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peptide-oligonucleotide conjugate (9) 9
biochemistry & molecular biology (7) 7
index medicus (7) 7
peptides (7) 7
peptides - chemistry (7) 7
oligonucleotides (5) 5
peptide (5) 5
antisense oligonucleotides (4) 4
chemistry, organic (4) 4
dna (4) 4
humans (4) 4
oligonucleotides - chemistry (4) 4
rna (4) 4
animals (3) 3
biophysics (3) 3
chemistry, multidisciplinary (3) 3
conjugates (3) 3
hybrids (3) 3
oligonucleotides - chemical synthesis (3) 3
peptide-oligonucleotide conjugates (3) 3
peptides - chemical synthesis (3) 3
self-assembly (3) 3
solid-phase synthesis (3) 3
synthesis (3) 3
alkynes (2) 2
antisense (2) 2
antisense oligonucleotide (2) 2
binding (2) 2
chemistry (2) 2
chemistry, analytical (2) 2
chemistry, medicinal (2) 2
chemistry, physical (2) 2
chemoselective oxime (2) 2
click chemistry (2) 2
conjugation (2) 2
cycloaddition (2) 2
deoxyribonucleic acid--dna (2) 2
design (2) 2
dna - chemistry (2) 2
dna nanotechnology (2) 2
fusion peptide (2) 2
gene expression (2) 2
highly efficient synthesis (2) 2
hybrid rnase s (2) 2
mice (2) 2
models, molecular (2) 2
molecular structure (2) 2
nucleopeptide (2) 2
oligonucleotide (2) 2
oligonucleotides, antisense - pharmacokinetics (2) 2
oligonucleotides, antisense - therapeutic use (2) 2
peptide-oligonucleotide (2) 2
peptide–oligonucleotide conjugate (2) 2
peptide–oligonucleotide conjugates (2) 2
pharmacology & pharmacy (2) 2
protein (2) 2
ribonuclease a (2) 2
s-peptide (2) 2
s-peptide-oligonucleotide conjugate (2) 2
s-protein (2) 2
sequence (2) 2
signal peptide (2) 2
ab:antibody (1) 1
activation (1) 1
adn (1) 1
advanced basic science (1) 1
aldehyde coupling reaction (1) 1
alkynes - chemistry (1) 1
amino-acids (1) 1
amyloid fibrillogenesis (1) 1
analogs (1) 1
analysis (1) 1
anti-mirna therapy (1) 1
antibodies (1) 1
antibodies - chemistry (1) 1
antibodies - immunology (1) 1
antikörper (1) 1
antiparallel tetraplex (1) 1
aptamers (1) 1
aptamers, nucleotide - chemistry (1) 1
arginine (1) 1
aromatic-amino-acids (1) 1
article (1) 1
artificial ribonucleases (1) 1
asparagine (1) 1
autonomous (1) 1
azide-alkyne cycloaddition (1) 1
azides - chemistry (1) 1
beta structural transition (1) 1
beta-sheet-forming peptide (1) 1
bilayers (1) 1
biochemistry (1) 1
biological macromolecules (1) 1
biological products (1) 1
biologie (1) 1
biology (1) 1
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1. Full Text Translocation of 5′ mRNA cap analogue — peptide conjugates across the membranes of giant unilamellar vesicles
by Worch, Remigiusz and Piecyk, Karolina and Kolasa, Anna Brygida and Jankowska-Anyszka, Marzena
BBA - Biomembranes, ISSN 0005-2736, 02/2016, Volume 1858, Issue 2, pp. 311 - 317
Cell-penetrating peptides (CPPs) have been extensively studied because of their ability to deliver various cargo molecules, which are often potential... 
Synthetic lipid bilayer | Cell penetrating peptides | Membrane transport | Peptide-oligonucleotide conjugate | Cap analogue | Fluorescence microscopy | LIFETIME IMAGING MICROSCOPY | LIPID DOMAINS | DESIGN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PENETRATING PEPTIDES | BILAYERS | MODEL MEMBRANES | BIOPHYSICS | Messenger RNA | Permeability | Peptides
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2. Full Text Synthesis of a Peptide-Human Telomere DNA Conjugate as a Fluorometric Imaging Reagent for Biological Sodium Ion
by SATO, Shinobu and IMAICHI, Yuuki and YOSHIURA, Yukiko and NAKAZAWA, Koji and TAKENAKA, Shigeori
Analytical Sciences, ISSN 0910-6340, 2019, Volume 35, Issue 1, pp. 85 - 90
A peptide-oligonucleotide conjugate (1) was synthesized by the attachment of FAM, TAMRA, and biotin moieties to a telomere DNA sequence of 5′-TAG GGT TAG GGT... 
