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1. Full Text Causes of Mortality in Patients With Peptic Ulcer Bleeding: A Prospective Cohort Study of 10,428 Cases
by Sung, Joseph J. Y and Tsoi, Kelvin K. F and Ma, Terry K. W and Yung, Man-Yee and Lau, James Y. W and Chiu, Philip W. Y
The American Journal of Gastroenterology, ISSN 0002-9270, 01/2010, Volume 105, Issue 1, pp. 84 - 89
OBJECTIVES: Despite advances in endoscopic and pharmacological treatment for peptic ulcer bleeding (PUB), mortality remains at 5-10% worldwide. Our aim was to... 
TRIAL | POPULATION-BASED COHORT | GASTROENTEROLOGY & HEPATOLOGY | HEMORRHAGE | ENDOSCOPIC TREATMENT | Prospective Studies | Comorbidity | Humans | Middle Aged | Risk Factors | Logistic Models | Male | Gastroscopy | Chi-Square Distribution | Cause of Death | Peptic Ulcer Hemorrhage - mortality | Hong Kong - epidemiology | Sex Factors | Female | Aged
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2. Full Text Weekend Versus Weekday Admission and Mortality From Gastrointestinal Hemorrhage Caused by Peptic Ulcer Disease
by Shaheen, Abdel Aziz M and Kaplan, Gilaad G and Myers, Robert P
Clinical Gastroenterology and Hepatology, ISSN 1542-3565, 2009, Volume 7, Issue 3, pp. 303 - 310
Background & Aims Management of upper gastrointestinal bleeding (UGIB) often requires urgent endoscopic intervention; limitations in its availability on... 
Gastroenterology and Hepatology | DISCHARGE | ENDOSCOPY | HOSPITALIZED-PATIENTS | COST | CIRRHOSIS | PATIENT | TIME | OUTCOMES | GASTROENTEROLOGY & HEPATOLOGY | CARE | EPIDEMIOLOGY | Peptic Ulcer - complications | Hospital Mortality | United States | Humans | Middle Aged | Male | Treatment Outcome | Hospitalization | Health Services Research | Peptic Ulcer Hemorrhage - therapy | Peptic Ulcer Hemorrhage - mortality | Time Factors | Hospital Charges - statistics & numerical data | Female | Patient Care - statistics & numerical data | Aged | Endoscopy | Length of Stay - statistics & numerical data | Peptic ulcer | Cytogenetics | Gastrointestinal bleeding | Health aspects | Mortality | Medical care, Cost of
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3. Full Text Challenges in the management of acute peptic ulcer bleeding
by Lau, James YW, Prof and Barkun, Alan, Prof and Fan, Dai-ming, Prof and Kuipers, Ernst J, Prof and Yang, Yun-sheng, Prof and Chan, Francis KL, Prof
Lancet, The, ISSN 0140-6736, 2013, Volume 381, Issue 9882, pp. 2033 - 2043
Summary Acute upper gastrointestinal bleeding is a common medical emergency worldwide, a major cause of which are bleeding peptic ulcers. Endoscopic treatment... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | TRANSCATHETER ARTERIAL EMBOLIZATION | EXPERT CONSENSUS DOCUMENT | TIME-TRENDS | UPPER-GASTROINTESTINAL HEMORRHAGE | RANDOMIZED-CONTROLLED-TRIALS | HELICOBACTER-PYLORI ERADICATION | ENDOSCOPIC TREATMENT | HIGH-RISK | PROTON PUMP INHIBITORS | NSAID USE | Decision Making | Antifibrinolytic Agents - therapeutic use | Risk Assessment - methods | Acute Disease | Resuscitation - methods | Humans | Treatment Outcome | Secondary Prevention | Fibrinolytic Agents | Proton Pump Inhibitors - therapeutic use | Resuscitation - statistics & numerical data | Contraindications | Peptic Ulcer Hemorrhage - mortality | Gastrointestinal Agents - therapeutic use | Peptic Ulcer Hemorrhage - prevention & control | Endoscopy, Gastrointestinal - statistics & numerical data | Blood Component Transfusion - statistics & numerical data | Peptic Ulcer Hemorrhage - diagnosis | Blood Coagulation Disorders - complications | Peptic ulcer | Endoscopic surgery | Care and treatment | Endoscopy | Diagnosis | Health aspects | Anticoagulants | Aspirin | Ulcers | Mortality
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4. Full Text Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects
by Higham, J and Kang, J-Y and Majeed, A
Gut, ISSN 0017-5749, 04/2002, Volume 50, Issue 4, pp. 460 - 464
Background: Although overall admission rates for peptic ulcer in England declined from the 1950s up until the mid 1980s, perforations among older women... 
