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Canadian Journal of Chemistry, ISSN 0008-4042, 2013, Volume 91, Issue 6, pp. 382 - 386
Two new lupane-type triterpenes, 24β-hydroxylupenone ( 1 ) and 3β-hydroxy-lup-20(29)-en-24-al ( 2 ), and two new ursane-type triterpenes,... 
Aquifoliaceae | triterpène | triterpene | Ilex cornuta | Aquifoliacée | Triterpene | GLYCOSIDES | ACID | URSANE | LEAVES | STEM BARK | PENTACYCLIC TRITERPENOIDS | TERPENOIDS | CHEMISTRY, MULTIDISCIPLINARY | CONSTITUENTS | Phytochemistry | Nuclear magnetic resonance spectroscopy | Chemical properties | Research | Terpenes | Identification and classification | Methods
Journal Article
Acta Pharmacologica Sinica, ISSN 1671-4083, 03/2018, Volume 39, Issue 3, pp. 492 - 498
Deubiquitinating protease USP7 is a promising therapeutic target for cancer treatment, and interest in developing USP7 inhibitors has greatly increased. In the... 
USP7 | Anticancer agent | RPMI8226 human myeloma cells | Ursolic acid | UHRF1 | Pentacyclic triterpenes | MULTIPLE-MYELOMA | APOPTOSIS | PREVENTION | STABILIZES | PROTEOLYSIS | CANCER | CHEMISTRY, MULTIDISCIPLINARY | anticancer agent | ursolic acid | SMALL-MOLECULE INHIBITOR | pentacyclic triterpenes | UBIQUITINATION | PHARMACOLOGY & PHARMACY | CCAAT-Enhancer-Binding Proteins - metabolism | Triterpenes - pharmacology | Humans | Ubiquitin-Specific Peptidase 7 - biosynthesis | Pentacyclic Triterpenes - pharmacology | Structure-Activity Relationship | Ubiquitin-Specific Peptidase 7 - antagonists & inhibitors | DNA (Cytosine-5-)-Methyltransferase 1 - metabolism | Neoplasms - drug therapy | Dose-Response Relationship, Drug | Triterpenes - antagonists & inhibitors | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Docking Simulation | Neoplasms - pathology | Proto-Oncogene Proteins c-mdm2 - metabolism | Cell proliferation | Ubiquitin | Triterpenes | MDM2 protein | Therapeutic applications | Proteinase | DNMT1 protein | Multiple myeloma | Proteinase inhibitors | Myeloma | Substrates | Molecular docking | Anticancer properties | Inhibitors | Acids | Protease inhibitors | Cell death | Protease | Antitumor activity | Carboxyl group | Inhibition | Hydroxyl groups | Cancer | Original
Journal Article
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, ISSN 1871-5206, 2018, Volume 18, Issue 10, pp. 1405 - 1416
Background: P. mucronata (Pm) comes from South America, Brazil and is characterized as "Maracuji de Restinga". It is used in folk medicine for its soothing... 
Passiflora mucronata | CHEMISTRY, MEDICINAL | phytosteroids | LEAVES | C-glycosilated-flavonoids | IDENTIFICATION | pentacyclic triterpenes | ONCOLOGY | CHEMICAL-COMPOSITION | GROWTH | INHIBITORS | MEDICINAL-PLANTS | cytotoxicity | Apoptosis
Journal Article
Free Radical Research, ISSN 1071-5762, 04/2014, Volume 48, Issue 4, pp. 402 - 411
Journal Article
Plant Physiology, ISSN 0032-0889, 2/2014, Volume 164, Issue 2, pp. 1028 - 1044
Sweet basil (Odmum basilicum) is well known for its diverse pharmacological properties and has been widely used in traditional medicine for the treatment of... 
Triterpenes | Yeasts | Leaves | Enzymes | Cellular metabolism | Metabolites | Complementary DNA | Basil | Biosynthesis | Plants | GENES, DEVELOPMENT, AND EVOLUTION | SECONDARY METABOLITES | URSOLIC ACID | AMYRIN SYNTHASE | CELL-SUSPENSION CULTURES | ARABIDOPSIS-THALIANA | OCIMUM-BASILICUM | PELTATE GLANDS | MOLECULAR-CLONING | MEDICINAL-PLANTS | OLEANOLIC ACID | PLANT SCIENCES | Transcription, Genetic - drug effects | Molecular Sequence Data | Saccharomyces cerevisiae - drug effects | Gene Expression Profiling | Plant Epidermis - genetics | Phylogeny | RNA, Messenger - metabolism | Saccharomyces cerevisiae - metabolism | Pentacyclic Triterpenes - biosynthesis | Biosynthetic Pathways - genetics | Time Factors | Cloning, Molecular | Ocimum basilicum - genetics | Plant Epidermis - cytology | Expressed Sequence Tags | Amino Acid Sequence | Intramolecular Transferases - genetics | Gene Library | Ocimum basilicum - drug effects | RNA, Messenger - genetics | Gene Expression Regulation, Developmental - drug effects | Cyclopentanes - pharmacology | Plant Epidermis - drug effects | Pentacyclic Triterpenes - chemistry | Intramolecular Transferases - metabolism | Sequence Homology, Amino Acid | Gene Expression Regulation, Plant - drug effects | Biosynthetic Pathways - drug effects | Oxylipins - pharmacology | Acetates - pharmacology | Botanical research | Physiological aspects | Genetic aspects | Genetic transcription | Terpenes | Plant metabolites
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 05/2017, Volume 17, Issue 14, pp. 1640 - 1645
Background: Mitigation of unwanted effects is a major issue to be addressed in drug discovery. The human genome shares a considerable degree of sequence... 
Glycogen phosphorylase inhibitors | Pentacyclic triterpenes | Glycogen phosphorylase | Cross reactivity | Comparative docking | TYPE-2 DIABETES THERAPY | SITE | ACTIVATION | CHEMISTRY, MEDICINAL | MECHANISM
Journal Article
Journal Article