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1. Full Text Allelic Variants of the Human Scavenger Receptor Class B Type 1 and Paraoxonase 1 on Coronary Heart Disease: Genotype–Phenotype Correlations
by Rodríguez-Esparragón, Francisco and Rodríguez-Pérez, José C and Hernández-Trujillo, Yaridé and Macías-Reyes, Antonio and Medina, Alfonso and Caballero, Araceli and Ferrario, Carlos M
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2005, Volume 25, Issue 4, pp. 854 - 860
OBJECTIVE—The antioxidant properties of high-density lipoprotein (HDL) have been attributed to paraoxonase (PON) enzyme activity. Human scavenger receptor... 
Scavenger receptor class B type 1 | CD36 and lysosomal integral membrane protein-II analogous-1 | Paraoxonase | Arylesterase | Polymorphism | HUMAN SERUM PARAOXONASE | MAJOR CARRIER | SR-BI | scavenger receptor class B type 1 | LIPID HYDROPEROXIDES | polymorphism | GENE POLYMORPHISMS | INHIBITS 3 | HIGH-DENSITY-LIPOPROTEIN | arylesterase | FACTOR-ACETYLHYDROLASE | PERIPHERAL VASCULAR DISEASE | CHOLESTEROL ESTERS | PLATELET-ACTIVATING-FACTOR | HEMATOLOGY | paraoxonase | Scavenger Receptors, Class B | Exons | Humans | Middle Aged | Coronary Disease - epidemiology | Male | Genetic Variation | Coronary Disease - metabolism | CD36 Antigens | Adult | Female | Genetic Predisposition to Disease - epidemiology | Gene Expression | Cholesterol, HDL - metabolism | Risk Factors | Genotype | RNA Stability | Aryldialkylphosphatase - genetics | Aryldialkylphosphatase - metabolism | Polymorphism, Genetic | Phenotype | Receptors, Scavenger | Coronary Disease - genetics | Alleles | Cholesterol, LDL - metabolism | Sex Distribution | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism
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2. Full Text Can paraoxonase 1 polymorphisms (L55 M and Q192 R) protect children with type 1 diabetes against lipid abnormalities?
by Fekih, Ons, PhD and Triki, Sonia, PhD and Hellara, Ilhem, PharmD and Neffati, Fadoua, PharmD and Rejeb, Jihen, PhD and Ommezzine, Asma, PharmD and Chouchane, Slaheddine, MD and Guediche, Mohamed Neji, MD and Bouslama, Ali, PharmD and Najjar, Mohamed Fadhel, PharmD
Journal of Clinical Lipidology, ISSN 1933-2874, 2014, Volume 8, Issue 3, pp. 249 - 255
Background Only a few studies have focused on the possible modulatory role of paraoxonase 1 (PON1) polymorphisms in lipid profiles, especially in children and... 
Cardiovascular | Lipid disorders | Paraoxonase 1 activity | Type 1 diabetes | Paraoxonase 1 polymorphisms | Cardiovascular risk | Keywords | ATHEROSCLEROSIS | RISK | GENE-CLUSTER POLYMORPHISMS | MELLITUS | SERUM PARAOXONASE | PON1 GENE | PLASMA-LIPOPROTEINS | PHARMACOLOGY & PHARMACY | CORONARY-HEART-DISEASE | ASSOCIATION | ARTERY-DISEASE | Haplotypes | Apolipoproteins - metabolism | Gene Frequency | Humans | Diabetes Mellitus, Type 1 - genetics | Spectrometry, Fluorescence | Genotype | Male | Cholesterol - metabolism | Aryldialkylphosphatase - genetics | Aryldialkylphosphatase - metabolism | Polymorphism, Genetic | Young Adult | Lipid Metabolism Disorders - genetics | Adolescent | Adult | Female | Child | Tunisia
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3. Full Text HDL functionality in type 1 diabetes
by Ganjali, Shiva and Dallinga-Thie, Geesje M and Simental-Mendía, Luis E and Banach, Maciej and Pirro, Matteo and Sahebkar, Amirhossein
Atherosclerosis, ISSN 0021-9150, 12/2017, Volume 267, pp. 99 - 109
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by absence of insulin secretion due to destruction of the pancreatic beta-cells. Patients... 
