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CNS drugs, ISSN 1172-7047, 2010, Volume 24, Issue 3, pp. 177 - 192
Parkinson's disease is the second most common age-related neurodegenerative disorder, typified by the progressive loss of substantia nigra pars compacta dopamine neurons and the consequent decrease... 
AMINO-ACID DECARBOXYLASE | PSYCHIATRY | ALPHA-SYNUCLEIN | VIRAL VECTORS | CLINICAL NEUROLOGY | ADENOASSOCIATED VIRUS TYPE-2 | TRANSGENE EXPRESSION | NIGRAL DOPAMINERGIC-NEURONS | L-DOPA | PHARMACOLOGY & PHARMACY | DEEP-BRAIN-STIMULATION | ENVIRONMENTAL RISK-FACTORS | CONVECTION-ENHANCED DELIVERY | Parkinson Disease - therapy | Genetic Therapy | Animals | Parkinson Disease - genetics | Humans
Journal Article
Acta neuropathologica, ISSN 1432-0533, 2013, Volume 125, Issue 6, pp. 795 - 813
Journal Article
Journal of controlled release, ISSN 0168-3659, 2015, Volume 207, pp. 18 - 30
.... In light of this, we developed a new exosomal-based delivery system for a potent antioxidant, catalase, to treat Parkinson's disease (PD... 
Oxidative stress | Neuroinflammation | Parkinson's disease | Catalase | Exosomes | Blood–brain barrier | Blood-brain barrier | ALZHEIMERS-DISEASE | REPEATED INJECTIONS | MACROPHAGE DELIVERY | MEDIATED TRANSFER | BLOOD-BRAIN-BARRIER | BIOLOGICAL BARRIERS | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | PEGYLATED LIPOSOMES | PHARMACOLOGY & PHARMACY | SUPEROXIDE-DISMUTASE | Antioxidants - chemistry | Antioxidants - metabolism | Oxidopamine | Anti-Inflammatory Agents - metabolism | PC12 Cells | Neuroprotective Agents - metabolism | Drug Carriers | Brain - metabolism | Nanoparticles | Parkinsonian Disorders - metabolism | Parkinsonian Disorders - drug therapy | Antiparkinson Agents - chemistry | Anti-Inflammatory Agents - administration & dosage | Female | Neurons - metabolism | Neuroprotective Agents - administration & dosage | Nanomedicine | Disease Models, Animal | Neuroprotective Agents - chemistry | Mice, Inbred C57BL | Solubility | Rats | Technology, Pharmaceutical - methods | Parkinsonian Disorders - chemically induced | Administration, Intranasal | Chemistry, Pharmaceutical | Brain - drug effects | Catalase - metabolism | Catalase - administration & dosage | Animals | Anti-Inflammatory Agents - chemistry | Antioxidants - administration & dosage | RAW 264.7 Cells | Antiparkinson Agents - administration & dosage | Mice | Kinetics | Oxidative Stress - drug effects | Antiparkinson Agents - metabolism | Catalase - chemistry | Drugs | Drug delivery systems | Proteases | Analysis | Antiparkinsonian agents | Vehicles | blood-brain barrier | neuroinflammation | exosomes | catalase | oxidative stress | Parkinson’s disease
Journal Article
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2002, Volume 296, Issue 5575, pp. 1991 - 1995
...Neurodegenerative disorders as diverse as Alzheimer's disease, Parkinson's disease, priori diseases, Huntington's disease, frontotemporal dementia, and motor... 
Nervous system diseases | Reviews | Neurodegenerative diseases | Disease models | Huntington disease | Parkinson disease | Prion diseases | Amyotrophic lateral sclerosis | Nervous system heredodegenerative disorders | Alzheimers disease | Genetic mutation | Parkinson Disease - therapy | Neurons - pathology | Prion Diseases - genetics | Humans | Peptides - genetics | Tauopathies - pathology | Alzheimer Disease - pathology | Peptides - metabolism | Tauopathies - therapy | Neurons - metabolism | Parkinson Disease - metabolism | Inclusion Bodies - metabolism | Prion Diseases - therapy | Parkinson Disease - pathology | Neurodegenerative Diseases - pathology | Amyotrophic Lateral Sclerosis - therapy | Amyotrophic Lateral Sclerosis - genetics | Alzheimer Disease - therapy | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - therapy | Prion Diseases - pathology | Neurodegenerative Diseases - metabolism | Parkinson Disease - genetics | Protein Folding | Trinucleotide Repeat Expansion | Proteins - genetics | Amyotrophic Lateral Sclerosis - pathology | Tauopathies - metabolism | Animals | Proteins - metabolism | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Mutation | Proteins - chemistry | Alzheimer Disease - genetics | Prion Diseases - metabolism | Parkinson's disease | Nervous system | Degeneration | Research | Alzheimer's disease | Proteins | Neurological disorders
Journal Article
Trends in Neurosciences, ISSN 0166-2236, 2009, Volume 32, Issue 11, pp. 591 - 601
.... Treatment with various HDAC inhibitors can correct these deficiencies and has emerged as a promising new strategy for therapeutic intervention in neurodegenerative disease... 
Neurology | SPINAL MUSCULAR-ATROPHY | SUBEROYLANILIDE HYDROXAMIC ACID | PROTECTS DOPAMINERGIC-NEURONS | INCREASES SMN EXPRESSION | VALPROIC ACID | HISTONE DEACETYLASE INHIBITORS | BDNF GENE-TRANSCRIPTION | TRANSGENIC MOUSE MODEL | HUNTINGTONS-DISEASE | NEUROSCIENCES | HEAT-SHOCK-PROTEIN | Neuroprotective Agents - therapeutic use | Amyotrophic Lateral Sclerosis - physiopathology | Humans | Muscular Atrophy, Spinal - enzymology | Parkinson Disease - drug therapy | Neurodegenerative Diseases - drug therapy | Stroke - physiopathology | Amyotrophic Lateral Sclerosis - drug therapy | Amyotrophic Lateral Sclerosis - enzymology | Acetylation | Huntington Disease - drug therapy | Huntington Disease - enzymology | Muscular Atrophy, Spinal - physiopathology | Huntington Disease - physiopathology | Disease Models, Animal | Alzheimer Disease - physiopathology | Neurodegenerative Diseases - pathology | Alzheimer Disease - drug therapy | Rats | Histone Deacetylases - metabolism | Stroke - drug therapy | Alzheimer Disease - enzymology | Parkinson Disease - physiopathology | Stroke - enzymology | Animals | Neurodegenerative Diseases - physiopathology | Neuroprotective Agents - classification | Parkinson Disease - enzymology | Muscular Atrophy, Spinal - drug therapy | Histone Deacetylase Inhibitors - therapeutic use | Histones - metabolism | Neurodegenerative Diseases - enzymology | Histones | Nervous system diseases | Analysis
Journal Article
Journal Article