X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
patched receptors (1157) 1157
animals (934) 934
humans (860) 860
patched-1 receptor (781) 781
receptors, cell surface - genetics (712) 712
index medicus (686) 686
mice (625) 625
signal transduction (494) 494
sonic hedgehog (427) 427
female (424) 424
receptors, cell surface - metabolism (424) 424
hedgehog proteins (404) 404
male (396) 396
hedgehog proteins - metabolism (388) 388
receptors, cell surface (351) 351
membrane proteins - genetics (333) 333
mutation (323) 323
cell biology (320) 320
developmental biology (305) 305
human homolog (296) 296
expression (286) 286
zinc finger protein gli1 (270) 270
oncology (261) 261
hedgehog proteins - genetics (252) 252
patched (250) 250
cancer (247) 247
hedgehog (239) 239
smoothened receptor (238) 238
gene (229) 229
biochemistry & molecular biology (210) 210
research (204) 204
genetics & heredity (199) 199
sonic-hedgehog (199) 199
mutations (198) 198
basal cell nevus syndrome - genetics (185) 185
genetic aspects (181) 181
gene expression regulation, developmental (178) 178
gene expression (173) 173
transcription factors - genetics (168) 168
adult (166) 166
proteins (166) 166
signal transduction - physiology (165) 165
tumors (165) 165
medulloblastoma (163) 163
transcription factors - metabolism (157) 157
middle aged (154) 154
skin neoplasms - genetics (153) 153
membrane proteins - metabolism (147) 147
article (145) 145
growth (142) 142
trans-activators - metabolism (139) 139
drosophila (138) 138
carcinoma, basal cell - genetics (137) 137
multidisciplinary sciences (134) 134
trans-activators (133) 133
mice, transgenic (132) 132
protein (132) 132
trans-activators - genetics (132) 132
immunohistochemistry (131) 131
analysis (129) 129
receptors, g-protein-coupled - metabolism (128) 128
patched protein (127) 127
hedgehog protein (125) 125
pathway (124) 124
basal-cell carcinoma (122) 122
basal cell carcinoma (121) 121
differentiation (120) 120
mice, knockout (120) 120
molecular sequence data (120) 120
signal transduction - genetics (118) 118
aged (117) 117
genes (117) 117
intracellular signaling peptides and proteins (117) 117
mice, inbred c57bl (115) 115
proliferation (114) 114
proteins - genetics (114) 114
physiological aspects (113) 113
patched gene (112) 112
receptors, g-protein-coupled - genetics (112) 112
cell proliferation (110) 110
in situ hybridization (109) 109
molecular biology (107) 107
phenotype (106) 106
cells, cultured (105) 105
reverse transcriptase polymerase chain reaction (105) 105
smoothened (105) 105
signal transduction - drug effects (104) 104
animal structures (103) 103
medulloblastoma - genetics (103) 103
cells (102) 102
base sequence (101) 101
cell line, tumor (99) 99
morphogenesis (99) 99
embryonic structures (98) 98
mouse (97) 97
dermatology (95) 95
kruppel-like transcription factors - metabolism (94) 94
gorlin syndrome (93) 93
kruppel-like transcription factors - genetics (93) 93
apoptosis (92) 92
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1501) 1501
Chinese (11) 11
French (9) 9
Japanese (4) 4
Spanish (3) 3
German (2) 2
Dutch (1) 1
Hungarian (1) 1
Polish (1) 1
Russian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Developmental Biology, ISSN 0012-1606, 07/2016, Volume 415, Issue 2, pp. 198 - 215
The Hedgehog signalling pathway plays a fundamental role in orchestrating normal craniofacial development in vertebrates. In particular, Sonic hedgehog (Shh)... 
Craniofacial development | Scube2 | Disease | Gpr161 | Holoprosencephaly | Sonic hedgehog | Dispatched | Smoothened | Boc | Gas1 | Patched1 | Patched2 | Lrp2/megalin | EvC1/2 | Cdon | CELL CARCINOMA SYNDROME | DEVELOPMENTAL BIOLOGY | EARLY EMBRYONIC-DEVELOPMENT | PRIMARY CILIA | VAN-CREVELD-SYNDROME | HUMAN SONIC HEDGEHOG | MOUSE PATCHED GENE | NEURAL CREST CELLS | PROTEIN-COUPLED RECEPTOR | WEYERS ACRODENTAL DYSOSTOSIS | IG SUPERFAMILY MEMBER | Cilia - physiology | Ectoderm - embryology | Ciliopathies - embryology | Holoprosencephaly - physiopathology | Face - abnormalities | Humans | Craniofacial Abnormalities - embryology | Endoderm - embryology | Hedgehog Proteins - physiology | Craniofacial Abnormalities - physiopathology | Ciliopathies - genetics | Maxillofacial Development - physiology | Gene Expression Regulation, Developmental | Membrane Proteins - physiology | Skull - abnormalities | Craniofacial Abnormalities - genetics | Maxillofacial Development - genetics | Disease Models, Animal | Neural Crest - cytology | Holoprosencephaly - genetics | Patched Receptors - physiology | Signal Transduction - genetics | Holoprosencephaly - embryology | Patched Receptors - genetics | Skull - embryology | Diencephalon - embryology | Animals | Ciliopathies - physiopathology | Neural Crest - embryology | Face - embryology | Cell Movement | Proteins | Cellular signal transduction | Analysis | Stem cells
Journal Article
Developmental Biology, ISSN 0012-1606, 04/2016, Volume 412, Issue 2, pp. 278 - 287
The hedgehog family includes Sonic hedgehog (Shh), Desert hedgehog, and Indian hedgehog, which are well known as a morphogens that play many important roles... 
