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Journal of Controlled Release, ISSN 0168-3659, 08/2016, Volume 235, pp. 72 - 81
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2016, Volume 113, Issue 34, pp. 9629 - 9634
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2012, Volume 287, Issue 39, pp. 32307 - 32311
Sirtuins are NAD-dependent protein deacetylases that were shown to have beneficial effects against age-related diseases. SIRT2 is a strong deacetylase that is... 
APOPTOSIS | MODELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AGGREGATION | PARKINSONS-DISEASE | Substantia Nigra - pathology | Apoptosis - drug effects | Apoptosis - genetics | Substantia Nigra - metabolism | MPTP Poisoning - therapy | Sirtuin 2 - metabolism | Parkinson Disease, Secondary - pathology | MPTP Poisoning - genetics | Striatonigral Degeneration - genetics | Striatonigral Degeneration - chemically induced | Striatonigral Degeneration - therapy | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | MPTP Poisoning - pathology | Parkinson Disease, Secondary - metabolism | Proto-Oncogene Proteins | Parkinson Disease, Secondary - chemically induced | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - adverse effects | Neurotoxins - adverse effects | Parkinson Disease, Secondary - therapy | Striatonigral Degeneration - metabolism | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Mice, Knockout | Membrane Proteins | Nerve Tissue Proteins - metabolism | Neurotoxins - pharmacology | Striatonigral Degeneration - mortality | Sirtuin 2 - genetics | Acetylation - drug effects | Animals | Apoptosis Regulatory Proteins | Parkinson Disease, Secondary - genetics | MPTP Poisoning - metabolism | Mice | Forkhead Box Protein O3 | Parkinson Disease | Reports | Cell Culture | Molecular cell Biology | Alpha-Synuclein | Apoptosis
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2017, Volume 127, Issue 2, pp. 720 - 734
Journal Article
by Wang, LZ and Wang, ZX and Zhu, R and Bi, JP and Feng, XY and Liu, WM and Wu, JX and Zhang, HH and Wu, H and Kong, W and Yu, B and Yu, XH
PLOS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0179476
Parkinson's disease (PD) is a progressive and age-associated neurodegenerative disorder. Patients at different stages of the disease course have distinguished... 
CDNF PREVENTS | OVEREXPRESSION | GDNF | PHASE-I TRIAL | TYROSINE-HYDROXYLASE | MULTIDISCIPLINARY SCIENCES | ANIMAL-MODELS | DOUBLE-BLIND | GENE-THERAPY | OPEN-LABEL | STRIATUM | Aromatic-L-Amino-Acid Decarboxylases - biosynthesis | Corpus Striatum - physiopathology | Rats, Wistar | Humans | Parkinson Disease, Secondary - therapy | Rats | Male | Dependovirus | Motor Activity | Nerve Growth Factors - biosynthesis | Corpus Striatum - metabolism | Recovery of Function | Oxidopamine - adverse effects | Animals | Oxidopamine - pharmacology | Parkinson Disease, Secondary - genetics | Nerve Growth Factors - genetics | Parkinson Disease, Secondary - metabolism | Parkinson Disease, Secondary - chemically induced | Transduction, Genetic - methods | Aromatic-L-Amino-Acid Decarboxylases - genetics | Genetic Therapy - methods | Drugs | Drug delivery systems | Parkinson's disease | Physiological aspects | Genetic aspects | Research | Drug therapy | Neurotrophic functions | Vehicles | Neuroprotection | Neurosciences | Basal ganglia | Animal models | Laboratories | Parkinsons disease | Clinical trials | Amino acids | Viruses | Vaccines | Motor task performance | Tyrosine 3-monooxygenase | Recovery | Proteins | Engineering | Acquired immune deficiency syndrome--AIDS | Neurodegeneration | Rodents | Life sciences | Lesions | Age | Movement disorders | Dopamine receptors | Recombinant | Tyrosine | Medical research | Enzymes | Dopamine | Effectiveness | Neurodegenerative diseases | Neurons | Hydroxylase | Central nervous system diseases | Patients | Carriers | Studies | Neurology | Gene therapy | Acquired immune deficiency syndrome | AIDS
Journal Article