TAMRA | antiparallel tetraplex | FAM | sodium ion | potassium ion | fluorometric imaging | Peptide-oligonucleotide conjugate | hybrid tetraplex | CHEMISTRY, ANALYTICAL | K+ SOLUTION | INDICATORS | SEQUENCE | G-QUADRUPLEX | BINDING | Fluorescent Dyes - chemical synthesis | Fluorescent Dyes - chemistry | DNA - chemistry | Peptides - chemistry | Sodium - analysis | Humans | Biosensing Techniques | Fluorescence Resonance Energy Transfer | HeLa Cells | Nucleic Acid Conformation | Circular Dichroism | Telomere | Conjugates | Peptides | Nucleotide sequence | Biotin | Sodium chloride | Potassium chloride | Cell surface | Sodium | Reagents | Streptavidin | Fluorescence resonance energy transfer | Potassium | Deoxyribonucleic acid--DNA | Sugar | Conformation
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3. Full Text Synthesis and purification of self‐assembling peptide‐oligonucleotide conjugates by solid‐phase peptide fragment condensation
by Kye, Mahnseok and Lim, Yong‐beom
Journal of Peptide Science, ISSN 1075-2617, 08/2018, Volume 24, Issue 8-9, pp. e3092 - n/a
Peptide‐oligonucleotide conjugates (POCs) are interesting molecules as they covalently combine 2 of the most important biomacromolecules. Sometimes, the... 
solid‐phase peptide fragment condensation | peptide | DNA | peptide‐oligonucleotide conjugate | self‐assembly | self-assembly | solid-phase peptide fragment condensation | peptide-oligonucleotide conjugate | AZIDE-ALKYNE CYCLOADDITION | CELLS | CHEMISTRY, ANALYTICAL | PROTEIN | SINGLE | LOCALIZATION SIGNAL PEPTIDE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY | MALEIMIDE | HYBRIDS | Solid-Phase Synthesis Techniques | Oligonucleotides - chemistry | Peptides - isolation & purification | Peptides - chemical synthesis | Peptides - chemistry | Molecular Structure | Oligonucleotides - isolation & purification | Oligonucleotides - chemical synthesis | Nitriles | Thiols | Peptides | Copper | Organic chemistry | Conjugates | Cycloaddition | Purification | Synthesis | Gel electrophoresis | Electrophoresis | Conjugation | Condensation | Functional groups | Alkynes
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4. Chemical strategies for oligonucleotide-conjugates synthesis
by Singh, Y and Spinelli, N and Defrancq, Eric
Current Organic Chemistry, ISSN 1385-2728, 03/2008, Volume 12, Issue 4, pp. 263 - 290
Oligonucleotide conjugates have found numerous applications in the field of diagnostics and therapeutics. Structurally diverse oligonucleotide conjugates have... 
PEPTIDE-OLIGONUCLEOTIDE | EXPRESSED PROTEIN LIGATION | COVALENT ATTACHMENT | OXIME BOND FORMATION | SOLID-PHASE SYNTHESIS | CLICK CHEMISTRY | CHEMISTRY, ORGANIC | LABELED OLIGONUCLEOTIDES | HIGHLY EFFICIENT SYNTHESIS | CHEMOSELECTIVE OXIME | ANTISENSE OLIGONUCLEOTIDES
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5. Full Text Antibody Activation using DNA‐Based Logic Gates
by Janssen, Brian M. G and van Rosmalen, Martijn and van Beek, Lotte and Merkx, Maarten
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2015, Volume 54, Issue 8, pp. 2530 - 2533
Oligonucleotide‐based molecular circuits offer the exciting possibility to introduce autonomous signal processing in biomedicine, synthetic biology, and... 
