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1. Full Text Antimicrobial properties of amine- and guanidine-functionalized derivatives of betulinic, ursolic and oleanolic acids: Synthesis and structure/activity evaluation
by Spivak, Anna Yu and Khalitova, Rezeda R and Nedopekina, Darya A and Gubaidullin, Rinat R
Steroids, ISSN 0039-128X, 02/2020, Volume 154, p. 108530
A series of 34 new amine- and guanidine-functionalized derivatives of betulinic, ursolic, and oleanolic acids were synthesized and tested for their... 
Antimicrobial activity | Ursolic acid | Amine- and guanidine derivatives | Pentacyclic triterpenoids | Betulinic acid | Oleanolic acid
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2. Full Text Identification of key genes involved in the biosynthesis of triterpenic acids in the mint family
by Aminfar, Z and Rabiei, B and Tohidfar, M and Mirjalili, MH
SCIENTIFIC REPORTS, ISSN 2045-2322, 11/2019, Volume 9, Issue 1, pp. 1 - 15
Triterpenic acids (TAs), a large group of natural compounds with diverse biological activity, are produced by several plant taxa. Betulinic, oleanolic, and... 
NETWORK ANALYSIS | URSOLIC ACID | BETULINIC ACID | ENHANCED TRITERPENE | SQUALENE SYNTHASE | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | MEDICINALLY IMPORTANT TRITERPENOIDS | PENTACYCLIC TRITERPENOIDS | MOLECULAR-CLONING | OLEANOLIC ACID | Medicinal plants | Acids | Metabolites | Squalene epoxidase | Squalene | Metabolic engineering | Biosynthesis | Genetic engineering | Phylogeny | Gene expression | Biological activity
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3. Full Text Nuclear magnetic resonance assignment strategy for pentacyclic triterpenes, using lup-20(29)-ene from Pilotrichella flexilis as model system, combining spectrally filtered proton-to-carbon schemes and DFT–GIAO approach
by Herbert-Pucheta, Jose Enrique and MejĂ­a-Lara, Cinthia and Reyes-Trejo, Benito and Reyes, Lino and Zuleta-Prada, Holber
Applied Biological Chemistry, ISSN 2468-0834, 12/2019, Volume 62, Issue 1, pp. 1 - 12
The present work comprises a method to obtain full proton-to-carbon nuclear magnetic resonance chemical shift assignment of a C30H50 lup-20(29)-ene, for the... 
Lupene | Chemistry | Weak long-range heteronuclear through-bound HMBC | Homonuclear proton long-range through-space EXSY | Pureshift NMR | Applied Microbiology | Biological Techniques | NMR spectroscopy | Pentacyclic triterpenes | Bioorganic Chemistry | REVISION | CHEMICAL-SHIFTS | FOOD SCIENCE & TECHNOLOGY | COUPLING-CONSTANTS | LUPANE | NMR-SPECTRA | PHARMACOLOGICAL-ACTIVITIES
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4. Full Text High throughput identification of pentacyclic triterpenes in Hippophae rhamnoides using multiple neutral loss markers scanning combined with substructure recognition (MNLSR)
by Sun, Yan and Feng, Feng and Nie, Bo and Cao, Junling and Zhang, Feng
Talanta, ISSN 0039-9140, 12/2019, Volume 205, p. 120011
A fast and simple analytical method was developed to fully understand the chemical diversity of pentacyclic triterpenes: lupane, oleanane and ursane type,... 
UHPLC/ESI Q-Orbitrap | Neutral loss markers screening | Structural fragment markers | Pentacyclic triterpenes | Mechanism of fragmentation | CHEMISTRY, ANALYTICAL | INHIBITORY-ACTIVITY | TERPENOIDS | OLEANOLIC ACID | URSOLIC ACID | LIQUID-CHROMATOGRAPHY | SAPONINS | BOTANICALS | SEPARATION
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5. Full Text Synthesis, biological evaluation and SAR studies of ursolic acid 3β-ester derivatives as novel CETP inhibitors
by Chen, Chao and Sun, Renhua and Sun, Yan and Chen, Xuan and Li, Fei and Wen, Xiaoan and Yuan, Haoliang and Chen, Dongyin
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2019, p. 126824
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6. Full Text Effects of Eugenia umbelliflora O. Berg (Myrtaceae)-leaf extract on inflammation and hypersensitivity
by Goldoni, Fernanda Capitânio and Barretta, Claiza and Nunes, Roberta and Broering, Milena Fronza and De Faveri, Renata and Molleri, Heloisa Tachini and Corrêa, Thiago Patrício and Farias, Ingrid Vicente and Amorin, Clarissa Krieger and Pastor, Maria Veronica Davila and Meyre-Silva, Christiane and Bresolin, Tania Mari Belle and de Freitas, Rilton Alves and Quintão, Nara Lins Meira and Santin, José Roberto
Journal of Ethnopharmacology, ISSN 0378-8741, 11/2019, Volume 244, p. 112133
The leaves of species are widely used in popular medicine to treat several diseases, such as arthritis, rheumatism and diabetes. O. Berg is popularly known in... 
