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PLoS Pathogens, ISSN 1553-7366, 11/2013, Volume 9, Issue 11, p. e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
PLoS Pathogens, ISSN 1553-7366, 08/2009, Volume 5, Issue 8, p. e1000559
The intraerythrocytic parasite Plasmodium-the causative agent of malaria-produces an inorganic crystal called hemozoin (Hz) during the heme detoxification... 
APOPTOSIS | INNATE IMMUNE RECEPTORS | INTERLEUKIN-1-BETA | MACROPHAGES | CASPASE-1 INFLAMMASOME | MICROBIOLOGY | KAPPA-B | NALP3 INFLAMMASOME | RESPONSES | VIROLOGY | IN-VIVO | MICE | PARASITOLOGY | Potassium - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Humans | Caspase 1 - metabolism | Male | Caspase 1 - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Hemeproteins - immunology | Signal Transduction - immunology | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | src-Family Kinases - metabolism | Cytoskeletal Proteins - metabolism | Female | Interleukin-1beta - biosynthesis | Phosphorylation - immunology | Malaria - metabolism | Syk Kinase | Carrier Proteins - immunology | Disease Models, Animal | Neutrophil Infiltration - immunology | Calcium-Binding Proteins - metabolism | Carrier Proteins - physiology | Apoptosis Regulatory Proteins - immunology | Plasmodium chabaudi - chemistry | Hemeproteins - metabolism | Malaria - immunology | Mice, Inbred C57BL | Cathepsin B - metabolism | Inflammation - immunology | Plasmodium chabaudi - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Malaria - parasitology | Proteomics | HSP90 Heat-Shock Proteins - metabolism | Hemeproteins - physiology | Mice | Phagocytosis | Hostages | Inflammation | Malaria | Phosphotransferases | Medical research | Salmonella | Phosphorylation | Lipids | Parasites | Experiments | Fever | Tropical diseases
Journal Article
Immunity, ISSN 1074-7613, 07/2012, Volume 37, Issue 1, pp. 108 - 121
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0169985
An 8-week feeding trial was conducted to evaluate the effects of dietary lipid sources on growth performance, fatty acid composition, rate-limiting enzyme... 
BASS DICENTRARCHUS-LABRAX | FISH-OIL REPLACEMENT | PARASITES CRYPTOCARYON-IRRITANS | LONG-TERM GROWTH | MULTIDISCIPLINARY SCIENCES | BREAM SPARUS-AURATA | COA-DIACYLGLYCEROL ACYLTRANSFERASE | GENE-EXPRESSION PROFILES | SALMON SALMO-SALAR | IMMUNE-RELATED GENES | TROUT ONCORHYNCHUS-MYKISS | Dietary Fats - metabolism | Liver - enzymology | Triglycerides - biosynthesis | Fatty Acid Synthases - metabolism | Soybean Oil - metabolism | Perciformes - genetics | Perciformes - growth & development | Perciformes - metabolism | Muscles - metabolism | Fatty Acid Synthases - genetics | Fatty Acids - chemistry | Liver - metabolism | Fatty Acids - analysis | Fish Proteins - metabolism | Lipid Metabolism | Lipase - metabolism | Triglycerides - metabolism | Animals | Diacylglycerol O-Acyltransferase - genetics | Linseed Oil - metabolism | Plant Oils - metabolism | Fish Oils - metabolism | Glucosephosphate Dehydrogenase - metabolism | Diacylglycerol O-Acyltransferase - metabolism | Peanut Oil | Physiological aspects | Phospholipids | Synthesis | Research | Fatty acids | Analysis | Phosphates | Growth rate | Transcription | Liver | Linseed oil | Diacylglycerol | Lipids | Superoxide dismutase | Cages | Lipoprotein lipase | Glucose | Floating | Lipase | Fatty acid composition | Glucose 6 phosphate dehydrogenase | Glucose dehydrogenase | Fatty liver | Enzymatic activity | Soya bean oil | Rodents | Fish | Lipid metabolism | Vegetable oils | Alanine | Fish oils | Condition factor | Muscles | Acyltransferase | Gene expression | Metabolism | Palmitoyltransferase | Fatty-acid synthase | Malondialdehyde | Cholesterol | Carnitine palmitoyltransferase | Carnitine | Rapeseed oil | Diet | Rapeseed | Alanine transaminase | Catabolism | Aspartate aminotransferase | Fats and oils | Feed efficiency
Journal Article
Journal Article
Journal Article
Science, ISSN 0036-8075, 3/2013, Volume 339, Issue 6126, pp. 1448 - 1453
Type I interferons (IFN-α and IFN-β) are important for protection against many viral infections, whereas type II interferon (IFN-γ) is essential for host... 
