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Endocrinology, ISSN 0013-7227, 09/2013, Volume 154, Issue 9, pp. 3410 - 3422
We recently created a mouse model displaying precocious Sertoli cell (SC) and spermatogenic development induced by SC-specific transgenic androgen receptor... 
MOUSE TESTIS | IMMATURE HYPOPHYSECTOMIZED RATS | TESTICULAR AROMATASE-ACTIVITY | DEPENDENT EXPRESSION | ESTROGEN SULFOTRANSFERASE | TESTOSTERONE SECRETION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | FOLLICLE-STIMULATING-HORMONE | POSTNATAL-DEVELOPMENT | LUTEINIZING-HORMONE | Leydig Cells - cytology | Up-Regulation | Receptors, Transforming Growth Factor beta - genetics | Testis - metabolism | Cell Count | Receptors, Androgen - metabolism | Male | Receptors, Peptide - genetics | Isoenzymes - metabolism | Leydig Cells - metabolism | Receptors, Androgen - biosynthesis | Sertoli Cells - cytology | Sexual Development | Cell Differentiation | Receptors, Cell Surface - biosynthesis | Patched Receptors | Receptor, Platelet-Derived Growth Factor alpha - biosynthesis | Animals, Newborn | Biomarkers - metabolism | Sertoli Cells - metabolism | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Testis - cytology | Testosterone Congeners - blood | Isoenzymes - genetics | Receptors, Cell Surface - metabolism | Mice, Transgenic | Receptors, Peptide - biosynthesis | Testis - growth & development | Hemizygote | Receptors, Transforming Growth Factor beta - biosynthesis | Animals | Receptors, Androgen - genetics | Receptors, Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Testosterone Congeners - metabolism | Ligands | Mice | Isoenzymes - biosynthesis | Patched-1 Receptor | Receptors, Cell Surface - genetics | Receptors, Peptide - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5952, pp. 572 - 574
The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a... 
Receptors | Relapse | Basal cell carcinoma | Medulloblastoma | Amino acids | Biopsies | Reports | Genetic mutation | Tumors | Resistance mechanisms | Cancer | PROTEIN-COUPLED RECEPTORS | CYCLOPAMINE | CANCER | MULTIDISCIPLINARY SCIENCES | Anilides - therapeutic use | Receptors, G-Protein-Coupled - metabolism | Humans | Brain Neoplasms - pathology | Hedgehog Proteins - metabolism | Molecular Sequence Data | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Mutation, Missense | Antineoplastic Agents - metabolism | Neoplasm Metastasis | Hedgehog Proteins - genetics | Medulloblastoma - pathology | Smoothened Receptor | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Patched Receptors | Medulloblastoma - genetics | Mutant Proteins - antagonists & inhibitors | Pyridines - therapeutic use | Amino Acid Sequence | Signal Transduction | Anilides - metabolism | Brain Neoplasms - genetics | Receptors, Cell Surface - metabolism | Mutant Proteins - metabolism | Hedgehog Proteins - antagonists & inhibitors | Brain Neoplasms - drug therapy | Cinnamates - pharmacology | Animals | Pyridines - metabolism | Mutant Proteins - chemistry | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Mice | Pyridines - pharmacology | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Receptors, G-Protein-Coupled - chemistry | Amino Acid Substitution | Receptors, Cell Surface - genetics | Gene mutations | Development and progression | Genetic aspects | Diagnosis | Drug resistance | Identification and classification | Signal transduction | Genotype & phenotype | Inhibitor drugs | Cellular biology | Brain cancer | Mutation | Index Medicus
Journal Article
Developmental Biology, ISSN 0012-1606, 04/2016, Volume 412, Issue 2, pp. 278 - 287
The hedgehog family includes Sonic hedgehog (Shh), Desert hedgehog, and Indian hedgehog, which are well known as a morphogens that play many important roles... 
