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Genes and Development, ISSN 0890-9369, 2009, Volume 23, Issue 16, pp. 1910 - 1928
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2009, Volume 11, Issue 6, pp. 739 - 746
Sonic hedgehog (Shh) and its main receptor, Patched (Ptc), are implicated in both neural development and tumorigenesis(1,2). Besides its classic morphogenic... 
PROTEIN | INHIBITION | GENE | MECHANISM | SONIC HEDGEHOG | NEURONAL DEATH | PRODUCT INDUCES APOPTOSIS | KAPPA-B | CASPASE ACTIVATION | CELL-DEATH | CELL BIOLOGY | RNA, Small Interfering - genetics | Caspase 9 - metabolism | Homeodomain Proteins - metabolism | Humans | Hedgehog Proteins - metabolism | Neoplasm Proteins - metabolism | CARD Signaling Adaptor Proteins - genetics | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Hedgehog Proteins - genetics | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Patched Receptors | Neoplasm Proteins - genetics | Cell Line | Receptors, Cell Surface - metabolism | Transcription Factors - genetics | Chick Embryo | Homeodomain Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | Animals | Adaptor Proteins, Signal Transducing - genetics | LIM-Homeodomain Proteins | Signal Transduction - physiology | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Causes of | Physiological aspects | Cell receptors | Research | Proteases | Apoptosis | Caspase 9 | Signal Transduction | Multiprotein Complexes | Receptors, Cell Surface | Cellular Biology | Hedgehog Proteins | Life Sciences | Muscle Proteins | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Homeodomain Proteins | Neoplasm Proteins | CARD Signaling Adaptor Proteins | RNA, Small Interfering | Transcription Factors | Development Biology | physiology | genetics | metabolism
Journal Article
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 04/2011, Volume 20, Issue 8, pp. 1560 - 1573
Mental retardation in Down syndrome (DS) appears to be related to severe neurogenesis impairment during critical phases of brain development. Recent lines of... 
TS65DN MOUSE MODEL | TARGET GENES | METHYLATION | SONIC HEDGEHOG | RESTORES NEUROGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | GENE-EXPRESSION | CELL-PROLIFERATION | MICE | FETUSES | INTRACELLULAR DOMAIN | Up-Regulation | Hedgehog Proteins - pharmacology | Lateral Ventricles - pathology | Cell Proliferation | Humans | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Male | RNA Interference | Smoothened Receptor | Acetylation | Patched Receptors | Hippocampus - embryology | Repressor Proteins - genetics | Thiophenes - pharmacology | Hippocampus - pathology | Polycomb Repressive Complex 1 | Mice | Receptors, G-Protein-Coupled - genetics | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - genetics | Patched-1 Receptor | Receptors, Cell Surface - genetics | Cell Cycle - genetics | Down Syndrome - metabolism | Lateral Ventricles - metabolism | Receptors, G-Protein-Coupled - agonists | Lateral Ventricles - embryology | DNA Methylation | Hedgehog Proteins - genetics | Cyclohexylamines - pharmacology | Amyloid beta-Protein Precursor - metabolism | Neurons - physiology | Veratrum Alkaloids - pharmacology | Female | Receptors, Cell Surface - biosynthesis | Nuclear Proteins - genetics | Protein Structure, Tertiary | Promoter Regions, Genetic | Mice, Inbred C57BL | Neural Stem Cells - physiology | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Down Syndrome - embryology | Hippocampus - metabolism | Animals | Down Syndrome - genetics | Forkhead Box Protein M1 | Cell proliferation | Cerebellum | Brain | subventricular zone | Animal models | Cell division | Data processing | Mental retardation | Neurogenesis | Amyloid precursor protein | Promoters | Membrane proteins | Molecular modelling | Down's syndrome | Hedgehog protein | Neural stem cells | Alzheimer's disease | Mitogens | Hippocampus
Journal Article
Developmental Cell, ISSN 1534-5807, 2006, Volume 10, Issue 2, pp. 187 - 197
The Hedgehog (Hh) pathway plays important roles during embryogenesis and carcinogenesis. Here, we show that ablation of the mouse Suppressor of fused ( ), an... 
