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1. Full Text The Cytosolic Bacterial Peptidoglycan Sensor Nod2 Affords Stem Cell Protection and Links Microbes to Gut Epithelial Regeneration
by Nigro, Giulia and Rossi, Raffaella and Commere, Pierre-Henri and Jay, Philippe and Sansonetti, Philippe J
Cell host & microbe, ISSN 1931-3128, 06/2014, Volume 15, Issue 6, pp. 792 - 798
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Epithelium - drug effects | Receptors, G-Protein-Coupled - metabolism | Mice, Inbred C57BL | Peptidoglycan - chemistry | Gastrointestinal Tract - microbiology | Acetylmuramyl-Alanyl-Isoglutamine - chemistry | Gastrointestinal Tract - drug effects | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Regeneration | Animals | Intestines - microbiology | Nod2 Signaling Adaptor Protein - metabolism | Organoids | Epithelium - microbiology | Stem Cells - drug effects | Cytosol - metabolism | Gastrointestinal Tract - cytology | Receptors, G-Protein-Coupled - genetics | Intestines - physiology | Cytoprotection | Intestines - cytology | Animal experimentation | Bacteria | Sensors | Microbiota (Symbiotic organisms) | Stem cells | Index Medicus | Gastrointestinal Tract/drug effects | Acetylmuramyl-Alanyl-Isoglutamine/pharmacology | Epithelium/drug effects | Life Sciences | Stem Cells/drug effects | Acetylmuramyl-Alanyl-Isoglutamine/chemistry | Gastrointestinal Tract/microbiology | Nod2 Signaling Adaptor Protein/metabolism | Intestines/microbiology | Epithelium/microbiology | Intestines/physiology | Bacteriology | Gastrointestinal Tract/cytology | Receptors, G-Protein-Coupled/genetics | Microbiology and Parasitology | Peptidoglycan/chemistry | Intestines/cytology | Receptors, G-Protein-Coupled/metabolism | AnimalsAnimals | Cytosol/metabolism
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2. Full Text Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice
by Beli, Eleni and Yan, Yuanqing and Yan, Yuanqing and Moldovan, Leni and Vieira, Cristiano P and Gao, Ruli and Gao, Ruli and Duan, Yaqian and Prasad, Ram and Bhatwadekar, Ashay and Bhatwadekar, Ashay and White, Fletcher A and White, Fletcher A and Townsend, Steven D and Townsend, Steven D and Chan, Luisa and Chan, Luisa and Ryan, Caitlin N and Morton, Daniel and Moldovan, Emil G and Chu, Fang-I and Chu, Fang-I and Oudit, Gavin Y and Derendorf, Hartmut and Adorini, Luciano and Adorini, Luciano and Wang, Xiaoxin X and Wang, Xiaoxin X and Evans-Molina, Carmella and Evans-Molina, Carmella and Mirmira, Raghavendra G and Mirmira, Raghavendra G and Boulton, Michael E and Yoder, Mervin C and Yoder, Mervin C and Li, Qiuhong and Levi, Moshe and Levi, Moshe and Busik, Julia V and Busik, Julia V and Grant, Maria B and Grant, Maria B
Diabetes (New York, N.Y.), ISSN 0012-1797, 09/2018, Volume 67, Issue 9, pp. 1867 - 1879
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Retina - drug effects | Leukocytes - pathology | Receptors, G-Protein-Coupled - metabolism | Colon - drug effects | Microvessels - metabolism | Microvessels - pathology | Colon - immunology | Male | Ganglia, Sensory - metabolism | Retina - immunology | Intestinal Mucosa - drug effects | Diabetic Retinopathy - complications | Retinal Vessels - pathology | Feces - microbiology | Intestinal Mucosa - immunology | Bacteroidetes - isolation & purification | Firmicutes - growth & development | Diabetic Retinopathy - immunology | Firmicutes - isolation & purification | Retinal Vessels - metabolism | Colon - pathology | Retinal Vessels - drug effects | Dysbiosis - therapy | Goblet Cells - metabolism | Colon - metabolism | Ganglia, Sensory - pathology | Diabetic Retinopathy - prevention & control | Gastrointestinal Microbiome - drug effects | Bile Acids and Salts - therapeutic use | Survival Analysis | Leukocytes - drug effects | Diabetes Mellitus, Type 2 - pathology | Dysbiosis - pathology | Retina - pathology | Intestinal Mucosa - pathology | Intestinal