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1. Full Text Heterogeneity of systemic inflammatory responses to periodontal therapy
by Behle, Jan H and Sedaghatfar, Michael H and Demmer, Ryan T and Wolf, Dana L and Celenti, Romanita and Kebschull, Moritz and Belusko, Paul B and Herrera-Abreu, Miriam and Lalla, Evanthia and Papapanou, Panos N
Journal of Clinical Periodontology, ISSN 0303-6979, 04/2009, Volume 36, Issue 4, pp. 287 - 294
Behle JH, Sedaghatfar MH, Demmer RT, Wolf DL, Celenti R, Kebschull M, Belusko PB, Herrera-Abreu M, Lalla E, Papapanou PN. Heterogeneity of systemic... 
Periodontal therapy | Inflammatory mediators | Atherosclerotic vascular disease | Systemic inflammation | C-REACTIVE PROTEIN | AGGRESSIVE PERIODONTITIS | MARKERS | NECROSIS-FACTOR-ALPHA | PERIPHERAL-BLOOD | periodontal therapy | SERUM ANTIBODY | inflammatory mediators | systemic inflammation | ADHESION MOLECULE EXPRESSION | DENTISTRY, ORAL SURGERY & MEDICINE | ENDOTHELIAL-CELLS | CARDIOVASCULAR-DISEASE | INFECTION | atherosclerotic vascular disease | Prospective Studies | Humans | Middle Aged | Tumor Necrosis Factor-alpha - blood | E-Selectin - blood | Periodontitis - blood | Male | Inflammation - blood | Young Adult | Dental Plaque - microbiology | Dental Scaling | Alveolar Bone Loss - surgery | Oral Hygiene - education | Cardiovascular Diseases - blood | Periodontitis - surgery | Adult | Female | Intercellular Adhesion Molecule-1 - blood | C-Reactive Protein - analysis | Antibodies, Bacterial - blood | Matrix Metalloproteinase 9 - blood | Alveolar Bone Loss - therapy | Interleukins - blood | Inflammation Mediators - blood | Periodontitis - therapy | Linear Models | Plasminogen Activator Inhibitor 1 - blood | Serum Amyloid P-Component - analysis | Vascular Cell Adhesion Molecule-1 - blood | Adiponectin - blood | Adolescent | Aged | Peroxidase - blood | Alveolar Bone Loss - blood | Immunoglobulin G | Inflammation | Index Medicus | Dentistry
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2. Full Text Increased serum PCSK9, a potential biomarker to screen for periodontitis, and decreased total bilirubin associated with probing depth in a Japanese community survey
by Tabeta, K and Hosojima, M and Nakajima, M and Miyauchi, S and Miyazawa, H and Takahashi, N and Matsuda, Y and Sugita, N and Komatsu, Y and Sato, K and Ishikawa, T and Akiishi, K and Yamazaki, K and Kato, K and Saito, A and Yoshie, H
Journal of Periodontal Research, ISSN 0022-3484, 06/2018, Volume 53, Issue 3, pp. 446 - 456
Background and Objectives: Previous reports suggest that several serum biomarkers play roles in the pathogenesis, inflammatory response, and oxidative stress... 
