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Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7670, pp. 96 - 100
Paediatric solid tumours arise from endodermal, ectodermal, or mesodermal lineages(1). Although the overall survival of children with solid tumours is 75%,... 
MULTIPLE-MYELOMA | HETEROGENEITY | BIOBANK | GENOMIC LANDSCAPE | MODELS | MULTIDISCIPLINARY SCIENCES | BORTEZOMIB | INHIBITOR | CANCER | DISCOVERY | PANOBINOSTAT LBH589 | Vincristine - pharmacology | Pyrazoles - therapeutic use | Epigenesis, Genetic | Heterografts - drug effects | Humans | Heterografts - metabolism | Bortezomib - pharmacology | Cell Cycle Proteins - antagonists & inhibitors | Neoplasms - genetics | Female | Indoles - pharmacology | Rhabdomyosarcoma - drug therapy | Clone Cells | Drug Therapy, Combination | Child | Heterografts - pathology | Hydroxamic Acids - pharmacology | Camptothecin - analogs & derivatives | High-Throughput Screening Assays - methods | Pyrazoles - pharmacology | Camptothecin - therapeutic use | Pyrimidines - pharmacology | Xenograft Model Antitumor Assays - methods | Neoplasms - drug therapy | Animals | Bortezomib - therapeutic use | Pyrimidines - therapeutic use | Nuclear Proteins - antagonists & inhibitors | Heterografts - transplantation | Vincristine - therapeutic use | Hydroxamic Acids - therapeutic use | Indoles - therapeutic use | Mice | Rhabdomyosarcoma - genetics | Camptothecin - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Tumors in children | Care and treatment | Diagnosis | Xenotransplantation | Methods | Pediatrics | Rhabdomyosarcoma | Multiple myeloma | Genomes | Neuroblastoma | Gene expression | Vincristine | Patients | Children & youth | Irinotecan | Chemotherapy | Autopsy | Xenografts | Mutation | Children | Cancer | Tumors | Index Medicus
Journal Article
Pediatrics & Neonatology, ISSN 1875-9572, 02/2018, Volume 59, Issue 1, pp. 65 - 70
Neonatal tumors are different from tumors of the older children and knowledge gained from treating older children can not be extrapolated to neonates. Neonates... 
antenatal diagnosis of neonatal tumors | congenital tumors | neonatal malignant tumors | neonatal tumors | INFANTILE FIBROSARCOMA | LIVER | PEDIATRICS | EXPERIENCE | NEUROBLASTOMA | RENAL TUMORS | CHEMOTHERAPY | CHILDREN
Journal Article
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7696, pp. 371 - 376
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 6, pp. 472 - 480
Summary Background Various human cancers have ALK gene translocations, amplifications, or oncogenic mutations, such as anaplastic large-cell lymphoma,... 
Hematology, Oncology and Palliative Medicine | LUNG-CANCER | FUSION | ALK GENE REARRANGEMENT | ONCOLOGY | ADOLESCENTS | KINASE | ONCOGENIC MUTATIONS | NEUROBLASTOMA | IDENTIFICATION | ACTIVATING MUTATIONS | CHEMOTHERAPY | Pyrazoles - therapeutic use | Age Factors | Humans | Child, Preschool | Pyridines - pharmacokinetics | Infant | Male | Antineoplastic Agents - therapeutic use | Lymphoma, Large-Cell, Anaplastic - enzymology | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Molecular Targeted Therapy | Young Adult | Pyridines - adverse effects | Neoplasms - genetics | Time Factors | Antineoplastic Agents - adverse effects | Biomarkers, Tumor - metabolism | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacokinetics | Biomarkers, Tumor - antagonists & inhibitors | Pyrazoles - pharmacokinetics | Child | Lymphoma, Large-Cell, Anaplastic - genetics | Pyrazoles - adverse effects | Pyridines - therapeutic use | Protein Kinase Inhibitors - pharmacokinetics | Drug Administration Schedule | Neoplasms - enzymology | Treatment Outcome | Receptor Protein-Tyrosine Kinases - metabolism | Disease Progression | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Maximum Tolerated Dose | Receptor Protein-Tyrosine Kinases - genetics | Protein Kinase Inhibitors - therapeutic use | Lymphoma, Large-Cell, Anaplastic - drug therapy | Adolescent | Biomarkers, Tumor - genetics | Lymphoma, Large-Cell, Anaplastic - pathology | Mutation | Neoplasms - pathology | Consortia | Pediatrics | Lymphomas | Safety and security measures | Lung cancer, Non-small cell | Index Medicus
Journal Article
The Lancet Oncology, ISSN 1470-2045, 05/2018, Volume 19, Issue 5, pp. 594 - 595
Journal Article
Journal of the American College of Nutrition, ISSN 0731-5724, 2019, pp. 1 - 7
: Our aims were to compare the vitamin D status of children with and without cancer and to examine the possible correlation between vitamin D levels in... 
supplementation | oncology prognosis | pediatric oncology | Vitamin D
Journal Article
The Lancet Oncology, ISSN 1470-2045, 05/2018, Volume 19, Issue 5, pp. 705 - 714
Gene fusions involving , or (TRK fusions) are found in a broad range of paediatric and adult malignancies. Larotrectinib, a highly selective small-molecule... 