Mucosa - metabolism | Retina - metabolism | Diabetes Mellitus, Type 2 - microbiology | Ganglia, Sensory - drug effects | Goblet Cells - drug effects | Diabetic Retinopathy - pathology | Receptors, G-Protein-Coupled - agonists | Dysbiosis - microbiology | Microvessels - immunology | Ganglia, Sensory - immunology | Goblet Cells - immunology | Leukocytes - immunology | Retinal Vessels - immunology | Mice, Mutant Strains | Diabetes Mellitus, Type 2 - therapy | Bacteroidetes - immunology | Mice, Inbred DBA | Verrucomicrobia - growth & development | Verrucomicrobia - immunology | Diabetes Mellitus, Type 2 - complications | Fasting | Microvessels - drug effects | Firmicutes - immunology | Verrucomicrobia - isolation & purification | Dysbiosis - complications | Animals | Bacteroidetes - growth & development | Gastrointestinal Microbiome - immunology | Goblet Cells - pathology | Prevention | Diabetic retinopathy | Usage | Diet therapy | Low-calorie diet | Rattus | Rats | Health aspects | Neuroprotection | Retinopathy | Diabetes mellitus | Peptidoglycans | Microbiomes | Retina | mRNA | Tumor necrosis factor-α | Feeding | Microbiota | Mucin | Metabolites | Cell number | Rodents | Hemoglobin | Microvasculature | Diabetes | Intestinal microflora | Capillaries | Ganglion cells | Cancer | Index Medicus | Abridged Index Medicus | Complications | 0107
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3. Full Text A new antibiotic kills pathogens without detectable resistance
by Ling, Losee L and Schneider, Tanja and Peoples, Aaron J and Spoering, Amy L and Engels, Ina and Conlon, Brian P and Mueller, Anna and Schäberle, Till F and Hughes, Dallas E and Epstein, Slava and Jones, Michael and Lazarides, Linos and Steadman, Victoria A and Cohen, Douglas R and Felix, Cintia R and Fetterman, K. Ashley and Millett, William P and Nitti, Anthony G and Zullo, Ashley M and Chen, Chao and Lewis, Kim
Nature (London), ISSN 0028-0836, 01/2015, Volume 517, Issue 7535, pp. 455 - 459
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Molecular Sequence Data | Biological Products - pharmacology | Depsipeptides - pharmacology | Drug Resistance, Microbial - genetics | Betaproteobacteria - chemistry | Mycobacterium tuberculosis - drug effects | Microbial Sensitivity Tests | Teichoic Acids - biosynthesis | Cell Wall - drug effects | Mycobacterium tuberculosis - cytology | Time Factors | Anti-Bacterial Agents - chemistry | Female | Staphylococcal Infections - microbiology | Depsipeptides - chemistry | Disease Models, Animal | Multigene Family - genetics | Staphylococcus aureus - genetics | Staphylococcal Infections - drug therapy | Microbial Viability - drug effects | Depsipeptides - isolation & purification | Depsipeptides - biosynthesis | Anti-Bacterial Agents - isolation & purification | Cell Wall - chemistry | Biological Products - isolation & purification | Betaproteobacteria - genetics | Staphylococcus aureus - chemistry | Peptidoglycan - biosynthesis | Biological Products - chemistry | Animals | Cell Wall - metabolism | Staphylococcus aureus - cytology | Anti-Bacterial Agents - biosynthesis | Anti-Bacterial Agents - pharmacology | Mice | Staphylococcus aureus - drug effects | Mycobacterium tuberculosis - genetics | Drug resistance in microorganisms | Antibiotics | Health aspects | Analysis | Soil microbiology | Proteins | Enzymes | Microorganisms | Bacteria | Antimicrobial agents | Lipids | Biosynthesis | Drug resistance | Drug dosages | Bacteriology | Deoxyribonucleic acid--DNA | Index Medicus
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4. Full Text Lysozyme Counteracts β-Lactam Antibiotics by Promoting the Emergence of L-Form Bacteria
by Kawai, Yoshikazu and Mickiewicz, Katarzyna and Errington, Jeff
Cell (Cambridge), ISSN 0092-8674, 02/2018, Volume 172, Issue 5, pp. 1038 - 1049.e10
