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Journal of Immunotherapy, ISSN 1524-9557, 07/2012, Volume 35, Issue 6, pp. 488 - 501
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1473 - 13
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0146279 - e0146279
Indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing intracellular enzyme of the L-kynurenine pathway, causes preneoplastic cells and tumor cells to... 
HEPATOCELLULAR-CARCINOMA | INHIBITION | DENDRITIC CELLS | IDO | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | PRENEOPLASTIC LESIONS | CHRONIC INFLAMMATION | EXPRESSION | TRYPTOPHAN CATABOLISM | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Pore Forming Cytotoxic Proteins - genetics | Pore Forming Cytotoxic Proteins - biosynthesis | Kynurenine - biosynthesis | Neoplasm Proteins - physiology | Tumor Necrosis Factor-alpha - genetics | Gene Expression Regulation, Neoplastic | Liver Neoplasms, Experimental - chemically induced | Adenoma - immunology | Male | Indoleamine-Pyrrole 2,3,-Dioxygenase - deficiency | Granzymes - genetics | Liver Neoplasms, Experimental - immunology | Kynurenine - physiology | T-Lymphocytes, Regulatory - immunology | Cyclooxygenase 2 - biosynthesis | Adenoma - enzymology | Cyclooxygenase 2 - genetics | Diethylnitrosamine | Granzymes - biosynthesis | Interferon-gamma - genetics | Neoplasm Proteins - genetics | T-Lymphocytes, Cytotoxic - immunology | Forkhead Transcription Factors - biosynthesis | Precancerous Conditions - enzymology | Mice, Inbred C57BL | Immune Tolerance | CD8 Antigens - biosynthesis | Forkhead Transcription Factors - genetics | Disease Progression | Mice, Knockout | Animals | CD8 Antigens - genetics | Liver Neoplasms, Experimental - enzymology | Mice | Precancerous Conditions - chemically induced | Tumor Necrosis Factor-alpha - biosynthesis | Adenoma - chemically induced | Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology | Interferon-gamma - biosynthesis | Oxidases | Liver cancer | Immune response | Development and progression | Genetic aspects | Regulation | Gene expression | Health aspects | CD8 antigen | Liver | Hepatocellular carcinoma | Tryptophan 2,3-dioxygenase | Infections | Adenoma | Kinases | Carcinogenesis | Neoplasms | Hepatitis | Carcinogens | Cell growth | Escape systems | Granzyme B | Lymphocytes | Rodents | Foxp3 protein | Lesions | Perforin | Immune system | University graduates | Enzymes | Antigens | Internal medicine | Tumor cells | Tryptophan | Inflammation | Tumor necrosis factor-α | Immunological tolerance | Medicine | Medical prognosis | γ-Interferon | Interferon | Clinical medicine | Cyclooxygenase-2 | Tumors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2011, Volume 108, Issue 8, pp. 3324 - 3329
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2003, Volume 171, Issue 11, pp. 6039 - 6045
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2017, Volume 23, Issue 3, pp. 804 - 813
Purpose: Immunotherapy of high-risk neuroblastoma using the anti-GD2 antibody dinutuximab induces antibody-dependent cell-mediated cytotoxicity (ADCC).... 
BREAST-CANCER | RECEPTOR KINASE INHIBITOR | TGF-BETA | GAMMA PRODUCTION | METASTASIS | ONCOLOGY | GROWTH | TUMOR-TISSUE | ANTITUMOR-ACTIVITY | EX-VIVO | CYTOTOXICITY | Receptor, Transforming Growth Factor-beta Type I | Receptors, Transforming Growth Factor beta - genetics | Humans | Neoplasm Proteins - physiology | Male | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Receptors, Transforming Growth Factor beta - physiology | Smad2 Protein - antagonists & inhibitors | Quinolines - pharmacology | RNA, Messenger - biosynthesis | Protein Processing, Post-Translational - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Phosphorylation - drug effects | Neuroblastoma - pathology | Transforming Growth Factor beta1 - biosynthesis | Pyrazoles - pharmacology | Killer Cells, Natural - transplantation | Specific Pathogen-Free Organisms | Immunotherapy, Adoptive | Protein-Serine-Threonine Kinases - physiology | Antibodies, Monoclonal - pharmacology | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Smad2 Protein - metabolism | Transforming Growth Factor beta1 - genetics | Transforming Growth Factor beta1 - physiology | Antineoplastic Agents, Immunological - pharmacology | Drug Synergism | Protein-Serine-Threonine Kinases - biosynthesis | Xenograft Model Antitumor Assays | Receptors, Transforming Growth Factor beta - biosynthesis | Animals | RNA, Neoplasm - biosynthesis | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Cell Line, Tumor | RNA, Neoplasm - genetics | Mice, Inbred NOD | Mice | Neuroblastoma - metabolism | Cytotoxicity, Immunologic | Phosphorylation | Smad protein | Severe combined immunodeficiency | Toxicity | Cytotoxicity | Activation | Neuroblastoma | Blood | Neuroblastoma cells | NKG2 antigen | Receptors | Smad2 protein | Immunotherapy | Xenografts | Bone marrow | Plasmas | CD226 antigen | Natural killer cells | Perforin | Antibody-dependent cell-mediated cytotoxicity | Cell survival | Transforming growth factor-b1 | Risk groups | Gene expression | Experimental design | Cell lines | TRAIL protein | Bone | Tumors | Cancer | TGFβR1 inhibitor | dinutuximab | adoptive cell therapy | galunisertib | immunotherapy
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 12/2014, Volume 96, Issue 6, pp. 1119 - 1129
NK cells directly kill mycobacteria through a contactdependent mechanism leading to the release of perforin and granulysin. Although the mechanisms underlying... 