HOSPITAL ADMISSIONS | UNITED-KINGDOM | DUODENAL-ULCER | SCOTLAND | DISEASE | COHORT | GASTROENTEROLOGY & HEPATOLOGY | CHANGING PATTERN | Age Distribution | Duodenal Ulcer - surgery | Proton Pump Inhibitors | Humans | Middle Aged | Peptic Ulcer Hemorrhage - surgery | Hospitalization - statistics & numerical data | Peptic Ulcer Perforation - surgery | Male | Survival Rate | Stomach Ulcer - surgery | Histamine H2 Antagonists - therapeutic use | Peptic Ulcer Perforation - mortality | Drug Prescriptions - statistics & numerical data | Peptic Ulcer Hemorrhage - mortality | Vagotomy - statistics & numerical data | England - epidemiology | Hospitalization - trends | Duodenal Ulcer - mortality | Sex Distribution | Adult | Female | Aged | Stomach Ulcer - mortality | Peptic ulcer | Demographic aspects | Analysis | Hospital utilization | Prevalence studies (Epidemiology) | Length of stay | Prescription drugs | Patient admissions | Womens health | Ulcers | Mortality | aspirin | peptic ulcer haemorrhage | gastric ulcer | Peptic Ulcer | peptic ulcer perforation | duodenal ulcer
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5. Full Text Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes
by Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan
世界胃肠病学杂志：英文版（电子版）, ISSN 1007-9327, 2014, Volume 20, Issue 46, pp. 17568 - 17577
AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer... 
ulcer | Digestive | Peptic | sys | Epidemiology | hemorrhage | Peptic ulcer hemorrhage | Mortality | Endoscopy | Digestive system surgical procedures | Incidence | Validation studies | SURGERY | SWEDEN | MANAGEMENT | HEMORRHAGE | CARE | TIME-TREND ANALYSIS | HOSPITALIZATION | NATIONWIDE | GASTROENTEROLOGY & HEPATOLOGY | CLINICAL-OUTCOMES | Recurrence | Prospective Studies | Patient Readmission | Humans | Middle Aged | Duodenal Ulcer - diagnosis | Male | Alberta - epidemiology | Stomach Ulcer - surgery | Time Factors | Duodenal Ulcer - epidemiology | Duodenal Ulcer - mortality | Adult | Female | Odds Ratio | Stomach Ulcer - mortality | Databases, Factual | Stomach Ulcer - diagnosis | International Classification of Diseases | Duodenal Ulcer - surgery | Hospital Mortality | Risk Factors | Peptic Ulcer Hemorrhage - surgery | Logistic Models | Treatment Outcome | Urban Health | Rural Health | Peptic Ulcer Hemorrhage - mortality | Hemostatic Techniques | Stomach Ulcer - epidemiology | Peptic Ulcer Hemorrhage - epidemiology | Aged | Peptic Ulcer Hemorrhage - diagnosis | Prospective Study
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6. Full Text Effect of comorbidity on mortality in patients with peptic ulcer bleeding: Systematic review and meta-analysis
by Leontiadis, Grigorios I and Molloy-Bland, Michael and Moayyedi, Paul and Howden, Colin W
American Journal of Gastroenterology, ISSN 0002-9270, 03/2013, Volume 108, Issue 3, pp. 331 - 345
OBJECTIVES: By systematic review and meta-analysis, we sought to assess the impact of comorbidity on short-term mortality in patients with peptic ulcer... 
DIAGNOSTIC-TEST ACCURACY | RISK-FACTORS | MANAGEMENT | UPPER-GASTROINTESTINAL HEMORRHAGE | PROGNOSTIC-FACTORS | ENDOSCOPIC TREATMENT | DISEASE | POPULATION-BASED COHORT | GASTROENTEROLOGY & HEPATOLOGY | ELDERLY-PATIENTS | EPIDEMIOLOGY | Predictive Value of Tests | Peptic Ulcer Hemorrhage - mortality | Hospital Mortality | Comorbidity | Humans | Sensitivity and Specificity | Peptic Ulcer Hemorrhage - epidemiology
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7. Full Text Duodenal ulcers are a major cause of gastrointestinal bleeding after cardiac surgery
by Krawiec, Frances, MHSc and Maitland, Andrew, MB and Duan, Qiuli, MSc and Faris, Peter, PhD and Belletrutti, Paul J., MD and Kent, William D.T., MD, MSc
Journal of Thoracic and Cardiovascular Surgery, The, ISSN 0022-5223, 2017, Volume 154, Issue 1, pp. 181 - 188
Abstract Objective To determine the incidence of gastrointestinal (GI) bleeding in patients after cardiac surgery, assess the perioperative risk factors, and... 