HDL functionality | Anti-inflammatory activity | Anti-oxidant activity | Type 1 diabetes | Cholesterol efflux | FAMILIAL HYPERCHOLESTEROLEMIA | CARDIAC & CARDIOVASCULAR SYSTEMS | LIPID-METABOLISM | TRANSFER PROTEIN-ACTIVITY | CHOLESTERYL ESTER TRANSFER | ACUTE CORONARY SYNDROME | PARAOXONASE ACTIVITY | HIGH-DENSITY-LIPOPROTEIN | ACUTE-PHASE RESPONSE | SERUM PARAOXONASE | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | Prevalence | Antioxidants - chemistry | Cardiovascular Diseases - metabolism | Diabetes Mellitus, Type 1 - physiopathology | Humans | Risk Factors | Diabetes Mellitus, Type 1 - complications | Cholesterol - metabolism | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Diabetes Mellitus, Type 1 - blood | Cholesterol, HDL - blood | Dyslipidemias - metabolism | Mice | Diabetes Mellitus, Type 2 - complications | Pancreatic beta cells | Chronic kidney failure | Low density lipoproteins | Diabetic nephropathies | Blood lipids | Risk factors
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4. Full Text Correlation of High‐Density Lipoprotein–Associated Paraoxonase 1 Activity With Systemic Inflammation, Disease Activity, and Cardiovascular Risk Factors in Psoriatic Disease
by Husni, M. Elaine and Wilson Tang, W. H and Lucke, Michael and Chandrasekharan, U. M and Brennan, Danielle M and Hazen, Stanley L
Arthritis & Rheumatology, ISSN 2326-5191, 08/2018, Volume 70, Issue 8, pp. 1240 - 1250
Objective To compare the activity of high‐density lipoprotein (HDL)–associated paraoxonase 1 (PON1) in patients with psoriasis (PsO) and patients with... 
INTIMA-MEDIA THICKNESS | RHEUMATOID-ARTHRITIS | ANTIBODIES | INDIVIDUALS | MYELOPEROXIDASE | ARYLESTERASE ACTIVITIES | SERUM PARAOXONASE | ATHEROSCLEROSIS | POLYMORPHISM | RHEUMATOLOGY | APOLIPOPROTEIN-A-I | Aryldialkylphosphatase - blood | Severity of Illness Index | Blood Sedimentation | Cardiovascular Diseases - etiology | Arthritis, Psoriatic - enzymology | Lipoproteins, HDL - blood | Humans | Middle Aged | Risk Factors | Male | Inflammation | Cardiovascular Diseases - enzymology | Psoriasis - complications | Carboxylic Ester Hydrolases - blood | Arthritis, Psoriatic - complications | Arthritis, Psoriatic - blood | Adult | Female | Psoriasis - enzymology | C-Reactive Protein - analysis | Psoriasis - blood | Arylesterase | Dyslipidemia | Paraoxonase 1 | Arthritis | Density | Risk factors | Proteins | Body mass index | Soil testing | Red blood cells | Lipoproteins (high density) | Hypertension | Psoriasis | Diabetes mellitus | Health risks | Paraoxonase | Risk analysis | Joint diseases | E.S.R | Sedimentation | Patients | Quality of life | Laboratory tests | Serum levels | Body mass | Body size | Cardiovascular diseases | Health risk assessment | Metabolic disorders | Smoking
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5. Full Text Paraoxonase 1 (PON1) status and substrate hydrolysis
by Richter, Rebecca J and Jarvik, Gail P and Furlong, Clement E
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2009, Volume 235, Issue 1, pp. 1 - 9
Paraoxonase 1 (PON1) hydrolyzes a number of organophosphorus (OP) compounds including insecticides and nerve agents. The efficacy of PON1 to protect against a... 
