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Cellular signalling, ISSN 0898-6568, 01/2018, Volume 42, pp. 281 - 291
... mechanisms is needed to develop improved drugs. Here, we review the literature to test the hypothesis that a break down in cyclic nucleotide signaling at the level of synthesis, execution, and/or degradation may contribute to these deficits... 
Cerebellum | PDE8 | PDE7 | Mild cognitive impairment | PDE1 | Memory | Cortex | PDE3 | cGMP | Parkinson's Disease | cAMP | Huntington's disease | Striatum | Age-related cognitive decline | Cyclic nucleotides | PDE11 | Aging | Alzheimer's disease | Hippocampus | Phosphodiesterase | Humans | Natriuretic Peptide, Brain - metabolism | Heterotrimeric GTP-Binding Proteins - metabolism | Cyclic GMP-Dependent Protein Kinases - metabolism | Heterotrimeric GTP-Binding Proteins - genetics | Cyclic GMP-Dependent Protein Kinases - genetics | Brain - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Aging - genetics | Guanine Nucleotide Exchange Factors - metabolism | Atrial Natriuretic Factor - genetics | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Natriuretic Peptide, Brain - genetics | Neurodegenerative Diseases - pathology | Atrial Natriuretic Factor - metabolism | Signal Transduction | Gene Expression Regulation | Neurodegenerative Diseases - genetics | Adenylyl Cyclases - metabolism | Neurodegenerative Diseases - metabolism | Cyclic AMP Response Element-Binding Protein - genetics | Cyclic GMP - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Brain - pathology | Adenylyl Cyclases - genetics | Aging - metabolism | NITRIC-OXIDE SYNTHASE | DEPENDENT PROTEIN-KINASE | ELEMENT-BINDING PROTEIN | ADENYLYL-CYCLASE ACTIVITY | NATRIURETIC-PEPTIDE LEVELS | CELL BIOLOGY | SOLUBLE GUANYLYL CYCLASE | CAMP-RESPONSE ELEMENT | LONG-TERM POTENTIATION | CAMP | AMYLOID PRECURSOR PROTEIN | Brain | Medical colleges | Neurosciences | Analysis | Cyclic adenylic acid | G proteins | Adenylic acid | Protein kinases | Protein binding | Natriuretic peptides | Huntington’s Disease | memory | cerebellum | striatum | cyclic nucleotides | Parkinson’s Disease | age-related cognitive decline | cyclase | cortex | PDE5 | Alzheimer’s disease | hippocampus | PDE2 | PDE4 | natriuretic peptide | PDE9 | PDE10 | mild cognitive impairment | aging | phosphodiesterase
Journal Article
The Plant cell, ISSN 1532-298X, 2012, Volume 24, Issue 7, pp. 2765 - 2778
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2016, Volume 291, Issue 7, pp. 3668 - 3681
The intracellular infections of Mycobacterium tuberculosis, which is the causative agent of tuberculosis, are regulated by many cyclic dinucleotide signaling. Rv2837c from M... 
enzyme degradation | PROTEIN | LONG-TERM SURVIVAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | structure-function | GMP | SPORULATION | IDENTIFICATION | Mycobacterium tuberculosis | AFFECT BACTERIAL-GROWTH | phosphodiesterases | LEADS | cyclic diadenosine monophosphate (c-di-AMP) | AMP PHOSPHODIESTERASE | REVEALS | Exoribonucleases - genetics | Bacterial Proteins - chemistry | Exoribonucleases - chemistry | Molecular Sequence Data | Substrate Specificity | Dinucleoside Phosphates - chemistry | Recombinant Fusion Proteins - metabolism | Cyclic AMP - chemistry | Cyclic AMP - analogs & derivatives | Cyclic GMP - analogs & derivatives | Cyclic GMP - chemistry | Conserved Sequence | Cyclic AMP - metabolism | Peptide Fragments - genetics | Recombinant Proteins - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Amino Acid Sequence | Catalytic Domain | Peptide Fragments - metabolism | Biocatalysis | 3',5'-Cyclic-GMP Phosphodiesterases - genetics | Bacterial Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | 3',5'-Cyclic-GMP Phosphodiesterases - chemistry | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Recombinant Fusion Proteins - chemistry | Dinucleoside Phosphates - metabolism | Peptide Fragments - chemistry | Sequence Alignment | 3',5'-Cyclic-AMP Phosphodiesterases - chemistry | 3',5'-Cyclic-GMP Phosphodiesterases - metabolism | Cyclic GMP - metabolism | Mycobacterium tuberculosis - enzymology | Bacterial Proteins - metabolism | Protein Conformation | Mutation | Exoribonucleases - metabolism | Enzymology
Journal Article
Diabetes (New York, N.Y.), ISSN 1939-327X, 2012, Volume 61, Issue 11, pp. 2842 - 2850
In insulin-secreting cells, expression of NADPH oxidase (NOX), a potent source of ROS, has been reported, along with controversial findings regarding its... 