Monocytes | Messenger RNA | Tuberculosis | Mycobacterium tuberculosis | Antimicrobials | REPORTS | Leprosy | Infections | Skin | Lesions | Gene expression | LISTERIA-MONOCYTOGENES | ACTIVATION | PROFILES | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | HUMAN TUBERCULOSIS | IL-1-BETA | INDUCTION | DEPENDENT ANTIMICROBIAL PATHWAY | SARCOIDOSIS | LEPROSY | Up-Regulation | Interferon-beta - immunology | Humans | Transcriptome | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics | Monocytes - metabolism | Monocytes - immunology | Interferon-gamma - metabolism | Antimicrobial Cationic Peptides - metabolism | RNA, Messenger - metabolism | Receptors, Calcitriol - genetics | Mycobacterium leprae - immunology | Interferon-beta - genetics | Interleukin-10 - metabolism | beta-Defensins - metabolism | Interferon-gamma - genetics | Antimicrobial Cationic Peptides - genetics | Leprosy, Lepromatous - genetics | Mycobacterium leprae - physiology | Leprosy, Tuberculoid - immunology | beta-Defensins - genetics | Leprosy, Lepromatous - immunology | RNA, Messenger - genetics | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism | Microbial Viability | Receptors, Calcitriol - metabolism | Leprosy, Tuberculoid - genetics | Tuberculosis - immunology | Leprosy, Lepromatous - metabolism | Interferon-beta - metabolism | Tuberculosis - genetics | Leprosy, Tuberculoid - metabolism | Interferon-gamma - immunology | Interleukin-10 - genetics | Interleukins | Physiological aspects | Host-parasite relationships | Anti-infective agents | Interferon | Genetic aspects | Health aspects | Antimicrobial agents | Pathogenesis | Genes | Bacteria | Human behavior | Antiinfectives and antibacterials | Digital signatures
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19987 - 19998
The eukaryotic protozoan parasite Trypanosoma brucei is the causative agent of human African trypanosomiasis. Polyamine biosynthesis is essential in T. brucei,... 
YEAST | FACTOR EF-P | HUMAN AFRICAN TRYPANOSOMIASIS | BLOOD-STREAM FORMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HOMOLOG | ACTIN CYTOSKELETON | CELL-GROWTH | HYPUSINE MODIFICATION | SACCHAROMYCES-CEREVISIAE | POLYAMINE METABOLISM | RNA, Protozoan - genetics | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Proteome - genetics | Protozoan Proteins - antagonists & inhibitors | Humans | Molecular Sequence Data | Protozoan Proteins - genetics | RNA, Messenger - metabolism | Gene Knockdown Techniques | Peptides - metabolism | Protozoan Proteins - metabolism | RNA, Messenger - antagonists & inhibitors | Escherichia coli - metabolism | Lysine - metabolism | Microfilament Proteins - metabolism | Flagella - genetics | Peptide Initiation Factors - antagonists & inhibitors | Microfilament Proteins - genetics | RNA-Binding Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Amino Acid Sequence | Lysine - analogs & derivatives | Flagella - ultrastructure | Trypanosoma brucei brucei - metabolism | RNA, Messenger - genetics | RNA, Protozoan - antagonists & inhibitors | Recombinant Proteins - genetics | Trypanosoma brucei brucei - genetics | Peptide Initiation Factors - metabolism | Sequence Homology, Amino Acid | Peptide Initiation Factors - genetics | RNA, Protozoan - metabolism | Trypanosoma brucei brucei - ultrastructure | Sequence Alignment | Animals | Flagella - metabolism | Escherichia coli - genetics | Protein Processing, Post-Translational | Proteome - metabolism | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | parasite metabolism | polyamine | spermidine | hypusine | Microbiology | eukaryotic initiation factor 5A (eIF5A) | Trypanosoma brucei
Journal Article