PON1 polymorphism | Chlorpyrifos | Pharmacogenetics | Paraoxonase 1 | Diazoxon | Chlorpyrifos oxon | Diazinon | CHLORPYRIFOS OXON | TOXICITY | Chlorpyrifos axon | ARYLESTERASE | GENE | Q192R POLYMORPHISM | PHARMACOLOGY & PHARMACY | HUMAN-SERUM PARAOXONASE | TOXICOLOGY | CORONARY-HEART-DISEASE | PROMOTER | MOLECULAR-BASIS | EXPRESSION | Chlorpyrifos - analogs & derivatives | Isoenzymes | Humans | Substrate Specificity | Aryldialkylphosphatase - genetics | Aryldialkylphosphatase - metabolism | Organophosphorus Compounds - metabolism | Polymorphism, Genetic | Chlorpyrifos - metabolism | Gene Expression Regulation, Enzymologic | Hydrolysis | Insecticides - metabolism | Molecular Structure | Enzymes | Enzyme inhibitors | War use | Analysis | Medical genetics | Gases, Asphyxiating and poisonous | Index Medicus | HYDROLYSIS | IN VIVO | 60 APPLIED LIFE SCIENCES | ENZYMES | SUBSTRATES | PARATHION
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6. Full Text Paraoxonase 1 (PON1) reduces macrophage inflammatory responses
by Aharoni, Saar and Aviram, Michael and Fuhrman, Bianca
Atherosclerosis, ISSN 0021-9150, 2013, Volume 228, Issue 2, pp. 353 - 361
Abstract Objectives Paraoxonase 1 (PON1) was suggested to play an anti-inflammatory role. In the present study we questioned whether PON1 has a direct impact... 
Cardiovascular | M1 activation | Inflammation | Paraoxonase 1 (PON1) | Macrophages | Atherosclerosis | CELLS | OXIDATIVE STRESS | ACTIVATION | LACTONASE ACTIVITY | MECHANISM | MEMBRANE | HIGH-AFFINITY | DENSITY-LIPOPROTEIN | PERIPHERAL VASCULAR DISEASE | TRANSGENIC MICE | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Interferon-gamma - metabolism | Necrosis | Inflammation Mediators - metabolism | Interleukin-6 - metabolism | Macrophages - immunology | Cell Line | Macrophages - pathology | Mice, Inbred C57BL | Mice, Transgenic | Inflammation - immunology | Aryldialkylphosphatase - genetics | Aryldialkylphosphatase - metabolism | Macrophages - enzymology | Phenotype | Animals | Lipopolysaccharides - pharmacology | Inflammation - genetics | Macrophages - drug effects | Inflammation - prevention & control | Mice | Scavenger Receptors, Class B - metabolism | Macrophage Activation - drug effects | Inflammation - enzymology | Phagocytosis
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7. Paraoxonase 1 Gene L55M Polymorphism and Paraoxonase 1 Activity in Obstructive Sleep Apnea Patients
by Plociniczak, A and Baszczuk, A and Ludziejewska, A and Winiarska, H and Michalak, S and Kasprzak, G and Formanowicz, D and Cofta, S and Wysocka, E
2019, Advances in Experimental Medicine and Biology, Volume 1150, 8
The antioxidant enzyme paraoxonase-1 (PON1) may limit oxidative stress in the development of cardiovascular diseases (CVD) and obstructive sleep apnea (OSA).... 
MEDICINE, RESEARCH & EXPERIMENTAL | Oxidative stress | MYOCARDIAL-INFARCTION | Antioxidant activity | PON1 | Paraoxonase enzyme | RISK | HEALTHY | Gene polymorphism | Obstructive sleep apnea | ENDOTHELIAL FUNCTION | SERUM PARAOXONASE | Q192R | RESPIRATORY SYSTEM | Atherosclerosis | DISEASE | BIOLOGY | STRESS | ASSOCIATION
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8. Full Text Albuminuria, the High-Density Lipoprotein Proteome, and Coronary Artery Calcification in Type 1 Diabetes Mellitus: The DCCT/EDIC Study
by Shao, Baohai and Zelnick, Leila R and Wimberger, Jake and Himmelfarb, Jonathan and Brunzell, John and Davidson, W Sean and Snell-Bergeon, Janet K and Bornfeldt, Karin E and de Boer, Ian H and Heinecke, Jay W and DCCT EDIC Res Grp and for the DCCT/EDIC Research Group
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2019, Volume 39, Issue 7, pp. 1483 - 1491
OBJECTIVE—Albuminuria is an important risk factor for cardiovascular disease in diabetes mellitus. We determined whether albuminuria associates with... 
