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BBA - General Subjects, ISSN 0304-4165, 06/2013, Volume 1830, Issue 6, pp. 3756 - 3766
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2011, Volume 121, Issue 12, pp. 4655 - 4669
Parathyroid hormone-related protein (PTHrP) is a secreted factor expressed in almost all normal fetal and adult tissues. It is involved in a wide range of... 
MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | HORMONE-RELATED PROTEIN | MAMMARY-GLAND DEVELOPMENT | CANCER METASTASIS | PROSTATE-CANCER | MOUSE MODEL | PARATHYROID-HORMONE | BONE METASTASIS | MONOCLONAL-ANTIBODY | TRANSGENIC MICE | Angiogenic Proteins - genetics | Cell Adhesion Molecules - genetics | Epithelial Cells - metabolism | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - immunology | Molecular Targeted Therapy | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - therapy | Mammary Glands, Animal - growth & development | Antibodies, Neutralizing - immunology | Antibodies, Neutralizing - therapeutic use | Mammary Neoplasms, Experimental - pathology | Apoptosis Regulatory Proteins - genetics | Cell Cycle Proteins - genetics | Female | Receptors, CXCR4 - genetics | Parathyroid Hormone-Related Protein - deficiency | Neoplasm Proteins - genetics | Angiogenic Proteins - biosynthesis | Apoptosis Regulatory Proteins - biosynthesis | Cell Adhesion Molecules - biosynthesis | Neoplasm Proteins - biosynthesis | Parathyroid Hormone-Related Protein - genetics | Cell Cycle Proteins - biosynthesis | Disease Progression | Mice, Knockout | Parathyroid Hormone-Related Protein - immunology | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Receptors, CXCR4 - physiology | Animals | Mammary Glands, Animal - metabolism | Receptors, CXCR4 - biosynthesis | Breast Neoplasms - pathology | Parathyroid Hormone-Related Protein - physiology | Mice | Cellular proteins | Breast tumors | Parathyroid hormone | Development and progression | Metastasis | Research | Properties | Index Medicus | Abridged Index Medicus
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 04/2012, Volume 302, Issue 8, pp. 1009 - 1015
Breast cells drive bone demineralization during lactation and metastatic cancers. A shared mechanism among these physiological and pathological states is... 
Osteoblast | RANK ligand | RUNX2/CBFA1 | Lactation | 5-hydroxytryptamine | Prolactin | CELLS | PHYSIOLOGY | prolactin | HYPERPROLACTINEMIA | FACTOR-KAPPA-B | osteoblast | HUMORAL HYPERCALCEMIA | PEPTIDE | BREAST-CANCER | lactation | CALCIUM | ENDOCRINOLOGY & METABOLISM | TRANSCRIPTION FACTOR | EXPRESSION | Epithelial Cells - metabolism | Humans | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Receptors, Serotonin, 5-HT2 - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Breast Neoplasms - metabolism | Epithelial Cells - secretion | Cattle | Female | Neoplasm Proteins - genetics | Tryptophan Hydroxylase - metabolism | Cell Line | Signal Transduction | Mice, Inbred C57BL | Parathyroid Hormone-Related Protein - genetics | Cells, Cultured | Gene Expression Regulation | Parathyroid Hormone-Related Protein - secretion | Parathyroid Hormone-Related Protein - metabolism | Mammary Glands, Animal - cytology | Mice, Knockout | Tryptophan Hydroxylase - genetics | Animals | Mammary Glands, Animal - metabolism | Serotonin - metabolism | Lactation - metabolism | Cell Line, Tumor | Mammary Glands, Animal - secretion | Mice | Core Binding Factor Alpha 1 Subunit - genetics | Prevention | Physiological aspects | Bone diseases | Serotonin | Parathyroid hormone | Health aspects | Proteins | Breast cancer | Hormones | Rodents | Cells | Tumors | Index Medicus | CBFA1 | RUNX2
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2009, Volume 284, Issue 41, pp. 28382 - 28391
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e85803 - e85803
Parathyroid hormone-related protein (PTHrP) possesses a variety of physiological and developmental functions and is also known to facilitate the progression of... 
