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Science, ISSN 0036-8075, 11/2011, Volume 334, Issue 6057, pp. 809 - 813
Phospholipase A₂ (PLA₂) enzymes are considered the primary source of arachidonic acid for cyclooxygenase (COX)-mediated biosynthesis of prostaglandins. Here,... 
Datasets | Brain | Enzymes | Prostaglandins | Cytokines | Neurodegenerative diseases | REPORTS | Eicosanoids | Lipids | Endocannabinoids | Vehicles | SYSTEM | INHIBITION | CYCLOOXYGENASE-2 | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | INJURY | LIPOPOLYSACCHARIDE | PHOSPHOLIPASE A | MICE | PARKINSONS-DISEASE | Cannabinoid Receptor Modulators - metabolism | Inflammation - pathology | Metabolomics | Arachidonic Acid - metabolism | Monoacylglycerol Lipases - antagonists & inhibitors | Monoacylglycerol Lipases - genetics | Brain - metabolism | Parkinsonian Disorders - metabolism | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Inflammation - metabolism | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Inflammation Mediators - pharmacology | Lung - metabolism | Cytokines - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Phospholipases A2 - metabolism | Prostaglandins - biosynthesis | Glycerides - metabolism | Brain - drug effects | Hydrolysis | Animals | Parkinsonian Disorders - pathology | Eicosanoids - metabolism | Lipopolysaccharides - pharmacology | Brain - pathology | Mice | Cyclooxygenase 1 - metabolism | Benzodioxoles - pharmacology | Phospholipases A2 - genetics | Prostaglandins - metabolism | Physiological aspects | Inflammation | Research | Risk factors | Hydrology | Neurology | Inflammatory diseases | Animal models | Index Medicus
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 06/2015, Volume 207, pp. 18 - 30
Exosomes are naturally occurring nanosized vesicles that have attracted considerable attention as drug delivery vehicles in the past few years. Exosomes are... 
Oxidative stress | Neuroinflammation | Parkinson's disease | Catalase | Exosomes | Blood–brain barrier | Blood-brain barrier | ALZHEIMERS-DISEASE | REPEATED INJECTIONS | MACROPHAGE DELIVERY | MEDIATED TRANSFER | BLOOD-BRAIN-BARRIER | BIOLOGICAL BARRIERS | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | PEGYLATED LIPOSOMES | PHARMACOLOGY & PHARMACY | SUPEROXIDE-DISMUTASE | Antioxidants - chemistry | Antioxidants - metabolism | Oxidopamine | Anti-Inflammatory Agents - metabolism | PC12 Cells | Neuroprotective Agents - metabolism | Drug Carriers | Brain - metabolism | Nanoparticles | Parkinsonian Disorders - metabolism | Parkinsonian Disorders - drug therapy | Antiparkinson Agents - chemistry | Anti-Inflammatory Agents - administration & dosage | Female | Neurons - metabolism | Neuroprotective Agents - administration & dosage | Nanomedicine | Disease Models, Animal | Neuroprotective Agents - chemistry | Mice, Inbred C57BL | Solubility | Rats | Technology, Pharmaceutical - methods | Parkinsonian Disorders - chemically induced | Administration, Intranasal | Chemistry, Pharmaceutical | Brain - drug effects | Catalase - metabolism | Catalase - administration & dosage | Animals | Anti-Inflammatory Agents - chemistry | Antioxidants - administration & dosage | RAW 264.7 Cells | Antiparkinson Agents - administration & dosage | Mice | Kinetics | Oxidative Stress - drug effects | Antiparkinson Agents - metabolism | Catalase - chemistry | Drugs | Drug delivery systems | Proteases | Analysis | Antiparkinsonian agents | Vehicles | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/2015, Volume 172, Issue 9, pp. 2354 - 2368
Background and Purpose Mild cognitive deficit in early Parkinson's disease (PD) has been widely studied. Here we have examined the effects of memantine in... 
