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1. Full Text Adverse Effects of Wheat Gluten
by Koning, Frits
Annals of Nutrition and Metabolism, ISSN 0250-6807, 11/2015, Volume 67, Issue 2, pp. 7 - 14
Man began to consume cereals approximately 10,000 years ago when hunter-gatherers settled in the fertile golden crescent in the Middle East. Gluten has been an... 
Gluten: Friend or Enemy? | Toxicity | T-CELL EPITOPES | CELIAC-DISEASE | Celiac disease | NUTRITION & DIETETICS | ENZYME | GLIADIN PEPTIDES | RECOGNIZE | USAGE | ENDOCRINOLOGY & METABOLISM | PROLYL ENDOPROTEASE | ALPHA-GLIADIN | DEGRADATION | SELECTION | Wheat | Gluten | Glutens - immunology | Secale - chemistry | Edible Grain - adverse effects | Nutritive Value | Humans | Hordeum - chemistry | Diet, Western - adverse effects | Triticum - adverse effects | Avena - chemistry | Celiac Disease - etiology | Hordeum - adverse effects | Secale - adverse effects | Glutens - adverse effects | Diet, Gluten-Free - methods | Triticum - chemistry | Edible Grain - chemistry | Celiac Disease - diet therapy | Index Medicus
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2. Full Text Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease
by Besler, Christian and Heinrich, Kathrin and Rohrer, Lucia and Doerries, Carola and Riwanto, Meliana and Shih, Diana M and Chroni, Angeliki and Yonekawa, Keiko and Stein, Sokrates and Schaefer, Nicola and Mueller, Maja and Akhmedov, Alexander and Daniil, Georgios and Manes, Costantina and Templin, Christian and Wyss, Christophe and Maier, Willibald and Tanner, Felix C and Matter, Christian M and Corti, Roberto and Furlong, Clement and Lusis, Aldons J and Von Eckardstein, Arnold and Fogelman, Alan M and Lüscher, Thomas F and Landmesser, Ulf
Journal of Clinical Investigation, ISSN 0021-9738, 07/2011, Volume 121, Issue 7, pp. 2693 - 2708
Therapies that raise levels of HDL, which is thought to exert atheroprotective effects via effects on endothelium, are being examined for the treatment or... 
MEDICINE, RESEARCH & EXPERIMENTAL | ENDOTHELIAL PROGENITOR CELLS | REENDOTHELIALIZATION | SERUM PARAOXONASE | NITRIC-OXIDE SYNTHASE | CHOLESTEROL EFFLUX | EXPRESSION | BINDING | SCAVENGER RECEPTOR-BI | HIGH-DENSITY-LIPOPROTEIN | APOLIPOPROTEIN-A-I | Tumor Necrosis Factor-alpha - metabolism | Nitric Oxide - biosynthesis | Coronary Artery Disease - metabolism | Humans | Middle Aged | Lipoproteins, HDL - metabolism | Male | NF-kappa B - metabolism | Aryldialkylphosphatase - metabolism | Animals | Coronary Artery Disease - physiopathology | Endothelium, Vascular - metabolism | Adult | Female | Aged | Mice | Nitric Oxide Synthase Type III - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Prevention | Enzymes | Care and treatment | High density lipoproteins | Physiological aspects | Research | Coronary heart disease | Endothelium | Index Medicus | Abridged Index Medicus
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3. Full Text Understanding the Adverse Effects of Ocriplasmin
by Beebe, David C
JAMA Ophthalmology, ISSN 2168-6165, 02/2015, Volume 133, Issue 2, pp. 229 - 229
OPHTHALMOLOGY | Electroretinography | Retina - drug effects | Tomography, Optical Coherence | Humans | Retinal Diseases - chemically induced | Fibrinolysin - adverse effects | Fibrinolytic Agents - adverse effects | Eye Diseases - drug therapy | Vision Disorders - chemically induced | Female | Peptide Fragments - adverse effects | Retinal Diseases - drug therapy | Blindness - chemically induced | Vitreous Body - drug effects | Index Medicus | Abridged Index Medicus
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4. Full Text OPINION Immunotherapy for Alzheimer disease-the challenge of adverse effects
by Liu, YH and Giunta, B and Zhou, HD and Tan, J and Wang, YJ
NATURE REVIEWS NEUROLOGY, ISSN 1759-4758, 08/2012, Volume 8, Issue 8, pp. 465 - 469
Amyloid-beta (A beta) plays a crucial part in the pathogenesis of Alzheimer disease (AD), making this peptide an attractive therapeutic target. However,... 