Branching morphogenesis | EGF receptor | Epithelio-mesenchymal interaction | Salivary gland | Shh | EGF | PATHWAYS | CELLS | ECTODYSPLASIN | MECHANISMS | DEVELOPMENTAL BIOLOGY | FACTOR RECEPTOR | IN-VITRO | EPIDERMAL-GROWTH-FACTOR | EPITHELIAL MORPHOGENESIS | GENE-EXPRESSION | Receptor, Epidermal Growth Factor - genetics | Hedgehog Proteins - pharmacology | Receptor, ErbB-3 - metabolism | Receptor, ErbB-2 - genetics | ErbB Receptors - genetics | Receptor, ErbB-2 - metabolism | Receptor, Epidermal Growth Factor - metabolism | Hedgehog Proteins - genetics | Female | Patched Receptors | Phosphorylation - drug effects | Organ Culture Techniques | ErbB Receptors - metabolism | Epidermal Growth Factor - genetics | Gene Expression Regulation, Developmental - drug effects | Submandibular Gland - metabolism | Receptors, Cell Surface - metabolism | Epidermal Growth Factor - metabolism | Receptor, ErbB-3 - genetics | Recombinant Proteins - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Inbred ICR | Pregnancy | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Morphogenesis - drug effects | Submandibular Gland - embryology | Patched-1 Receptor | Mitogen-Activated Protein Kinase 1 - metabolism | Receptors, Cell Surface - genetics | RNA | Epidermal growth factor | Index Medicus
Journal Article
Journal Article
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Journal Article
Development (Cambridge, England), ISSN 0950-1991, 2014, Volume 141, Issue 17, pp. 3331 - 3339
Journal Article
Science, ISSN 0036-8075, 12/2013, Volume 342, Issue 6163, pp. 1247 - 1250
The centrosome is essential for cytotoxic T lymphocyte (CTL) function, contacting the plasma membrane and directing cytotoxic granules for secretion at the... 
T lymphocytes | Killing | Messenger RNA | REPORTS | Centrosomes | Actins | Antibodies | Immunological synapses | Synapses | T cell antigen receptors | Cilia | ACTIVATION | TRANSPORT | INHIBITION | MULTIDISCIPLINARY SCIENCES | INDIAN HEDGEHOG | DIFFERENTIATION | POLARIZATION | PRIMARY CILIUM | Cell Polarity | Receptors, G-Protein-Coupled - metabolism | Hedgehog Proteins - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | CD8-Positive T-Lymphocytes - metabolism | Receptors, Antigen, T-Cell - immunology | Neuropeptides - genetics | Patched Receptors | T-Lymphocytes, Cytotoxic - immunology | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Receptors, Cell Surface - metabolism | Mice, Transgenic | Neuropeptides - metabolism | Centrosome - metabolism | Immunological Synapses | Models, Immunological | Animals | T-Lymphocytes, Cytotoxic - metabolism | Mice | Mice, Inbred BALB C | Zinc Finger Protein GLI1 | CD8-Positive T-Lymphocytes - immunology | Kruppel-Like Transcription Factors - genetics | rac1 GTP-Binding Protein - metabolism | Cytotoxicity, Immunologic | rac1 GTP-Binding Protein - genetics | Sonic hedgehog | Lymphocytes | Physiological aspects | Research | T cells | Molecular biology | Health aspects | Immune system | Proteins | Signal transduction | Cellular biology | Index Medicus | Polarization | Receptors | Effectors
Journal Article
Nature Cell Biology, ISSN 1465-7392, 06/2009, Volume 11, Issue 6, pp. 739 - 746
Sonic hedgehog (Shh) and its main receptor, Patched (Ptc), are implicated in both neural development and tumorigenesis. Besides its classic morphogenic... 
PROTEIN | INHIBITION | GENE | MECHANISM | SONIC HEDGEHOG | NEURONAL DEATH | PRODUCT INDUCES APOPTOSIS | KAPPA-B | CASPASE ACTIVATION | CELL-DEATH | CELL BIOLOGY | RNA, Small Interfering - genetics | Caspase 9 - metabolism | Homeodomain Proteins - metabolism | Humans | Hedgehog Proteins - metabolism | Neoplasm Proteins - metabolism | CARD Signaling Adaptor Proteins - genetics | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Hedgehog Proteins - genetics | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Patched Receptors | Neoplasm Proteins - genetics | Cell Line | Receptors, Cell Surface - metabolism | Transcription Factors - genetics | Chick Embryo | Homeodomain Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | Animals | Adaptor Proteins, Signal Transducing - genetics | LIM-Homeodomain Proteins | Signal Transduction - physiology | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Causes of | Physiological aspects | Cell receptors | Research | Proteases | Apoptosis | Index Medicus | Caspase 9 | Signal Transduction | Multiprotein Complexes | Receptors, Cell Surface | Cellular Biology | Hedgehog Proteins | Life Sciences | Muscle Proteins | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Homeodomain Proteins | Neoplasm Proteins | CARD Signaling Adaptor Proteins | RNA, Small Interfering | Transcription Factors | Development Biology | physiology | genetics | metabolism
Journal Article
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