BREAST-CANCER | SIGNALING PATHWAYS | STEM-CELLS | TGF-BETA | TUMOR PROGRESSION | BONE METASTASES | MULTIDISCIPLINARY SCIENCES | PTH/PTHRP RECEPTOR | INDIAN HEDGEHOG | E-CADHERIN | FLUORESCENT PROTEIN | Bone and Bones - pathology | Epithelial-Mesenchymal Transition - physiology | Humans | Gene Expression Regulation, Neoplastic | Male | Transplantation, Heterologous | Prostatic Neoplasms - physiopathology | Epithelial-Mesenchymal Transition - genetics | Prostatic Neoplasms - genetics | Protein Isoforms - metabolism | RNA Interference | Matrix Metalloproteinase 9 - genetics | Vimentin - genetics | Bone and Bones - metabolism | Cadherins - genetics | Snail Family Transcription Factors | Prostatic Neoplasms - pathology | Parathyroid Hormone-Related Protein - genetics | Transcription Factors - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Parathyroid Hormone-Related Protein - metabolism | Protein Isoforms - physiology | Bone and Bones - physiopathology | Animals | Mice, Nude | Parathyroid Hormone-Related Protein - physiology | Cell Line, Tumor | Mice | Microscopy, Fluorescence | Protein Isoforms - genetics | Stem cells | Physiological aspects | Development and progression | Metastasis | Hormones | Intermediate filament proteins | Health aspects | Prostate cancer | Vimentin | Motility | Mesenchyme | Destruction | Otolaryngology | Stem cell transplantation | Kinases | E-cadherin | Metastases | Cell adhesion & migration | Parathyroid hormone-related protein | Bone resorption | Proteins | Signal transduction | Allografts | Surgery | Parathyroid | Breast cancer | siRNA | Signaling | Parathyroid hormone | Bone | Laboratory animals | Prostate | Tumors | Cancer | Index Medicus
Journal Article
Biochimica et Biophysica Acta - Molecular Basis of Disease, ISSN 0925-4439, 2014, Volume 1842, Issue 9, pp. 1350 - 1363
Prostate cancer frequently metastasizes to the skeleton but the underlying mechanism remains largely undefined. Discoidin domain receptor 2 (DDR2) is a member... 
Bone metastasis | PTHrP | Prostate cancer | DDR2 | Runx2 | TRANSCRIPTION FACTORS | CELLS | TGF-BETA | INCREASED EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR | FIBROBLASTS | BIOPHYSICS | UP-REGULATION | Prostatic Neoplasms - metabolism | RNA, Small Interfering - genetics | Phosphorylation | Cell Proliferation | Luciferases - metabolism | Humans | Gene Expression Regulation, Neoplastic | Bone Neoplasms - secondary | Male | Wound Healing | Osteoclasts - cytology | Bone Neoplasms - metabolism | Discoidin Domain Receptors | Collagen Type I - genetics | Prostatic Neoplasms - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Bone Neoplasms - genetics | Electrophoretic Mobility Shift Assay | Osteoblasts - cytology | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Promoter Regions, Genetic | Prostatic Neoplasms - pathology | Collagen Type I - metabolism | Signal Transduction | Receptors, Mitogen - antagonists & inhibitors | Parathyroid Hormone-Related Protein - genetics | RNA, Messenger - genetics | Receptors, Mitogen - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Osteoclasts - metabolism | Parathyroid Hormone-Related Protein - metabolism | Blotting, Western | Animals | Transforming Growth Factor beta - genetics | Receptor Protein-Tyrosine Kinases - genetics | Mice | Osteoblasts - metabolism | Transforming Growth Factor beta - metabolism | Cell Movement | Receptors, Mitogen - genetics | Memory (Computers) | Collagen | Analysis | Bone morphogenetic proteins | Metastasis | Hormones | Transforming growth factors
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 02/2018, Volume 314, Issue 2, pp. C242 - C253
Injury of mesangial cells (MC) is a prominent feature of glomerulonephritis. Activated MC secrete inflammatory mediators that induce cell apoptosis.... 
Mesangial cells | Signaling | Inflammation | Cyclooxygenase-2 | Parathyroid hormone-related peptide | Apoptosis | GLOMERULONEPHRITIS | PHYSIOLOGY | signaling | cyclooxygenase-2 | apoptosis | DIABETIC-NEPHROPATHY | RENAL-DISEASE | CYTOKINE | PTHRP | mesangial cells | RAT MODEL | CELL BIOLOGY | parathyroid hormone-related peptide | inflammation | ENDOTHELIAL-CELLS | SMOOTH-MUSCLE-CELLS | CHEMOKINE RECEPTORS | NF-KAPPA-B | Up-Regulation | Interleukin-1beta - pharmacology | Apoptosis - drug effects | Mice, Inbred C57BL | Parathyroid Hormone-Related Protein - genetics | Cells, Cultured | Glomerulonephritis - genetics | Male | NF-kappa B - metabolism | Peptide Fragments - pharmacology | Parathyroid Hormone-Related Protein - metabolism | Mesangial Cells - drug effects | Parathyroid Hormone-Related Protein - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Signal Transduction - drug effects | Time Factors | Glomerulonephritis - pathology | Cyclooxygenase 2 - metabolism | Inflammation Mediators - metabolism | Mesangial Cells - enzymology | Mesangial Cells - pathology | Glomerulonephritis - enzymology | Prevention | Physiological aspects | Kidney glomerulus | Parathyroid hormone | Glomerulonephritis | Cell culture | Lymphocytes T | Hormones | Macrophages | Thymus | Parathyroid hormone-related protein | Prostaglandin endoperoxide synthase | Interleukin 6 | Lysates | Cell activation | Interleukin 1 | Parathyroid | CCL17 protein | HuR protein | NF-κB protein | Cell survival | Cytokines | T cell receptors | Interleukin 16 | Cells | Interleukin 17 | CXCL11 protein | Macrophage inflammatory protein | Chemokines | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 7, pp. e0160034 - e0160034
Prolonged skeletal unloading through bedrest results in bone loss similar to that observed in elderly osteoporotic patients, but with an accelerated timeframe.... 
