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Nature Genetics, ISSN 1061-4036, 09/2009, Volume 41, Issue 9, pp. 1027 - 1031
The primary cilium is an antenna-like structure that protrudes from the cell surface of quiescent/ differentiated cells and participates in extracellular... 
NETWORK | INOSITOL-POLYPHOSPHATE 5-PHOSPHATASE | POLYCYSTIC KIDNEY-DISEASE | BIOLOGY | GENETICS & HEREDITY | DISORDERS | PROTEINS | FIBROBLASTS | Humans | Fluorescent Dyes - metabolism | Culture Media, Serum-Free | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Fibroblasts - ultrastructure | Obesity - genetics | Embryo, Mammalian - metabolism | Intellectual Disability - genetics | Indoles - metabolism | Tubulin - metabolism | Cell Nucleus - metabolism | Transfection | Mice, Mutant Strains | Cilia - ultrastructure | Bardet-Biedl Syndrome - genetics | Chromones - pharmacology | Microsatellite Repeats | Fibroblasts - metabolism | Genetic Linkage | Cell Line | Green Fluorescent Proteins - metabolism | Phosphoric Monoester Hydrolases - genetics | Cilia - pathology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Fluorescent Antibody Technique, Direct | Retinal Degeneration - genetics | Cells, Cultured | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Mice, Transgenic | Genetic Markers | Cilia - metabolism | Cilia - genetics | Pigment Epithelium of Eye - metabolism | Animals | Embryo, Mammalian - cytology | Signal Transduction - physiology | Fibroblasts - cytology | Mice | Polymorphism, Single Nucleotide | Mutation | Pigment Epithelium of Eye - cytology | Penis - abnormalities | Gene mutations | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors | Brain diseases | Proteins | Tissue | Scanning electron microscopy | Transmission electron microscopy | Cysts | Rodents | Cell division
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0170427
Our previous studies had reported that Human Tissue Kallikrein 1 (hKLK1) preserved erectile function in aged transgenic rats, while the detailed mechanism of... 
THERAPY | COUNTRIES | ENDOTHELIAL DYSFUNCTION | CORPUS CAVERNOSUM | GENE | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | ASYMMETRIC DIMETHYLARGININE | TRANSGENIC RATS | EXPRESSION | EPIDEMIOLOGY | Erectile Dysfunction - physiopathology | Humans | Cytochrome P-450 Enzyme System - metabolism | Male | Tissue Kallikreins - genetics | RNA, Messenger - metabolism | Arginine - analogs & derivatives | Aging - genetics | Cyclooxygenase 2 - genetics | Erectile Dysfunction - genetics | Nitric Oxide Synthase Type III - metabolism | Intramolecular Oxidoreductases - metabolism | Cyclic AMP - metabolism | Amidohydrolases - metabolism | Recombinant Proteins - metabolism | Rats, Transgenic | Signal Transduction | RNA, Messenger - genetics | Rats | Recombinant Proteins - genetics | Nitric Oxide Synthase Type III - genetics | Rats, Sprague-Dawley | Erectile Dysfunction - metabolism | Animals | Tissue Kallikreins - physiology | Aging - physiology | Cyclic GMP - metabolism | Intramolecular Oxidoreductases - genetics | Penis - metabolism | Nitric Oxide Synthase Type I - metabolism | Cyclooxygenase 2 - metabolism | Cytochrome P-450 Enzyme System - genetics | Nitric Oxide Synthase Type I - genetics | Penile Erection - physiology | Arginine - metabolism | Penile Erection - genetics | Genetically modified mice | Usage | Impotence | Kallikrein | Genetic aspects | Genetic engineering | Cyclic adenylic acid | Research | Health aspects | Immunohistochemistry | Transgenic | Science | Smooth muscle | Urology | Signal transduction | Tissue kallikrein | Pathways | Rodents | Cyclic GMP | Blood pressure | Age | Construction | Cyclic AMP | Nitric-oxide synthase | Polymerase chain reaction | Signaling | Androgens | Hospitals | Nitric oxide | Diabetes | Cyclooxygenase-2 | Laboratory animals
Journal Article
The Journal of Sexual Medicine, ISSN 1743-6095, 10/2013, Volume 10, Issue 10, pp. 2430 - 2442
The renin angiotensin system plays a crucial role in erectile function. It has been shown that elevated angiotensin‐II levels contribute to the development of... 