Branching morphogenesis | EGF receptor | Epithelio-mesenchymal interaction | Salivary gland | Shh | EGF | PATHWAYS | CELLS | ECTODYSPLASIN | MECHANISMS | DEVELOPMENTAL BIOLOGY | FACTOR RECEPTOR | IN-VITRO | EPIDERMAL-GROWTH-FACTOR | EPITHELIAL MORPHOGENESIS | GENE-EXPRESSION | Receptor, Epidermal Growth Factor - genetics | Hedgehog Proteins - pharmacology | Receptor, ErbB-3 - metabolism | Receptor, ErbB-2 - genetics | ErbB Receptors - genetics | Receptor, ErbB-2 - metabolism | Receptor, Epidermal Growth Factor - metabolism | Hedgehog Proteins - genetics | Female | Patched Receptors | Phosphorylation - drug effects | Organ Culture Techniques | ErbB Receptors - metabolism | Epidermal Growth Factor - genetics | Gene Expression Regulation, Developmental - drug effects | Submandibular Gland - metabolism | Receptors, Cell Surface - metabolism | Epidermal Growth Factor - metabolism | Receptor, ErbB-3 - genetics | Recombinant Proteins - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Inbred ICR | Pregnancy | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Morphogenesis - drug effects | Submandibular Gland - embryology | Patched-1 Receptor | Mitogen-Activated Protein Kinase 1 - metabolism | Receptors, Cell Surface - genetics | RNA | Epidermal growth factor
Journal Article
by Kool, Marcel and Jones, David T.W and Jäger, Natalie and Northcott, Paul A and Pugh, Trevor J and Hovestadt, Volker and Piro, Rosario M and Esparza, L. Adriana and Markant, Shirley L and Remke, Marc and Milde, Till and Bourdeaut, Franck and Ryzhova, Marina and Sturm, Dominik and Pfaff, Elke and Stark, Sebastian and Hutter, Sonja and Şeker-Cin, Huriye and Johann, Pascal and Bender, Sebastian and Schmidt, Christin and Schmidt, Sabine and Rausch, Tobias and Shih, David and Reimand, Jüri and Sieber, Laura and Wittmann, Andrea and Linke, Linda and Witt, Olaf and Witt, Hendrik and Weber, Ursula D and Zapatka, Marc and König, Rainer and Beroukhim, Rameen and Bergthold, Guillaume and van Sluis, Peter and Volckmann, Richard and Koster, Jan and Versteeg, Rogier and Wolf, Stephan and Lawerenz, Chris and Bartholomae, Cynthia C and von Kalle, Christof and Unterberg, Andreas and Herold-Mende, Christel and Hofer, Silvia and Kulozik, Andreas E and von Deimling, Andreas and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Hasselblatt, Martin and Crawford, John R and Grant, Gerald A and Jabado, Nada and Perry, Arie and Cowdrey, Cynthia and Croul, Sydney and Zadeh, Gelareh and Korbel, Jan O and Doz, Francois and Delattre, Olivier and Bader, Gary D and McCabe, Martin G and Collins, V. Peter and Kieran, Mark W and Cho, Yoon-Jae and Pomeroy, Scott L and Brors, Benedikt and Taylor, Michael D and Schüller, Ulrich and Korshunov, Andrey and Eils, Roland and Wechsler-Reya, Robert J and Lichter, Peter and Pfister, Stefan M and ICGC PedBrain Tumor Project
Cancer Cell, ISSN 1535-6108, 03/2014, Volume 25, Issue 3, pp. 393 - 405
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To... 