APOPTOSIS | IN-VITRO | RESORPTION | BONE-MINERAL DENSITY | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | SPACE-FLIGHT | DIFFERENTIATION | SPACEFLIGHT | BED REST | MESENCHYMAL STEM-CELLS | Extracellular Matrix Proteins - genetics | Mice, Inbred C57BL | Parathyroid Hormone-Related Protein - genetics | Cells, Cultured | Male | Osteoporosis - etiology | Parathyroid Hormone-Related Protein - metabolism | Apoptosis Regulatory Proteins - metabolism | Prolactin - metabolism | Prolactin - genetics | Animals | Osteoporosis - metabolism | Weightlessness - adverse effects | Apoptosis Regulatory Proteins - genetics | Female | Mice | Osteoblasts - metabolism | Extracellular Matrix Proteins - metabolism | Osteoporosis | Physiological aspects | Development and progression | Genetic aspects | Research | Thyroid hormones | Risk factors | Elderly people | Wnt protein | Immobilization | Genomes | Biochemistry | Bone (trabecular) | Osteoblasts | Parathyroid hormone-related protein | Proteins | Genotype & phenotype | Biocompatibility | Bones | Physiology | Bone density | Bone loss | Bone matrix | Microgravity | Parathyroid | Bone composition | Gravity | Gravitation | Cell survival | Unloading | Space flight | Bone turnover | Gene expression | Metabolism | Insulin | Patients | Ablation | Signaling | Satellites | Bone mass | Cell death | Parathyroid hormone | Stem cells | Astronauts | Bone | Viability | Elderly | Chemokines | Geriatrics | Apoptosis | Index Medicus
Journal Article
Endocrinology, ISSN 0013-7227, 05/2009, Volume 150, Issue 5, pp. 2027 - 2035
Journal Article
Journal Article
Development, ISSN 0950-1991, 06/2008, Volume 135, Issue 11, pp. 1947 - 1956
Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte hypertrophy is also required in... 
Ihh | Patched 1 | Cartilage | Chondrocyte hypertrophy | PTHrP | PATHWAYS | OSTEOBLAST | cartilage | chondrocyte hypertrophy | PROLIFERATION | DEVELOPMENTAL BIOLOGY | CARTILAGE DEVELOPMENT | ENDOCHONDRAL BONE | SKELETON | patched 1 | HORMONE-RELATED-PROTEIN | GROWTH-PLATE | DIFFERENTIATION | Immunohistochemistry | Hedgehog Proteins - pharmacology | Bone Morphogenetic Proteins - physiology | Hedgehog Proteins - metabolism | Hedgehog Proteins - physiology | Wnt Proteins - metabolism | Cell Differentiation - genetics | Bone Morphogenetic Proteins - metabolism | In Situ Hybridization | Wnt Proteins - genetics | Hedgehog Proteins - genetics | Receptors, Cell Surface - physiology | beta Catenin - physiology | Patched Receptors | Bone Morphogenetic Proteins - genetics | Cell Differentiation - physiology | Chondrocytes - metabolism | Organ Culture Techniques | Recombinant Proteins - metabolism | Chondrocytes - pathology | Parathyroid Hormone-Related Protein - genetics | Cells, Cultured | Receptors, Cell Surface - metabolism | Signal Transduction - genetics | Cell Enlargement | Recombinant Proteins - pharmacology | Forelimb - metabolism | Reverse Transcriptase Polymerase Chain Reaction | beta Catenin - metabolism | beta Catenin - genetics | Animals | Signal Transduction - drug effects | Parathyroid Hormone-Related Protein - physiology | Signal Transduction - physiology | Forelimb - cytology | Mice | Wnt Proteins - physiology | Mutation | Patched-1 Receptor | Receptors, Cell Surface - genetics | Index Medicus
Journal Article