Erectile Dysfunction | Hypercholesterolemia | Oxidative Stress | Angiotensin‐(1‐7) | Mas Receptor | Fibrosis | Hydroxypropyl‐Cyclodextrin | Hydroxypropyl-Cyclodextrin | Angiotensin-(1-7) | SYSTEM | ACTIVATION | PHYSIOLOGY | PENILE ERECTION | ENDOTHELIUM-DEPENDENT RELAXATION | MODEL | SMOOTH-MUSCLE | UROLOGY & NEPHROLOGY | CARDIAC FIBROSIS | AXIS | Impotence, Vasculogenic - drug therapy | Impotence, Vasculogenic - etiology | Reactive Oxygen Species - metabolism | Apolipoproteins E - deficiency | Receptors, G-Protein-Coupled - metabolism | Endothelium, Vascular - drug effects | Male | Phosphoproteins - metabolism | Penis - drug effects | Penile Erection - drug effects | Nitric Oxide Synthase Type III - metabolism | Penis - blood supply | Disease Models, Animal | Proto-Oncogene Proteins - metabolism | Nitric Oxide - blood | Administration, Oral | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Angiotensin I - administration & dosage | Endothelium, Vascular - physiopathology | Penis - physiopathology | Impotence, Vasculogenic - physiopathology | Mice, Knockout | Collagen - metabolism | Animals | Penis - metabolism | Endothelium, Vascular - metabolism | Apolipoproteins E - genetics | Cyclodextrins - administration & dosage | Nitric Oxide Synthase Type I - metabolism | Receptor, Angiotensin, Type 1 - metabolism | Impotence, Vasculogenic - metabolism | Hypercholesterolemia - complications | Hypercholesterolemia - physiopathology | Mice | Hypercholesterolemia - genetics | Oxidative Stress - drug effects | Vasodilation - drug effects | Hypercholesterolemia - metabolism | Vasodilator Agents - administration & dosage | Phosphates | Niacinamide | Impotence | Collagen | Nitric oxide | Angiotensin | Cyclodextrins
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e36027
Objective: Erectile dysfunction (ED) is considered as an early sign of vascular disease due to its high prevalence in patients with cardiovascular risk... 
CA2+ SENSITIZATION | SMOOTH-MUSCLE | NITRIC-OXIDE SYNTHASE | KINASE SIGNALING PATHWAY | BIOLOGY | ENDOTHELIUM-DEPENDENT RELAXATION | HUMAN CORPUS CAVERNOSUM | ALPHA-LIPOIC ACID | DIABETIC DB/DB MOUSE | ERECTILE DYSFUNCTION | VASCULAR-DISEASE | Electric Stimulation | Oxidative Stress | Calcium - metabolism | NADPH Oxidases - metabolism | Male | Metabolic Syndrome - metabolism | Biopterin - analogs & derivatives | Biopterin - metabolism | Acetophenones - pharmacology | Superoxides - metabolism | Penis - blood supply | Signal Transduction | NADPH Oxidases - antagonists & inhibitors | Insulin Resistance | Rats | Erectile Dysfunction - etiology | GTP Cyclohydrolase - metabolism | Metabolic Syndrome - complications | Obesity - metabolism | Obesity - pathology | Rats, Zucker | Animals | Endothelium, Vascular - metabolism | Arteries - physiopathology | Nitric Oxide Synthase - metabolism | Metabolic Syndrome - pathology | Vasodilation - drug effects | Nitric Oxide - metabolism | Arginine - metabolism | Oxidases | Obesity | Vasodilators | Blood vessels | Superoxide | Insulin | Risk factors | Arteries | Endothelium | Blood circulation disorders | Arginine | Dilatation | Nitric oxide | Insulin resistance | Comparative analysis | Oxidative stress | GTP | Calcium | Kinases | NAD(P)H oxidase | Vasodilation | Vascular diseases | Tetrahydrobiopterin | Rodents | Tyrosine | Calcium (intracellular) | Incubation | Diabetes mellitus | Health risks | Substrate inhibition | Erectile dysfunction | Risk analysis | Nitric-oxide synthase | Signaling | Penis | Cardiovascular diseases | Metabolic disorders | Veins & arteries
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2010, Volume 159, Issue 3, pp. 604 - 616
Background and purpose:  The aim of the current study was to investigate the role of arachidonic acid (AA) metabolism via cyclooxygenase (COX) in the... 