ANTIBODIES | PATHOGENESIS | AUTOANTIBODIES | IMMUNIZATION AN1792 | PROTEIN TRANSGENIC MICE | DEPOSITION | AMYLOID-BETA-PEPTIDE | A-BETA | NEUROPATHOLOGY | BRAIN | CLINICAL NEUROLOGY
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5. Full Text Adverse Effects of Cigarette Smoke on NO Bioavailability: Role of Arginine Metabolism and Oxidative Stress
by Zhang, Wei-Zheng and Venardos, Kylie and Chin-Dusting, Jaye and Kaye, David M
Hypertension, ISSN 0194-911X, 08/2006, Volume 48, Issue 2, pp. 278 - 285
Endothelial dysfunction is a hallmark of cardiovascular disease, and the l-arginine:NO pathway plays a critical role in determining endothelial function.... 
Metabolism | Endothelium | Smoking | endothelium | ARTERY ENDOTHELIAL-CELLS | ISOFORMS | NITRIC-OXIDE SYNTHASE | AMINO-ACID TRANSPORTERS | PEPTIDE | ASYMMETRICAL DIMETHYLARGININE | PLASMA | smoking | PERIPHERAL VASCULAR DISEASE | metabolism | DYSFUNCTION | EXPRESSION | EXTRACT | Smoking - adverse effects | Arginine - pharmacokinetics | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Biological Availability | Cationic Amino Acid Transporter 1 - metabolism | Male | Arginine - analogs & derivatives | Cotinine - blood | Cattle | Adult | Biological Transport - drug effects | Citrulline - blood | Culture Media - chemistry | Smoking - blood | Endothelial Cells - metabolism | Smoke - adverse effects | Cells, Cultured | Antioxidants - pharmacology | Enzyme Activation - drug effects | Tobacco | Animals | Endothelial Cells - cytology | Arginine - blood | Culture Media - pharmacology | Nitric Oxide Synthase - metabolism | Nitric Oxide - metabolism | Arginine - metabolism | Endothelial Cells - drug effects | Index Medicus
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6. Full Text Desalted duck egg white peptides promote calcium uptake by counteracting the adverse effects of phytic acid
by Hou, Tao and Liu, Weiwei and Shi, Wen and Ma, Zhili and He, Hui
Food Chemistry, ISSN 0308-8146, 03/2017, Volume 219, pp. 428 - 435
The structure of the desalted duck egg white peptides-calcium chelate was characterized by fluorescence spectroscopy, fourier transform infrared spectroscopy,... 