molecular computing | DNA nanotechnology | peptide–oligonucleotide conjugates | antibodies | aptamers | Antibodies | Peptide-oligonucleotide conjugates | Molecular computing | Aptamers | OPERATIONS | peptide-oligonucleotide conjugates | NANOSTRUCTURES | COMPUTATION | CHEMISTRY, MULTIDISCIPLINARY | CIRCUIT | Oligonucleotides - chemistry | DNA - chemistry | Peptides - chemistry | Antibodies - chemistry | Hemagglutinins - chemistry | Peptides - immunology | Antibodies - immunology | Aptamers, Nucleotide - chemistry | Orthomyxoviridae - metabolism | Kinetics | Viral antibodies | Peptides | Analysis | DNA | Molecular biology | Nanotechnology | Protein binding | Deoxyribonucleic acid--DNA | Conjugates | Strands | Activation | Locks | Logic | Autonomous | Displacement
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6. Full Text Peptide Assembly Directed and Quantified Using Megadalton DNA Nanostructures
by Jin, J and Baker, EG and Wood, CW and Bath, J and Woolfson, DN and Turberfield, AJ
ACS NANO, ISSN 1936-0851, 09/2019, Volume 13, Issue 9, pp. 9927 - 9935
In nature, co-assembly of polypeptides, nucleic acids, and polysaccharides is used to create functional supramolecular structures. Here, we show that DNA... 
DNA nanostructure | peptide | SET | ORIGAMI | SHAPES | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | PROTEIN DESIGN | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | peptide-oligonucleotide conjugate | COILED-COILS | PREDICTION | self-assembly | polyvalent binding | COMPUTATIONAL DESIGN | heterodimeric coiled coil | Index Medicus | peptide−oligonucleotide conjugate
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7. Synthesis of peptide-oligonucleotide conjugates using a heterobifunctional crosslinker
by Williams, Berea A.R and Chaput, John C
Current Protocols in Nucleic Acid Chemistry, ISSN 1934-9270, 2010, Volume Chapter 4, Issue 42, p. 4.41.20
Peptide-oligonucleotide conjugates (POCs) are molecular chimeras composed of a nucleic acid moiety covalently attached to a polypeptide moiety. POCs have been... 
succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC) | fragment conjugation | synbodies | DNA nanotechnology | nanodisplay | peptide-oligonucleotide conjugate | antisense | Cross-Linking Reagents | Oligonucleotides - chemistry | Peptides - chemical synthesis | Proteins - metabolism | Peptides - chemistry | Models, Molecular | Electrophoretic Mobility Shift Assay | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Chromatography, High Pressure Liquid | Maleimides - chemistry | Oligonucleotides - chemical synthesis
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8. Full Text The oxime bond formation as a useful tool for the preparation of oligonucleotide conjugates
by Singh, Yashveer and Edupuganti, Om Prakash and Villien, Mathilde and Defrancq, Éric and Dumy, Pascal
Comptes rendus - Chimie, ISSN 1631-0748, 2005, Volume 8, Issue 5, pp. 789 - 796
Synthetic oligonucleotides are attracting considerable interest as potential therapeutic agents for the selective inhibition of gene expression. The attainment... 
DNA | Oxime | Oligonucleotide | Conjugué | Conjugation | ADN | Peptide | peptide | THIAZOLIDINE | ANALOGS | STRATEGY | oxime | OLIGODEOXYRIBONUCLEOTIDES | conjugation | CHEMISTRY, MULTIDISCIPLINARY | oligonucleotide | PEPTIDE-OLIGONUCLEOTIDE | ALDEHYDE COUPLING REACTION | HIGHLY EFFICIENT SYNTHESIS | CHEMOSELECTIVE OXIME | Gene expression
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9. Full Text Stabilization of DNA duplexes by covalently-linked peptides
by Marchán, Vicente and Debéthune, Laurent and Pedroso, Enrique and Grandas, Anna
Tetrahedron, ISSN 0040-4020, 2004, Volume 60, Issue 25, pp. 5461 - 5469
The hybridization properties of various peptide-oligonucleotide hybrids were assessed from UV thermal denaturation experiments. Analysis of these and other... 
Nucleopeptide | Peptide–oligonucleotide conjugate | Melting temperature | Hybridization | Duplex stability | Peptide-oligonucleotide conjugate | OLIGONUCLEOTIDE HYBRIDS | SOLID-PHASE SYNTHESIS | STABILITY | duplex stability | CHEMISTRY, ORGANIC | hybridization | peptide-oligonucleotide conjugate | NUCLEOPEPTIDES | melting temperature | nucleopeptide | SEQUENCE | CONJUGATE | TRIFUNCTIONAL AMINO-ACID | ANTISENSE OLIGONUCLEOTIDES | BINDING
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10. Full Text miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells
by Patutina, Olga A and Bichenkova, Elena V and Miroshnichenko, Svetlana K and Mironova, Nadezhda L and Trivoluzzi, Linda T and Burusco, Kepa K and Bryce, Richard A and Vlassov, Valentin V and Zenkova, Marina A
Biomaterials, ISSN 0142-9612, 2017, Volume 122, pp. 163 - 178
Abstract MicroRNAs (miRNAs) are active regulators in malignant growth and constitute potential targets for anticancer therapy. Consequently, considerable... 