Cardiothoracic Surgery | gastrointestinal hemorrhage | cardiac surgery | peptic ulcer disease | SURGERY | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | CARDIOPULMONARY-BYPASS | PREVALENCE | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | HELICOBACTER-PYLORI INFECTION | RESPIRATORY SYSTEM | PREDICTORS | DISEASE | COMPLICATIONS | Humans | Middle Aged | Postoperative Hemorrhage - diagnosis | Duodenal Ulcer - diagnosis | Male | Cardiac Surgical Procedures - adverse effects | Cardiac Surgical Procedures - mortality | Alberta - epidemiology | Gastrointestinal Hemorrhage - mortality | Gastrointestinal Hemorrhage - epidemiology | Incidence | Time Factors | Duodenal Ulcer - epidemiology | Aged, 80 and over | Duodenal Ulcer - mortality | Female | Retrospective Studies | Databases, Factual | Postoperative Hemorrhage - mortality | Risk Assessment | Postoperative Hemorrhage - epidemiology | Risk Factors | Treatment Outcome | Gastrointestinal Hemorrhage - diagnosis | Peptic Ulcer Hemorrhage - mortality | Peptic Ulcer Hemorrhage - epidemiology | Aged | Peptic Ulcer Hemorrhage - diagnosis | Medicine, Experimental | Medical research | Health aspects | Gastrointestinal system | Cardiac patients | Peptic ulcer | Anticoagulants (Medicine) | Risk factors | Chronic kidney failure | Coronary artery bypass | Gastrointestinal bleeding | Analysis | Helicobacter infections | Endoscopy
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8. Full Text Improving quality of care in peptic ulcer bleeding: Nationwide cohort study of 13,498 consecutive patients in the Danish clinical register of emergency surgery
by Rosenstock, Steffen J and Møller, Morten H and Larsson, Heidi and Johnsen, Søren P and Madsen, Anders H and Bendix, Jørgen and Adamsen, Sven and Jensen, Anders G and Zimmermann-Nielsen, Erik and Nielsen, Ann-Sophie and Kallehave, Finn and Oxholm, Dorthe and Skarbye, Mona and Jølving, Line R and Jørgensen, Henrik S and De Muckadell, Ove B. Schaffalitzky and Thomsen, Reimar W
American Journal of Gastroenterology, ISSN 0002-9270, 09/2013, Volume 108, Issue 9, pp. 1449 - 1457
OBJECTIVES: The treatment of peptic ulcer bleeding (PUB) is complex, and mortality remains high. We present results from a nationwide initiative to monitor and... 
UNITED-STATES | MORTALITY | UPPER GASTROINTESTINAL HEMORRHAGE | RISK-FACTORS | MANAGEMENT | HOSPITAL ADMISSION | DISEASE | POPULATION-BASED COHORT | GASTROENTEROLOGY & HEPATOLOGY | EPIDEMIOLOGY | TIME-TREND ANALYSIS | Duodenal Ulcer - surgery | Prognosis | Prospective Studies | Humans | Middle Aged | Endoscopy, Gastrointestinal | Duodenal Ulcer - diagnosis | Male | Risk | Treatment Outcome | Stomach Ulcer - surgery | Peptic Ulcer Hemorrhage - therapy | Peptic Ulcer Hemorrhage - mortality | Quality Improvement | Aged, 80 and over | Denmark | Duodenal Ulcer - mortality | Female | Aged | Peptic Ulcer Hemorrhage - diagnosis | Stomach Ulcer - mortality | Health Care Surveys | Quality of Health Care | Stomach Ulcer - diagnosis
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9. Full Text Independent risk factors of 30‐day outcomes in 1264 patients with peptic ulcer bleeding in the USA: large ulcers do worse
by Camus, M and Jensen, D. M and Kovacs, T. O and Jensen, M. E and Markovic, D and Gornbein, J
Alimentary Pharmacology & Therapeutics, ISSN 0269-2813, 05/2016, Volume 43, Issue 10, pp. 1080 - 1089
Summary Background Predictors of worse outcomes (rebleeding, surgery and death) of peptic ulcer bleeds (PUBs) are essential indicators because of significant... 
