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Chemical Research in Toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a... 
ACYL GLUCURONIDES | CHEMISTRY, MEDICINAL | PROTEIN | RAT | REACTIVE METABOLITES | TIENILIC ACID | HEPATIC-NECROSIS | BIOACTIVATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | TOXICOLOGY | HUMAN URINE | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7599, pp. 334 - 339
The serotonin transporter (SERT) terminates serotonergic signalling through the sodium-and chloride-dependent reuptake of neurotransmitter into presynaptic... 
HIGH-AFFINITY RECOGNITION | NEUROTRANSMITTER TRANSPORTERS | NOREPINEPHRINE TRANSPORTERS | N-LINKED GLYCOSYLATION | ALLOSTERIC BINDING | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVE RECOGNITION | MEMBRANE-PROTEINS | DOPAMINE TRANSPORTER | Citalopram - pharmacology | Humans | Protein Conformation - drug effects | Crystallography, X-Ray | Dopamine Plasma Membrane Transport Proteins - chemistry | Structure-Activity Relationship | Antidepressive Agents - metabolism | Citalopram - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Extracellular Space - metabolism | Antidepressive Agents - chemistry | Protein Binding - drug effects | Drug Design | Antidepressive Agents - pharmacology | Protein Stability | Allosteric Regulation - drug effects | Ions - chemistry | Serotonin Plasma Membrane Transport Proteins - immunology | Allosteric Site - drug effects | Models, Molecular | Ions - metabolism | Paroxetine - metabolism | Serotonin Plasma Membrane Transport Proteins - metabolism | Citalopram - chemistry | Intracellular Space - metabolism | Serotonin - metabolism | Ligands | Immunoglobulin Fab Fragments - immunology | Paroxetine - pharmacology | Paroxetine - chemistry | Drug metabolism | Paroxetine | Physiological research | Research | Serotonin | Binding sites (Biochemistry) | X rays | Mutation | Antidepressants | Binding sites
Journal Article
Journal of Neural Transmission, ISSN 0300-9564, 01/2009, Volume 116, Issue 12, pp. 1591 - 1599
N,N-dimethyltryptamine (DMT) is a potent plant hallucinogen that has also been found in human tissues. When ingested, DMT and related N,N-dialkyltryptamines... 
Methylisopropyltryptamine | Paroxetine | Diisopropyltryptamine | MIPT | Serotonin | DIPT | DPT | DMT | Tetrabenazine | Sigma-1 receptor | Dihydrotetrabenazine | Psychedelic | Dimethyltryptamine | Biogenic amine | Dipropyltryptamine | SIGMA-RECEPTORS | SCHIZOPHRENIC-PATIENTS | CEREBROSPINAL-FLUID | DIFFERENTIAL INTERACTIONS | CLINICAL NEUROLOGY | NEUROTRANSMITTER UPTAKE | CENTRAL-NERVOUS-SYSTEM | PLATELET 5-HYDROXYTRYPTAMINE | NEUROSCIENCES | TRANSMEMBRANE DOMAIN-I | INDOLE(ETHYL)AMINE N-METHYLTRANSFERASE | RAT-BRAIN | Tetrabenazine - metabolism | Vesicular Monoamine Transport Proteins - metabolism | Humans | N,N-Dimethyltryptamine - pharmacology | Tritium | Serotonin - chemistry | N,N-Dimethyltryptamine - chemistry | Spodoptera | Serotonin Plasma Membrane Transport Proteins - chemistry | Tryptamines - pharmacology | Tetrabenazine - pharmacology | Tetrabenazine - chemistry | Blood Platelets - drug effects | Serotonin Uptake Inhibitors - metabolism | Cell Line | Tryptamines - chemistry | Tetrabenazine - analogs & derivatives | Hallucinogens - pharmacology | Vesicular Monoamine Transport Proteins - chemistry | Blood Platelets - chemistry | Hallucinogens - metabolism | Hallucinogens - chemistry | Rats | Serotonin Uptake Inhibitors - chemistry | N,N-Dimethyltryptamine - metabolism | Paroxetine - metabolism | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Blood Platelets - metabolism | Tryptamines - metabolism | Serotonin - metabolism | Paroxetine - pharmacology | Serotonin Uptake Inhibitors - pharmacology | Paroxetine - chemistry | Enzymes | Alkaloids | Phenols | Exhibitions | Hallucinogenic drugs | Catecholamines | Universities and colleges | Public health
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 34, pp. 20649 - 20659
G protein-coupled receptor kinases (GRKs) regulate cell signaling by initiating the desensitization of active G protein-coupled receptors. The two most widely... 
