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Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 34, pp. 20841 - 20855
Apoptosis is triggered by the activation of caspases and characterized by chromatin condensation and nuclear fragmentation (type II nuclear morphology).... 
CANCER-CELLS | IN-VITRO | HUMAN PROMONOCYTIC CELLS | CORTICAL-NEURONS | DNA FRAGMENTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYDROGEN-PEROXIDE | GLUTATHIONE DEPLETION | HIPPOCAMPAL-NEURONS | NECROSIS-APOPTOSIS SWITCH | MOLECULAR-MECHANISMS | Chromatin - metabolism | Colchicine - pharmacology | Apoptosis - drug effects | Humans | Nocodazole - pharmacology | Apoptosis - genetics | Quinolines - pharmacology | Caspases - metabolism | Amino Acid Chloromethyl Ketones - pharmacology | Rotenone - pharmacology | Antineoplastic Agents - pharmacology | Microfilament Proteins - metabolism | Chromatin - drug effects | Microfilament Proteins - genetics | Chromatin - ultrastructure | Peptidomimetics - pharmacology | Signal Transduction | Caspases - genetics | Neurons | Antibodies, Monoclonal - pharmacology | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Enzyme Activation - drug effects | Benzophenanthridines - pharmacology | Necrosis - chemically induced | Carrier Proteins - genetics | Carrier Proteins - metabolism | Cell Line, Tumor | Thapsigargin - pharmacology | Necrosis - genetics | Necrosis - enzymology | Staurosporine - pharmacology | Index Medicus | DNA and Chromosomes | apoptotic nuclear morphology | cell death | thiolic oxidative stress | chelerythrine | apoptosis | necrosis (necrotic death) | oxidative stress | caspase
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e84248 - e84248
Since the serendipitous discovery of cisplatin, platinum-based drugs have become well-established antitumor agents, despite the fact that their clinical use is... 
20S PROTEASOME | DESIGN | CANCER CELLS | MULTIDISCIPLINARY SCIENCES | COMPLEXES | OLIGOPEPTIDES | BORTEZOMIB | GOLD(III) DITHIOCARBAMATE DERIVATIVES | PROTEASOME INHIBITORS | COUPLED PEPTIDE TRANSPORTERS | APOPTOSIS INDUCERS | Free Radical Scavengers - pharmacology | Apoptosis - drug effects | Humans | Antineoplastic Agents - administration & dosage | Molecular Targeted Therapy | Peptidomimetics - administration & dosage | Thiocarbamates - pharmacology | Chromans - pharmacology | Organogold Compounds - administration & dosage | Drug Design | Female | Antineoplastic Agents - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Organogold Compounds - chemistry | Disease Models, Animal | Peptidomimetics - pharmacology | Thiocarbamates - administration & dosage | Proteasome Inhibitors - pharmacology | Peptidomimetics - chemistry | Cisplatin - pharmacology | Thiocarbamates - chemistry | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Organogold Compounds - pharmacology | Tumor Burden - drug effects | Breast Neoplasms - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Proteasome Endopeptidase Complex - metabolism | Chemotherapy | Peptides | Health aspects | Cancer | Drugs | Delivery systems | Clinical trials | Homeostasis | Oncology | Biochemistry | Metastasis | Kinases | Cancer therapies | Anticancer properties | Proteins | Antitumor agents | Platinum | Xenografts | Cell cycle | Inhibition | Sulfur | Gold | Enzymes | Medical research | Departments | Cultures | Breast cancer | Pharmacology | Shrinkage | Cisplatin | Medicine | Pathology | Chemistry | Side effects | Peptidomimetics | Breast | Ligands | Drug discovery | Prostate cancer | Apoptosis | Index Medicus
Journal Article
Peptides, ISSN 0196-9781, 05/2017, Volume 91, pp. 40 - 48
We previously reported a series of novel endomorphin analogs with unnatural amino acid modifications. These analogs display good binding affinity and... 