proprotein convertase subtilisin/kexin type 9 | periodontitis | bilirubin | diagnosis | biomarker | serum | PCSK | proprotein convertase subtilisin/kexin type 9 (PCSK9) | RISK-FACTORS | PORPHYROMONAS-GINGIVALIS | MARKERS | MATRIX METALLOPROTEINASES | ANTIBODY-TITERS | LIPOPROTEIN | DENTISTRY, ORAL SURGERY & MEDICINE | CARDIOVASCULAR-DISEASE | INFECTION | INDEX | CORONARY-ARTERY-DISEASE | Cholesterol - blood | Humans | Middle Aged | Tumor Necrosis Factor-alpha - blood | Male | C-Reactive Protein - metabolism | Chronic Periodontitis - enzymology | Interleukin-6 - blood | Proprotein Convertase 9 - blood | Adult | Cholesterol, LDL - blood | Cross-Sectional Studies | Japan | Biomarkers - blood | Chronic Periodontitis - diagnosis | Lipoproteins - blood | Lipopolysaccharide Receptors - blood | Adiponectin - blood | Asian Continental Ancestry Group | Bilirubin - blood | Triglycerides - blood | Cholesterol, HDL - blood | Chronic Periodontitis - blood | Matrix Metalloproteinase 3 - blood | Longitudinal Studies | Cohort Studies | Surveys | Medical research | Blood circulation disorders | Bacterial infections | C-reactive protein | Interleukins | Periodontitis | Low density lipoproteins | Medicine, Experimental | Bilirubin | Blood lipids | Investigations | Lipoproteins (low density) | Oxidative stress | Lipids | Population studies | Subtilisin | Triglycerides | Inflammation | Matrix metalloproteinase | CD14 antigen | Cholesterol | Adiponectin | Serum lipids | Ankle | Kexin | Vascular diseases | Arteriosclerosis | Biomarkers | Aorta | Peroxidase | Metalloproteinase | Index Medicus | Dentistry
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3. Full Text Correlation of Toll‐Like Receptor 4, Interleukin‐18, Transaminases, and Uric Acid in Patients With Chronic Periodontitis and Healthy Adults
by Banu, Shaheena and Jabir, Nasimudeen R and Mohan, Rekha and Manjunath, Nanjappa C and Kamal, Mohammad Amjad and Vinod Kumar, Kopparam Rajendra and Zaidi, Syed Kashif and Khan, Mohd Shahnawaz and Tabrez, Shams
Journal of Periodontology, ISSN 0022-3492, 03/2015, Volume 86, Issue 3, pp. 431 - 439
Background: Because of the potential association between periodontal disease and inflammation, the purpose of the present study is to examine the level of... 
Toll‐like receptor 4 | transaminases | Enzyme‐linked immunosorbent assay | uric acid | interleukin‐18 | periodontitis | Uric acid | Periodontitis | Interleukin-18 | Transaminases | Enzyme-linked immunosorbent assay | Toll-like receptor 4 | CELLS | ACTIVATION | CYTOKINES | MARKERS | interleukin-18 | DENTISTRY, ORAL SURGERY & MEDICINE | DISEASE | LIPOPOLYSACCHARIDE | INFECTION | INFLAMMATORY RESPONSE | ASSOCIATION | EXPRESSION | Cholesterol - blood | Humans | Middle Aged | Male | Alanine Transaminase - blood | Saliva - chemistry | Insulin - blood | Transaminases - analysis | Interleukin-18 - analysis | Adult | Cholesterol, LDL - blood | Female | Uric Acid - blood | Toll-Like Receptor 4 - analysis | Periodontal Pocket - metabolism | Blood Glucose - analysis | Interleukin-18 - blood | Aspartate Aminotransferases - analysis | Biomarkers - analysis | Dental Plaque Index | Alanine Transaminase - analysis | Biomarkers - blood | Uric Acid - analysis | Toll-Like Receptor 4 - blood | Aspartate Aminotransferases - blood | Triglycerides - blood | Cholesterol, HDL - blood | Transaminases - blood | Aged | Chronic Periodontitis - blood | Chronic Periodontitis - metabolism | Periodontal Pocket - blood | Index Medicus | Dentistry
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4. Full Text Changes in Inflammatory and Metabolic Parameters After Periodontal Treatment in Patients With and Without Obesity
by Altay, Umut and Gürgan, Cem A and Ağbaht, Kemal
Journal of Periodontology, ISSN 0022-3492, 01/2013, Volume 84, Issue 1, pp. 13 - 23
Background: Non‐surgical periodontal treatment decreases serum levels of inflammatory cytokines in patients with and without obesity. However, the changes in... 