LOCALIZATION | ACTIVATION | POTENT | RHODOPSIN KINASE | PHOSPHORYLATION | DESENSITIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SITES | IDENTIFICATION | MOLECULAR-BASIS | EXPRESSION | Cardiovascular Agents - chemical synthesis | Heart Ventricles - cytology | Pyridines - chemistry | Molecular Sequence Data | Myocardial Contraction - drug effects | Crystallography, X-Ray | Enzyme Inhibitors - chemical synthesis | Myocytes, Cardiac - enzymology | G-Protein-Coupled Receptor Kinase 5 - chemistry | Cattle | Heart Septum - cytology | Enzyme Inhibitors - chemistry | Heart Ventricles - enzymology | Drug Design | Protein Interaction Domains and Motifs | Catalytic Domain | Gene Expression | Heart Septum - chemistry | Myocytes, Cardiac - cytology | Protein Structure, Secondary | Enzyme Inhibitors - pharmacology | Pyridines - chemical synthesis | Models, Molecular | Heart Septum - drug effects | Myocytes, Cardiac - chemistry | Heart Septum - enzymology | Cardiovascular Agents - pharmacology | Heart Ventricles - chemistry | Sequence Alignment | Animals | Myocytes, Cardiac - drug effects | Hydrogen Bonding | G-Protein-Coupled Receptor Kinase 5 - isolation & purification | Hydrophobic and Hydrophilic Interactions | Mice | Pyridines - pharmacology | Kinetics | Mutation | Paroxetine - pharmacology | G-Protein-Coupled Receptor Kinase 5 - genetics | Cardiovascular Agents - chemistry | Heart Ventricles - drug effects | Paroxetine - chemistry | site-directed mutagenesis | G protein-coupled receptor kinase | x-ray crystallography | rational drug design | crystallography | membrane targeting | Signal Transduction | enzyme inhibitor | plasma membrane | protein kinase
Journal Article
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 6/2014, Volume 406, Issue 15, pp. 3697 - 3702
Journal Article
Kidney International, ISSN 0085-2538, 06/2015, Volume 87, Issue 6, pp. 1097 - 1099
Journal Article
Journal of Computer-Aided Molecular Design, ISSN 0920-654X, 04/2016, Volume 30, Issue 4, pp. 305 - 321
Chagas disease is a parasitic infection caused by the protozoa Trypanosoma cruzi that affects about 6 million people in Latin America. Despite its sanitary... 
Chagas disease | Drug repositioning | Paroxetine | Trypanosomatids virtual screening | Triclabendazole | Polyamines | TRYPANOSOMA-CRUZI EPIMASTIGOTES | TARGET | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHAGAS-DISEASE | TRYPANOCIDAL ACTIVITY | TOXICITY | MOLECULES | IN-VITRO | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | BIOPHYSICS | TRYPANOTHIONE SYNTHETASE | BIOLOGICAL EVALUATION | Thiophenes - therapeutic use | User-Computer Interface | Chagas Disease - parasitology | Amide Synthases - antagonists & inhibitors | Humans | Imidazoles - chemistry | Spermidine - analogs & derivatives | Spermidine - chemistry | Polyamines - therapeutic use | Amide Synthases - chemistry | Trypanosoma cruzi - pathogenicity | Nitroimidazoles - therapeutic use | Computer Simulation | Imidazoles - therapeutic use | Nitroimidazoles - chemistry | Glutathione - therapeutic use | Glutathione - analogs & derivatives | Polyamines - chemistry | Antiprotozoal Agents - chemistry | Drug Repositioning | Spermidine - therapeutic use | Chagas Disease - drug therapy | Trypanosoma cruzi - drug effects | Glutathione - chemistry | Thiophenes - chemistry | Drugs | Parasitic diseases | Ligases | Antidepressants | Analysis | Physiological aspects | Nucleic acids | Chagas' disease | Cell differentiation | Parasitic protozoa | Molecular structure | Computer aided design--CAD | Pharmaceutical sciences | Analogs | Uptakes | Databases | Medical services | Mathematical models | Assaying | Life Sciences
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2013, Volume 346, Issue 1, pp. 113 - 120
An X-ray crystal structure of CYP2B4 in complex with the drug paroxetine [(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine] was... 
MAMMALIAN CYTOCHROME P4502B4 | SUBSTRATE RECOGNITION SITE | MACROMOLECULAR STRUCTURES | X-RAY CRYSTALLOGRAPHY | MICROSOMAL CYTOCHROME | 2B4 | CRYSTAL-STRUCTURES | PHARMACOLOGY & PHARMACY | FACIAL AMPHIPHILES | MEMBRANE-PROTEINS | RESIDUES | Catalytic Domain - drug effects | Antidepressive Agents, Second-Generation - chemistry | Cytochrome P-450 Enzyme Inhibitors | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Crystallography, X-Ray | Cytochrome P450 Family 2 | Databases, Protein | Enzyme Inhibitors - chemistry | Aryl Hydrocarbon Hydroxylases - chemistry | Mutant Proteins - antagonists & inhibitors | Peptide Fragments - genetics | Molecular Conformation - drug effects | Recombinant Proteins - metabolism | Serotonin Uptake Inhibitors - metabolism | Rabbits | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Peptide Fragments - metabolism | Recombinant Proteins - antagonists & inhibitors | Enzyme Inhibitors - metabolism | Enzyme Inhibitors - pharmacology | Mutant Proteins - genetics | Models, Molecular | Rats | Recombinant Proteins - chemistry | Serotonin Uptake Inhibitors - chemistry | Mutant Proteins - metabolism | Antidepressive Agents, Second-Generation - pharmacology | Aryl Hydrocarbon Hydroxylases - metabolism | Paroxetine - metabolism | Cytochrome P-450 Enzyme System - chemistry | Peptide Fragments - chemistry | Animals | Peptide Fragments - antagonists & inhibitors | Mutant Proteins - chemistry | Protein Structure, Secondary - drug effects | Cytochrome P-450 Enzyme System - genetics | Protein Binding | Ligands | Antidepressive Agents, Second-Generation - metabolism | Paroxetine - pharmacology | Serotonin Uptake Inhibitors - pharmacology | Amino Acid Substitution | Paroxetine - chemistry
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2007, Volume 129, Issue 2, pp. 290 - 291
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 07/2013, Volume 11, Issue 25, pp. 4232 - 4239
Journal Article
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