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1. Full Text Presence of leishmania RNA virus 1 in leishmania guyanensis increases the risk of first-line treatment failure and symptomatic relapse
by Bourreau, Eliane and Ginouves, Marine and Prévot, Ghislaine and Hartley, Mary-Anne and Gangneux, Jean-Pierre and Robert-Gangneux, Florence and Dufour, Julie and Sainte-Marie, Dominique and Bertolotti, Antoine and Pratlong, Francine and Martin, Ricardo and Schütz, Frédéric and Couppié, Pierre and Fasel, Nicolas and Ronet, Catherine
The Journal of infectious diseases, ISSN 0022-1899, 01/2016, Volume 213, Issue 1, pp. 105 - 111
leishmaniasis; L. guyanensis; Leishmania RNA virus; drug treatment; pentamidine; mutualism exclusive | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Leishmaniasis, Mucocutaneous - epidemiology | Leishmaniavirus | Recurrence | Humans | Pentamidine - therapeutic use | Male | Leishmania guyanensis - drug effects | Antiprotozoal Agents - pharmacology | Leishmaniasis, Mucocutaneous - drug therapy | Leishmania guyanensis - virology | Treatment Failure | Leishmaniasis, Mucocutaneous - virology | Adult | Female | Antiprotozoal Agents - therapeutic use | Cohort Studies | Pentamidine - pharmacology | Treatment outcome | Care and treatment | Relapse | Leishmania | Analysis | Research | Leishmaniasis | Risk factors | Diseases | Index Medicus | Abridged Index Medicus | Antiprotozoal Agents/pharmacology | Leishmaniasis, Mucocutaneous/drug therapy | Leishmaniasis, Mucocutaneous/virology | Life Sciences | Leishmania guyanensis/drug effects | Leishmaniasis, Mucocutaneous/epidemiology | Leishmania guyanensis/virology | Antiprotozoal Agents/therapeutic use | Pentamidine/pharmacology | Pentamidine/therapeutic use
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2. Full Text inPentasomes: An innovative nose-to-brain pentamidine delivery blunts MPTP parkinsonism in mice
by Rinaldi, F and Seguella, L and Gigli, S and Hanieh, P.N and Del Favero, E and Cantù, L and Pesce, M and Sarnelli, G and Marianecci, C and Esposito, G and Carafa, M
Journal of controlled release, ISSN 0168-3659, 01/2019, Volume 294, pp. 17 - 26
S100B-pentamidine inhibition | Neuroinflammation | Pentamidine | Parkinson's disease | Nose-to-brain delivery | Chitosan coated niosomes | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Male | Brain - metabolism | Parkinsonian Disorders - metabolism | Pentamidine - pharmacokinetics | Parkinsonian Disorders - drug therapy | Antiparkinson Agents - chemistry | Anti-Inflammatory Agents - administration & dosage | Anti-Inflammatory Agents - pharmacokinetics | Nasal Mucosa - metabolism | Dopamine - metabolism | Mice, Inbred C57BL | Chitosan - administration & dosage | Pentamidine - administration & dosage | Administration, Intranasal | Antiparkinson Agents - pharmacokinetics | Brain - drug effects | Animals | Anti-Inflammatory Agents - chemistry | Chitosan - chemistry | Parkinsonian Disorders - pathology | Pentamidine - chemistry | Chitosan - pharmacokinetics | Brain - pathology | Drug Liberation | Antiparkinson Agents - administration & dosage | Liposomes | Index Medicus
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3. The Lomidine files
: the untold story of a medical disaster in colonial Africa
by Lachenal, Guillaume, 1978- author
2017, ISBN 9781421423234, 237 pages
Prevention | Chemotherapy | Side effects | Complications | Pentamidine | History | Medicine, Preventive | African trypanosomiasis | Medical ethics | France ColoniesHistory
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4. Full Text Systematic exploration of synergistic drug pairs
by Cokol, Murat and Chua, Hon Nian and Tasan, Murat and Mutlu, Beste and Weinstein, Zohar B and Suzuki, Yo and Nergiz, Mehmet E and Costanzo, Michael and Baryshnikova, Anastasia and Giaever, Guri and Nislow, Corey and Myers, Chad L and Andrews, Brenda J and Boone, Charles and Roth, Frederick P
Molecular systems biology, ISSN 1744-4292, 2011, Volume 7, Issue 1, pp. 544 - n/a
drug discovery | chemical genetics | genetic interactions | drug combinations | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Antifungal Agents - pharmacology | Drug Synergism | Pentamidine - pharmacokinetics | Saccharomyces cerevisiae - metabolism | Drug Interactions | Saccharomyces cerevisiae - genetics | Antifungal Agents - pharmacokinetics | Tacrolimus - pharmacology | Biological Availability | Saccharomyces cerevisiae - drug effects | Tacrolimus - pharmacokinetics | Pentamidine - pharmacology | Drugs | Organic chemistry | Fungicides | Tacrolimus | Genes | Relative abundance | Pentamidine | Bioavailability | Synergism | Index Medicus