atherosclerosis | KIDNEY-DISEASE | COMPLICATIONS TRIAL/EPIDEMIOLOGY | proteomics | RISK | triglycerides | GENE POLYMORPHISMS | albuminuria | HEART-DISEASE | INTERVENTIONS | SERUM PARAOXONASE | kidney diseases | INFLAMMATION | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | HDL CHOLESTEROL | HEMATOLOGY | lipoproteins
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9. Full Text Onion extract (Allium cepa L.), quercetin and catechin up‐regulate paraoxonase 1 activity with concomitant protection against low‐density lipoprotein oxidation in male Wistar rats subjected to oxidative stress
by Jaiswal, Nidhi and Rizvi, Syed Ibrahim
Journal of the Science of Food and Agriculture, ISSN 0022-5142, 10/2014, Volume 94, Issue 13, pp. 2752 - 2757
BACKGROUND Paraoxonase 1 (PON1) protects the oxidative modification of low‐density lipoprotein (LDL) and is a major anti‐atherosclerotic protein component of... 
paraoxonase 1 | quercetin | catechin | low‐density lipoproteins | onion | oxidative stress | Oxidative stress | Catechin | Onion | Low-density lipoproteins | Paraoxonase 1 | Quercetin | ANTIOXIDANT ACTIVITY | DIETARY POLYPHENOLS | LIPID-PEROXIDATION | FOOD SCIENCE & TECHNOLOGY | ATHEROSCLEROSIS | PON1 ACTIVITY | low-density lipoproteins | IN-VITRO | SERUM PARAOXONASE | LDL | AGRICULTURE, MULTIDISCIPLINARY | GENE-EXPRESSION | MICE | CHEMISTRY, APPLIED | Aryldialkylphosphatase - blood | Up-Regulation | Oxidative Stress | Rats, Wistar | Onions - chemistry | Male | Aryldialkylphosphatase - chemistry | Onions - economics | Atherosclerosis - enzymology | Phytotherapy - adverse effects | Catechin - therapeutic use | Dietary Supplements - adverse effects | Catechin - adverse effects | Quercetin - therapeutic use | Lipoproteins, LDL - analysis | Biomarkers - blood | Random Allocation | India | Atherosclerosis - blood | Antioxidants - therapeutic use | Animals | Lipoproteins, LDL - antagonists & inhibitors | Plant Roots - chemistry | Quercetin - adverse effects | Antioxidants - adverse effects | Lipid Peroxidation | Plant Extracts - therapeutic use | Atherosclerosis - prevention & control | Plant Extracts - adverse effects | Flavonoids | Flavones | Bioflavonoids | Low density lipoproteins | Oxidation-reduction reaction | Blood lipids
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10. Full Text Humana paraoksonaza 1, 2 i 3
by Rajkovic, Marija Grdic and Rumora, Lada and Barisic, Karmela
Biochemia Medica, ISSN 1330-0962, 06/2011, Volume 21, Issue 2, pp. 122 - 130
Paraoxonase 3 | Paraoxonase 2 | Paraoxonase 1
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11. Full Text Relationship of Paraoxonase 1 (PON1) Gene Polymorphisms and Functional Activity With Systemic Oxidative Stress and Cardiovascular Risk
by Bhattacharyya, Tamali and Nicholls, Stephen J and Topol, Eric J and Zhang, Renliang and Yang, Xia and Schmitt, David and Fu, Xiaoming and Shao, Mingyuan and Brennan, Danielle M and Ellis, Stephen G and Brennan, Marie-Luise and Allayee, Hooman and Lusis, Aldons J and Hazen, Stanley L
JAMA, ISSN 0098-7484, 03/2008, Volume 299, Issue 11, pp. 1265 - 1276
CONTEXT Paraoxonase 1 (PON1) is reported to have antioxidant and cardioprotective properties. The relationship between PON1 genotypes and functional activity... 