RECURRENT HEMORRHAGE | MORTALITY | METAANALYSIS | MANAGEMENT | EPINEPHRINE INJECTION | ENDOSCOPIC INJECTION THERAPY | PREDICTORS | PROTON PUMP INHIBITORS | PHARMACOLOGY & PHARMACY | GASTROENTEROLOGY & HEPATOLOGY | HEMOSTASIS | FAILURE | United States - epidemiology | Prospective Studies | Humans | Middle Aged | Risk Factors | Male | Proton Pump Inhibitors - therapeutic use | Histamine H2 Antagonists - therapeutic use | Peptic Ulcer Hemorrhage - therapy | Histamine H2 Antagonists - administration & dosage | Peptic Ulcer Hemorrhage - mortality | Proton Pump Inhibitors - administration & dosage | Hemostasis, Endoscopic - methods | Adult | Female | Aged | Histamine | Surgical clinics | Patient outcomes | Mortality | Peptic ulcer | Proton pump inhibitors | Risk factors | ulcer size | bleeding | stigmata of recent hemorrhage | peptic ulcer | outcomes
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10. Full Text Clinical characteristics of peptic ulcer perforation in Korea
by Yang, Young Joo and Bang, Chang Seok and Shin, Suk Pyo and Park, Tae Young and Suk, Ki Tae and Baik, Gwang Ho and Kim, Dong Joon
World Journal of Gastroenterology, ISSN 1007-9327, 04/2017, Volume 23, Issue 14, pp. 2566 - 2574
To elucidate the epidemiological characteristics and associated risk factors of perforated peptic ulcer (PPU). We retrospectively reviewed medical records of... 
Stomach ulcer | Duodenal ulcer | Peptic ulcer perforation | Helicobacter pylori | Non-steroidal anti-inflammatory drugs | Multivariate Analysis | Age Factors | Humans | Middle Aged | Duodenal Ulcer - diagnosis | Male | Stomach Ulcer - surgery | Peptic Ulcer Perforation - diagnosis | Peptic Ulcer Perforation - epidemiology | Time Factors | Duodenal Ulcer - epidemiology | Duodenal Ulcer - mortality | Adult | Female | Retrospective Studies | Odds Ratio | Republic of Korea - epidemiology | Stomach Ulcer - mortality | Stomach Ulcer - diagnosis | Duodenal Ulcer - surgery | Comorbidity | Risk Factors | Helicobacter Infections - epidemiology | Hospitals, University | Peptic Ulcer Hemorrhage - surgery | Peptic Ulcer Perforation - surgery | Logistic Models | Treatment Outcome | Postoperative Complications - epidemiology | Alcohol Drinking - adverse effects | Peptic Ulcer Perforation - mortality | Peptic Ulcer Hemorrhage - mortality | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Alcohol Drinking - epidemiology | Stomach Ulcer - epidemiology | Peptic Ulcer Hemorrhage - epidemiology | Aged | Helicobacter pylori - isolation & purification | Peptic Ulcer Hemorrhage - diagnosis | Helicobacter Infections - microbiology | Retrospective Study
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11. Full Text The use of selective serotonin receptor inhibitors (SSRIs) is not associated with increased risk of endoscopy‐refractory bleeding, rebleeding or mortality in peptic ulcer bleeding
by Laursen, S. B and Leontiadis, G. I and Stanley, A. J and Hallas, J and Schaffalitzky de Muckadell, O. B
Alimentary Pharmacology & Therapeutics, ISSN 0269-2813, 08/2017, Volume 46, Issue 3, pp. 355 - 363
Summary Background Observational studies have consistently shown an increased risk of upper gastrointestinal bleeding in users of selective serotonin receptor... 