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5. Full Text Oral pentamidine-loaded poly(d,l-lactic-co-glycolic) acid nanoparticles: an alternative approach for leishmaniasis treatment
by Valle, Isabela Viol and Machado, Monique Etnea and Araújo, Cristina da Costa Bernardes and da Cunha-Junior, Edézio Ferreira and da Silva Pacheco, Juliana and Torres-Santos, Eduardo Caio and da Silva, Luiz Cláudio Rodrigues Pereira and Cabral, Lucio Mendes and do Carmo, Flávia Almada and Sathler, Plínio Cunha
Nanotechnology, ISSN 0957-4484, 08/2019, Volume 30, Issue 45, pp. 455102 - 455102
nanoparticles | oral administration | leishmaniasis | pentamidine | poly(dl-lactic-co-glycolic) acid | Physical Sciences | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology - Other Topics | Physics | Science & Technology | Physics, Applied | Nanoparticles - chemistry | Administration, Oral | Parasite Load | Polylactic Acid-Polyglycolic Acid Copolymer - chemistry | Biological Availability | Leishmaniasis - drug therapy | Antiprotozoal Agents - chemistry | Pentamidine - administration & dosage | Particle Size | Pentamidine - pharmacokinetics | Antiprotozoal Agents - pharmacokinetics | Organ Size - drug effects | Animals | Pentamidine - chemistry | Antiprotozoal Agents - administration & dosage | Leishmaniasis - parasitology | Mice | Mice, Inbred BALB C | Disease Models, Animal | Index Medicus
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6. Full Text Prophylaxie pour la pneumonie a Pneumocystis jirovecii chez une femme de 42 ans suivant un traitement immunosuppresseur.(PRATIQUE: DECISIONS)
by Andany, Nisha and Halani, Sheliza and Shah, Rupal
Canadian Medical Association journal (CMAJ), ISSN 0820-3946, 01/2021, Volume 193, Issue 1, p. E34
Pneumonia | Corticosteroids | Bacterial pneumonia | Pentamidine isethionate | Prednisone
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7. Full Text The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models
by Ji, Yuan and Varkevisser, Rosanne and Opacic, gan and Bossu, Alexane and Kuiper, Marion and Beekman, Jet D. M and Yang, Sihyung and Khan, Azinwi Phina and Dobrev, Dobromir and Voigt, Niels and Wang, Michael Zhuo and Verheule, Sander and Vos, Marc A and van der Heyden, Marcel A. G
British journal of pharmacology, ISSN 0007-1188, 08/2017, Volume 174, Issue 15, pp. 2576 - 2590
TORSADES-DE-POINTES | CURRENT I-K1 | CARDIAC REPOLARIZATION | HUMAN AFRICAN TRYPANOSOMIASIS | POTASSIUM CURRENT | ATRIOVENTRICULAR-BLOCK | IONIC MECHANISMS | III DRUGS | TRANSMURAL CONDUCTION | UP-REGULATION | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Atrial Fibrillation - chemically induced | Administration, Intravenous | Animals | Humans | Dogs | Female | Pentamidine - administration & dosage | Pentamidine - analogs & derivatives | Goals | Disease Models, Animal | Pentamidine - pharmacology | Muscles | Heart beat | Goats | Analysis | Atrial fibrillation | Cardiac arrhythmia | Animal models | Cardiomyocytes | Pentamidine | Skeletal muscle | Heart rate | Infusion | Fibrillation | Inhibitors | Sinus | Bioaccumulation | Rectifiers | Refractory period | Electrocardiography | Plasma levels | Ventricle | Heart diseases | Prolongation | Index Medicus | Research Papers | Research Paper
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8. Full Text Antiparasitic compounds that target DNA
by Wilson, W. David and Tanious, Farial A and Mathis, Amanda and Tevis, Denise and Hall, James Edwin and Boykin, David W
Biochimie, ISSN 0300-9084, 2008, Volume 90, Issue 7, pp. 999 - 1014
Antiparasitic drugs | Kinetoplast DNA | DNA topology | Heterocyclic diamidines | DNA binding | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | Models, Molecular | Pentamidine - analogs & derivatives | Nucleic Acid Conformation - drug effects | Drug Delivery Systems | Animals | Heterocyclic Compounds - chemistry | Pentamidine - chemistry | DNA, Protozoan - drug effects | Antiparasitic Agents - pharmacology | Eukaryota - drug effects | DNA, Protozoan - chemistry | Antiparasitic Agents - chemistry | Pentamidine - pharmacology | Index Medicus
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9. Drug resistance in human African trypanosomiasis
by Barrett, Michael P and Vincent, Isabel M and Burchmore, Richard Js and Kazibwe, Anne Jn and Matovu, Enock
