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Experimental & molecular medicine, ISSN 2092-6413, 2015, Volume 47, Issue 3, pp. e147 - e147
Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy... 
MEDICINE, RESEARCH & EXPERIMENTAL | UBIQUITIN-PROTEASOME SYSTEM | CHAPERONE-MEDIATED AUTOPHAGY | ALPHA-SYNUCLEIN AGGREGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | QUALITY CONTROL DEGRADATION | CENTRAL-NERVOUS-SYSTEM | AMYOTROPHIC-LATERAL-SCLEROSIS | SOD1 TRANSGENIC MICE | ENDOPLASMIC-RETICULUM STRESS | END RULE PATHWAY | PARKINSONS-DISEASE | Proteostasis Deficiencies - metabolism | Humans | Ubiquitin - metabolism | tau Proteins - metabolism | Parkinson Disease - drug therapy | Molecular Targeted Therapy | Neurodegenerative Diseases - drug therapy | Amyotrophic Lateral Sclerosis - drug therapy | Autophagy - drug effects | DNA-Binding Proteins - metabolism | PrPSc Proteins - metabolism | Lysosomes - metabolism | Proteolysis | Amyloid beta-Peptides - metabolism | Parkinson Disease - metabolism | Huntington Disease - drug therapy | Superoxide Dismutase - metabolism | Prion Diseases - drug therapy | Alzheimer Disease - drug therapy | Neurodegenerative Diseases - metabolism | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Huntington Disease - genetics | Mutation | Proteasome Endopeptidase Complex - metabolism | alpha-Synuclein - metabolism | Prion Diseases - metabolism | Review
Journal Article
Journal of the Neurological Sciences, ISSN 0022-510X, 2012, Volume 323, Issue 1-2, pp. 1 - 8
...), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). Several studies have demonstrated that altered kynurenine metabolism plays an important role in the pathogenesis of this group of diseases... 
Neurology | Aging | Alzheimer's disease (AD) | Amyotrophic lateral sclerosis (ALS) | Huntington's disease (HD) | Parkinson's disease (PD) | Kynurenine pathway | TRYPTOPHAN-METABOLISM | ACID | ALZHEIMERS-DISEASE | INDOLEAMINE 2,3-DIOXYGENASE | DISORDERS | NEUROSCIENCES | CLINICAL NEUROLOGY | QUINOLINATE LEVELS | CELL-DEATH | 3-MONOOXYGENASE | BRAIN | PARKINSONS-DISEASE | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Neuroprotective Agents - therapeutic use | Microglia - metabolism | Kynurenine - therapeutic use | Humans | Neurodegenerative Diseases - prevention & control | Parkinson Disease - drug therapy | Kynurenic Acid - metabolism | Molecular Targeted Therapy | Neurodegenerative Diseases - drug therapy | Quinolinic Acid - antagonists & inhibitors | Tryptophan - metabolism | Amyotrophic Lateral Sclerosis - drug therapy | Inflammation - metabolism | Neuroprotective Agents - pharmacology | Alzheimer Disease - prevention & control | Neurons - metabolism | Parkinson Disease - metabolism | Kynurenine - metabolism | Huntington Disease - drug therapy | Receptors, G-Protein-Coupled - drug effects | Receptors, G-Protein-Coupled - physiology | Receptors, N-Methyl-D-Aspartate - drug effects | Kynurenine - pharmacology | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Neurodegenerative Diseases - metabolism | Enzyme Inhibitors - therapeutic use | Huntington Disease - metabolism | Kynurenine - analogs & derivatives | Receptors, N-Methyl-D-Aspartate - physiology | Parkinson Disease - prevention & control | Animals | Quinolinic Acid - metabolism | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Neurotoxins - metabolism | Kynurenic Acid - antagonists & inhibitors | Aging - metabolism | Enzymes | Nervous system diseases | Enzyme inhibitors | Parkinson's disease | Metabolites | Huntington's chorea | Analysis | Physiological aspects | Tryptophan | Amyotrophic lateral sclerosis | Health aspects | Alzheimer's disease | Index Medicus
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2015, Volume 16, Issue 11, pp. 26797 - 26812
.... Recent studies have suggested that impairments of the autophagic process are associated with several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease... 