DEVBIO | SIGNALING | Devbio | Signaling | INTRAFLAGELLAR TRANSPORT PROTEINS | VENTRAL NEURAL-TUBE | CELL CARCINOMA SYNDROME | CUBITUS-INTERRUPTUS | FLOOR PLATE | DROSOPHILA-MELANOGASTER | GLI PROTEINS | DEVELOPMENTAL BIOLOGY | SENSORY CILIA | TRANSCRIPTION FACTOR | HUMAN HOMOLOG | CELL BIOLOGY | Skin - metabolism | Humans | Receptors, Cell Surface | Green Fluorescent Proteins - genetics | Receptors, G-Protein-Coupled - agonists | Recombinant Fusion Proteins - metabolism | Hedgehog Proteins | Intracellular Signaling Peptides and Proteins - deficiency | Basal Cell Nevus Syndrome - pathology | Membrane Proteins - deficiency | Gene Expression Regulation, Developmental | Kruppel-Like Transcription Factors - metabolism | Mice, Mutant Strains | Smoothened Receptor | Female | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Patched Receptors | Nervous System - embryology | Intracellular Signaling Peptides and Proteins - genetics | Basal Cell Nevus Syndrome - metabolism | Repressor Proteins - metabolism | Skin - pathology | Disease Models, Animal | Fibroblasts - metabolism | Green Fluorescent Proteins - metabolism | Signal Transduction | Membrane Proteins - genetics | Embryonic Development - genetics | Repressor Proteins - genetics | Mice, Knockout | Pregnancy | Phenotype | Animals | Receptors, G-Protein-Coupled - antagonists & inhibitors | Recombinant Fusion Proteins - genetics | Trans-Activators - metabolism | Mice | Zinc Finger Protein GLI1 | Basal Cell Nevus Syndrome - genetics | Kruppel-Like Transcription Factors - genetics | Genetic disorders
Journal Article
Cell, ISSN 0092-8674, 2001, Volume 105, Issue 5, pp. 599 - 612
Sonic hedgehog (Shh) signaling from the posterior zone of polarizing activity (ZPA) is the primary determinant of anterior-posterior polarity in the vertebrate... 
TRANSDUCING HEDGEHOG | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE PATCHED GENE | TOUT-VELU | NEURAL-TUBE | DEVELOPING CHICK LIMB | POLARIZING ACTIVITY | HEPARAN-SULFATE | PATTERNING ACTIVITY | VERTEBRATE LIMB | FEEDBACK LOOP | CELL BIOLOGY | Oncogene Proteins - genetics | Homeodomain Proteins - metabolism | Repressor Proteins | Zinc Finger Protein Gli3 | Fibroblast Growth Factors - genetics | Male | Hedgehog Proteins | Fibroblast Growth Factors - metabolism | Bone Morphogenetic Proteins - metabolism | Patched Receptors | Transforming Growth Factor beta | Basic Helix-Loop-Helix Transcription Factors | Limb Buds - physiology | Oncogene Proteins - metabolism | Nerve Tissue Proteins | Xenopus Proteins | Membrane Proteins | Phenotype | Mice | Zinc Finger Protein GLI1 | Patched-1 Receptor | Forelimb - embryology | Forelimb - physiology | Hindlimb - physiology | Receptors, Cell Surface | DNA-Binding Proteins - metabolism | Gene Expression Regulation, Developmental | Hindlimb - embryology | Female | Bone Morphogenetic Proteins - genetics | Bone Morphogenetic Protein 4 | Bone Morphogenetic Protein 2 | Intercellular Signaling Peptides and Proteins | Trans-Activators | Zebrafish Proteins | Intracellular Signaling Peptides and Proteins | Transcription Factors - genetics | Cholesterol - metabolism | DNA-Binding Proteins - genetics | Limb Buds - embryology | Homeodomain Proteins - genetics | Body Patterning - physiology | Kruppel-Like Transcription Factors | Proteins - genetics | Transcription Factors - metabolism | Animals | Proteins - metabolism | Signal Transduction - physiology | Chimera | Proteins | Physiological aspects | Cellular signal transduction | Polarity (Biology) | Structure | Cholesterol
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7409, pp. 106 - 110
Medulloblastomas are themost commonmalignant brain tumours in children(1). Identifying and understanding the genetic events that drive these tumours is... 