bacterial cell biology | penicillin | lysozyme | Bacillus subtilis | antibiotic resistance | bacterial cell wall | bacterial genetics | macrophage | Staphylococcus aureus | antibiotic action | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Hydrolases - metabolism | L Forms - drug effects | Peptidoglycan - metabolism | Bacteriolysis - drug effects | Microbial Viability - drug effects | Prophages - drug effects | Muramidase - metabolism | Osmoregulation - drug effects | Penicillin G - pharmacology | Penicillin-Binding Proteins | Macrophages - metabolism | beta-Lactams - pharmacology | Animals | Cell Wall - drug effects | Cell Wall - metabolism | Macrophages - drug effects | RAW 264.7 Cells | Anti-Bacterial Agents - pharmacology | Mice | Bacillus subtilis - drug effects | Index Medicus
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5. Full Text Gram-positive bacterial cell envelopes: The impact on the activity of antimicrobial peptides
by Malanovic, Nermina and Lohner, Karl
Biochimica et biophysica acta. Biomembranes, ISSN 0005-2736, 05/2016, Volume 1858, Issue 5, pp. 936 - 946
Peptidoglycan | Antibacterial activity | Membrane mimics | Lipoteichoic acid | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Species Specificity | Gram-Positive Bacteria - drug effects | Anti-Infective Agents - pharmacology | Gram-Positive Bacteria - chemistry | Structure-Activity Relationship | Teichoic Acids - chemistry | Candida albicans - growth & development | Cell Membrane - chemistry | Candida albicans - drug effects | Cell Wall - drug effects | Candida albicans - chemistry | Teichoic Acids - pharmacology | Anti-Infective Agents - chemistry | Gram-Positive Bacteria - growth & development | Cell Membrane - drug effects | Fatty Acids - chemistry | Antimicrobial Cationic Peptides - chemistry | Antimicrobial Cationic Peptides - pharmacology | Phospholipids - chemistry | Cell Wall - chemistry | Phospholipids - pharmacology | Gram-Negative Bacteria - drug effects | Gram-Negative Bacteria - chemistry | Gram-Negative Bacteria - growth & development | Lipopolysaccharides - pharmacology | Lipopolysaccharides - chemistry | Drug Resistance, Multiple, Bacterial - drug effects | Fatty Acids - pharmacology | Surface active agents | Blood lipids | Organic compounds
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6. Evaluation of antibacterial and antibiofilm mechanisms by usnic acid against methicillin-resistant Staphylococcus aureus
by Pompilio, Arianna and Riviello, Antonella and Crocetta, Valentina and Di Giuseppe, Fabrizio and Pomponio, Stefano and Sulpizio, Marilisa and Di Ilio, Carmine and Angelucci, Stefania and Barone, Luana and Di Giulio, Andrea and Di Bonaventura, Giovanni
Future microbiology, ISSN 1746-0913, 10/2016, Volume 11, Issue 10, pp. 1315 - 1338
usnic acid | Staphylococcus aureus | biofilm | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virulence - drug effects | Methicillin-Resistant Staphylococcus aureus - ultrastructure | Microscopy, Electron, Transmission - methods | Propidium - metabolism | Real-Time Polymerase Chain Reaction - methods | Benzofurans - administration & dosage | Benzofurans - pharmacology | Colony Count, Microbial | Carrier Proteins - drug effects | Adhesins, Bacterial - drug effects | DNA, Bacterial | Protein Interaction Maps | Microbial Sensitivity Tests | Methicillin-Resistant Staphylococcus aureus - pathogenicity | Microscopy, Electron, Scanning - methods | Time Factors | Virulence - genetics | Staphylococcal Infections - microbiology | Proteomics - methods | Methicillin-Resistant Staphylococcus aureus - genetics | Cell Membrane - drug effects | Biofilms - drug effects | Bacterial Proteins - antagonists & inhibitors | Cell Survival - drug effects | Microbial Viability - drug effects | Cystic Fibrosis - microbiology | Down-Regulation | Methicillin-Resistant Staphylococcus aureus - drug effects | Bacterial Proteins - genetics | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods | Bacterial Proteins - drug effects | Peptidoglycan - biosynthesis | Peptidoglycan - drug effects | Bacterial Proteins - metabolism | Lipase - drug effects | Anti-Bacterial Agents - pharmacology | Anti-Bacterial Agents - administration & dosage | Cystic Fibrosis - drug therapy
