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Journal of Biological Chemistry, ISSN 0021-9258, 05/2009, Volume 284, Issue 21, pp. 14645 - 14656
Anthrolysin O (ALO) is a pore-forming, cholesterol-dependent cytolysin (CDC) secreted by Bacillus anthracis , the etiologic agent for anthrax. Growing evidence... 
LISTERIA-MONOCYTOGENES | TIGHT JUNCTIONS | CELLS | CONFORMATIONAL-CHANGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO MODEL | MEMBRANE INSERTION | THETA-TOXIN | PORE-FORMING TOXINS | PERFRINGOLYSIN-O | BIOLOGICAL WEAPON | Solubility - drug effects | Epithelial Cells - metabolism | Membrane Glycoproteins - metabolism | Calcium - metabolism | Bacteriocins - chemistry | Epithelial Cells - drug effects | Humans | Membrane Glycoproteins - chemistry | Protein Multimerization | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Hemolysin Proteins - chemistry | Occludin | Protein Binding - drug effects | Protein Structure, Quaternary | Membrane Proteins - metabolism | Bacteriocins - metabolism | Epithelial Cells - cytology | Bacillus anthracis - metabolism | Tight Junctions - drug effects | Caco-2 Cells | Protein Structure, Tertiary | Tight Junctions - metabolism | Amino Acid Sequence | Permeability - drug effects | Intracellular Space - drug effects | Protein Structure, Secondary | Perforin - chemistry | Models, Molecular | Bacillus anthracis - cytology | Cholesterol - metabolism | Bacterial Toxins - chemistry | Bacterial Toxins - metabolism | Intracellular Space - metabolism | Ionomycin - pharmacology | Bacterial Proteins - metabolism | Perforin - metabolism | Hemolysin Proteins - metabolism | Intestines - cytology | Life Sciences | Biochemistry, Molecular Biology | HUMAN POPULATIONS | PATHOGENESIS | ELEMENTS | CALCIUM | LIGHT SCATTERING | CRYSTAL STRUCTURE | DIMERIZATION | MATERIALS SCIENCE | BACILLUS | FUNCTIONS | PROTEINS | ULTRACENTRIFUGATION
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 153 - 158
Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial infection and danger signals. When activated, they cleave mouse and... 
LISTERIA-MONOCYTOGENES | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | MIXED LINEAGE KINASE | PERFORIN | NLRP3 INFLAMMASOME | INTRACELLULAR BACTERIA | GRANZYMES | CASPASE-1 ACTIVATION | GRANULYSIN | CELL-DEATH | Conserved Sequence - genetics | Inflammasomes - metabolism | Phosphatidylinositol Phosphates - metabolism | Pyroptosis - drug effects | Escherichia coli - drug effects | Humans | Molecular Sequence Data | Neoplasm Proteins - pharmacology | Escherichia coli - cytology | Neoplasm Proteins - metabolism | Escherichia coli - metabolism | Protein Multimerization - genetics | Listeria monocytogenes - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Listeria monocytogenes - cytology | Porosity - drug effects | Neoplasm Proteins - genetics | Cell Membrane - drug effects | Staphylococcus aureus - metabolism | Amino Acid Sequence | Cell Line | Microbial Viability - drug effects | Membrane Proteins - genetics | Mice, Inbred C57BL | Phosphatidylserines - metabolism | Neoplasm Proteins - chemistry | Cardiolipins - metabolism | Cell Membrane - ultrastructure | Protein Structure, Tertiary - genetics | Microscopy, Electron | Pyroptosis - genetics | Protein Transport | Liposomes - chemistry | Animals | Membrane Proteins - chemistry | Cell Membrane Permeability - drug effects | Staphylococcus aureus - cytology | Liposomes - metabolism | Mice | Mutation | Staphylococcus aureus - drug effects | Listeria monocytogenes - drug effects | Observations | Apoptosis | Proteins | Membranes | Bacterial infections | Immunology | Plasmids | Bacteria | Infections | Cells
Journal Article
Blood, ISSN 0006-4971, 02/2013, Volume 121, Issue 8, pp. 1345 - 1356
Journal Article
Blood, ISSN 0006-4971, 09/2007, Volume 110, Issue 6, pp. 1906 - 1915
Familial hemophagocytic lymphohistiocytosis (FHL) is typically an early onset, fatal disease characterized by a sepsislike illness with cytopenia,... 