DEPRESSION | ACTIVATION | CONCISE GUIDE | NEUROTROPHIC FACTOR | PHARMACOLOGY | LONG-TERM-POTENTIATION | PHARMACOLOGY & PHARMACY | DOPAMINERGIC-NEURONS | MODEL | COGNITIVE FUNCTION | PARKINSONS-DISEASE | Memory Disorders - physiopathology | Antiparkinson Agents - pharmacology | Membrane Glycoproteins - metabolism | Protein-Tyrosine Kinases - metabolism | Memory Disorders - metabolism | Neuronal Plasticity - drug effects | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Hippocampus - drug effects | Parkinsonian Disorders - metabolism | Synapses - metabolism | Time Factors | Behavior, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Disease Models, Animal | Parkinsonian Disorders - physiopathology | Synapses - drug effects | Memantine - pharmacology | Memory Disorders - psychology | 1-Methyl-4-phenylpyridinium - pharmacology | Mice, Inbred C57BL | Parkinsonian Disorders - psychology | Memory, Long-Term - drug effects | Parkinsonian Disorders - chemically induced | Hippocampus - metabolism | Memory Disorders - prevention & control | Animals | Signal Transduction - drug effects | Calcium Signaling - drug effects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Parkinsonian Disorders - prevention & control | In Vitro Techniques | Hippocampus - physiopathology | Memory Disorders - chemically induced | Calpain | Mice | Pyridine | Analysis | Index Medicus | Research Papers
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2014, Volume 124, Issue 7, pp. 3107 - 3120
Parkinsonism and attention deficit hyperactivity disorder (ADHD) are widespread brain disorders that involve disturbances of dopaminergic signaling. The... 
MEDICINE, RESEARCH & EXPERIMENTAL | SEQUENCE VARIATION | C-TERMINUS | GENE | DEFICIT HYPERACTIVITY DISORDER | DISEASE | NEUROTRANSMITTER SODIUM SYMPORTERS | BINDING-SITE | MONOAMINE TRANSPORTERS | CONFORMATIONAL DYNAMICS | OUTWARD-OPEN | Xenopus | Dopamine Plasma Membrane Transport Proteins - metabolism | Brain - diagnostic imaging | Parkinsonian Disorders - complications | Humans | Tomography, Emission-Computed, Single-Photon | Molecular Sequence Data | Dopamine Plasma Membrane Transport Proteins - chemistry | Male | Positron-Emission Tomography | Mutation, Missense | Sodium - metabolism | Brain - metabolism | Parkinsonian Disorders - metabolism | Attention Deficit Disorder with Hyperactivity - metabolism | DNA Mutational Analysis | HEK293 Cells | Attention Deficit Disorder with Hyperactivity - complications | Adult | Female | Parkinsonian Disorders - genetics | Dopamine - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Oocytes - metabolism | Mutant Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Recombinant Proteins - genetics | Dopamine Plasma Membrane Transport Proteins - genetics | Sequence Homology, Amino Acid | Animals | Attention Deficit Disorder with Hyperactivity - genetics | Pedigree | Mutant Proteins - chemistry | Protein Conformation | Amino Acid Substitution | Cohort Studies | Parkinson's disease | Genetic variation | Attention-deficit hyperactivity disorder | Development and progression | Genetic aspects | Identification and classification | Membrane proteins | Attention deficit disorder | Autism | Medical research | Mutation | Index Medicus | Abridged Index Medicus
Journal Article
Science, ISSN 0036-8075, 7/2006, Volume 313, Issue 5785, pp. 324 - 328
Alpha-synuclein (αSyn) misfolding is associated with several devastating neu rodegenerative disorders, including Parkinson's disease (PD). In yeast cells and... 
Yeasts | Animal models | Neuroscience | Neurodegenerative diseases | Neurons | Midbrain | Research Articles | Open reading frames | Secretory pathway | Genetic screening | Vacuoles | YEAST | CARBOXYPEPTIDASE-Y | TRANSPORT | PROTEIN | MULTIDISCIPLINARY SCIENCES | DISEASE | MUTATION | DEGRADATION | REQUIRES | NEURODEGENERATION | STRESS | Saccharomyces cerevisiae - genetics | Humans | Endoplasmic Reticulum - metabolism | Neurons - cytology | rab GTP-Binding Proteins - genetics | Recombinant Fusion Proteins - metabolism | Parkinsonian Disorders - metabolism | Saccharomyces cerevisiae - metabolism | Dopamine - physiology | Neurons - physiology | alpha-Synuclein - genetics | Disease Models, Animal | rab GTP-Binding Proteins - metabolism | Parkinsonian Disorders - physiopathology | Gene Expression | Gene Library | rab1 GTP-Binding Proteins - metabolism | Animals, Genetically Modified | Cell Survival | Drosophila | Cells, Cultured | Rats | Saccharomyces cerevisiae Proteins - genetics | Protein Folding | Protein Transport | alpha-Synuclein - chemistry | rab1 GTP-Binding Proteins - genetics | Caenorhabditis elegans | Animals | Proteins - metabolism | Parkinsonian Disorders - pathology | Saccharomyces cerevisiae Proteins - metabolism | Golgi Apparatus - metabolism | Mice | Proteasome Endopeptidase Complex - metabolism | Proteins - chemistry | Nerve Degeneration | alpha-Synuclein - metabolism | Models | Protein folding | Toxicity | Parkinsons disease | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2015, Volume 112, Issue 38, pp. E5308 - E5317
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 10/2013, Volume 110, Issue 42, pp. E4016 - E4025
Journal Article
Nature, ISSN 0028-0836, 05/2018, Volume 557, Issue 7704, pp. 177 - 182
Loss of dopamine in Parkinson's disease is hypothesized to impede movement by inducing hypo-and hyperactivity in striatal spiny projection neurons (SPNs) of... 
