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humans (327) 327
animals (255) 255
index medicus (202) 202
peptidylprolyl isomerase - antagonists & inhibitors (200) 200
peptidylprolyl isomerase - metabolism (183) 183
peptidylprolyl isomerase (181) 181
biochemistry & molecular biology (159) 159
nima-interacting peptidylprolyl isomerase (155) 155
peptidylprolyl isomerase - genetics (107) 107
mice (104) 104
phosphorylation (102) 102
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amino acid sequence (96) 96
molecular sequence data (95) 95
cyclosporine - pharmacology (92) 92
carrier proteins - metabolism (81) 81
protein binding (81) 81
cyclophilin (74) 74
cyclosporine-a (69) 69
cell biology (68) 68
pin1 (67) 67
amino acid isomerases - antagonists & inhibitors (66) 66
carrier proteins - antagonists & inhibitors (65) 65
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tacrolimus binding proteins (45) 45
base sequence (43) 43
immunosuppressive agents - pharmacology (42) 42
cell line (41) 41
isomerization (41) 41
prolyl isomerase pin1 (41) 41
enzyme inhibitors - chemistry (40) 40
expression (40) 40
signal transduction (40) 40
carrier proteins - genetics (38) 38
multidisciplinary sciences (37) 37
article (36) 36
cloning, molecular (36) 36
inhibition (36) 36
peptidylprolyl isomerase - chemistry (36) 36
phosphoprotein phosphatases - antagonists & inhibitors (36) 36
structure-activity relationship (36) 36
chemistry, medicinal (35) 35
binding (34) 34
escherichia-coli (34) 34
activation (33) 33
binding-protein (33) 33
models, molecular (33) 33
cyclosporine - metabolism (32) 32
gene expression (32) 32
naphthoquinones - pharmacology (32) 32
oncology (32) 32
cis-trans isomerase (31) 31
hela cells (31) 31
signal transduction - drug effects (31) 31
amino acid isomerases - genetics (30) 30
catalysis (30) 30
cyclosporin a (30) 30
biophysics (29) 29
neurosciences (29) 29
peptidyl-prolyl isomerase (29) 29
substrate specificity (29) 29
breast-cancer (28) 28
cyclosporins - pharmacology (28) 28
fk506 (28) 28
mutation (28) 28
protein folding (28) 28
sequence homology, amino acid (28) 28
tacrolimus - analogs & derivatives (28) 28
blotting, western (27) 27
cyclophilins - antagonists & inhibitors (27) 27
protein conformation (27) 27
tacrolimus (27) 27
phosphoprotein phosphatases - metabolism (26) 26
cell proliferation - drug effects (25) 25
cyclophilins - metabolism (25) 25
enzymes (25) 25
protein structure, tertiary (25) 25
antineoplastic agents - pharmacology (24) 24
biochemistry (24) 24
calmodulin-binding proteins - antagonists & inhibitors (24) 24
cell cycle (24) 24
cells (24) 24
nima-interacting peptidylprolyl isomerase - antagonists & inhibitors (24) 24
nima-interacting peptidylprolyl isomerase - metabolism (24) 24
peptidylprolyl isomerase - physiology (24) 24
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Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 2011, Volume 42, Issue 2, pp. 147 - 159
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7547, pp. 378 - 382
Infectious agents develop intricate mechanisms to interact with host cell pathways and hijack their genetic and epigenetic machinery to change host cell... 
ARABIDOPSIS-THALIANA | CIS/TRANS ISOMERASE | UBIQUITIN LIGASE | DOCKING | MULTIDISCIPLINARY SCIENCES | IN-VIVO | PIN1 | BUPARVAQUONE | ANNULATA | C-JUN | CANCER | Host-parasite relationships | Isomerases | Theileria | Leukocytes | Health aspects | Identification and classification | Proteins | Leucocytes | Signal transduction | Peptides | Genomics | Parasites | Mutation
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2013, Volume 288, Issue 30, pp. 21955 - 21971
Parkinson disease (PD) is a chronic neurodegenerative disease characterized by a slow and progressive degeneration of dopaminergic neurons in substantia nigra.... 