ONCOLOGY | INFANTILE FIBROSARCOMA | MOLECULAR-DETECTION | RESPONSE ASSESSMENT | ACQUIRED-RESISTANCE | CONGENITAL FIBROSARCOMA | QUALITY-OF-LIFE | KINASE INHIBITOR LOXO-101 | TROPOMYOSIN | SOFT-TISSUE SARCOMA | MESOBLASTIC NEPHROMA | Age Factors | Discoidin Domain Receptor 2 - antagonists & inhibitors | United States | Humans | Receptor, trkA - antagonists & inhibitors | Child, Preschool | Infant | Male | Receptor, trkB - genetics | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Young Adult | Membrane Glycoproteins - antagonists & inhibitors | Neoplasms - genetics | Time Factors | Antineoplastic Agents - adverse effects | Receptor, trkB - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Biomarkers, Tumor - antagonists & inhibitors | Child | Discoidin Domain Receptor 2 - genetics | Pyrazoles - adverse effects | Drug Administration Schedule | Administration, Oral | Pyrimidines - administration & dosage | Gene Fusion | Treatment Outcome | Membrane Glycoproteins - genetics | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Pyrazoles - administration & dosage | Receptor Protein-Tyrosine Kinases - genetics | Adolescent | Pyrimidines - adverse effects | Receptor, trkA - genetics | Biomarkers, Tumor - genetics | Neoplasms - pathology | Genetic research | Pediatrics | Analysis | Index Medicus
Journal Article
Biomaterials, ISSN 0142-9612, 2015, Volume 79, pp. 69 - 78
Abstract In addition to surgery, local tumor control in pediatric oncology requires new treatments as an alternative to radiotherapy. SN-38 is an anticancer... 
Advanced Basic Science | Dentistry | Poly(lactic acid) electrospun nanofibers | SN-38 | Microdialysis | Local chemotherapy delivery | Pharmacokinetics | Pediatric solid tumor | IRINOTECAN CPT-11 | MATERIALS SCIENCE, BIOMATERIALS | PROGNOSTIC-FACTORS | PHASE-II WINDOW | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | CONTROLLED-RELEASE | CANCER | CHEMOTHERAPY | EWING SARCOMA | GENOMIC LANDSCAPE | HIGH-RISK NEUROBLASTOMA | Camptothecin - chemistry | Humans | Child, Preschool | Male | Nanocapsules - chemistry | Nanocapsules - ultrastructure | Neoplasm Recurrence, Local - pathology | Tissue Distribution | Antineoplastic Agents, Phytogenic - administration & dosage | Camptothecin - administration & dosage | Female | Diffusion | Neoplasms, Experimental - surgery | Camptothecin - analogs & derivatives | Camptothecin - pharmacokinetics | Nanofibers - chemistry | Nanofibers - ultrastructure | Neoplasm Recurrence, Local - metabolism | Neoplasm Recurrence, Local - prevention & control | Treatment Outcome | Postoperative Care - methods | Particle Size | Animals | Cell Line, Tumor | Mice | Neoplasms, Experimental - metabolism | Neoplasms, Experimental - drug therapy | Drugs | Pediatrics | Drug delivery systems | Sarcoma | Analysis | Therapeutics | Children | Health aspects | Nanotechnology | Homeopathy | Materia medica and therapeutics | Vehicles | Index Medicus | Surgical implants | Biomedical materials | Surgery | Electrospinning | Nanostructure | Tumors | Tractament | Teixits mèdics | methods | Teixits | Ciències de la salut | Chemotherapy | Nanofibres | Farmacocinètica | Tumors in children | Enginyeria tèxtil | Medicina | Nanofibers | Quimioteràpia | Àrees temàtiques de la UPC
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2017, Volume 23, Issue 10, pp. 2433 - 2441
Purpose: The cyclin-dependent kinase (CDK) 4/6 inhibitor, ribociclib (LEE011), displayed preclinical activity in neuroblastoma and malignant rhabdoid tumor... 
CRITERIA | FREQUENT | ONCOLOGY | LANDSCAPE | PATHWAY | THERAPEUTIC TARGET | CELL-CYCLE ARREST | CYCLIN-D1 | MUTATIONS | HIGH-RISK NEUROBLASTOMA | CANCER | Kidney Neoplasms - genetics | Cyclin-Dependent Kinase 4 - genetics | Humans | Aminopyridines - pharmacokinetics | Brain Neoplasms - pathology | Aminopyridines - adverse effects | Child, Preschool | Infant | Male | Purines - administration & dosage | Rhabdoid Tumor - pathology | Drug-Related Side Effects and Adverse Reactions - pathology | Dose-Response Relationship, Drug | Young Adult | Adult | Female | Purines - adverse effects | Child | Neuroblastoma - pathology | Aminopyridines - administration & dosage | Rhabdoid Tumor - drug therapy | Neuroblastoma - genetics | Purines - pharmacokinetics | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Disease-Free Survival | Maximum Tolerated Dose | Rhabdoid Tumor - genetics | Neuroblastoma - drug therapy | Adolescent | Kidney Neoplasms - pathology | Kidney Neoplasms - drug therapy | Drug-Related Side Effects and Adverse Reactions - classification | Malignant rhabdoid tumor | Pediatrics | Toxicity | Central nervous system | Neuroblastoma | Cyclin-dependent kinase 4 | Cyclin-dependent kinase | Regression models | Vomiting | Safety engineering | Mathematical models | Cyclin-dependent kinase inhibitors | Cyclin D | Safety | Neutropenia | Thrombocytopenia | Leukopenia | Anemia | Cyclin-dependent kinases | Fatigue | Nausea | Pharmacology | INK4 protein | Patients | Inhibitors | Equivalence | Lymphopenia | Experimental design | Overdose | Adults | Solid tumors | Pharmacokinetics | Retinoblastoma | Bayesian analysis | Prolongation | Tumors | Cancer | Index Medicus
Journal Article
11/2013
Low Dose Metronomic (LDM) chemotherapy, combined with VEGF pathway inhibitors, is a highly effective strategy to coordinately inhibit angiogenesis and tumor... 
Angiogenesis | Pediatric cancer | 0992 | Metronomic topotecan | Pazopanib
Dissertation