicity | Humans | Brain Neoplasms - pathology | Diazepam - toxicity | Xenobiotics - toxicity | Xenobiotics - pharmacokinetics | Caffeine - pharmacokinetics | Diazepam - pharmacokinetics | Calcium Channels - physiology | Neurotoxicity Syndromes - pathology | Endpoint Determination | Nerve Tissue Proteins - biosynthesis | Pesticides - pharmacokinetics | Neuroblastoma - pathology | Calcium Channels - drug effects | Anticonvulsants - pharmacokinetics | Hypnotics and Sedatives - pharmacokinetics | Rats | Caffeine - toxicity | Lethal Dose 50 | Models, Statistical | Central Nervous System Stimulants - toxicity | Anticonvulsants - toxicity | Acrylamide - toxicity | Animals | Hypnotics and Sedatives - toxicity | Central Nervous System Stimulants - pharmacokinetics | Pesticides - toxicity | Acrylamide - pharmacokinetics | Kinetics | Phenytoin - pharmacokinetics | Parathion | Animal models | Toxicity | Cytotoxicity | Lethality | In vitro testing | Butyric acid | Acrylamide | Signal transduction | Toxicology | γ-Aminobutyric acid | Risk assessment | Biocompatibility | Diazepam | Caffeine | Excretion | Integration | Paraoxon | Lindane | Excitability | Protein biosynthesis | Exposure | Metabolism | Adsorption | Protein synthesis | Human performance | In vivo methods and tests | Acetylcholine | Transduction | Phenytoin | Neurology | Cell culture | Hazardous substances | Estimating techniques | Index Medicus | Calcium/metabolism | Cell Line;/pharmacology | Gliotoxin/pharmacology | Neurites/metabolism | Neuroblastoma/metabolism | Cell Differentiation | Immunosuppressive Agents/pharmacology | Calpain/metabolism | Spectrin/metabolism | Caspases/metabolism
Journal Article
Archives of Toxicology, ISSN 0340-5761, 8/2017, Volume 91, Issue 8, pp. 2837 - 2847
The freshwater planarian Dugesia japonica has recently emerged as an animal model for developmental neurotoxicology and found to be sensitive to... 
Biomedicine, general | Environmental Health | Biomedicine | Occupational Medicine/Industrial Medicine | Planarians | Organophosphorus pesticides | Pharmacology/Toxicology | Acetylcholinesterase kinetics and inhibition | Fluoride and oxime reactivation | MOLECULAR CHARACTERIZATION | BUTYRYLCHOLINESTERASE | TORPEDO-CALIFORNICA | MODEL SYSTEM | SPECIFICITY | ACETYLCHOLINESTERASE GENES | NEMATODE CAENORHABDITIS-ELEGANS | PHOSPHYLATED CHOLINESTERASES | ACTING OXIME REACTIVATORS | TOKYO SUBWAY | TOXICOLOGY | Species Specificity | Cholinesterase Reactivators - pharmacology | Humans | Animals | Cholinesterase Inhibitors - pharmacology | Butyrylcholinesterase - metabolism | Pesticides - toxicity | Models, Animal | Cholinesterases - metabolism | Organophosphorus Compounds - toxicity | In Vitro Techniques | Acetylcholinesterase - metabolism | Enzymes | Enzyme inhibitors | Surface active agents | Pesticides | Carbamates | Fluorides | Catalysis | Separation | Toxicity | Staining | Nervous system | Activation | Acetylcholinesterase | Diazinon | Toxicology | Fluoride | Neostigmine | Esterase | Agrochemicals | Donepezil | Inhibition | Tacrine | Pesticide toxicity | Chlorpyrifos | Quaternary | Paraoxon | Physostigmine | Cholinesterase | Vertebrates | Inhibitors | Sodium | Carbaryl | Dichlorvos | Pyridostigmine | Cholinergic nerves | Sodium fluoride | In vitro methods and tests | Index Medicus | organophosphorus pesticides | acetylcholinesterase kinetics and inhibition | planarians | fluoride and oxime reactivation
Journal Article
Journal Article
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2015, Volume 288, Issue 1, pp. 114 - 120
Parathion, a widely used organophosphate insecticide, is considered a high priority chemical threat. Parathion toxicity is dependent on its metabolism by the... 
Parathion | Redox cycling | Menadione | Cytochrome P450 system | Cytochrome P450 reductase | ACTIVATION | MECHANISMS | ACUTE TOXICITY | DELETION | GESTATIONAL EXPOSURE | CHLORPYRIFOS | LIVER | PURIFICATION | REDUCTASE | PHARMACOLOGY & PHARMACY | P450 | TOXICOLOGY | Activation, Metabolic | Organophosphate Poisoning - enzymology | Cholinesterase Inhibitors - toxicity | Liver - enzymology | Parathion - toxicity | Humans | Rats, Long-Evans | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 Enzyme Inhibitors - metabolism | Parathion - metabolism | Dose-Response Relationship, Drug | Paraoxon - toxicity | Cholinesterase Inhibitors - metabolism | Liver - drug effects | Paraoxon - metabolism | Time Factors | Microsomes, Liver - drug effects | Female | Microsomes, Liver - enzymology | NADP - metabolism | Cytoprotection | Disease Models, Animal | Recombinant Proteins - metabolism | Oxidation-Reduction | Organophosphate Poisoning - prevention & control | GPI-Linked Proteins - metabolism | Vitamin K 3 - pharmacology | Vitamin K 3 - metabolism | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Insecticides - metabolism | Organophosphate Poisoning - etiology | Insecticides - toxicity | Acetylcholinesterase - metabolism | Sulfites | Metabolites | Cytochrome P-450 | Physiological aspects | Insecticides | Poisoning | Vitamins | Phosphates | Liver | Acetylcholine | Index Medicus | CHOLINESTERASE | METABOLITES | ACETYLCHOLINE | RATS | SYMPTOMS | TOXICITY | 60 APPLIED LIFE SCIENCES | PARATHION | CYTOCHROMES | INHIBITION | METABOLISM | MICROSOMES | PHOSPHATES | VITAMINS | RECEPTORS | BRAIN | OXIDOREDUCTASES | redox cycling | cytochrome P450 reductase | parathion | menadione | cytochrome P450 system
Journal Article