Future microbiology, ISSN 1746-0913, 09/2011, Volume 6, Issue 9, pp. 1037 - 1047
nitroreductase | eflornithine transporter | HAPT1 | P2 transporter | treatment failure | human African trypanosomiasis | drug resistance | sleeping sickness | Life Sciences & Biomedicine | Microbiology | Science & Technology | Trypanosomiasis, African - drug therapy | Humans | Pentamidine - therapeutic use | Eflornithine - pharmacokinetics | Eflornithine - pharmacology | Eflornithine - therapeutic use | Trypanocidal Agents - pharmacokinetics | Drug Resistance - genetics | Nifurtimox - pharmacology | Animals | Protozoan Proteins - metabolism | Nifurtimox - pharmacokinetics | Trypanocidal Agents - pharmacology | Trypanosoma - drug effects | Trypanosoma - metabolism | Treatment Failure | Membrane Transport Proteins - metabolism | Trypanocidal Agents - therapeutic use | Pentamidine - metabolism | Nifurtimox - therapeutic use | Trypanosoma - physiology | Pentamidine - pharmacology | International cooperation | nifurtimox | Central nervous system | Plasma membranes | Amino acids | Pentamidine | Parasites | Drug resistance | African trypanosomiasis | Eflornithine
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10. Full Text Pentamidine analogs as inhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptors
by Berger, Michael L and Maciejewska, Dorota and Vanden Eynde, Jean Jacques and Mottamal, Madhusoodanan and Żabiński, Jerzy and Kaźmierczak, Paweł and Rezler, Mateusz and Jarak, Ivana and Piantanida, Ivo and Karminski-Zamola, Grace and Mayence, Annie and Rebernik, Patrick and Kumar, Arvind and Ismail, Mohamed A and Boykin, David W and Huang, Tien L
Bioorganic & medicinal chemistry, ISSN 0968-0896, 08/2015, Volume 23, Issue 15, pp. 4489 - 4500
Ifenprodil | Polyamine | Radioligand binding | Bisbenzamidine | Pentamidine | Coupling | NMDA receptor | Alkylation | Rat brain | Molecular docking | Protein Structure, Tertiary | Piperidines - chemistry | Piperidines - metabolism | Dizocilpine Maleate - chemistry | Receptors, N-Methyl-D-Aspartate - metabolism | Pentamidine - chemical synthesis | Rats | Piperazines - metabolism | Pentamidine - analogs & derivatives | Piperazines - chemistry | Tritium - chemistry | Dizocilpine Maleate - metabolism | Brain - metabolism | Animals | Receptors, N-Methyl-D-Aspartate - chemistry | Molecular Docking Simulation | Pentamidine - metabolism | Binding Sites | Brain | Index Medicus
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11. Full Text Structure‐activity relationships of pentamidine‐affected ion channel trafficking and dofetilide mediated rescue
by Varkevisser, R and Houtman, M J C and Linder, T and Git, K C G and Beekman, H D M and Tidwell, R R and IJzerman, A P and Stary‐Weinzinger, A and Vos, M A and Heyden, M A G
British journal of pharmacology, ISSN 0007-1188, 07/2013, Volume 169, Issue 6, pp. 1322 - 1334
hERG | pentamidine | chemical substructures | drug‐induced trafficking defects | KIR2.1 | Long QT syndrome | ion channel trafficking | safety pharmacology | dofetilide | drug-induced trafficking defects | 2.1 | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Membrane Transport Modulators - chemistry | Arrhythmias, Cardiac - chemically induced | Anti-Arrhythmia Agents - pharmacology | Humans | Ether-A-Go-Go Potassium Channels - metabolism | Structure-Activity Relationship | ERG1 Potassium Channel | Membrane Transport Modulators - pharmacology | HEK293 Cells | Cell Membrane - drug effects | Potassium Channel Blockers - pharmacology | Pentamidine - pharmacology | Arrhythmias, Cardiac - metabolism | Recombinant Proteins - metabolism | Shab Potassium Channels - genetics | Ether-A-Go-Go Potassium Channels - chemistry | Phenethylamines - pharmacology | Sulfonamides - chemistry | Shab Potassium Channels - chemistry | Endocytosis - drug effects | Phenethylamines - chemistry | Recombinant Proteins - chemistry | Antiprotozoal Agents - chemistry | Pentamidine - analogs & derivatives | Anti-Arrhythmia Agents - chemistry | Ether-A-Go-Go Potassium Channels - genetics | Sulfonamides - pharmacology | Antiprotozoal Agents - pharmacology | Molecular Dynamics Simulation | Shab Potassium Channels - metabolism | Animals | Antiprotozoal Agents - adverse effects | Pentamidine - chemistry | Pentamidine - adverse effects | Dogs | Mice | Kinetics | Membrane Transport Modulators - adverse effects | Potassium Channel Blockers - chemistry | Heterocyclic compounds | Analysis | Index Medicus | Research Papers
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