ANTIDEPRESSANTS | EVENTS | DEPRESSED-PATIENTS | PLATELET-FUNCTION | REUPTAKE INHIBITORS | PAROXETINE | PHARMACOLOGY & PHARMACY | GASTROENTEROLOGY & HEPATOLOGY | Humans | Middle Aged | Risk Factors | Endoscopy - methods | Serotonin Uptake Inhibitors - adverse effects | Male | Risk | Hospitalization | Peptic Ulcer Hemorrhage - mortality | Serotonin Uptake Inhibitors - administration & dosage | Hemostasis, Endoscopic - methods | Aged, 80 and over | Denmark | Peptic Ulcer Hemorrhage - epidemiology | Female | Aged | Odds Ratio | Cohort Studies | Serotonin | Mortality | Peptic ulcer | Phenols | Serotonin uptake inhibitors | Endoscopy | Health aspects | Sensitivity analysis | Platelet aggregation | Agglomeration | Regression analysis | Hemorrhage | Patients | Bleeding | Confidence intervals | Sensitivity | Inhibitors | Endoscopes | Ulcers | Health risk assessment
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12. Full Text Stress ulcer prophylaxis with a proton pump inhibitor versus placebo in critically ill patients (SUP-ICU trial): study protocol for a randomised controlled trial
by Krag, Mette and Perner, Anders and Wetterslev, Jorn and Wise, Matt P and Borthwick, Mark and Bendel, Stepani and Pelosi, Paolo and Keus, Frederik and Guttormsen, Anne Berit and Schefold, Joerg C and Moller, Morten Hylander and SUP-ICU Investigators and SUP-ICU investigators and the SUP-ICU investigators
TRIALS, ISSN 1745-6215, 04/2016, Volume 17, Issue 1, p. 205
Background: Critically ill patients in the intensive care unit (ICU) are at risk of clinically important gastrointestinal bleeding, and acid suppressants are... 
Critically ill | Gastrointestinal bleeding | Randomised clinical trial | Stress ulcer prophylaxis | Placebo | Adverse event | Intensive care unit | MEDICINE, RESEARCH & EXPERIMENTAL | RECEPTOR ANTAGONISTS | HYDROXYETHYL STARCH | PREVENTION | RISK | GASTRIC-ACID SUPPRESSION | GASTROINTESTINAL HEMORRHAGE | INTENSIVE-CARE-UNIT | INFECTION | COMPLICATIONS | SEVERE SEPSIS | Drug Costs | Hospital Costs | Proton Pump Inhibitors - economics | Anti-Ulcer Agents - economics | Cross Infection - etiology | Humans | Clinical Protocols | Critical Illness | Peptic Ulcer - prevention & control | Peptic Ulcer Hemorrhage - etiology | Peptic Ulcer - economics | Proton Pump Inhibitors - administration & dosage | Time Factors | Peptic Ulcer Hemorrhage - prevention & control | Peptic Ulcer - mortality | Proton Pump Inhibitors - adverse effects | Pneumonia - etiology | Drug Administration Schedule | Europe | Risk Factors | Anti-Ulcer Agents - adverse effects | Treatment Outcome | Anti-Ulcer Agents - administration & dosage | Enterocolitis, Pseudomembranous - etiology | Peptic Ulcer Hemorrhage - mortality | Myocardial Ischemia - etiology | Cost-Benefit Analysis | Peptic Ulcer Hemorrhage - economics | Research Design | Peptic Ulcer - etiology | Placebos | Proton pump inhibitors | Usage | Comparative analysis | Health aspects
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13. Full Text Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcers
by Lau, James Y.W and Sung, Joseph J.Y and Lee, Kenneth K.C and Lee, C.W and Yung, Man-yee and Wong, Simon K.H and Wu, Justin C.Y and Chan, Angus C.W and Chan, Francis K.L and Ng, Enders K.W and You, Joyce H.S and Chung, S.C. Sydney
The New England Journal of Medicine, ISSN 0028-4793, 08/2000, Volume 343, Issue 5, pp. 310 - 316
Endoscopic treatment is effective for bleeding peptic ulcers, but bleeding recurs in 15 to 20 percent of patients. The mortality rate in these patients is... 
TRIALS | MEDICINE, GENERAL & INTERNAL | INTRAGASTRIC PH | THERAPY | HEMORRHAGE | INJECTION | COAGULATION | INFUSIONS | PROBE | PLACEBO-CONTROLLED MULTICENTER | RANITIDINE | Injections, Intravenous | Humans | Middle Aged | Male | Risk | Secondary Prevention | Epinephrine - therapeutic use | Peptic Ulcer Hemorrhage - prevention & control | Female | Peptic Ulcer - mortality | Length of Stay | Vasoconstrictor Agents - therapeutic use | Anti-Ulcer Agents - therapeutic use | Omeprazole - therapeutic use | Electrocoagulation | Double-Blind Method | Proton Pump Inhibitors | Omeprazole - administration & dosage | Peptic Ulcer Hemorrhage - surgery | Endoscopy, Gastrointestinal | Combined Modality Therapy | Peptic Ulcer Hemorrhage - drug therapy | Anti-Ulcer Agents - administration & dosage | Peptic Ulcer Hemorrhage - mortality | Aged | Peptic Ulcer - drug therapy | Peptic Ulcer - surgery | Omeprazole | Prevention | Peptic ulcer | Evaluation | Drug therapy | Gastrointestinal bleeding | Health care | Ulcers
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