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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 07/2012, Volume 109, Issue 27, pp. E1839 - E1847
In the course of apoptosis, activated caspases cleave ∼500 to ∼1,000 different proteins in a mammalian cell. The dynamics of apoptosis involve a number of... 
ATE1 | Arginylation | UBR1 | Proteolysis | APOPTOSIS | ACTIVATION | UBIQUITIN LIGASE | MULTIDISCIPLINARY SCIENCES | KAPPA-B | DEGRADATION SIGNALS | CANCER | arginylation | CASPASES | RIP | proteolysis | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Humans | Aminoacyltransferases - genetics | Caspase 3 - metabolism | bcl-X Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | Phosphoproteins - metabolism | Lim Kinases - metabolism | Mice, Mutant Strains | BRCA1 Protein - metabolism | HEK293 Cells | Antibodies - immunology | Apoptosis Regulatory Proteins - genetics | Peptide Fragments - genetics | BH3 Interacting Domain Death Agonist Protein - metabolism | Rabbits | Peptide Fragments - metabolism | TNF Receptor-Associated Factor 1 - metabolism | Ubiquitin-Protein Ligases - metabolism | TNF Receptor-Associated Factor 1 - genetics | Phosphoproteins - genetics | Apoptosis Regulatory Proteins - metabolism | BRCA1 Protein - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Adaptor Proteins, Signal Transducing - genetics | Lim Kinases - genetics | Aminoacyltransferases - metabolism | Mice | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | bcl-X Protein - metabolism | Arginine - metabolism | Proteins | Mutation | Metabolism | Proteases | Apoptosis | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
PLoS pathogens, ISSN 1553-7366, 2013, Volume 9, Issue 9, pp. e1003618 - e1003618
A desirable but as yet unachieved property of a human immunodeficiency virus type 1 (HIV-1) vaccine candidate is the ability to induce broadly neutralizing... 
ENVELOPE GLYCOPROTEIN TRIMERS | PROTEIN | VACCINE | GP41 | MICROBIOLOGY | GP120 | CONFORMATIONAL EPITOPE | POTENT | VIROLOGY | IMMUNODEFICIENCY-VIRUS TYPE-1 | BINDING-SITE | MONOCLONAL-ANTIBODIES | PARASITOLOGY | Protein Aggregates | Antibody Specificity | HIV Infections - prevention & control | Molecular Weight | Humans | Antibodies, Neutralizing - metabolism | env Gene Products, Human Immunodeficiency Virus - metabolism | AIDS Vaccines - therapeutic use | HIV Infections - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | Immunoglobulin Fab Fragments - metabolism | env Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors | Protein Stability | Mutant Proteins - antagonists & inhibitors | Peptide Fragments - genetics | env Gene Products, Human Immunodeficiency Virus - chemistry | HIV Antibodies - metabolism | Peptide Fragments - metabolism | Solubility | Antibody Affinity | Mutant Proteins - metabolism | Epitopes | Recombinant Fusion Proteins - chemistry | HIV-1 - immunology | Peptide Fragments - chemistry | Peptide Fragments - antagonists & inhibitors | Mutant Proteins - chemistry | Antibodies, Monoclonal - metabolism | Amino Acid Substitution | Physiological aspects | Genetic aspects | Research | Nucleotide sequencing | HIV (Viruses) | Gene expression | Health aspects | DNA sequencing | Index Medicus | Medical research | AIDS | Human immunodeficiency virus | Vaccines | HIV | Acquired immune deficiency syndrome
Journal Article
Science, ISSN 0036-8075, 12/2011, Volume 334, Issue 6060, pp. 1241 - 1245
Aβ (beta-amyloid peptide) is an important contributor to Alzheimer's disease (AD). We modeled Aβ toxicity in yeast by directing the peptide to the secretory... 