Eugenia astringens | Air-pouch | Flavonoids | Baguaçú | Herbal product | Inflammation | Carrageenan | FRUITS | CHEMISTRY, MEDICINAL | ASSAY | ACID | Baguaga | ANTIOXIDANT CAPACITY | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | PENTACYCLIC TRITERPENE | PHARMACOLOGY & PHARMACY | ANTIINFLAMMATORY ACTIVITIES | AMYRIN | DERIVATIVES
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7. Full Text A One-Pot Intramolecular Tandem Michael–Aldol Annulation Reaction for the Synthesis of Chiral Pentacyclic Terpenes
by Lu, Jianyu and Koldas, Serkan and Fan, Huafang and Desper, John and Day, Victor W and Hua, Duy H
Synthesis, ISSN 0039-7881, 11/2019, Volume 51, Issue 21, pp. 3964 - 3972
Abstract A chiral tricyclic terpene possessing a 6,6,6-tricyclic framework and a 3,3-dimethyl-7-oxooctylidenyl side chain undergoes a double ring-closing... 
paper | pentacyclic triterpenes | double ring-closing | 4-addition | chiral synthesis | CHEMISTRY, ORGANIC | TRITERPENES | DERIVATIVES | tandem Michael-aldol annulation | MYRICERIC ACID | ENDOTHELIN RECEPTOR ANTAGONIST
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8. Full Text Unravelling triterpene biosynthesis through functional characterization of an oxidosqualene cyclase (OSC) from Cleome arabica L
by Ladhari, Afef and Chappell, Joseph
Plant Physiology and Biochemistry, ISSN 0981-9428, 11/2019, Volume 144, pp. 73 - 84
is a medicinal plant contains diverse bioactive compounds and terpenoids are the major components However, the isolation and purification of the active... 
Pentacyclic triterpene | Oxidosqualene cyclase | Cleome arabica | Lupeol | Heterologous expression | BETA-AMYRIN SYNTHASE | CDNA | TERPENE PRODUCTION | PLANT SCIENCES | ANTIOXIDANT | MOLECULAR-CLONING | ACCUMULATION | EXPRESSION | Oxidosqualene cyclese
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9. Full Text Anti-inflammatory and phytochemical evaluation of Combretum aculeatum Vent growing in Sudan
by Hamad, Kamal M and Sabry, Manal M and Elgayed, Sabah H and El Shabrawy, Abdel-Rahman and El-Fishawy, Ahlam M and Abdel Jaleel, Gehad A
Journal of Ethnopharmacology, ISSN 0378-8741, 10/2019, Volume 242, p. 112052
Vent was traditionally used in Sudan, Eretria and Ethiopia as anti-inflammatory in case of skin inflammation, catarrh, wounds, scorpion stings and snake bites.... 
Combretum aculeatum | Combretaceae | Anti-inflammatory | Phytochemical | CARRAGEENAN | CHEMISTRY, MEDICINAL | ACID | RAT | PAW | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | ANTIOXIDANT | EDEMA | PENTACYCLIC TRITERPENES | PHARMACOLOGY & PHARMACY | INFLAMMATORY RESPONSE | EXTRACT
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10. Full Text Comparative Investigation of Frankincense Nutraceuticals: Correlation of Boswellic and Lupeolic Acid Contents with Cytokine Release Inhibition and Toxicity against Triple-Negative Breast Cancer Cells
by Schmiech and Lang and Ulrich and Werner and Rashan and Syrovets and Simmet
Nutrients, ISSN 2072-6643, 10/2019, Volume 11, Issue 10, p. 2341
For centuries, frankincense extracts have been commonly used in traditional medicine, and more recently, in complementary medicine. Therefore, frankincense... 