NATURAL-KILLER-CELLS | GRANULE EXOCYTOSIS | IMMUNE-SYSTEM | MEDIATED CYTOTOXICITY | NK CELLS | DENDRITIC CELLS | FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS | CLASS-I | PERFORIN GENE-MUTATIONS | INHIBITORY RECEPTORS | HEMATOLOGY | Lymphohistiocytosis, Hemophagocytic - pathology | Pore Forming Cytotoxic Proteins - genetics | Cell Proliferation | Membrane Glycoproteins - metabolism | Homeodomain Proteins - metabolism | Humans | Child, Preschool | Infant | Male | Intracellular Signaling Peptides and Proteins - metabolism | Muscle Proteins - metabolism | Qa-SNARE Proteins - genetics | Adult | Female | Membrane Proteins - metabolism | Lymphohistiocytosis, Hemophagocytic - genetics | Perforin | Intracellular Signaling Peptides and Proteins - genetics | Lymphocytes - metabolism | Pore Forming Cytotoxic Proteins - metabolism | Cytokines - metabolism | LIM Domain Proteins | Membrane Proteins - genetics | Gene Expression Regulation | Lymphocytes - cytology | Transcription Factors - genetics | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Muscle Proteins - genetics | Transcription Factors - metabolism | Killer Cells, Natural - cytology | Lymphocyte Subsets | Lymphohistiocytosis, Hemophagocytic - metabolism | Qa-SNARE Proteins - metabolism | LIM-Homeodomain Proteins | Killer Cells, Natural - metabolism | Immunobiology
Journal Article
Journal Article
Reproduction, ISSN 1470-1626, 2017, Volume 154, Issue 6, pp. 815 - 825
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 12/2006, Volume 203, Issue 13, pp. 2865 - 2877
Journal Article
Immunity, ISSN 1074-7613, 2009, Volume 31, Issue 1, pp. 99 - 109
Cytotoxic lymphocytes kill target cells by releasing the content of secretory lysosomes at the immune synapse. To understand the dynamics and control of... 
MOLIMMUNO | CELLIMMUNO | CELL IMMUNOLOGICAL SYNAPSE | RING JUNCTION | ACTIVATION | NK CELLS | RECOGNITION | COSTIMULATION | IMMUNOLOGY | RECEPTORS | POLARIZATION | CONTRIBUTES | T-CELLS | Antigens, CD - immunology | CD18 Antigens - immunology | Humans | NK Cell Lectin-Like Receptor Subfamily K - immunology | Lymphocyte Function-Associated Antigen-1 - metabolism | Immunological Synapses - metabolism | Antigens, CD - metabolism | Lymphocyte Function-Associated Antigen-1 - immunology | Lysosome-Associated Membrane Glycoproteins - immunology | Lysosomes - metabolism | NK Cell Lectin-Like Receptor Subfamily K - metabolism | Killer Cells, Natural - immunology | Perforin - immunology | Receptors, Immunologic - immunology | Lysosome-Associated Membrane Glycoproteins - metabolism | Intercellular Adhesion Molecule-1 - immunology | Signaling Lymphocytic Activation Molecule Family | Transport Vesicles - immunology | Cell Degranulation - immunology | CD18 Antigens - metabolism | Killer Cells, Natural - cytology | Intercellular Adhesion Molecule-1 - metabolism | Immunological Synapses - immunology | Perforin - metabolism | Killer Cells, Natural - metabolism | Lysosomes - immunology | Receptors, Immunologic - metabolism | Cytotoxicity, Immunologic | Medical colleges | Immunogenetics | Lymphocytes | Integrins | Proteins | Antigens | Insects | Microscopy | Cloning | Lipids | Cytotoxicity | Ligands | Infections | Immune system
Journal Article
Gastroenterology, ISSN 0016-5085, 2007, Volume 132, Issue 7, pp. 2328 - 2339
Journal Article
Journal Article
Nature immunology, ISSN 1529-2908, 2013, Volume 14, Issue 3, pp. 221 - 229
Journal Article