Caco-2 monolayer model | Desalted duck egg white peptides | Phytic acid | Transient receptor potential vanilloid 6 | Calcium bioavailability | DIETARY CALCIUM | IRON-ABSORPTION | FOOD SCIENCE & TECHNOLOGY | BIOAVAILABILITY | ZINC | IN-VITRO | NUTRITION & DIETETICS | GREEN LEAFY VEGETABLES | PHOSPHOPEPTIDES | HT-29 TUMOR-CELLS | CHEMISTRY, APPLIED | ABSORPTION INHIBITORS | EXPRESSION | Caco-2 Cells | Phytic Acid - pharmacology | Calcium - metabolism | Enterocytes - metabolism | Zinc - metabolism | Humans | Egg White | Ducks | Peptides - pharmacology | Amino Acids - metabolism | Animals | Peptides - metabolism | Enterocytes - drug effects | Phosphates | Peptides | Index Medicus
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7. Full Text GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals
by Hu, Shuxin and Begum, Aynun N and Jones, Mychica R and Oh, Mike S and Beech, Walter K and Beech, Beverly Hudspeth and Yang, Fusheng and Chen, Pingping and Ubeda, Oliver J and Kim, Peter C and Davies, Peter and Ma, Qiulan and Cole, Greg M and Frautschy, Sally A
Neurobiology of Disease, ISSN 0969-9961, 2008, Volume 33, Issue 2, pp. 193 - 206
Abstract The dysregulation of glycogen synthase kinase-3 (GSK3) has been implicated in Alzheimer disease (AD) pathogenesis and in Aβ-induced neurotoxicity,... 
Neurology | Tau | Neuron damage | c- jun N-terminal kinase | GSK3 | Beta-amyloid | Alzheimer's | c-jun N-terminal kinase | NEUROFIBRILLARY TANGLES | TYROSINE PHOSPHORYLATION | GLYCOGEN-SYNTHASE KINASE-3 | AMYLOID PLAQUES | NEUROSCIENCES | NEUROPSYCHIATRIC SYMPTOMS | IN-VIVO | PRECURSOR PROTEIN | REDUCES TAU PHOSPHORYLATION | TRANSGENIC MICE | COGNITIVE DEFICITS | Phosphorylation | Amyloid beta-Peptides - pharmacology | Caspase 3 - metabolism | Gliosis - chemically induced | Maleimides - adverse effects | tau Proteins - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Hippocampus - drug effects | Glycogen - metabolism | Maleimides - therapeutic use | DNA Fragmentation | Neurons - metabolism | Alzheimer Disease - chemically induced | Neurons - drug effects | Disease Models, Animal | Enzyme Inhibitors - adverse effects | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Alzheimer Disease - therapy | Cells, Cultured | Rats | Glycogen Synthase Kinase 3 - metabolism | Enzyme Inhibitors - therapeutic use | Rats, Sprague-Dawley | Animals | Indoles - adverse effects | Maze Learning | Indoles - therapeutic use | Hippocampus - physiology | Nerve Degeneration - drug therapy | Proteolipids | Enzymes | Lipoproteins | Synthesis | Glycogen | Neurons | Analysis | Depression, Mental | GABA | Blood lipoproteins | Saturated fatty acids | Alzheimer's disease | Index Medicus
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8. Full Text Formaldehyde induces toxicity in mouse bone marrow and hematopoietic stem/progenitor cells and enhances benzene-induced adverse effects
by Wei, Chenxi and Wen, Huaxiao and Yuan, Langyue and McHale, Cliona M and Li, Hui and Wang, Kun and Yuan, Junlin and Yang, Xu and Zhang, Luoping
Archives of Toxicology, ISSN 0340-5761, 2/2017, Volume 91, Issue 2, pp. 921 - 933
Formaldehyde (FA) is a human leukemogen and is hematotoxic in human and mouse. The biological plausibility of FA-induced leukemia is controversial because few... 