Spinal antinociception | Antagonist | Endomorphin | Antibody | Dynorphin | CORD | MORPHINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | INVOLVEMENT | RELEASE | MU-OPIOID RECEPTOR | POTENT | PEPTIDOMIMETICS | ADMINISTERED ENDOMORPHIN-1 | ENDOCRINOLOGY & METABOLISM | PHARMACOLOGY & PHARMACY | ANALGESIA | Analgesics, Opioid - antagonists & inhibitors | Naltrexone - analogs & derivatives | Opioid Peptides - pharmacology | Analgesics, Opioid - pharmacology | Male | Enkephalin, Leucine - administration & dosage | Opioid Peptides - administration & dosage | Receptors, sigma - antagonists & inhibitors | Dynorphins - chemistry | Enkephalin, Methionine - pharmacology | Pain - metabolism | Enkephalin, Leucine - antagonists & inhibitors | Naltrexone - pharmacology | Enkephalin, Methionine - chemistry | Pain - drug therapy | Enkephalin, Leucine - pharmacology | Analgesics, Opioid - chemistry | Antibodies - immunology | Enkephalin, Methionine - administration & dosage | Naltrexone - administration & dosage | Oligopeptides - chemistry | Enkephalin, Methionine - antagonists & inhibitors | Injections, Spinal | Oligopeptides - antagonists & inhibitors | Receptors, Opioid, kappa - antagonists & inhibitors | Receptors, Opioid, mu - antagonists & inhibitors | Dynorphins - antagonists & inhibitors | Enkephalin, Leucine - chemistry | Analgesia | Opioid Peptides - chemistry | Animals | Dynorphins - administration & dosage | Analysis of Variance | Analgesics, Opioid - administration & dosage | Naloxone - pharmacology | Opioid Peptides - antagonists & inhibitors | Narcotic Antagonists - pharmacology | Dynorphins - pharmacology | Mice | Oligopeptides - administration & dosage | Naloxone - administration & dosage | Oligopeptides - pharmacology | Pain Measurement | Fluorine - chemistry | Viral antibodies | Antibodies | Yuan (China) | Analysis | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 13, pp. 3526 - 3533
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2017, Volume 60, Issue 16, pp. 6991 - 6997
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2016, Volume 60, Issue 10, pp. 5995 - 6002
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 28, pp. 24882 - 24895
BH3 mimetics are small molecules designed or discovered to mimic the binding of BH3-only proteins to the hydrophobic groove of antiapoptotic BCL2 proteins. The... 
CYTOCHROME-C | APOPTOSIS | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | SENSITIVITY | BAX | BCL-2 PROTEINS | INHIBITORS | RELEASE | CELL-DEATH | Humans | Peptide Fragments - pharmacology | Endoplasmic Reticulum Stress - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Apoptosis Regulatory Proteins - genetics | bcl-Associated Death Protein - metabolism | Membrane Proteins - metabolism | Activating Transcription Factor 3 - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - pharmacology | bcl-Associated Death Protein - genetics | Peptidomimetics - pharmacology | Endoplasmic Reticulum Stress - drug effects | Membrane Proteins - genetics | Activating Transcription Factor 4 - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Signal Transduction - genetics | Sulfonamides - pharmacology | Activating Transcription Factor 3 - metabolism | Piperazines - pharmacology | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Apoptosis Regulatory Proteins - metabolism | Up-Regulation - drug effects | Activating Transcription Factor 4 - metabolism | Signal Transduction - drug effects | Myeloid Cell Leukemia Sequence 1 Protein | K562 Cells | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Index Medicus | BH3 Mimetics | Vinblastine | ER Stress | Leukemia | Microtubules | BCL2 | Anticancer Drug | Cell Biology | Apoptosis | MCL1
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2012, Volume 55, Issue 7, pp. 3076 - 3087
Furoxans (1,2,5-oxadiazole-N-oxides) are thiol-bioactivated NO-mimetics that have not hitherto been studied in the CNS. Incorporation of varied substituents... 
IN-VITRO | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | THERAPEUTIC AGENTS | MOUSE MODEL | NITRIC-OXIDE | BIOLOGICAL EVALUATION | NITRATE ESTER | LONG-TERM POTENTIATION | HIPPOCAMPAL-NEURONS | PROTEASE INHIBITORS | Nitric Oxide Donors - chemistry | Peptidomimetics - chemical synthesis | Stereoisomerism | Crystallography, X-Ray | Neurons - cytology | Guanylate Cyclase - antagonists & inhibitors | Structure-Activity Relationship | Hippocampus - drug effects | Quinoxalines - pharmacology | Neuroprotective Agents - pharmacology | Long-Term Potentiation - drug effects | Oxadiazoles - pharmacology | Cysteine - metabolism | Nitric Oxide Donors - pharmacology | Neurons - drug effects | Oxadiazoles - chemistry | Synapses - drug effects | Peptidomimetics - pharmacology | Neuroprotective Agents - chemistry | Oxadiazoles - chemical synthesis | Signal Transduction | Amyloid beta-Peptides - toxicity | Synapses - physiology | Cells, Cultured | Rats | Nitric Oxide - physiology | Soluble Guanylyl Cyclase | Peptidomimetics - chemistry | Nootropic Agents - chemical synthesis | Nootropic Agents - chemistry | Neuroprotective Agents - chemical synthesis | Animals | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Nitric Oxide Donors - chemical synthesis | Hippocampus - physiology | In Vitro Techniques | Nootropic Agents - pharmacology | Index Medicus | OXYGEN | THIOLS | PEPTIDES | LEARNING | CELL CULTURES | GLUCOSE | INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY | THERAPEUTIC USES | MODULATION | Neuroprotection | Furoxan | Alzheimer's disease | Amyloid Beta | Nitric oxide | Synaptic plasticity
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2016, Volume 114, pp. 59 - 64
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2012, Volume 11, Issue 9, pp. 1936 - 1947
Src kinase is elevated in breast tumors that are ER/PR negative and do not overexpress HER2, but clinical trials with Src inhibitors have shown little... 