Oligomers | Yeasts | Endocytosis | Receptors | Neurons | Secretion | RESEARCH ARTICLES | Predisposing factors | Cell membranes | Alzheimers disease | Genetic screening | COMMON VARIANTS | CELLS | IDENTIFIES VARIANTS | MEMBRANE | MULTIDISCIPLINARY SCIENCES | ENDOPLASMIC-RETICULUM | ALPHA-SYNUCLEIN | SACCHAROMYCES-CEREVISIAE | PEPTIDE | OLIGOMERS | GENOME-WIDE ASSOCIATION | Genetic Testing | Saccharomyces cerevisiae - genetics | Humans | Protein Multimerization | Secretory Pathway | Glutamates - metabolism | Saccharomyces cerevisiae - metabolism | Monomeric Clathrin Assembly Proteins - genetics | Amyloid beta-Peptides - genetics | Monomeric Clathrin Assembly Proteins - metabolism | Amyloid beta-Peptides - metabolism | Neurons - physiology | Cell Membrane - metabolism | Peptide Fragments - genetics | Peptide Fragments - metabolism | Caenorhabditis elegans - metabolism | Disease Susceptibility | Genetic Association Studies | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Risk Factors | Cells, Cultured | Rats | Saccharomyces cerevisiae Proteins - genetics | Clathrin - metabolism | Protein Transport | Saccharomyces cerevisiae - cytology | Peptide Fragments - chemistry | Animals | Caenorhabditis elegans - cytology | Alzheimer Disease - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Cytoskeleton - metabolism | Amyloid beta-Peptides - chemistry | Alzheimer Disease - genetics | Saccharomyces cerevisiae - growth & development | Index Medicus | Basic Medicine | Other Basic Medicine | peptide | membrane | Medical and Health Sciences | Medicin och hälsovetenskap | oligomers | alpha-synuclein | saccharomyces cerevisiae | cells | identifies variants | Medicinska och farmaceutiska grundvetenskaper | Annan medicinsk grundvetenskap | genome-wide association | endoplasmic reticulum | common variants
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2013, Volume 123, Issue 11, pp. 4627 - 4640
Journal Article
Nature, ISSN 0028-0836, 2012, Volume 485, Issue 7400, pp. 651 - 655
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 09/2017, Volume 28, Issue 9, pp. 2694 - 2707
Renal ischemia-reperfusion (I/R) injury is the most common cause of AKI, which associates with high mortality and has no effective therapy. ELABELA (ELA) is a... 
ISCHEMIA-REPERFUSION INJURY | ACUTE KIDNEY INJURY | APOPTOSIS | DNA-DAMAGE RESPONSE | INFLAMMATION | UROLOGY & NEPHROLOGY | ACUTE-RENAL-FAILURE | ENDOPLASMIC-RETICULUM STRESS | RETINAL INJURY | APELIN RECEPTOR | PROXIMAL TUBULE | Cell Adhesion Molecules - genetics | Peptide Hormones - pharmacology | Phosphorylation | Ataxia Telangiectasia Mutated Proteins - metabolism | Gene Expression - drug effects | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Peptide Fragments - pharmacology | Acute Kidney Injury - genetics | Hepatitis A Virus Cellular Receptor 1 - genetics | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Autophagy - drug effects | Cell Hypoxia | Carrier Proteins - pharmacology | Carrier Proteins - therapeutic use | Peptide Fragments - genetics | Reperfusion Injury - genetics | Reperfusion Injury - metabolism | Cell Line | Cell Survival - drug effects | DNA Repair - drug effects | Interleukin-6 - genetics | Rats | Transforming Growth Factor beta1 - genetics | Acute Kidney Injury - physiopathology | Acute Kidney Injury - prevention & control | Kidney Tubules - cytology | Carrier Proteins - genetics | Checkpoint Kinase 1 - metabolism | Animals | Reperfusion Injury - prevention & control | Intercellular Adhesion Molecule-1 - genetics | Reperfusion Injury - physiopathology | Inflammation - genetics | Peptide Hormones - therapeutic use | Inflammation - prevention & control | Mice | Peptide Fragments - therapeutic use | Histones - metabolism | Acute Kidney Injury - metabolism | Index Medicus | acute kidney injury | ELABELA | DNA damage response | inflammation | Basic Research
Journal Article
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 05/2009, Volume 29, Issue 10, pp. 2570 - 2581
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2010, Volume 184, Issue 9, pp. 4936 - 4946
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2008, Volume 380, Issue 2, pp. 425 - 436
Journal Article