SIGNAL-TRANSDUCTION | NAD(P)H OXIDASE | RESPIRATORY BURST | OXIDATIVE STRESS | PROTEIN | ISLETS | SUPEROXIDE-PRODUCTION | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | DEPENDENT PATHWAY | Islets of Langerhans - drug effects | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Humans | NADPH Oxidases - metabolism | Secretory Vesicles - metabolism | Insulin-Secreting Cells - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Islets of Langerhans - metabolism | Isoenzymes - metabolism | Islets of Langerhans - cytology | NADPH Oxidases - genetics | Insulin-Secreting Cells - cytology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - metabolism | Insulin Secretion | Cyclic AMP-Dependent Protein Kinases - metabolism | Second Messenger Systems - drug effects | Glucagon-Like Peptide 1 - metabolism | Isoenzymes - genetics | Tissue Culture Techniques | Mice, Inbred C57BL | NADPH Oxidases - antagonists & inhibitors | Cells, Cultured | Gene Silencing | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Mice, Knockout | Cyclic AMP - antagonists & inhibitors | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Secretory Vesicles - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Cyclic AMP - agonists | Isoenzymes - antagonists & inhibitors | Oxidases | Physiological aspects | Pancreatic beta cells | Research | Analysis | NADP (Coenzyme) | Islet Studies
Journal Article
PloS one, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e94926
Analogs of the cyclic nucleotides cAMP and cGMP have been extensively used to mimic or modulate cellular events mediated by protein kinase A (PKA... 
MICROCYSTIN-INDUCED APOPTOSIS | INTACT-CELLS | RAT HEPATOCYTES | PHOSPHATASE INHIBITORS | CORTISOL SYNTHESIS | DRUG-INTERACTIONS | MULTIDISCIPLINARY SCIENCES | POLYPEPTIDE 1B3 | DEPENDENT PROTEIN-KINASE | CGMP ANALOGS | CAMP | Cyclic GMP - pharmacology | Glycocholic Acid - metabolism | Organic Anion Transporters, Sodium-Independent - genetics | Rats, Wistar | Apoptosis - drug effects | Humans | Organic Anion Transporters - chemistry | Bacterial Toxins - pharmacokinetics | Glycocholic Acid - pharmacokinetics | Male | Peptides, Cyclic - pharmacology | Hepatocytes - metabolism | Cyclic GMP-Dependent Protein Kinases - metabolism | Organic Anion Transporters - metabolism | Peptides, Cyclic - metabolism | Dose-Response Relationship, Drug | Hepatocytes - cytology | Organic Anion Transporters - genetics | Cyclic AMP - analogs & derivatives | Cyclic GMP - analogs & derivatives | Guanine Nucleotide Exchange Factors - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | HEK293 Cells | Biological Transport - drug effects | Cyclic AMP - metabolism | Glycocholic Acid - pharmacology | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Cyclic AMP-Dependent Protein Kinases - metabolism | Nucleotides, Cyclic - pharmacology | Protein Structure, Tertiary | Cells, Cultured | Organic Anion Transporters, Sodium-Independent - chemistry | Models, Molecular | Peptides, Cyclic - pharmacokinetics | Nucleotides, Cyclic - chemistry | Cyclic AMP - pharmacology | Microscopy, Confocal | Bacterial Toxins - metabolism | Animals | Cyclic GMP - metabolism | Bacterial Toxins - pharmacology | Solute Carrier Organic Anion Transporter Family Member 1b1 | Physiological aspects | Purines | Peptides | Analysis | Apoptosis | Drugs | Protein kinase A | Liver | Protein kinase G | Nucleotides | Cholic acid | Kinases | Phosphatase | Analogs | Proteins | Metabolites | Rodents | Cyclic GMP | Inhibition | Enzymes | Adenosine | Polypeptides | Cyclic AMP | Metabolism | Nucleotide analogs | Camps | Organic anion transporting polypeptide | Cyclic nucleotides | Hepatocytes | Transport | Transporter | Cancer
Journal Article
The Plant cell, ISSN 1532-298X, 2013, Volume 25, Issue 2, pp. 558 - 571
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 563, Issue 7729, pp. 131 - 136
.... Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that activates innate immunity by initiating the STING-IRF3-type I IFN signalling cascade(1,2... 
CELLS | CYCLIC GMP-AMP | MULTIDISCIPLINARY SCIENCES | DOUBLE-STRAND BREAKS | CYTOSOLIC DNA | HISTONE H2AX | HOMOLOGOUS RECOMBINATION | PARP-1 | CANCER | Neoplasms - metabolism | Phosphorylation | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Neoplasm Proteins - metabolism | DNA Breaks, Double-Stranded | Cell Nucleus - enzymology | Cell Cycle Proteins - antagonists & inhibitors | Nucleotidyltransferases - deficiency | Cell Nucleus - metabolism | Neoplasms - genetics | Protein Binding - drug effects | HEK293 Cells | src-Family Kinases - metabolism | Adult | Female | Membrane Proteins - metabolism | Active Transport, Cell Nucleus | Nucleotidyltransferases - metabolism | Recombinational DNA Repair - genetics | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Poly (ADP-Ribose) Polymerase-1 - metabolism | Piperazines - pharmacology | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Phthalazines - pharmacology | Animals | Cell Line, Tumor | Mice | DNA Damage | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Cellular signal transduction | Research | Carcinogenesis | DNA repair | Transferases | Animal models | Homologous recombination | DNA damage | Lung cancer | Poly(ADP-ribose) | Homology | Innate immunity | Genomes | Kinases | Immunity | Cancer therapies | Genomic instability | Proteins | Ribose | Cyclic GMP | Cell cycle | Fibroblasts | Tumorigenesis | Localization | Repair | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Tyrosine | Translocation | Stability | AMP | Adenosine diphosphate | Nuclear transport | Poly(ADP-ribose) Polymerase 1 | Interferon regulatory factor 3 | Micronuclei | Instability | Interferon | Tumors | Cancer | Apoptosis
Journal Article