antibacterial activity | NKG2D | innate immunity | NCR | tuberculosis | Antibacterial activity | Innate immunity | Tuberculosis | FUNCTIONAL-CHARACTERIZATION | IMMUNOLOGY | CELL BIOLOGY | MEDIATED CYTOLYSIS | MEMBRANE-BINDING | MICROBICIDAL ACTIVITY | HOST-DEFENSE | ACTIVATING RECEPTORS | PORE-FORMING PROTEIN | HEMATOLOGY | CYTOTOXICITY | T-CELLS | Natural Cytotoxicity Triggering Receptor 2 - biosynthesis | Bacteriolysis - drug effects | Transcription, Genetic - drug effects | MAP Kinase Signaling System - physiology | Perforin - genetics | Humans | Nanotubes | Natural Cytotoxicity Triggering Receptor 3 - genetics | Cell Wall - drug effects | RNA Interference | Natural Cytotoxicity Triggering Receptor 3 - biosynthesis | Antigens, Differentiation, T-Lymphocyte - physiology | Killer Cells, Natural - immunology | Natural Cytotoxicity Triggering Receptor 2 - antagonists & inhibitors | Killer Cells, Natural - secretion | RNA, Small Interfering - pharmacology | Mycobacterium kansasii | Natural Cytotoxicity Triggering Receptor 3 - antagonists & inhibitors | NK Cell Lectin-Like Receptor Subfamily K - genetics | Bacteriolysis - physiology | NK Cell Lectin-Like Receptor Subfamily K - biosynthesis | Killer Cells, Natural - ultrastructure | MAP Kinase Signaling System - drug effects | NK Cell Lectin-Like Receptor Subfamily K - antagonists & inhibitors | Mycobacterium tuberculosis | Antigens, Differentiation, T-Lymphocyte - genetics | Cell Line, Tumor | Natural Cytotoxicity Triggering Receptor 2 - genetics | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Antigens, Differentiation, T-Lymphocyte - pharmacology | Perforin - secretion | Perforin - biosynthesis | Perforin - pharmacology
Journal Article
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 07/2013, Volume 173, Issue 1, pp. 150 - 160
Summary Bronchiolitis obliterans syndrome (BOS) is associated with lack of immunosuppression of T cell proinflammatory cytokines and increased T cell granzyme... 
proinflammatory T cells | lung transplant | BOS | CD28null | CD28 | Lung transplant | Proinflammatory T cells | LUNG | TOLERANCE | IMMUNOLOGY | T-Lymphocyte Subsets - immunology | Up-Regulation | Postoperative Complications - etiology | Receptors, OX40 - genetics | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Male | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | CTLA-4 Antigen - biosynthesis | Costimulatory and Inhibitory T-Cell Receptors - biosynthesis | Postoperative Complications - immunology | Case-Control Studies | Lung Transplantation | CD28 Antigens - analysis | Perforin - analysis | Adult | Female | Interferon-gamma - genetics | Granzymes - analysis | Costimulatory and Inhibitory T-Cell Receptors - genetics | Lymphocyte Activation | Bronchiolitis Obliterans - etiology | Bronchiolitis Obliterans - immunology | CD40 Ligand - biosynthesis | CTLA-4 Antigen - genetics | Cyclosporine - therapeutic use | Tacrolimus - therapeutic use | CD40 Ligand - genetics | T-Lymphocyte Subsets - metabolism | Receptors, OX40 - biosynthesis | Tumor Necrosis Factor-alpha - biosynthesis | Interferon-gamma - biosynthesis | Tumor Necrosis Factor Receptor Superfamily, Member 9 - biosynthesis | Biological response modifiers | T cells | Respiratory tract diseases | Animal Studies
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 09/2000, Volume 165, Issue 6, pp. 3058 - 3064
Allergic contact dermatitis (ACD) is the result of an exaggerated immune reaction to haptens mediated by skin-homing T cells, but the effector mechanisms... 