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7. Full Text Substitutions in PBP2b from β-lactam resistant Streptococcus pneumoniae have different effects on enzymatic activity and drug reactivity
by Calvez, Philippe and Breukink, Eefjan and Roper, David I and Dib, Mélanie and Contreras-Martel, Carlos and Zapun, Ané
The Journal of biological chemistry, ISSN 0021-9258, 01/2017, Volume 292, Issue 7, pp. 2854 - 2865
peptidoglycan | Streptococcus | cell wall | antibiotic resistance | enzyme kinetics | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Recombinant Proteins - metabolism | Amino Acid Sequence | Streptococcus pneumoniae - drug effects | Recombinant Proteins - chemistry | Penicillin-Binding Proteins - genetics | Recombinant Proteins - genetics | Penicillin-Binding Proteins - metabolism | Sequence Homology, Amino Acid | beta-Lactams - pharmacology | Penicillin-Binding Proteins - chemistry | Streptococcus pneumoniae - metabolism | Protein Denaturation | Drug Resistance, Bacterial - drug effects | Cephalosporins - metabolism | Index Medicus | Life Sciences | Biomolecules | Biochemistry, Molecular Biology | Microbiology
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8. Full Text Vancomycin–Arginine Conjugate Inhibits Growth of Carbapenem-Resistant E. coli and Targets Cell-Wall Synthesis
by Antonoplis, Alexandra and Zang, Xiaoyu and Wegner, Tristan and Wender, Paul A and Cegelski, Lynette
ACS chemical biology, ISSN 1554-8929, 09/2019, Volume 14, Issue 9, pp. 2065 - 2070
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Hemolysis - drug effects | Peptidoglycan - metabolism | Escherichia coli - drug effects | Humans | Arginine - toxicity | Pseudomonas aeruginosa - drug effects | Arginine - analogs & derivatives | Microbial Sensitivity Tests | Cell Wall - drug effects | Vancomycin - toxicity | Arginine - pharmacology | Cell Membrane Permeability - drug effects | Vancomycin - analogs & derivatives | Vancomycin - pharmacology | Cell Line, Tumor | Acinetobacter baumannii - drug effects | Staphylococcus aureus - drug effects | Vibrio cholerae - drug effects | Index Medicus
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9. Full Text LytA, major autolysin of Streptococcus pneumoniae, requires access to nascent peptidoglycan
by Mellroth, Peter and Daniels, Robert and Eberhardt, Alice and Rönnlund, Daniel and Blom, Hans and Widengren, Jerker and Normark, Staffan and Henriques-Normark, Birgitta
The Journal of biological chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 14, pp. 11018 - 11029
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Peptidoglycan - metabolism | Bacteriolysis - drug effects | Detergents - pharmacology | Streptococcus pneumoniae - drug effects | Extracellular Space - drug effects | Cytoplasm - metabolism | Protein Transport - drug effects | N-Acetylmuramoyl-L-alanine Amidase - genetics | Streptococcus pneumoniae - cytology | Cell Division - drug effects | Protein Sorting Signals | N-Acetylmuramoyl-L-alanine Amidase - metabolism | Peptidoglycan - biosynthesis | Extracellular Space - metabolism | Deoxycholic Acid - pharmacology | N-Acetylmuramoyl-L-alanine Amidase - pharmacology | Streptococcus pneumoniae - metabolism | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Cytoplasm - drug effects | Streptococcus pneumoniae - enzymology | N-Acetylmuramoyl-L-alanine Amidase - chemistry | Index Medicus | Cell Wall | Autolysis | Peptidoglycan | Streptococcus | Microbiology | Molecular Biology | Antibiotics | Pneumococcus | LytA | Medicin och hälsovetenskap
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10. Full Text In situ structure and assembly of the multidrug efflux pump AcrAB-TolC
by Shi, Xiaodong and Chen, Muyuan and Yu, Zhili and Bell,