LIPOPROTEIN | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | PROTEIN | SERUM PARAOXONASE | ATHEROSCLEROSIS | MICE | CORONARY-HEART-DISEASE | ASSOCIATION | GENOME | ARTERY-DISEASE | Aryldialkylphosphatase - blood | Prognosis | Prospective Studies | Humans | Middle Aged | Oxidative Stress - physiology | Risk Factors | Proportional Hazards Models | Logistic Models | Male | Chromatography, High Pressure Liquid | Aryldialkylphosphatase - genetics | Cardiovascular Diseases - genetics | Polymorphism, Genetic | Tandem Mass Spectrometry | Polymerase Chain Reaction | Cardiovascular Diseases - blood | Cardiovascular Diseases - epidemiology | Female | Aged | Fluorescence Polarization | Oxidative stress | Genetic aspects | Research | Cardiovascular diseases | Health aspects | Risk factors | Genetic polymorphisms | Antioxidants | Genetics | Cardiovascular disease | Polymorphism
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12. Full Text Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: The hunt goes on
by Costa, Lucio G and Giordano, Gennaro and Furlong, Clement E
Biochemical Pharmacology, ISSN 0006-2952, 2011, Volume 81, Issue 3, pp. 337 - 344
Paraoxonase 1 (PON1) is a high density lipoprotein (HDL)-associated enzyme displaying esterase and lactonase activity. PON1 hydrolyzes several organophosphorus... 
Antioxidants | Anti-diabetic drugs | Paraoxonase 1 | Polyphenols | Alcohol | Statins | Hypolipemic drugs | OXIDATIVE STRESS | PARAOXONASE/ARYLESTERASE ACTIVITIES | LIPID-PEROXIDATION | ANTIOXIDANT ENZYME | INCREASES SERUM PARAOXONASE | CHOLESTERYL ESTER TRANSFER | HIGH-DENSITY-LIPOPROTEIN | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | E-DEFICIENT MICE | APOLIPOPROTEIN-A-I | Enzyme Activators - pharmacology | Cardiovascular Diseases - prevention & control | Humans | Esterases - metabolism | Antioxidants - pharmacology | Alcohol Drinking | Hypolipidemic Agents - pharmacology | Aryldialkylphosphatase - genetics | Aryldialkylphosphatase - metabolism | Hypoglycemic Agents - pharmacology | Polymorphism, Genetic | Gene Expression Regulation, Enzymologic | Diet | Environmental Pollutants - antagonists & inhibitors | Flavonoids - pharmacology | Phenols - pharmacology | Index Medicus | alcohol | polyphenols | antioxidants | statins | anti-diabetic drugs | hypolipemic drugs
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13. Full Text Lowered plasma paraoxonase (PON)1 activity is a trait marker of major depression and PON1 Q192R gene polymorphism–smoking interactions differentially predict the odds of major depression and bipolar disorder
by Bortolasci, Chiara Cristina and Vargas, Heber Odebrecht and Souza-Nogueira, André and Barbosa, Décio Sabbatini and Moreira, Estefania Gastaldello and Nunes, Sandra Odebrecht Vargas and Berk, Michael and Dodd, Seetal and Maes, Michael
Journal of Affective Disorders, ISSN 0165-0327, 2014, Volume 159, pp. 23 - 30
Abstract Background Major depression and bipolar disorder are accompanied by the activation of immune-inflammatory and Oxidative and Nitrosative Stress (O&NS)... 
Psychiatry | Oxidative stress | Depression | Bipolar disorder | Inflammation | Paraoxonase | Cytokines | PATHWAYS | PSYCHIATRY | INTERLEUKIN-6 | CLINICAL NEUROLOGY | CIGARETTE-SMOKING | SERUM PARAOXONASE | RISK-FACTOR | SUICIDAL-BEHAVIOR | ASSOCIATION | EXPRESSION | Aryldialkylphosphatase - blood | Depressive Disorder, Major - blood | Humans | Middle Aged | Genotype | Logistic Models | Male | Smoking - genetics | Biomarkers - blood | Genetic Markers | Aryldialkylphosphatase - genetics | Bipolar Disorder - genetics | Gene-Environment Interaction | Polymorphism, Genetic | Depressive Disorder, Major - genetics | Adult | Female | Antioxidants | Medical research | Medical colleges | Genetic research | Physiological aspects | Medicine, Experimental | Genetic aspects | Major depressive disorder | Index Medicus
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