Advanced Basic Science | Dentistry | Peptide-oligonucleotide conjugates | Antisense oligonucleotides | Oncogenic miRNA | miR-21 | RNA cleavage | Anti-miRNA therapy | TARGET | MATERIALS SCIENCE, BIOMATERIALS | RNA | ENGINEERING, BIOMEDICAL | CLEAVAGE | MICRORNA SPONGES | BREAST-CANCER | ARTIFICIAL RIBONUCLEASES | RT-PCR | PROSTATE-CANCER | IN-VIVO | Oligonucleotides - chemistry | Peptides - chemistry | Ribonucleases - chemistry | Ribonucleases - administration & dosage | MicroRNAs - metabolism | Lymphoma, Non-Hodgkin - genetics | Peptides - administration & dosage | Animals | Lymphoma, Non-Hodgkin - metabolism | Cell Line, Tumor | Mice | MicroRNAs - genetics | Oligonucleotides - administration & dosage | Biological products | MicroRNA | Peptides | Therapeutics | Hodgkin's disease | Homeopathy | Materia medica and therapeutics
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11. Synthesis and properties of peptide-oligonucleotide conjugates
by Chen, CP and Min, JM and Zhang, LH
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, ISSN 1000-3282, 12/2001, Volume 28, Issue 6, pp. 783 - 787
Antisense-oligonucleotide can be employed as gene expression inhibibor and potential therapeutic agents. However, many classes of oligonucleotide are polyanion... 
signal peptide | synthesis | fusion peptide | PHASE SYNTHESIS | FUSION | BIOPHYSICS | NUCLEAR-LOCALIZATION PROPERTIES | MEMBRANE TRANSLOCATION | antisense oligonucleotide | BIOCHEMISTRY & MOLECULAR BIOLOGY | peptide-oligonucleotide conjugate | HYBRIDS
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12. Synthesis and properties of peptide-oligonucleotide conjugates
by Chen, Chang-Po and Min, Ji-Mei and Zhang, Li-He
Progress in Biochemistry and Biophysics, ISSN 1000-3282, 2001, Volume 28, Issue 6, p. 787
Synthesis | Peptide-oligonucleotide conjugate | Signal peptide | Antisense oligonucleotide | Fusion peptide
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13. Synthesis of Ser-His-Gly-DNA conjugates
by Li, XQ and Liu, H and Zhuang, M and Tan, B and Zhao, YF and Lu, CD
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, ISSN 1672-9145, 07/2002, Volume 34, Issue 4, pp. 506 - 511
There are strong interactions between the bases of oligonucleotides. Based on Watson-Crick principle, they can form stable secondary and tertiary structure... 
peptide | phosphoramidite | PEPTIDES | BIOPHYSICS | AMINO-ACIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Ser-His-Gly | oligonucleotide backbone | OLIGONUCLEOTIDES | HYBRIDS
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14. Full Text Solution Structure and Stability of Tryptophan‐Containing Nucleopeptide Duplexes
by Gómez‐Pinto, Irene and Marchán, Vicente and Gago, Federico and Grandas, Anna and González, Carlos
ChemBioChem, ISSN 1439-4227, 01/2003, Volume 4, Issue 1, pp. 40 - 49
Covalently linked peptide–oligonucleotide hybrids were used as models for studying tryptophan–DNA interactions. The structure and stability of several hybrids... 
stacking interactions | NMR spectroscopy | peptide–oligonucleotide conjugate | DNA structures | Stacking interactions | Peptide-oligonucleotide conjugate | CHEMISTRY, MEDICINAL | BIOLOGICAL MACROMOLECULES | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | OVERHAUSER EFFECT SPECTRA | PARTICLE MESH EWALD | INDOLE-DERIVATIVES | STRANDED PENTANUCLEOTIDE D(ACGCC) | peptide-oligonucleotide conjugate | AROMATIC-AMINO-ACIDS | DNA INTERACTIONS | MATRIX ANALYSIS | PULSE SEQUENCES | Nucleoproteins - chemistry | Oligonucleotides - genetics | Magnetic Resonance Spectroscopy | Peptides - chemistry | Models, Molecular | Tryptophan - chemistry | Homoserine - chemistry | Hot Temperature | Chemistry, Physical | Oligonucleotides - chemical synthesis | Nucleoproteins - chemical synthesis | Thermodynamics | Peptides - chemical synthesis | Chemical Phenomena | Protein Conformation | Lysine - chemistry
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15. Preparation and properties of a hybrid RNase S' formed by S-protein and S-S conjugate of [Nle-13, Cys-20]S-Peptide with 3'-thiopropyl(dT)(15)
by Senchenko, VN and Guzaev, AP and Boitsova, SF and Maiorov, VA and Dudich, IV and Shlyapnikov, SV and Karpeiskii, MY
MOLECULAR BIOLOGY, ISSN 0026-8933, 05/1996, Volume 30, Issue 3, pp. 406 - 412
An analog of the natural S-peptide with Nle and Cys substituted for Met-13 and Ala-20, respectively, was synthesized by the solid-phase method and conjugated... 