Neurodegenerative Diseases | Neuroprotection | Dopamine | PROTEIN | Juglone | PHOSPHORYLATION | ALZHEIMERS-DISEASE | SERINE 129 | BIOCHEMISTRY & MOLECULAR BIOLOGY | Neurobiology | COUPLED RECEPTOR KINASES | ALPHA-SYNUCLEIN | Caspase-3 | CELL-DEATH | Parkinson Disease | CIS/TRANS ISOMERASES | NONMOTOR SYMPTOMS | MOUSE MODEL | Pin1 | MPTP | Immunohistochemistry | Up-Regulation | Gene Expression - drug effects | Humans | Motor Activity - drug effects | Peptidylprolyl Isomerase - antagonists & inhibitors | Immunoblotting | Male | Substantia Nigra - metabolism | Dopaminergic Neurons - cytology | Brain - metabolism | RNA Interference | Dopaminergic Neurons - metabolism | Dopaminergic Neurons - drug effects | Parkinson Disease, Secondary - metabolism | Peptidylprolyl Isomerase - metabolism | Parkinson Disease, Secondary - chemically induced | Peptidylprolyl Isomerase - genetics | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | Parkinson Disease - pathology | RNA-Directed DNA Polymerase | 1-Methyl-4-phenylpyridinium - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Naphthoquinones - pharmacology | NIMA-Interacting Peptidylprolyl Isomerase | Parkinson Disease - genetics | Brain - drug effects | Neurotoxins - pharmacology | Substantia Nigra - drug effects | Animals | Parkinson Disease, Secondary - genetics | Parkinson Disease - enzymology | Mice | Apoptosis - physiology | Index Medicus | Molecular Bases of Disease
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 01/2014, Volume 6, Issue 1, pp. 99 - 119
Mammary epithelial stem cells are fundamental to maintain tissue integrity. Cancer stem cells (CSCs) are implicated in both treatment resistance and disease... 
stem cells | breast cancer | Fbxw7 E3 ubiquitin‐ligase | prolyl‐isomerase Pin1 | Notch | Breast cancer | Prolyl-isomerase Pin1 | Fbxw7 E3 ubiquitin-ligase | Stem cells | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | ACTIVATION | prolyl-isomerase Pin1 | PHOSPHORYLATION | MOLECULAR HETEROGENEITY | P53 | EPITHELIAL-MESENCHYMAL TRANSITION | THERAPEUTIC TARGET | TUMOR-SUPPRESSOR | GROWTH-FACTOR | F-Box-WD Repeat-Containing Protein 7 | Neoplastic Stem Cells - cytology | Receptors, Notch - metabolism | Humans | Peptidylprolyl Isomerase - antagonists & inhibitors | Receptors, Notch - genetics | Transplantation, Heterologous | Antineoplastic Agents - therapeutic use | Stem Cells - cytology | Stem Cells - metabolism | Breast Neoplasms - metabolism | Neoplastic Stem Cells - metabolism | Triple Negative Breast Neoplasms - pathology | Cell Cycle Proteins - genetics | Female | Peptidylprolyl Isomerase - metabolism | Peptidylprolyl Isomerase - genetics | Proto-Oncogene Proteins - metabolism | Mammary Glands, Human - cytology | Signal Transduction | F-Box Proteins - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Proto-Oncogene Proteins - genetics | NIMA-Interacting Peptidylprolyl Isomerase | Receptor, Notch1 - metabolism | Mice, SCID | Breast Neoplasms - drug therapy | Mice, Knockout | Animals | Breast Neoplasms - pathology | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | Mice | Receptor, Notch1 - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Receptor, Notch4 | Ubiquitin | Ligases | Phenotypes | Phosphorylation | Metastasis | Gene expression | Kinases | Pin1 protein | Experiments | Metastases | Signal transduction | Disease resistance | Cell fate | Proteasomes | Breast | Mutation | Ubiquitin-protein ligase | Tumors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2017, Volume 292, Issue 28, pp. 11886 - 11895
The prolyl isomerase Pin1 binds to the phosphorylated Ser/Thr-Pro motif of target proteins and enhances their cis-trans conversion. This report is the first to... 
PATHOGENESIS | TRANSCRIPTIONAL ACTIVITY | OBESITY | PROTEIN | ISLET HYPERPLASIA | CYCLIN D1 | COMPENSATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | RESISTANCE | NONALCOHOLIC STEATOHEPATITIS | NIMA-Interacting Peptidylprolyl Isomerase - metabolism | Cell Proliferation | Humans | Diet, High-Fat - adverse effects | NIMA-Interacting Peptidylprolyl Isomerase - antagonists & inhibitors | Recombinant Fusion Proteins - metabolism | Insulin-Secreting Cells - metabolism | NIMA-Interacting Peptidylprolyl Isomerase - chemistry | RNA Interference | Mice, Mutant Strains | Obesity - etiology | Insulin-Secreting Cells - cytology | Binding Sites | Insulin Secretion | Calcium Signaling | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Protein-Serine-Threonine Kinases - genetics | Enzyme Induction | Mice, Transgenic | NIMA-Interacting Peptidylprolyl Isomerase - genetics | Recombinant Fusion Proteins - chemistry | Mice, Knockout | Obesity - metabolism | Obesity - pathology | Insulin - metabolism | Animals | Recombinant Fusion Proteins - genetics | Diet, Carbohydrate Loading - adverse effects | Protein-Serine-Threonine Kinases - chemistry | Mutation | Amino Acid Substitution | Insulin-Secreting Cells - enzymology | pancreatic islet | salt inducible kinase | cell proliferation | prolyl isomerase | insulin secretion | Metabolism | diabetes
Journal Article