Cell proliferation | Toxicity | Medical services | Cytotoxicity | Arthritis | Biosynthesis | Metastasis | Drug development | Kinases | Inflammatory diseases | Interleukin 6 | Biomedical materials | Arachidonate 5-lipoxygenase | Tumor necrosis factor-TNF | Biocompatibility | Inhibition | Interleukin 8 | Nutraceuticals | Functional foods & nutraceuticals | Cytokines | Medical treatment | Dietary supplements | Health risks | Inflammation | Breast cancer | Tumor cell lines | Tumor necrosis factor-α | Gene expression | Anti-inflammatory agents | Chromatography | Asthma | Studies | Inflammatory bowel disease | Monocytes | Acids | Leukotrienes | Natural products | Rheumatoid arthritis | Collagen | Cell lines | Colitis | Lipoxygenase | Osteoarthritis | Prostate cancer | Prostate | Apoptosis | lupeolic acid | cytokine | triterpenoid | akba | boswellic acid | pentacyclic triterpenic acid | chorioallantoic membrane assay | boswellia | frankincense | breast cancer
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11. Full Text Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity
by Ciftci, HI and Radwan, MO and Ozturk, SE and Ulusoy, NG and Sozer, E and Ellakwa, DE and Ocak, Z and Can, M and Ali, TFS and Abd-Alla, HI and Yayli, N and Tateishi, H and Otsuka, M and Fujita, M
MOLECULES, ISSN 1420-3049, 10/2019, Volume 24, Issue 19, p. 3535
Imatinib, an Abelson (ABL) tyrosine kinase inhibitor, is a lead molecular-targeted drug against chronic myelogenous leukemia (CML). To overcome its resistance... 
pentacyclic triterpenes | leukemia | gypsogenin | ABL kinase | NATURAL-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2ND | chronic myelogenous leukemia | apoptosis | INHIBITORS | CANCER | CHEMISTRY, MULTIDISCIPLINARY | abl kinase
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12. Full Text Allelopathic activity and chemical constituents of extracts from roots of Euphorbia heterophylla L
by da Silva, Ueveton Pimentel and Furlani, Gabriela Milane and Demuner, Antônio Jacinto and da Silva, Otávio Luis Marques and Varejão, Eduardo Vinícius Vieira
Natural Product Research, ISSN 1478-6419, 09/2019, Volume 33, Issue 18, pp. 2681 - 2684
Euphorbia heterophylla L. is regarded as a major weed worldwide. Its high aggressiveness in agricultural environment prompted us to investigate the allelopatic... 
pentacyclic triterpenes | Allelopathy | phytotoxins | derivatization | fatty acids | wild poinsettia | CHEMISTRY, MEDICINAL | PHYTOTOXIC ACTIVITY | CHEMISTRY, APPLIED | Agricultural chemicals | Nuclear magnetic resonance--NMR | Germination | Roots | Sorghum | Esters | Organic acids | Plant extracts | Organic chemistry | Metabolites | Chemical activity | Methanol | Constitution
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13. Full Text Structure-aided optimization of 3-O-β-chacotriosyl ursolic acid as novel H5N1 entry inhibitors with high selective index
by Liao, Yixian and Chen, Lizhu and Li, Sumei and Li, Hui and Cui, Zi-ning and Lei, Zhiwei and Liu, Shuwen and Song, Gaopeng
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2019, Volume 27, Issue 18, pp. 4048 - 4058
3- -β-chacotriosyl ursolic acid amide derivative 14 displayed strong anti-H5N1 (IC50 = 1.05 μM) and the selectivity index greater than 952. Currently, entry... 
Structure-activity relationships | 3-O-β-chacotriosyl pentacyclic triterpenoids | H5N1 entry inhibitors | CHEMISTRY, MEDICINAL | VIRUS-INFECTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | 3-O-beta chacotriosyl pentacyclic triterpenoids | INFLUENZA | CHEMISTRY, ORGANIC | DISCOVERY | PENTACYCLIC TRITERPENOIDS | AGENTS | DERIVATIVES | BINDING
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14. Full Text Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1
by Song, Pei-Fang and Zhu, Ya-Di and Ma, Hong-Ying and Wang, Yi-Nan and Wang, Dan-Dan and Zou, Li-Wei and Ge, Guang-Bo and Yang, Ling
Fitoterapia, ISSN 0367-326X, 09/2019, Volume 137, p. 104199
Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes, is responsible for the hydrolysis of endogenous esters (such as cholesteryl... 
