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Steroids, ISSN 0039-128X, 02/2020, Volume 154, p. 108530
A series of 34 new amine- and guanidine-functionalized derivatives of betulinic, ursolic, and oleanolic acids were synthesized and tested for their... 
Antimicrobial activity | Ursolic acid | Amine- and guanidine derivatives | Pentacyclic triterpenoids | Betulinic acid | Oleanolic acid
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 11/2019, Volume 9, Issue 1, pp. 1 - 15
Journal Article
Talanta, ISSN 0039-9140, 12/2019, Volume 205, p. 120011
A fast and simple analytical method was developed to fully understand the chemical diversity of pentacyclic triterpenes: lupane, oleanane and ursane type,... 
UHPLC/ESI Q-Orbitrap | Neutral loss markers screening | Structural fragment markers | Pentacyclic triterpenes | Mechanism of fragmentation | CHEMISTRY, ANALYTICAL | INHIBITORY-ACTIVITY | TERPENOIDS | OLEANOLIC ACID | URSOLIC ACID | LIQUID-CHROMATOGRAPHY | SAPONINS | BOTANICALS | SEPARATION
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2019, p. 126824
Journal Article
Synthesis, ISSN 0039-7881, 11/2019, Volume 51, Issue 21, pp. 3964 - 3972
Abstract A chiral tricyclic terpene possessing a 6,6,6-tricyclic framework and a 3,3-dimethyl-7-oxooctylidenyl side chain undergoes a double ring-closing... 
paper | pentacyclic triterpenes | double ring-closing | 4-addition | chiral synthesis | CHEMISTRY, ORGANIC | TRITERPENES | DERIVATIVES | tandem Michael-aldol annulation | MYRICERIC ACID | ENDOTHELIN RECEPTOR ANTAGONIST
Journal Article
Plant Physiology and Biochemistry, ISSN 0981-9428, 11/2019, Volume 144, pp. 73 - 84
is a medicinal plant contains diverse bioactive compounds and terpenoids are the major components However, the isolation and purification of the active... 
Pentacyclic triterpene | Oxidosqualene cyclase | Cleome arabica | Lupeol | Heterologous expression | BETA-AMYRIN SYNTHASE | CDNA | TERPENE PRODUCTION | PLANT SCIENCES | ANTIOXIDANT | MOLECULAR-CLONING | ACCUMULATION | EXPRESSION | Oxidosqualene cyclese
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 10/2019, Volume 242, p. 112052
Vent was traditionally used in Sudan, Eretria and Ethiopia as anti-inflammatory in case of skin inflammation, catarrh, wounds, scorpion stings and snake bites.... 
Combretum aculeatum | Combretaceae | Anti-inflammatory | Phytochemical | CARRAGEENAN | CHEMISTRY, MEDICINAL | ACID | RAT | PAW | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | ANTIOXIDANT | EDEMA | PENTACYCLIC TRITERPENES | PHARMACOLOGY & PHARMACY | INFLAMMATORY RESPONSE | EXTRACT
Journal Article
Journal Article
MOLECULES, ISSN 1420-3049, 10/2019, Volume 24, Issue 19, p. 3535
Imatinib, an Abelson (ABL) tyrosine kinase inhibitor, is a lead molecular-targeted drug against chronic myelogenous leukemia (CML). To overcome its resistance... 
pentacyclic triterpenes | leukemia | gypsogenin | ABL kinase | NATURAL-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2ND | chronic myelogenous leukemia | apoptosis | INHIBITORS | CANCER | CHEMISTRY, MULTIDISCIPLINARY | abl kinase
Journal Article
Natural Product Research, ISSN 1478-6419, 09/2019, Volume 33, Issue 18, pp. 2681 - 2684
Euphorbia heterophylla L. is regarded as a major weed worldwide. Its high aggressiveness in agricultural environment prompted us to investigate the allelopatic... 
pentacyclic triterpenes | Allelopathy | phytotoxins | derivatization | fatty acids | wild poinsettia | CHEMISTRY, MEDICINAL | PHYTOTOXIC ACTIVITY | CHEMISTRY, APPLIED | Agricultural chemicals | Nuclear magnetic resonance--NMR | Germination | Roots | Sorghum | Esters | Organic acids | Plant extracts | Organic chemistry | Metabolites | Chemical activity | Methanol | Constitution
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2019, Volume 27, Issue 18, pp. 4048 - 4058
3- -β-chacotriosyl ursolic acid amide derivative 14 displayed strong anti-H5N1 (IC50 = 1.05 μM) and the selectivity index greater than 952. Currently, entry... 
Structure-activity relationships | 3-O-β-chacotriosyl pentacyclic triterpenoids | H5N1 entry inhibitors | CHEMISTRY, MEDICINAL | VIRUS-INFECTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | 3-O-beta chacotriosyl pentacyclic triterpenoids | INFLUENZA | CHEMISTRY, ORGANIC | DISCOVERY | PENTACYCLIC TRITERPENOIDS | AGENTS | DERIVATIVES | BINDING
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 09/2019, Volume 20, Issue 17, p. 4101
Journal Article
MOLECULES, ISSN 1420-3049, 08/2019, Volume 24, Issue 15, p. 2703
In addition to natural rubber (NR), several triterpenes are synthesized in laticifers of the Russian dandelion (Taraxacum koksaghyz). Detailed analysis of NR... 
pentacyclic triterpenes | RNA interference | SYNTHASE GENE | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | oxidosqualene cyclases | MEVALONATE PATHWAY | EXPRESSION | CHEMISTRY, MULTIDISCIPLINARY | polyisoprenes | Taraxacum koksaghyz
Journal Article