arachidonic acid | penile arteries | COX-1 | constitutive COX-2 | insulin resistance | endothelial dysfunction | obese Zucker rat | COX‐1 | constitutive COX‐2 | Constitutive COX-2 | Obese Zucker rat | Penile arteries | Endothelial dysfunction | Insulin resistance | Arachidonic acid | RABBIT CORPUS CAVERNOSUM | DEPENDENT RELAXATION | SMOOTH-MUSCLE TONE | NITRIC-OXIDE SYNTHASE | PROSTACYCLIN SYNTHASE | RESISTANCE ARTERIES | DIABETES-MELLITUS | INSULIN-RESISTANCE | VASOACTIVE PROSTANOIDS | PHARMACOLOGY & PHARMACY | ERECTILE DYSFUNCTION | Prediabetic State - metabolism | Norepinephrine - pharmacology | Arachidonic Acid - metabolism | Hyperemia - metabolism | Male | Acetylcholine - metabolism | Cyclooxygenase 1 - pharmacology | Arteries - metabolism | Vasoconstriction - physiology | Cyclooxygenase 2 - pharmacology | Arteries - physiology | Vasodilator Agents - metabolism | Vasodilation - physiology | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Insulin Resistance | Nitric Oxide Synthase Type III | Penis - physiopathology | Rats | Obesity - physiopathology | Vasoconstriction - drug effects | Obesity - metabolism | Rats, Zucker | Animals | Norepinephrine - metabolism | Penis - metabolism | Prediabetic State - physiopathology | Vasoconstrictor Agents - metabolism | Arteries - physiopathology | Hyperemia - physiopathology | Arachidonic Acid - pharmacology | Cyclooxygenase 2 - metabolism | Cyclooxygenase 1 - metabolism | Vasodilation - drug effects | Obesity | Metabolism | Rodents | Endothelium | Research Papers
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e108954
Male circumcision provides partial protection against multiple sexually transmitted infections (STIs), including HIV, but the mechanisms are not fully... 
SEXUALLY-TRANSMITTED INFECTIONS | TARGET-CELLS | MULTIDISCIPLINARY SCIENCES | TIGHT-JUNCTIONS | IN-VIVO | MALE CIRCUMCISION | OCCLUDIN | UNCIRCUMCISED MEN | SKIN | EXPRESSION | PSORIASIS | Foreskin - metabolism | HIV Infections | Epidermis - pathology | Epithelial Cells - metabolism | Cytokines - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Humans | Cells, Cultured | Circumcision, Male | Male | Foreskin - pathology | Occludin - metabolism | Receptors, CCR5 - metabolism | Claudin-1 - metabolism | Homosexuality, Male | Transgender Persons | Epidermis - physiology | Claudin-4 - metabolism | Adult | Female | Chemokine CCL5 - metabolism | Epithelial Cells - cytology | Chemokine CXCL10 - metabolism | CD4 Antigens - metabolism | Fibronectins | HIV (Viruses) | Health aspects | HIV infection | Risk factors | Circumcision | Sexually transmitted diseases--STD | RANTES | Dermis | Infections | Males | Fibronectin | Proteins | Keratin | Human immunodeficiency virus--HIV | Syphilis | IP-10 protein | Localization | Bioinformatics | Deposition | Pathogens | Medical research | CCR5 protein | Stratum corneum | Cytokines | Granulocyte-macrophage colony-stimulating factor | Health risks | Epidermis | Inflammation | Permeability | CD4 antigen | Studies | Infectious diseases | Neural networks | Skin | Females | Cancer | STD | Sexually transmitted diseases | HIV | Human immunodeficiency virus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 11/2016, Volume 359, Issue 2, pp. 230 - 237
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, p. e0172191
Erectile dysfunction (ED) is a common clinical disease that is difficult to treat. We previously found that hypoxia modulates the phenotype of primary corpus... 
VENOOCCLUSIVE DYSFUNCTION | FIBROSIS | PDGFR-BETA | CELL PHENOTYPE | MULTIDISCIPLINARY SCIENCES | DISEASE | PROLIFERATION | MODEL | ERECTILE DYSFUNCTION | MODULATION | MOLECULAR-MECHANISMS | Phosphorylation | Vimentin - metabolism | Actins - metabolism | Male | Cell Hypoxia | Dose-Response Relationship, Drug | RNA Interference | Erectile Dysfunction - drug therapy | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-sis - pharmacology | Myocytes, Smooth Muscle - metabolism | STAT3 Transcription Factor - metabolism | Collagen Type I - metabolism | Signal Transduction | Cells, Cultured | Rats | Becaplermin | Muscle, Smooth - metabolism | Rats, Sprague-Dawley | Phenotype | Animals | Penis - metabolism | Muscle Contraction - drug effects | Receptors, Platelet-Derived Growth Factor - metabolism | RNA, Small Interfering - metabolism | Smooth muscle | Genetic aspects | Platelet-derived growth factor | Research | Impotence | Vimentin | Transformation | Transcription | Disease | Pathogenesis | AKT protein | Kinases | Experiments | Urology | Proteins | Signal transduction | Chinese medicine | Pathways | Actin | Rodents | Atherosclerosis | Inhibition | Growth factors | Elongation | Threonine | Stat3 protein | Muscles | siRNA | Erectile dysfunction | Muscle contraction | Platelet-derived growth factor BB | Desmin | Signaling | Hospitals | Protein kinase | Penis | Morphology | Collagen | Hypoxia | Laboratory animals | Cancer
Journal Article