CELLS | LUNG | INVADOPODIA | ANGIOGENESIS | ONCOLOGY | QUANTIFICATION | DASATINIB | IDENTIFICATION | CARCINOMA | NEGATIVE BREAST-CANCER | C-SRC | Paclitaxel - pharmacology | Apoptosis - drug effects | Tubulin Modulators - pharmacology | Humans | Receptor, ErbB-2 - metabolism | Acetamides - pharmacology | Antineoplastic Agents - therapeutic use | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Acetamides - therapeutic use | Lung Neoplasms - secondary | src-Family Kinases - metabolism | Estrogen Receptor alpha - metabolism | Female | Neovascularization, Pathologic - prevention & control | Antineoplastic Agents - pharmacology | Neoplasm Micrometastasis - prevention & control | Focal Adhesion Kinase 1 - metabolism | Pyridines - therapeutic use | Dasatinib | Peptidomimetics - pharmacology | Neoplasm Invasiveness | Breast Neoplasms - blood supply | Pyrimidines - pharmacology | Breast Neoplasms - drug therapy | Paclitaxel - therapeutic use | Tubulin Modulators - therapeutic use | Drug Synergism | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Lung Neoplasms - prevention & control | Tumor Burden - drug effects | Breast Neoplasms - pathology | Mice, Nude | Peptidomimetics - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Pyridines - pharmacology | Thiazoles - pharmacology | Index Medicus | microtubule | paclitaxel | Breast cancer | KX-01 (KX2-391) | src | preclinical
Journal Article
Journal Article
The FEBS Journal, ISSN 1742-464X, 08/2018, Volume 285, Issue 16, pp. 3077 - 3096
Four plasmepsins (PMs) in the food vacuole of Plasmodium falciparum degrade human hemoglobin. Being responsible for the survival of the parasite makes them... 
inhibitors | plasmepsins | drug designing | malaria | crystal structures | KNI | KNI inhibitors | DESIGN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTAL-STRUCTURES | DIGESTIVE VACUOLE | HEMOGLOBIN DEGRADATION | ASPARTIC PROTEASE | REFINEMENT | IN-VITRO | DISRUPTION | PLASMODIUM-FALCIPARUM | FALCIPARUM FOOD VACUOLE | Recombinant Fusion Proteins - isolation & purification | Humans | Crystallography, X-Ray | Aspartic Acid Endopeptidases - genetics | Plasmodium falciparum - drug effects | Recombinant Fusion Proteins - metabolism | Isoquinolines - chemistry | Protease Inhibitors - pharmacology | Isoquinolines - pharmacology | Molecular Targeted Therapy - methods | Aspartic Acid Endopeptidases - chemistry | Drug Evaluation, Preclinical - methods | Peptidomimetics - pharmacology | Aspartic Acid Endopeptidases - antagonists & inhibitors | Ethylenediamines - chemistry | Hemoglobins - metabolism | Protease Inhibitors - chemistry | Peptidomimetics - chemistry | Ethylenediamines - pharmacology | Antimalarials - pharmacology | Aspartic Acid Endopeptidases - metabolism | Antimalarials - chemistry | Recombinant Fusion Proteins - genetics | Protein Conformation | Thiazoles - chemistry | Thiazoles - pharmacology | Malaria | Proteases | Crystals | Hemoglobin | Drug discovery | Drug therapy, Combination | Structure | Drug resistance | Cells | Vector-borne diseases | Toxicity | Blocking | Cytotoxicity | Optimization | Antimalarial activity | Inhibitors | Antimalarial agents | Food vacuoles | Catabolism | Bonding | Crystal structure | Recombinant | Index Medicus | Crystal structures | Plasmepsins | Drug-designing
Journal Article