ALLERGIC CONTACT-DERMATITIS | FAS ANTIGEN | INTERFERON-GAMMA | CONSTITUTIVELY EXPRESS | LYMPHOCYTE-MEDIATED CYTOTOXICITY | DEFICIENT MICE | IMMUNOLOGY | CTL CLONES | EFFECTOR CD8(+) | LYTIC PATHWAYS | CULTURED KERATINOCYTES | T-Lymphocyte Subsets - immunology | Cytotoxicity Tests, Immunologic | Humans | Membrane Glycoproteins - biosynthesis | Serine Endopeptidases - physiology | CD4-Positive T-Lymphocytes - enzymology | fas Receptor - biosynthesis | CD4-Positive T-Lymphocytes - immunology | Nickel - immunology | RNA, Messenger - biosynthesis | Cytoplasmic Granules - enzymology | Dermatitis, Contact - immunology | Exocytosis - immunology | Membrane Glycoproteins - physiology | Intercellular Adhesion Molecule-1 - biosynthesis | Clone Cells | Histocompatibility Antigens Class I - biosynthesis | Pore Forming Cytotoxic Proteins | fas Receptor - physiology | Epitopes, T-Lymphocyte - immunology | Perforin | B-Lymphocytes - metabolism | T-Lymphocytes, Cytotoxic - immunology | Cell Line | Dermatitis, Contact - metabolism | CD4-Positive T-Lymphocytes - metabolism | Histocompatibility Antigens Class II - biosynthesis | Immunophenotyping | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | T-Lymphocytes, Cytotoxic - enzymology | Keratinocytes - immunology | Membrane Glycoproteins - genetics | Fas Ligand Protein | B-Lymphocytes - immunology | T-Lymphocytes, Cytotoxic - metabolism | Up-Regulation - immunology | Down-Regulation - immunology | Keratinocytes - metabolism | T-Lymphocyte Subsets - enzymology | T-Lymphocyte Subsets - metabolism | Ligands | Cytotoxicity, Immunologic - immunology | Cytoplasmic Granules - immunology | Cell Line, Transformed | Cytokines - biosynthesis
Journal Article
Immunologic Research, ISSN 0257-277X, 4/2012, Volume 52, Issue 1, pp. 139 - 156
NK cells have become a subject of investigation not only in the field of tumor immunology and infectious diseases, but also within all aspects of immunology,... 
Allergology | NK cells | Immunology | Medicine & Public Health | Malignancies | Cytokine modulation | Activating and inhibitory receptors | Internal Medicine | Perforin | Medicine/Public Health, general | NATURAL-KILLER-CELLS | HUMAN-BREAST-CANCER | IFN-GAMMA | INHIBITORY RECEPTORS | MELANOMA PATIENTS | IMMUNOLOGY | ANTIGEN-EXPRESSION | IN-VITRO | INTERFERON-ALPHA | PERIPHERAL-BLOOD LYMPHOCYTES | TNF-ALPHA | Immunotherapy - methods | Lymphocyte Activation | Receptors, KIR2DL3 - biosynthesis | Humans | L-Lactate Dehydrogenase - biosynthesis | Receptors, KIR2DL1 - biosynthesis | Th1 Cells - immunology | NK Cell Lectin-Like Receptor Subfamily K - biosynthesis | Th1 Cells - metabolism | Animals | Neoplasms - immunology | NK Cell Lectin-Like Receptor Subfamily B - biosynthesis | Killer Cells, Natural - immunology | Mice | Perforin - immunology | Perforin - metabolism | Killer Cells, Natural - metabolism | Cytokines - biosynthesis | Autoimmunity | Enzymes | Melanoma | Non-Hodgkin's lymphomas | Investigations | Cells | Fc receptors | Killer cells | Lymphocytes | Immunotherapy | Lymphomas | Universities and colleges | Tumors | Cancer | Cytokines | Helper cells | Cytotoxicity | Lymphocytes T | Malignancy | Lymph nodes | NKG2 antigen | Interleukin 2 | Peripheral blood | Natural killer cells | Immunoregulation | Tumor cells | Hypersensitivity | Data processing | Breast cancer | Cell membranes | Non-Hodgkin's lymphoma | L-Lactate dehydrogenase | Infectious diseases | Interferon | Kinetics | Receptor mechanisms | Autoimmune diseases | Hodgkin's disease
Journal Article