dyslipidemias | Cytokines | insulin resistance | leptin | obesity | periodontitis | Obesity | Insulin resistance | Dyslipidemias | Periodontitis | Leptin | C-REACTIVE PROTEIN | WEIGHT-LOSS | GINGIVAL CREVICULAR FLUID | LEPTIN LEVELS | NECROSIS-FACTOR-ALPHA | SERUM LEPTIN | INTERLEUKIN-6 | THERAPY | INSULIN-RESISTANCE | DENTISTRY, ORAL SURGERY & MEDICINE | DISEASE | Anti-Infective Agents, Local - therapeutic use | Root Planing - methods | Dyslipidemias - complications | Cholesterol - blood | Humans | Middle Aged | Tumor Necrosis Factor-alpha - blood | Male | Insulin - blood | Obesity - blood | Dyslipidemias - blood | Leptin - blood | Insulin Resistance - physiology | Interleukin-6 - blood | Lipids - blood | Adult | Cholesterol, LDL - blood | Female | Lipoprotein(a) - blood | C-Reactive Protein - analysis | Chronic Periodontitis - therapy | Chronic Periodontitis - complications | Periodontal Attachment Loss - classification | Blood Glucose - analysis | Obesity - complications | Inflammation Mediators - blood | Dental Plaque Index | Chlorhexidine - therapeutic use | Periodontal Index | Triglycerides - blood | Cholesterol, HDL - blood | Dental Scaling - methods | Index Medicus | Dentistry
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5. Full Text Aggressive and Chronic Periodontitis Correlate With Distinct Cellular Sources of Key Immunoregulatory Cytokines
by Lima, Patrícia Maria A and Souza, Paulo Eduardo A and Costa, José Eustáquio and Gomez, Ricardo Santiago and Gollob, Kenneth John and Dutra, Walderez Ornelas
Journal of Periodontology, ISSN 0022-3492, 01/2011, Volume 82, Issue 1, pp. 86 - 95
Background: Chronic periodontitis (CP) and aggressive periodontitis (AP) are inflammatory diseases and the main cause of dental loss in adults. We aimed to... 
monocytes | cell adhesion molecules | cytokines | T‐lymphocytes | chronic periodontitis | Aggressive periodontitis | Monocytes | T-lymphocytes | Chronic periodontitis | Cytokines | Cell adhesion molecules | MESSENGER-RNA EXPRESSION | PORPHYROMONAS-GINGIVALIS | CHAGAS-DISEASE | GINGIVAL CREVICULAR FLUID | ADULT PERIODONTITIS | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | DENTISTRY, ORAL SURGERY & MEDICINE | IN-VIVO | T-CELLS | DISEASE PROGRESSION | Humans | Middle Aged | Interleukin-10 - blood | Male | Monocytes - immunology | Antigens, Differentiation, T-Lymphocyte - blood | CD11a Antigen - blood | CD4-Positive T-Lymphocytes - immunology | Young Adult | Interleukin-12 - blood | CD11b Antigen - blood | Leukocytes, Mononuclear - immunology | Chronic Periodontitis - immunology | Adult | Female | Intercellular Adhesion Molecule-1 - blood | Cytokines - blood | Inflammation Mediators - immunology | Lectins, C-Type - blood | Lipopolysaccharide Receptors - blood | Macrophage-1 Antigen - blood | Tumor Necrosis Factor-alpha - analysis | Antigens, CD - blood | Interleukin-4 - blood | Aggressive Periodontitis - blood | Adolescent | Leukocytes - classification | Lymphocyte Function-Associated Antigen-1 - blood | Aggressive Periodontitis - immunology | Antigens, CD19 - blood | CD8-Positive T-Lymphocytes - immunology | Chronic Periodontitis - blood | Interferon-gamma - blood | Index Medicus | Dentistry
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6. Full Text Evaluation of Lipid Peroxidation and Oxidative DNA Damage in Patients With Periodontitis and Hyperlipidemia
by Fentoğlu, Özlem and Kırzıoğlu, F. Yeşim and Bulut, Memduha Tözüm and Kumbul Doğuç, Duygu and Kulaç, Esin and Önder, Canan and Günhan, Meral
Journal of Periodontology, ISSN 0022-3492, 05/2015, Volume 86, Issue 5, pp. 682 - 688
Background: The purpose of this study is to determine the serum levels of malondialdehyde (MDA), as a lipid peroxidation marker, and 8‐hydroxydeoxyguanosine... 