Biomedicine, general | Environmental Health | Biomedicine | Occupational Medicine/Industrial Medicine | Benzene | Bone marrow | Myeloid progenitor | Hematotoxicity | Pharmacology/Toxicology | Formaldehyde | OXIDATIVE STRESS | STEM-CELLS | COVALENT BINDING | RISK | METABOLIC INCORPORATION | C-14 FORMALDEHYDE | INHALED H-3 FORMALDEHYDE | MICE | TOXICOLOGY | LEUKEMIA | EXPOSED RATS | Hematopoietic Stem Cells - drug effects | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Bone Marrow Cells - pathology | Caspase 3 - metabolism | Male | Spleen - drug effects | Blood Cell Count | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Benzene - adverse effects | Bone Marrow Cells - drug effects | Toxicity Tests - methods | Mice, Inbred BALB C | Formaldehyde - toxicity | Receptors, Growth Factor - metabolism | Complications and side effects | Yuan (China) | Medical examination | Leukemia | Blood | Aldehydes | Toxicity | Rodents | Index Medicus | hematotoxicity | formaldehyde | myeloid progenitor | benzene | bone marrow
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9. Full Text Understanding the Adverse Effects of Ocriplasmin—Reply
by Johnson, Mark W and Fahim, Abigail T
JAMA Ophthalmology, ISSN 2168-6165, 02/2015, Volume 133, Issue 2, pp. 230 - 230
OPHTHALMOLOGY | CNS | LAMININ | Electroretinography | Retina - drug effects | Tomography, Optical Coherence | Humans | Retinal Diseases - chemically induced | Fibrinolysin - adverse effects | Fibrinolytic Agents - adverse effects | Eye Diseases - drug therapy | Vision Disorders - chemically induced | Female | Peptide Fragments - adverse effects | Retinal Diseases - drug therapy | Blindness - chemically induced | Vitreous Body - drug effects | Index Medicus | Abridged Index Medicus
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10. Full Text Relationship Between Endogenous Opioid Function and Opioid Analgesic Adverse Effects
by Gupta, Rajnish K and Bruehl, Stephen and Burns, John W and Buvanendran, Asokumar and Chont, Melissa and Schuster, Erik and France, Christopher R
Regional Anesthesia and Pain Medicine, ISSN 1098-7339, 05/2014, Volume 39, Issue 3, pp. 219 - 224
BACKGROUND AND OBJECTIVESOur recent work indicates that endogenous opioid activity influences analgesic responses to opioid medications. This secondary... 
RESPONSES | BACK-PAIN PATIENTS | POTENTIATION | TOLERANCE | NALOXONE | RESTRAINT | SENSITIVITY | ANESTHESIOLOGY | HEALTHY-VOLUNTEERS | SEX-DIFFERENCES | MORPHINE ANALGESIA | Cross-Over Studies | Analgesics, Opioid - adverse effects | Chronic Pain - drug therapy | Opioid Peptides - physiology | Double-Blind Method | Humans | Sex Factors | Adult | Female | Male | Morphine - adverse effects | Index Medicus
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11. Full Text Adverse effects of incretin‐based therapies on major cardiovascular and arrhythmia events: meta‐analysis of randomized trials
by Wang, Tiansheng and Wang, Fei and Zhou, Junwen and Tang, Huilin and Giovenale, Sharon
Diabetes/Metabolism Research and Reviews, ISSN 1520-7552, 11/2016, Volume 32, Issue 8, pp. 843 - 857
Background Recent cardiovascular outcome trials of incretin-based therapies (IBT) in type 2 diabetes have not demonstrated either benefit or harm in terms of... 