TERT PROMOTER MUTATIONS | ONCOLOGY | GROWTH | RESISTANCE | HEDGEHOG PATHWAY INHIBITOR | ITRACONAZOLE | SUBGROUPS | PEDIATRIC MEDULLOBLASTOMA | TUMORS | MOUSE MODELS | ADULT | CELL BIOLOGY | Neoplasm Transplantation | Oncogene Proteins - genetics | Humans | Zinc Finger Protein Gli2 | Child, Preschool | Molecular Sequence Data | Infant | Male | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Biphenyl Compounds - therapeutic use | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Young Adult | Telomerase - genetics | Hedgehog Proteins - genetics | Base Sequence | Smoothened Receptor | Adult | Female | N-Myc Proto-Oncogene Protein | Patched Receptors | Medulloblastoma - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Child | Pyridines - therapeutic use | Cerebellar Neoplasms - drug therapy | Repressor Proteins - genetics | DNA Copy Number Variations - genetics | Signal Transduction - genetics | Cerebellar Neoplasms - genetics | Mice, SCID | Phosphatidylinositol 3-Kinases - genetics | DEAD-box RNA Helicases - genetics | Drug Resistance, Neoplasm - genetics | Animals | Adolescent | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Kruppel-Like Transcription Factors - genetics | Patched-1 Receptor | Receptors, Cell Surface - genetics | Genetic aspects | Nucleotide sequencing | Analysis | Medulloblastoma | Genomics | DNA sequencing
Journal Article
Experimental and Molecular Medicine, ISSN 1226-3613, 2017, Volume 49, Issue 12, pp. e412 - e412
This study aimed to investigate the effect of Patched-1 (PTC1) and PTC2 silencing in a rat model, on Hedgehog (Hh) pathwaymediated recovery from spinal cord... 
MEDICINE, RESEARCH & EXPERIMENTAL | FUNCTIONAL RECOVERY | CELLS | IN-VITRO | INHIBITION | SONIC HEDGEHOG | REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICE | PROLIFERATION | DIFFERENTIATION | CONTRIBUTES | Genetic Therapy | Inflammation - pathology | Genetic Vectors - administration & dosage | Humans | Spinal Cord Injuries - genetics | Patched-1 Receptor - genetics | Smoothened Receptor - genetics | Spinal Cord Injuries - pathology | Patched-1 Receptor - antagonists & inhibitors | Hedgehog Proteins - genetics | Regeneration - genetics | Spinal Cord - pathology | Nestin - genetics | Lentivirus - genetics | Spinal Cord Injuries - therapy | Disease Models, Animal | Gene Expression Regulation - genetics | Zinc Finger Protein GLI1 - genetics | Rats | Signal Transduction - genetics | Genetic Vectors - genetics | Inflammation - therapy | Animals | Patched-2 Receptor - genetics | Inflammation - genetics | Patched-2 Receptor - antagonists & inhibitors | Immunohistochemistry | Nestin | Brain tumors | RNA-mediated interference | Glial fibrillary acidic protein | mRNA | Spinal cord injury | Gene expression | Patched protein | Neuronal-glial interactions | Western blotting | Polymerase chain reaction | Proteins | Regeneration | Signal transduction | Glioma | Blood-brain barrier | Hedgehog protein | Rodents | Neurofilament protein | Spinal cord injuries | Original
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7409, pp. 106 - 110
Medulloblastomas are themost commonmalignant brain tumours in children(1). Identifying and understanding the genetic events that drive these tumours is... 