deoxyguanosine | lipids | malondialdehyde | Chronic periodontitis | oxidative stress | hyperlipidemias | Hyperlipidemias | Oxidative stress | Lipids | Deoxyguanosine | Malondialdehyde | PROTEIN OXIDATION | MARKER | TISSUE | GINGIVAL | SALIVA | RISK-FACTOR | DENTISTRY, ORAL SURGERY & MEDICINE | DISEASE | 8-HYDROXYDEOXYGUANOSINE | STRESS | ASSOCIATION | Deoxyguanosine - blood | Hyperlipidemias - genetics | Hyperlipidemias - blood | Cholesterol - blood | Humans | Middle Aged | Oxidative Stress - physiology | Male | Periodontal Attachment Loss - genetics | Case-Control Studies | Periodontal Pocket - genetics | DNA Damage - physiology | Chronic Periodontitis - genetics | Malondialdehyde - blood | Adult | Cholesterol, LDL - blood | Female | Deoxyguanosine - analogs & derivatives | Biomarkers - blood | Cholesterol, VLDL - blood | Lipid Peroxidation - physiology | Periodontal Attachment Loss - blood | Periodontal Index | Triglycerides - blood | Cholesterol, HDL - blood | Aged | Alveolar Bone Loss - genetics | Chronic Periodontitis - blood | Periodontal Pocket - blood | Alveolar Bone Loss - blood | Index Medicus | Dentistry
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7. Full Text Gingivitis and Periodontitis Are Related to Repeated High Levels of Circulating Tumor Necrosis Factor‐Alpha in Patients With Rheumatoid Arthritis
by Nilsson, Mikael and Kopp, Sigvard
Journal of Periodontology, ISSN 0022-3492, 09/2008, Volume 79, Issue 9, pp. 1689 - 1696
Background: Several studies have indicated a relationship between rheumatoid arthritis and periodontal disease. The aim of this study was to investigate the... 
cytokines | periodontal diseases | inflammation | tooth loss | rheumatoid factor | Blood | Periodontal diseases | Rheumatoid factor | Inflammation | Tooth loss | Cytokines | TEMPOROMANDIBULAR-JOINTS | JUVENILE IDIOPATHIC ARTHRITIS | blood | INFLAMMATORY MARKERS | TOBACCO SMOKING | BONE LOSS | RADIOGRAPHIC CHANGES | DENTISTRY, ORAL SURGERY & MEDICINE | DISEASE | TNF-ALPHA | HEALTH | PROGRESSION | Blood Platelets - pathology | Tooth Mobility - blood | Blood Sedimentation | Rheumatoid Factor - blood | Follow-Up Studies | Arthritis, Rheumatoid - blood | Humans | Middle Aged | Periodontitis - blood | Male | Interleukin-1beta - blood | Periodontal Pocket - complications | Serotonin - blood | Adult | Female | C-Reactive Protein - analysis | Furcation Defects - complications | Furcation Defects - blood | Inflammation Mediators - blood | Dinoprostone - blood | Gingival Hemorrhage - complications | Tooth Mobility - complications | Tumor Necrosis Factor-alpha - analysis | Gingival Hemorrhage - blood | Periodontal Attachment Loss - blood | Periodontal Attachment Loss - complications | Aged | Periodontitis - complications | Gingivitis - blood | Periodontal Pocket - blood | Gingivitis - complications | Index Medicus | Dentistry
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8. Full Text Serum Cytokine and Periodontal Profiles in Relation to Disease Activity of Rheumatoid Arthritis in Japanese Adults
by Kobayashi, Tetsuo and Yokoyama, Tomoko and Ishida, Kohei and Abe, Asami and Yamamoto, Kouji and Yoshie, Hiromasa
Journal of Periodontology, ISSN 0022-3492, 05/2010, Volume 81, Issue 5, pp. 650 - 657
Background: Rheumatoid arthritis (RA) and periodontitis are common chronic inflammatory conditions and share many pathologic features. A similar profile of... 