Human carboxylesterase 1 | Inhibitor | Pentacyclic triterpenoids | Betulinic acid | ACTIVATION | DESIGN | CHEMISTRY, MEDICINAL | TUMOR-TISSUE | SENSOR | LIQUID-CHROMATOGRAPHY | METABOLISM | LIVER | PROGRESS | PHARMACOLOGY & PHARMACY | DERIVATIVES | FLUORESCENT-PROBE | Triterpenoids | Amino acid sequence | Esters | Triglycerides | Selectivity | Adipocytes | Metabolism | Structure-activity relationships | Carboxylesterase | Substrates | Hydrolysis | Oseltamivir | Inhibitors | Luciferin | Docking | Clopidogrel | Carboxyl group | Inhibition
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15. Full Text α-Glucosidase and α-amylase inhibitory activities of medicinal plants in Thai antidiabetic recipes and bioactive compounds from Vitex glabrata R. Br. stem bark
by Thengyai, Suriyan and Thiantongin, Pitchanan and Sontimuang, Chonlatid and Ovatlarnporn, Chitchamai and Puttarak, Panupong
Journal of Herbal Medicine, ISSN 2210-8033, 09/2019, p. 100302
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16. Full Text An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases
by Roy, NK and Parama, D and Banik, K and Bordoloi, D and Devi, AK and Thakur, KK and Padmavathi, G and Shakibaei, M and Fan, L and Sethi, G and Kunnumakkara, AB
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 09/2019, Volume 20, Issue 17, p. 4101
Natural compounds, in recent years, have attracted significant attention for their use in the prevention and treatment of diverse chronic diseases as they are... 
chronic diseases | MUTANT TERT PROMOTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | STAT3 SIGNALING CASCADE | molecular targets | ACETYL-11-KETO-BETA-BOSWELLIC ACID | CHEMISTRY, MULTIDISCIPLINARY | PERFORMANCE LIQUID-CHROMATOGRAPHY | ISCHEMIA-REPERFUSION INJURY | bioavailability | boswellic acid | PENTACYCLIC TRITERPENIC ACIDS | pharmacokinetics | XENOGRAFT MOUSE MODEL | HUMAN HEPATOCELLULAR-CARCINOMA | ACETATE INDUCES DIFFERENTIATION | NF-KAPPA-B
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17. Full Text Oxidosqualene Cyclase Knock-Down in Latex of Taraxacum koksaghyz Reduces Triterpenes in Roots and Separated Natural Rubber
by van Deenen, N and Unland, K and Prufer, D and Gronover, CS
MOLECULES, ISSN 1420-3049, 08/2019, Volume 24, Issue 15, p. 2703
In addition to natural rubber (NR), several triterpenes are synthesized in laticifers of the Russian dandelion (Taraxacum koksaghyz). Detailed analysis of NR... 
pentacyclic triterpenes | RNA interference | SYNTHASE GENE | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | oxidosqualene cyclases | MEVALONATE PATHWAY | EXPRESSION | CHEMISTRY, MULTIDISCIPLINARY | polyisoprenes | Taraxacum koksaghyz
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18. Full Text Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity
by Ren, Yulin and Kinghorn, A. Douglas
Planta Medica, ISSN 0032-0943, 08/2019, Volume 85, Issue 11/12, pp. 802 - 814
Abstract Triterpenoids are distributed widely in higher plants and are of interest because of their structural diversity and broad range of bioactivities. In... 
Biological and Pharmacological Activity | HEPATOCELLULAR-CARCINOMA CELLS | CHEMISTRY, MEDICINAL | synthetic derivatives | triterpenoids | DEPENDENT APOPTOSIS | OLEANOLIC ACID | CUCURBITACIN D | PLANT SCIENCES | natural products | URSOLIC ACID | CYTOTOXIC CONSTITUENTS | structure-activity relationships | BETULINIC ACID | antitumor activity | INTEGRATIVE & COMPLEMENTARY MEDICINE | mechanisms of anticancer activity | BARDOXOLONE METHYL | PHARMACOLOGY & PHARMACY | PENTACYCLIC TRITERPENOIDS | GINSENOSIDE RH2
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19. Full Text Rapid simultaneous determination of pentacyclic triterpenoids by mixed-mode liquid chromatography–tandem mass spectrometry