COMPLEX | STRUCTURAL BASIS | LANDSCAPE | CHILDHOOD | MULTIDISCIPLINARY SCIENCES | GENES | Transcription Factors - chemistry | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Promoter Regions, Genetic - genetics | Tumor Suppressor Protein p53 - genetics | TCF Transcription Factors - metabolism | Patched Receptors | Cerebellar Neoplasms - classification | DEAD-box RNA Helicases - metabolism | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DEAD-box RNA Helicases - chemistry | DNA Helicases - genetics | Intracellular Signaling Peptides and Proteins - genetics | DNA Helicases - chemistry | Histone-Lysine N-Methyltransferase - genetics | Signal Transduction | Models, Molecular | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Protein Structure, Tertiary - genetics | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nuclear Proteins - chemistry | beta Catenin - metabolism | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Histone Methyltransferases | Histone-Lysine N-Methyltransferase - metabolism | LIM Domain Proteins - genetics | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Nucleotide sequencing | Metastasis | DNA sequencing | Cancer
Journal Article
by Jones, David T. W and Jäger, Natalie and Kool, Marcel and Zichner, Thomas and Hutter, Barbara and Sultan, Marc and Cho, Yoon-Jae and Pugh, Trevor J and Hovestadt, Volker and Stütz, Aian M and Rausch, Tobias and Warnatz, Hans-Jörg and Ryzhova, Marina and Bender, Sebastian and Sturm, Dominik and Pleier, Sabrina and Cin, Huriye and Pfaff, Elke and Sieber, Laura and Wittmann, Anea and Remke, Marc and Witt, Henik and Hutter, Sonja and Tzaridis, Theophilos and Weischenfeldt, Joachim and Raeder, Benjamin and Avci, Meryem and Amstislavskiy, Vyacheslav and Zapatka, Marc and Weber, Ursula D and Wang, Qi and Lasitschka, Bärbel and Bartholomae, Cynthia C and Schmidt, Manfred and von Kalle, Christof and Ast, Volker and Lawerenz, Chris and Eils, Jürgen and Kabbe, Rolf and Benes, Vladimir and van Sluis, Peter and Koster, Jan and Volckmann, Richard and Shih, David and Betts, Matthew J and Russell, Robert B and Coco, Simona and Tonini, Gian Paolo and Schüller, Ulrich and Hans, Volkmar and Graf, Norbert and Kim, Yoo-Jin and Monoranu, Camelia and Roggendorf, Wolfgang and Unterberg, Aneas and Herold-Mende, Christel and Milde, Till and Kulozik, Aneas E and von Deimling, Aneas and Witt, Olaf and Maass, Eberhard and Rössler, Jochen and Ebinger, Martin and Schuhmann, Martin U and Frühwald, Michael C and Hasselblatt, Martin and Jabado, Nada and Rutkowski, Stefan and von Bueren, Ané O and Williamson, Dan and Clifford, Steven C and McCabe, Martin G and Collins, V. Peter and Wolf, Stephan and Wiemann, Stefan and Lehrach, Hans and Brors, Benedikt and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Northcott, Paul A and Taylor, Michael D and Meyerson, Matthew and Pomeroy, Scott L and Yaspo, Marie-Laure and Korbel, Jan O and Korshunov, Aney and Eils, Roland and Pfister, Stefan M and Lichter, Peter
Nature, ISSN 0028-0836, 2012, Volume 488, Issue 7409, pp. 100 - 105
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children,... 
ACTIVATION | PATHWAY | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | GENES | TETRAPLOID TUMOR-CELLS | TBR1 | MUTATIONS | SUBGROUPS | CANCER | Chromatin - metabolism | Cerebellar Neoplasms - diagnosis | Genomics | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Histone Demethylases - genetics | Aging - genetics | Medulloblastoma - pathology | Cerebellar Neoplasms - pathology | Patched Receptors | Cerebellar Neoplasms - classification | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DNA Helicases - genetics | Amino Acid Sequence | Polyploidy | Signal Transduction | Chromosomes, Human - genetics | Medulloblastoma - diagnosis | Mutation Rate | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | T-Box Domain Proteins - genetics | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Phosphoprotein Phosphatases - genetics | Sequence Analysis, RNA | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | High-Throughput Nucleotide Sequencing | Methylation | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Metastasis | Cancer
Journal Article
Molecular Cancer, ISSN 1476-4598, 06/2014, Volume 13, Issue 1, pp. 137 - 137
Background: Although long-term estrogen (E2) exposure is associated with increased breast cancer (BC) risk, and E2 appears to sustain growth of BC cells that... 
Epithelial-mesenchymal transition | Sonic hedgehog | Shh | Estrogen | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR EXPRESSION | SELF-RENEWAL | ALPHA | PROLIFERATION | THERAPY | DISSOCIATION | ONCOLOGY | RESISTANCE | MAMMARY-GLAND | RNA, Small Interfering - genetics | Receptors, Estrogen - metabolism | Estrogens - pharmacology | Neoplastic Stem Cells - drug effects | Polycomb Repressive Complex 1 - metabolism | Homeodomain Proteins - metabolism | Humans | Retinal Dehydrogenase - metabolism | Gene Expression Regulation, Neoplastic | Hedgehog Proteins - metabolism | Epithelial-Mesenchymal Transition - drug effects | Breast Neoplasms - metabolism | SOXB1 Transcription Factors - metabolism | Polycomb Repressive Complex 1 - genetics | Hedgehog Proteins - genetics | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | Isoenzymes - metabolism | Neoplastic Stem Cells - pathology | Female | Patched Receptors | Estrogens - metabolism | Nanog Homeobox Protein | Receptors, Estrogen - genetics | Signal Transduction | Isoenzymes - genetics | Neoplasm Invasiveness | Receptors, Cell Surface - metabolism | Transcription Factors - antagonists & inhibitors | Retinal Dehydrogenase - genetics | Transcription Factors - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Zinc Finger Protein GLI1 | Patched-1 Receptor | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Comparative analysis | Health aspects | Chromatin | Medical research | Breast cancer | Stem cells
Journal Article