MOVEMENT-DISORDERS | OPTOGENETIC CONTROL | DOPA-INDUCED DYSKINESIA | BASAL GANGLIA | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | RECEPTOR OCCUPANCY | PROJECTION NEURONS | BRAIN | STRIATUM | Neostriatum - physiopathology | Male | Receptors, Dopamine D2 - metabolism | Receptors, Dopamine D1 - metabolism | Parkinsonian Disorders - metabolism | Dopamine - deficiency | Receptors, Dopamine D1 - agonists | Female | Neostriatum - metabolism | Neurons - metabolism | Calcium Signaling | Dopamine - metabolism | Levodopa - pharmacology | Movement - drug effects | Neostriatum - pathology | Parkinsonian Disorders - physiopathology | Receptors, Dopamine D2 - agonists | Dyskinesias - pathology | Dyskinesias - physiopathology | Dyskinesias - etiology | Dyskinesias - metabolism | Animals | Parkinsonian Disorders - pathology | Models, Biological | Mice | Levodopa - metabolism | Physiological aspects | Neural circuitry | Parkinson's disease | Health aspects | Movement disorders | Dihydroxyphenylalanine | Basal ganglia | Medical imaging | Dopamine | Neurodegenerative diseases | Hyperactivity | Abnormalities | Medical treatment | Parkinsons disease | Central nervous system diseases | Ganglia | Depletion | Dopamine D1 receptors | Psychopharmacology | Neostriatum | Clusters | Software | Levodopa | Dopa | Dopamine D2 receptors | Dyskinesia | Index Medicus
Journal Article
Movement Disorders, ISSN 0885-3185, 07/2017, Volume 32, Issue 7, pp. 1016 - 1024
Background and Objectives : To study selective regional binding for tau pathology in vivo, using PET with [ 11 C]PBB3 in PSP patients, and other conditions not... 
SNCA mutations | MSA | PSP | Tau PET imaging | PBB3 | ALPHA-SYNUCLEIN | PATHOLOGY | CLINICAL NEUROLOGY | SUPRANUCLEAR | F-18-AV-1451 | POSITRON-EMISSION-TOMOGRAPHY | FLUORESCENCE | DISEASE | NACP/ALPHA-SYNUCLEIN | LEWY BODIES | BRAIN | Basal Ganglia - diagnostic imaging | Humans | Middle Aged | Basal Ganglia - metabolism | tau Proteins - metabolism | Positron-Emission Tomography - methods | Parkinsonian Disorders - metabolism | Multiple System Atrophy - metabolism | Parkinsonian Disorders - diagnostic imaging | Supranuclear Palsy, Progressive - metabolism | Supranuclear Palsy, Progressive - diagnostic imaging | Aged | alpha-Synuclein - genetics | alpha-Synuclein - metabolism | Benzothiazoles | Carbon Radioisotopes | Dynactin Complex - genetics | Multiple System Atrophy - diagnostic imaging | Medicine, Experimental | Medical research | Brain research | Tracers (Biology) | Protein binding | Cerebellum | Temporal lobe | Frontal lobe | Basal ganglia | Mesencephalon | Image processing | Neurodegenerative diseases | Central nervous system diseases | Substantia alba | Synuclein | Putamen | Nuclei | Pedunculopontine tegmental nucleus | Ganglia | Tau protein | Neostriatum | Thalamus | Parietal lobe | Movement disorders | Index Medicus | Neurologi | Clinical Medicine | Neurology | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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Journal Article