COMPLEX | STRUCTURAL BASIS | LANDSCAPE | CHILDHOOD | MULTIDISCIPLINARY SCIENCES | GENES | Transcription Factors - chemistry | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Promoter Regions, Genetic - genetics | Tumor Suppressor Protein p53 - genetics | TCF Transcription Factors - metabolism | Patched Receptors | Cerebellar Neoplasms - classification | DEAD-box RNA Helicases - metabolism | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DEAD-box RNA Helicases - chemistry | DNA Helicases - genetics | Intracellular Signaling Peptides and Proteins - genetics | DNA Helicases - chemistry | Histone-Lysine N-Methyltransferase - genetics | Signal Transduction | Models, Molecular | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Protein Structure, Tertiary - genetics | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nuclear Proteins - chemistry | beta Catenin - metabolism | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Histone Methyltransferases | Histone-Lysine N-Methyltransferase - metabolism | LIM Domain Proteins - genetics | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Nucleotide sequencing | Metastasis | DNA sequencing | Cancer
Journal Article
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5952, pp. 572 - 574
The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a... 
Receptors | Relapse | Basal cell carcinoma | Medulloblastoma | Amino acids | Biopsies | Reports | Genetic mutation | Tumors | Resistance mechanisms | Cancer | PROTEIN-COUPLED RECEPTORS | CYCLOPAMINE | CANCER | MULTIDISCIPLINARY SCIENCES | Anilides - therapeutic use | Receptors, G-Protein-Coupled - metabolism | Humans | Brain Neoplasms - pathology | Hedgehog Proteins - metabolism | Molecular Sequence Data | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Mutation, Missense | Antineoplastic Agents - metabolism | Neoplasm Metastasis | Hedgehog Proteins - genetics | Medulloblastoma - pathology | Smoothened Receptor | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Patched Receptors | Medulloblastoma - genetics | Mutant Proteins - antagonists & inhibitors | Pyridines - therapeutic use | Amino Acid Sequence | Signal Transduction | Anilides - metabolism | Brain Neoplasms - genetics | Receptors, Cell Surface - metabolism | Mutant Proteins - metabolism | Hedgehog Proteins - antagonists & inhibitors | Brain Neoplasms - drug therapy | Cinnamates - pharmacology | Animals | Pyridines - metabolism | Mutant Proteins - chemistry | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Mice | Pyridines - pharmacology | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Receptors, G-Protein-Coupled - chemistry | Amino Acid Substitution | Receptors, Cell Surface - genetics | Gene mutations | Development and progression | Genetic aspects | Diagnosis | Drug resistance | Identification and classification | Signal transduction | Genotype & phenotype | Inhibitor drugs | Cellular biology | Brain cancer | Mutation
Journal Article
Development, ISSN 0950-1991, 06/2008, Volume 135, Issue 11, pp. 1947 - 1956
Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte hypertrophy is also required in... 
Ihh | Patched 1 | Cartilage | Chondrocyte hypertrophy | PTHrP | PATHWAYS | OSTEOBLAST | cartilage | chondrocyte hypertrophy | PROLIFERATION | DEVELOPMENTAL BIOLOGY | CARTILAGE DEVELOPMENT | ENDOCHONDRAL BONE | SKELETON | patched 1 | HORMONE-RELATED-PROTEIN | GROWTH-PLATE | DIFFERENTIATION | Immunohistochemistry | Hedgehog Proteins - pharmacology | Bone Morphogenetic Proteins - physiology | Hedgehog Proteins - metabolism | Hedgehog Proteins - physiology | Wnt Proteins - metabolism | Cell Differentiation - genetics | Bone Morphogenetic Proteins - metabolism | In Situ Hybridization | Wnt Proteins - genetics | Hedgehog Proteins - genetics | Receptors, Cell Surface - physiology | beta Catenin - physiology | Patched Receptors | Bone Morphogenetic Proteins - genetics | Cell Differentiation - physiology | Chondrocytes - metabolism | Organ Culture Techniques | Recombinant Proteins - metabolism | Chondrocytes - pathology | Parathyroid Hormone-Related Protein - genetics | Cells, Cultured | Receptors, Cell Surface - metabolism | Signal Transduction - genetics | Cell Enlargement | Recombinant Proteins - pharmacology | Forelimb - metabolism | Reverse Transcriptase Polymerase Chain Reaction | beta Catenin - metabolism | beta Catenin - genetics | Animals | Signal Transduction - drug effects | Parathyroid Hormone-Related Protein - physiology | Signal Transduction - physiology | Forelimb - cytology | Mice | Wnt Proteins - physiology | Mutation | Patched-1 Receptor | Receptors, Cell Surface - genetics
Journal Article