Arthritis, rheumatoid | cytokines | serum | C‐reactive protein | periodontitis | Rheumatoid | Serum | Arthritis | C-reactive protein | Cytokines | Periodontitis | BLOOD CELL-CULTURES | AGGRESSIVE PERIODONTITIS | ATTACHMENT LOSS | JUVENILE IDIOPATHIC ARTHRITIS | PERIPHERAL-BLOOD | GENE POLYMORPHISMS | rheumatoid | INTERLEUKIN-18 | INFLAMMATION | DENTISTRY, ORAL SURGERY & MEDICINE | INFECTION | Rheumatoid Factor - blood | Dental Plaque - classification | Arthritis, Rheumatoid - blood | Humans | Middle Aged | Periodontitis - blood | Dental Plaque - blood | Interleukin-12 Subunit p40 - blood | Male | Case-Control Studies | Interleukin-1beta - blood | Interleukin-12 - blood | Time Factors | Interleukin-6 - blood | Aged, 80 and over | Adult | Female | Arthritis, Rheumatoid - classification | C-Reactive Protein - analysis | Antirheumatic Agents - therapeutic use | Cytokines - blood | Severity of Illness Index | Periodontal Attachment Loss - classification | Periodontitis - classification | Disease Susceptibility | Interleukin-18 - blood | Periodontal Pocket - classification | Tumor Necrosis Factor-alpha - analysis | Gingival Hemorrhage - blood | Rheumatoid Nodule - classification | Periodontal Attachment Loss - blood | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Gingival Hemorrhage - classification | Aged | Periodontal Pocket - blood | Index Medicus | Dentistry
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9. Full Text Chronic Periodontitis and C‐Reactive Protein Levels
by Gomes‐Filho, Isaac Suzart and Freitas Coelho, Julita Maria and da Cruz, Simone Seixas and Passos, Johelle Santana and Teixeira de Freitas, Camila Oliveira and Aragão Farias, Naiara Silva and Amorim da Silva, Ruany and Silva Pereira, Milena Novais and Lima, Thiago Lopes and Barreto, Maurício Lima
Journal of Periodontology, ISSN 0022-3492, 07/2011, Volume 82, Issue 7, pp. 969 - 978
Background: This study aims to analyze the relationship between chronic periodontitis and C‐reactive protein (CRP) by considering associated variables in... 
inflammation | C‐reactive protein | myocardial infarction | periodontitis | Myocardial infarction | Inflammation | C-reactive protein | Periodontitis | INFECTIONS | RISK-FACTORS | MYOCARDIAL-INFARCTION | CARDIOVASCULAR EVENTS | MARKERS | STROKE | INCREASE | DENTISTRY, ORAL SURGERY & MEDICINE | CORONARY-HEART-DISEASE | ASSOCIATION | Body Mass Index | Diabetes Mellitus - blood | Myocardial Infarction - blood | Age Factors | Blood Glucose - analysis | Cross-Sectional Studies | Smoking - blood | Cholesterol - blood | Humans | Middle Aged | Male | Educational Status | Case-Control Studies | Gingival Hemorrhage - blood | Periodontal Attachment Loss - blood | Sex Factors | Triglycerides - blood | Cholesterol, HDL - blood | Adult | Cholesterol, LDL - blood | Female | C-Reactive Protein - analysis | Chronic Periodontitis - blood | Periodontal Pocket - blood | Index Medicus | Dentistry
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10. Full Text The Effect of Periodontal Treatment on Serum Leptin, Interleukin‐6, and C‐Reactive Protein
by Shimada, Yasuko and Komatsu, Yasutaka and Ikezawa‐Suzuki, Ikuyo and Tai, Hideaki and Sugita, Noriko and Yoshie, Hiromasa
Journal of Periodontology, ISSN 0022-3492, 08/2010, Volume 81, Issue 8, pp. 1118 - 1123
Background: Previous studies suggest that periodontitis is closely related to obesity and metabolic syndrome. Leptin, a pleiotrophic hormone produced by... 