meta‐analysis | cardiovascular risk | randomized controlled trials | glucagon‐like peptide 1 receptor agonists | dipeptidylpeptidase‐4 inhibitors | incretin drugs | meta-analysis | dipeptidylpeptidase-4 inhibitors | glucagon-like peptide 1 receptor agonists | PEPTIDE-1 RECEPTOR AGONIST | INITIAL COMBINATION THERAPY | TWICE-DAILY EXENATIDE | BIPHASIC INSULIN ASPART | DRUG-NAIVE PATIENTS | ADD-ON THERAPY | DIPEPTIDYL PEPTIDASE-4 INHIBITORS | IMPROVES GLYCEMIC CONTROL | ENDOCRINOLOGY & METABOLISM | PLACEBO-CONTROLLED TRIAL | TYPE-2 DIABETES-MELLITUS | Arrhythmias, Cardiac - chemically induced | Prognosis | Humans | Incretins - adverse effects | Cardiovascular Diseases - chemically induced | Diabetes Mellitus, Type 2 - drug therapy | Case-Control Studies | Randomized Controlled Trials as Topic | Heart failure | Type 2 diabetes | Complications and side effects | Peptides | Arrhythmia | Analysis | Index Medicus
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12. Full Text Understanding the Adverse Effects of Ocriplasmin—Reply
by Tibbetts, Michael D and Reichel, Elias and Witkin, Andre J
JAMA Ophthalmology, ISSN 2168-6165, 02/2015, Volume 133, Issue 2, pp. 229 - 230
OPHTHALMOLOGY | Electroretinography | Retina - drug effects | Fibrinolytic Agents - adverse effects | Tomography, Optical Coherence | Humans | Retinal Diseases - chemically induced | Female | Peptide Fragments - adverse effects | Blindness - chemically induced | Fibrinolysin - adverse effects | Index Medicus | Abridged Index Medicus
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13. Full Text Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects
by Sadhasivam, S and Zhang, X and Chidambaran, V and Mavi, J and Pilipenko, V and Mersha, T.B and Meller, J and Kaufman, K.M and Martin, L.J and McAuliffe, J
Pharmacogenomics Journal, ISSN 1470-269X, 10/2015, Volume 15, Issue 5, pp. 436 - 442
Opioid effects are potentiated by cannabinoid agonists including anandamide, an endocannabinoid. Inter-individual variability in responses to opioids is a... 
ACID AMIDE HYDROLASE | MORPHINE | PEDIATRIC SLEEP QUESTIONNAIRE | PHARMACOGENOMIC-TWIN | PAIN SENSITIVITY | ANANDAMIDE | GENETICS & HEREDITY | ENDOCANNABINOID SYSTEM | MISSENSE MUTATION | PHARMACOLOGY & PHARMACY | MICE | PROBLEM DRUG-USE | Opioid-Related Disorders - drug therapy | Opioid-Related Disorders - pathology | HapMap Project | Polyunsaturated Alkamides - adverse effects | Humans | Male | Drug Users | Drug-Related Side Effects and Adverse Reactions - pathology | Analgesics, Opioid - adverse effects | Arachidonic Acids - administration & dosage | Drug-Related Side Effects and Adverse Reactions - genetics | Opioid-Related Disorders - genetics | Female | Child | Endocannabinoids - adverse effects | Genetic Association Studies | Amidohydrolases - genetics | Polyunsaturated Alkamides - administration & dosage | Endocannabinoids - administration & dosage | Analgesics, Opioid - administration & dosage | Arachidonic Acids - adverse effects | Adolescent | Cannabinoids - agonists | Polymorphism, Single Nucleotide | Tonsillectomy - adverse effects | Drugs | Enzymes | Genetic variation | Drug metabolism | Adverse and side effects | Hydrolases | Genetic aspects | Properties | Health aspects | Risk factors | Index Medicus
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14. Full Text The combination of opioid and neurotensin receptor agonists improves their analgesic/adverse effect ratio
by Eiselt, Emilie and Côté, Jérôme and Longpré, Jean-Michel and Blais, Véronique and Sarret, Philippe and Gendron, Louis
European Journal of Pharmacology, ISSN 0014-2999, 04/2019, Volume 848, pp. 80 - 87
Opioid and neurotensin (NT) receptors are expressed in both central and peripheral nervous systems where they modulate nociceptive responses. Nowadays, opioid... 
Formalin | Analgesia | Morphine | Isobologram | Neurotensin | Constipation | MANAGEMENT | CHRONIC PAIN | ANALOGS | PEPTIDE | SYNERGY | PHARMACOLOGY & PHARMACY | MICE | FORMALIN TEST | MODULATION | NOCICEPTION | Drugs | Prescribing | Care and treatment | Pain | Lubrication and lubricants | Analysis | Gastrointestinal system | Physiological aspects | Neuropeptides | Formaldehyde
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