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Endocrinology, ISSN 0013-7227, 09/2013, Volume 154, Issue 9, pp. 3410 - 3422
We recently created a mouse model displaying precocious Sertoli cell (SC) and spermatogenic development induced by SC-specific transgenic androgen receptor expression (TgSCAR... 
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Leydig Cells - cytology | Up-Regulation | Receptors, Transforming Growth Factor beta - genetics | Testis - metabolism | Cell Count | Receptors, Androgen - metabolism | Male | Receptors, Peptide - genetics | Isoenzymes - metabolism | Leydig Cells - metabolism | Receptors, Androgen - biosynthesis | Sertoli Cells - cytology | Sexual Development | Cell Differentiation | Receptors, Cell Surface - biosynthesis | Patched Receptors | Receptor, Platelet-Derived Growth Factor alpha - biosynthesis | Animals, Newborn | Biomarkers - metabolism | Sertoli Cells - metabolism | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Testis - cytology | Testosterone Congeners - blood | Isoenzymes - genetics | Receptors, Cell Surface - metabolism | Mice, Transgenic | Receptors, Peptide - biosynthesis | Testis - growth & development | Hemizygote | Receptors, Transforming Growth Factor beta - biosynthesis | Animals | Receptors, Androgen - genetics | Receptors, Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Testosterone Congeners - metabolism | Ligands | Mice | Isoenzymes - biosynthesis | Patched-1 Receptor | Receptors, Cell Surface - genetics | Receptors, Peptide - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Nature (London), ISSN 0028-0836, 07/2019, Volume 571, Issue 7764, pp. 284 - 288
.... Analogous to other G protein-coupled receptors, the activation of SMO is associated with subtle motions in the extracellular domain, and larger intracellular... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Catalytic Domain - drug effects | Sterols - metabolism | Smoothened Receptor - agonists | Hedgehog Proteins - metabolism | Smoothened Receptor - metabolism | Hedgehog Proteins - agonists | Xenopus Proteins - chemistry | Cell Membrane - chemistry | Cholesterol - chemistry | Patched-1 Receptor - metabolism | Patched-1 Receptor - antagonists & inhibitors | Cell Membrane - metabolism | Protein Stability | Binding Sites | Smoothened Receptor - antagonists & inhibitors | Sterols - pharmacology | Sterols - chemistry | Models, Molecular | Cholesterol - metabolism | Molecular Dynamics Simulation | Animals | Signal Transduction - drug effects | Biosensing Techniques | Cholesterol - pharmacology | Ligands | Protein Conformation | Mice | Single-Chain Antibodies - immunology | Smoothened Receptor - chemistry | Physiological aspects | Development and progression | Sterols | Hedgehog proteins | Tumors | Plasma | G protein-coupled receptors | Molecular dynamics | Activation | Hydrophobicity | Drug resistance | Inactivation | Proteins | Signal transduction | Receptors | Embryogenesis | Physiology | Crystal structure | Dynamic structural analysis | Deactivation | Computer simulation | Tissue engineering | Cholesterol | Patched protein | Embryonic growth stage | Regeneration | Signaling | Molecular modelling | Hedgehog protein | Medulloblastoma | Software | Mutation | Intracellular | Transporter | Binding sites | Cancer | Index Medicus
Journal Article
Journal Article
Endocrinology, ISSN 0013-7227, 07/2015, Volume 156, Issue 7, pp. 2395 - 2408
Medulloblastoma (Med) is the most common malignant brain tumor in children. The role of ESR2 [estrogen receptor (ER)-β] in promoting Med growth was comprehensively examined in three in vivo models and human cell lines... 
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Receptor, IGF Type 1 - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Apoptosis - genetics | Male | Insulin-Like Growth Factor I - genetics | Insulin-Like Growth Factor I - drug effects | RNA, Messenger - metabolism | Tumor Suppressor Protein p53 - genetics | Estrogen Receptor beta - metabolism | Insulin-Like Growth Factor II - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Estrogen Receptor beta - genetics | Insulin-Like Growth Factor II - genetics | Receptor, IGF Type 1 - drug effects | Female | Gene Expression Regulation, Neoplastic - drug effects | Patched Receptors | Medulloblastoma - genetics | Estradiol - pharmacology | Gene Expression Regulation, Neoplastic - genetics | RNA, Messenger - drug effects | Up-Regulation - genetics | Medulloblastoma - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Receptor, IGF Type 1 - genetics | Insulin-Like Growth Factor II - metabolism | Mice, Knockout | Up-Regulation - drug effects | Animals | Proto-Oncogene Proteins c-bcl-2 - drug effects | Cell Line, Tumor | Mice | Insulin-Like Growth Factor I - metabolism | Patched-1 Receptor | Receptors, Cell Surface - genetics | Index Medicus | Abridged Index Medicus | Original Research
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 12/2018, Volume 13, Issue 12, pp. e0208221 - e0208221
The aim of this study was to investigate the prognostic value of the Hedgehog (Gli, Patched1, Shh, Smo) and Notch (Jag1, Notch2, Notch3) pathway members, in... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Jagged-1 Protein - metabolism | Prognosis | Receptors, Notch - metabolism | Humans | Middle Aged | Endometrial Neoplasms - metabolism | Hedgehog Proteins - metabolism | Receptor, Notch2 - genetics | Receptors, Notch - genetics | DNA Mismatch Repair - genetics | Patched-1 Receptor - genetics | Patched-1 Receptor - metabolism | DNA Mismatch Repair - physiology | Endometrial Neoplasms - genetics | Hedgehog Proteins - genetics | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Receptor, Notch3 - genetics | Receptor, Notch3 - metabolism | Receptor, Notch2 - metabolism | Signal Transduction - genetics | Jagged-1 Protein - genetics | Endometrial Neoplasms - pathology | Signal Transduction - physiology | Aged | Biomarkers, Tumor - genetics | Cluster Analysis | Immunohistochemistry | Usage | Care and treatment | Endometrial cancer | Analysis | Outcome and process assessment (Health Care) | Genetic aspects | Research | Diagnosis | Gene expression | Cluster analysis | Health sciences | Yeast | Laboratories | Pathogenesis | p53 Protein | Risk | Oncology | Systematic review | Clinical outcomes | Proteins | Pathways | Mismatch repair | Endometrium | Deoxyribonucleic acid--DNA | Medical research | Mortality | Gynecology | Risk reduction | Histology | Clustering | Patients | Obstetrics | ErbB-2 protein | Patched protein | Medicine | Pathology | Hospitals | Hedgehog protein | Medical prognosis | Ligands | Mutation | PTEN protein | Tumors | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article