metabolic syndrome | Cytokines | obesity | periodontitis | Obesity | Periodontitis | Metabolic syndrome | RHEUMATOID-ARTHRITIS | CELLS | INFLAMMATION | DENTISTRY, ORAL SURGERY & MEDICINE | DISEASE | GINGIVAL CREVICULAR FLUID | PROLIFERATION | HEALTH | Root Planing | Follow-Up Studies | Humans | Middle Aged | Tumor Necrosis Factor-alpha - blood | Male | Dental Scaling | Metabolic Syndrome - blood | Leptin - blood | Interleukin-6 - blood | Gingival Hemorrhage - therapy | Periodontal Pocket - therapy | Female | C-Reactive Protein - analysis | Chronic Periodontitis - therapy | Patient Education as Topic | Body Mass Index | Periodontal Attachment Loss - therapy | Alveolar Bone Loss - therapy | Smoking - blood | Dental Plaque Index | Oral Hygiene | Adiponectin - blood | Gingival Hemorrhage - blood | Periodontal Attachment Loss - blood | Periodontal Index | Chronic Periodontitis - blood | Periodontal Pocket - blood | Alveolar Bone Loss - blood | Index Medicus | Dentistry
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11. Full Text Oxidative Stress, Systemic Inflammation, and Severe Periodontitis
by D’Aiuto, F and Nibali, L and Parkar, M and Patel, K and Suvan, J and Donos, N
Journal of Dental Research, ISSN 0022-0345, 11/2010, Volume 89, Issue 11, pp. 1241 - 1246
Periodontal infections have been associated with a state of chronic inflammation. To ascertain whether severe periodontitis and its treatment are associated... 
CRP | antioxidant | Oxidative Stress | inflammation | periodontitis | PROTEIN | LIPID-PEROXIDATION | INJURY | MARKERS | GINGIVAL CREVICULAR FLUID | SERUM | HIGH-CHOLESTEROL DIET | THERAPY | DENTISTRY, ORAL SURGERY & MEDICINE | GENDER | REACTIVE OXYGEN METABOLITES | Age Factors | Follow-Up Studies | Humans | Middle Aged | Oxidative Stress - physiology | Periodontitis - blood | Male | Case-Control Studies | Periodontitis - physiopathology | Ethnic Groups | Interleukin-6 - blood | Lipids - blood | Periodontal Pocket - therapy | Female | Alveolar Bone Loss - physiopathology | Aggressive Periodontitis - therapy | C-Reactive Protein - analysis | Aggressive Periodontitis - physiopathology | Antioxidants - analysis | Chronic Periodontitis - therapy | Periodontal Pocket - physiopathology | Alveolar Bone Loss - therapy | Chronic Periodontitis - physiopathology | Reactive Oxygen Species - blood | Periodontitis - therapy | Pilot Projects | Aggressive Periodontitis - blood | Sex Factors | Chronic Periodontitis - blood | Periodontal Pocket - blood | Alveolar Bone Loss - blood | Inflammation - physiopathology | Smoking | Index Medicus | Dentistry | Research Reports
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