hybrid RNase S | BIOCHEMISTRY & MOLECULAR BIOLOGY | HELICES | RIBONUCLEASE-S | MODEL | PEPTIDE | S-peptide | S-peptide-oligonucleotide conjugate | S-protein | ENZYME | DNA HYBRID | SITE-SELECTIVE CLEAVAGE | GENERATION | ribonuclease A (S)
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16. Preparation and properties of a hybrid RNase S′ formed by S-protein and S-S conjugate of [Nle-13, Cys-20]S-peptide with 3′-thiopropyl(dT)15
by Senchenko, V.N and Guzaev, A.P and Boitsova, S.F and Maiorov, V.A and Dudich, I.V and Shlyapnikov, S.V and Karpeiskii, M.Ya
Molecular Biology, ISSN 0026-8933, 05/1996, Volume 30, Issue 3, pp. 406 - 412
S-protein | Hybrid RNase S | Ribonuclease A (S) | S-peptide | S-peptide-oligonucleotide conjugate
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17. Full Text Cellular delivery of antisense oligonucleotides
by Lebedeva, Irina and Benimetskaya, Lyuba and Stein, C.A and Vilenchik, Maria
2000, Volume 50, Issue 1, 19
Antisense oligonucleotides can be successfully employed to inhibit specifically gene expression. However, many oligonucleotide classes are polyanions and... 
Peptide–oligonucleotide conjugates | Antisense oligonucleotides | Dendrimers | Delivery | In vivo delivery | Cationic lipids | Peptide-oligonucleotide conjugates | delivery | PEPTIDE NUCLEIC-ACIDS | dendrimers | MESSENGER-RNA EXPRESSION | peptide-oligonucleotide conjugates | RECEPTOR-MEDIATED DELIVERY | BLOOD-BRAIN-BARRIER | EFFICIENT DNA DELIVERY | in vivo delivery | C-ALPHA EXPRESSION | cationic lipids | PH-SENSITIVE LIPOSOMES | antisense oligonucleotides | DIRECTED GENE-TRANSFER | HEPATITIS-B VIRUS | PHARMACOLOGY & PHARMACY | FIBROBLAST GROWTH-FACTOR | Animals | Humans | Oligonucleotides, Antisense - pharmacokinetics | Oligonucleotides, Antisense - therapeutic use | Cells - metabolism | Oligonucleotides, Antisense - administration & dosage | Liposomes | Pharmaceutical Vehicles
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18. Conjugation of peptides to antisense interleukin-6 via click chemistry
by Wang, Chang-Fang and Auriola, Seppo and Hirvonen, Jouni and Santos, Hélder A
Current Medicinal Chemistry, ISSN 0929-8673, 2014, Volume 21, Issue 10, pp. 1247 - 1254
Low molecular weight oligonucleotides have been discovered to have potential use for gene therapy by selectively inhibiting the expression of certain genes.... 
Antisense | Click chemistry | Targeting peptides | Interleukin-6 | Peptide-oligonucleotide conjugation | CHEMISTRY, MEDICINAL | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | click chemistry | RECEPTOR | targeting peptides | TUMOR VASCULATURE | interleukin-6 | OLIGONUCLEOTIDES | THERAPY | peptide-oligonucleotide conjugation | INTRACELLULAR DELIVERY | PHARMACOLOGY & PHARMACY | NUCLEIC-ACID THERAPEUTICS | Copper - chemistry | Oligonucleotides, Antisense - chemical synthesis | Peptides - chemistry | Click Chemistry | Humans | Interleukin-6 - chemistry | Oligonucleotides, Antisense - chemistry | Alkynes - chemistry | Molecular Structure | Molecular Targeted Therapy | Azides - chemistry | Cycloaddition Reaction
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