Alzheimer’s disease | ALS | Huntington’s disease | SENDA | Mitophagy | Autophagy | Parkinson’s disease | autophagy | Parkinson's disease | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELECTIVE MACROAUTOPHAGY | FRONTOTEMPORAL DEMENTIA | AMYOTROPHIC-LATERAL-SCLEROSIS | Huntington's disease | CHEMISTRY, MULTIDISCIPLINARY | CELL-DEATH | RECESSIVE JUVENILE PARKINSONISM | mitophagy | LYSOSOME FUSION | ENDOPLASMIC-RETICULUM | SIGMA-1 RECEPTOR | Alzheimer's disease | HUNTINGTONS-DISEASE | Neurons - pathology | AMP-Activated Protein Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Huntington Disease - pathology | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Alzheimer Disease - pathology | Autophagy-Related Protein-1 Homolog | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Lysosomes - metabolism | TOR Serine-Threonine Kinases - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Neurons - metabolism | Parkinson Disease - metabolism | Autophagy - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Beclin-1 | Parkinson Disease - pathology | Signal Transduction | Membrane Proteins - genetics | Amyotrophic Lateral Sclerosis - genetics | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Parkinson Disease - genetics | Huntington Disease - metabolism | Apoptosis Regulatory Proteins - metabolism | Amyotrophic Lateral Sclerosis - pathology | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Huntington Disease - genetics | Alzheimer Disease - genetics | AMP-Activated Protein Kinases - genetics | Biodegradation | Disease | Neurodegeneration
Journal Article
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2002, Volume 296, Issue 5575, pp. 1991 - 1995
...Neurodegenerative disorders as diverse as Alzheimer's disease, Parkinson's disease, priori diseases, Huntington's disease, frontotemporal dementia, and motor... 
Nervous system diseases | Reviews | Neurodegenerative diseases | Disease models | Huntington disease | Parkinson disease | Prion diseases | Amyotrophic lateral sclerosis | Nervous system heredodegenerative disorders | Alzheimers disease | Genetic mutation | Parkinson Disease - therapy | Neurons - pathology | Prion Diseases - genetics | Humans | Peptides - genetics | Tauopathies - pathology | Alzheimer Disease - pathology | Peptides - metabolism | Tauopathies - therapy | Neurons - metabolism | Parkinson Disease - metabolism | Inclusion Bodies - metabolism | Prion Diseases - therapy | Parkinson Disease - pathology | Neurodegenerative Diseases - pathology | Amyotrophic Lateral Sclerosis - therapy | Amyotrophic Lateral Sclerosis - genetics | Alzheimer Disease - therapy | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - therapy | Prion Diseases - pathology | Neurodegenerative Diseases - metabolism | Parkinson Disease - genetics | Protein Folding | Trinucleotide Repeat Expansion | Proteins - genetics | Amyotrophic Lateral Sclerosis - pathology | Tauopathies - metabolism | Animals | Proteins - metabolism | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Mutation | Proteins - chemistry | Alzheimer Disease - genetics | Prion Diseases - metabolism | Parkinson's disease | Nervous system | Degeneration | Research | Alzheimer's disease | Proteins | Neurological disorders
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2017, Volume 357, Issue 6357, pp. 1255 - 1261
Mitochondrial and lysosomal dysfunction have been implicated in substantia nigra dopaminergic neurodegeneration in Parkinson's disease (PD... 
GLUCOCEREBROSIDASE | PACEMAKING | DJ-1 | ALPHA-SYNUCLEIN | SUBSTANTIA-NIGRA | MULTIDISCIPLINARY SCIENCES | Mitochondria - enzymology | Mesencephalon - metabolism | Humans | Protein Deglycase DJ-1 - genetics | Substantia Nigra - metabolism | Melanins - metabolism | Glucosylceramidase - deficiency | Lysosomes - metabolism | Dopaminergic Neurons - metabolism | Tacrolimus - pharmacology | Parkinson Disease - metabolism | Dopamine - metabolism | Disease Models, Animal | Substantia Nigra - enzymology | Cell Line | Calcineurin Inhibitors - pharmacology | Oxidation-Reduction | Mesencephalon - enzymology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Parkinson Disease - genetics | Mice, Knockout | Animals | Parkinson Disease - enzymology | Mice | Oxidative Stress - drug effects | alpha-Synuclein - metabolism | Oxidation-reduction reaction | Development and progression | Mitochondria | Dopamine | Parkinson's disease | Health aspects | Brain | Energy metabolism | Animal models | Target recognition | Mesencephalon | Pathogenesis | Substantia nigra | Parkinsons disease | Lysosomes | Synuclein | Accumulation | Pathways | Enzymatic activity | Neurodegeneration | Rodents | Oxidation | Degeneration | Species | Movement disorders | Dopamine receptors | Neurodegenerative diseases | Neurons | Medical treatment | Metabolism | Patients | Glucosylceramidase | Index Medicus
Journal Article