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Molecular Therapy, ISSN 1525-0016, 03/2015, Volume 23, Issue 3, pp. 423 - 433
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2018, Volume 20, Issue 3, pp. 307 - 319
Reactive oxygen species (ROS) contribute to tissue damage and remodelling mediated by the inflammatory response after injury. Here we show that ROS, which... 
STEM-CELLS | PHAGOCYTOSIS | ACTIVATION | SUPEROXIDE-PRODUCTION | ROS | KINASE | PTEN | NEURONS | MECHANISMS | OUTGROWTH | CELL BIOLOGY | Ganglia, Spinal - injuries | Sciatic Nerve - injuries | Axons - enzymology | Reactive Oxygen Species - metabolism | Exosomes - pathology | Sciatic Nerve - physiopathology | Spinal Cord Injuries - genetics | Spinal Cord Injuries - pathology | Endocytosis | CX3C Chemokine Receptor 1 - metabolism | Ganglia, Spinal - enzymology | Peripheral Nerve Injuries - physiopathology | Spinal Cord Injuries - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Disease Models, Animal | Dyneins - metabolism | Cell Line | NADPH Oxidase 2 - deficiency | Macrophages - pathology | Signal Transduction | Sciatic Nerve - pathology | Mice, Inbred C57BL | Peripheral Nerve Injuries - pathology | PTEN Phosphohydrolase - metabolism | Nuclear Proteins - metabolism | Endosomes - pathology | Nerve Regeneration | Macrophages - enzymology | Mice, Knockout | Animals | Peripheral Nerve Injuries - enzymology | NADPH Oxidase 2 - metabolism | Axons - pathology | Ganglia, Spinal - pathology | Exosomes - enzymology | Endosomes - enzymology | Spinal Cord Injuries - physiopathology | NADPH Oxidase 2 - genetics | Nerve Degeneration | Peripheral Nerve Injuries - genetics | Sciatic Nerve - enzymology | Axons | Regeneration | Reactive oxygen species | NADP (Coenzyme) | Nervous system | Cellular signal transduction | Research | Gene expression | Oxidase | Recovery of function | Spinal injuries | CX3CR1 protein | Inflammatory response | AKT protein | Exosomes | Macrophages | Inactivation | NAD(P)H oxidase | Signal transduction | Dorsal root ganglia | Neurodegeneration | Dieback | CYBB protein | Degeneration | Cell body | Oxygen | Deactivation | Inflammation | Ganglia | 1-Phosphatidylinositol 3-kinase | Signaling | Dynein | PTEN protein | Sciatic nerve | Endosomes | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2015, Volume 290, Issue 11, pp. 6937 - 6950
Myelination of the peripheral nervous system is required for axonal function and long term stability. After peripheral nerve injury, Schwann cells transition... 
TRANSCRIPTION FACTORS | CHIP-SEQ | MARIE-TOOTH-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ERK-SIGNALING PATHWAY | IN-VIVO | MYELIN PROTEIN ZERO | AXONAL REGENERATION | LARGE GENE LISTS | C-JUN | HUMAN-GENOME | Sciatic Nerve - injuries | Demyelinating Diseases - genetics | Early Growth Response Protein 2 - genetics | Epigenesis, Genetic | Demyelinating Diseases - complications | Male | Demyelinating Diseases - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Myelin Sheath - metabolism | Sciatic Nerve - metabolism | Peripheral Nerve Injuries - metabolism | Demyelinating Diseases - pathology | Peripheral Nerve Injuries - complications | Myelin Sheath - pathology | Signal Transduction | SOXE Transcription Factors - metabolism | Sciatic Nerve - pathology | Cells, Cultured | Gene Expression Regulation | Peripheral Nerve Injuries - pathology | Rats | Schwann Cells - pathology | Schwann Cells - metabolism | Transcription Factors - genetics | Rats, Sprague-Dawley | Transcription Factors - metabolism | Animals | Histones - genetics | Enhancer Elements, Genetic | Proto-Oncogene Proteins c-jun - metabolism | Myelin Sheath - genetics | Early Growth Response Protein 2 - metabolism | Mice | Histones - metabolism | Peripheral Nerve Injuries - genetics | Core Binding Factor Alpha 1 Subunit - genetics | SOXE Transcription Factors - genetics | Index Medicus | Gene Regulation | Glial Cell | ChIP Sequencing (ChIP-seq) | Schwann Cells | Histone Modification | Neurobiology | Chromatin Immunoprecipitation (ChiP)
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e65034 - e65034
Previously, we demonstrated i) that ergocalciferol (vitamin D-2) increases axon diameter and potentiates nerve regeneration in a rat model of transected... 
ADULT-RAT BRAIN | CONTROLLED-TRIAL | MESSENGER-RNA | NEUROTROPHIC FACTOR | MULTIDISCIPLINARY SCIENCES | D DEFICIENCY | TIBIALIS-ANTERIOR MUSCLE | 1,25-DIHYDROXYVITAMIN D-3 | GROWTH-FACTOR | AFFERENT ACTIVITIES | D-RECEPTOR | Peroneal Nerve - physiology | Peripheral Nerve Injuries - rehabilitation | Motor Activity - drug effects | Myelin Sheath - drug effects | Male | Axons - physiology | Gene Expression Profiling | Muscle Fibers, Skeletal - drug effects | Gene Regulatory Networks | Neurogenesis - genetics | Cholecalciferol - administration & dosage | Time Factors | Peripheral Nerve Injuries - metabolism | Muscle, Skeletal - drug effects | Neurogenesis - drug effects | Muscle Fibers, Skeletal - physiology | Muscle, Skeletal - anatomy & histology | Axons - drug effects | Organ Size | Rats | Gene Expression Regulation - drug effects | Animals | Peroneal Nerve - drug effects | Signal Transduction - drug effects | Nerve Regeneration - drug effects | Peripheral Nerve Injuries - genetics | Cholecalciferol - pharmacology | Vitamin D | Calcifediol | Alfacalcidol | Vitamin D2 | Brain | Peroneal nerve | Vitamin D3 | Spinal cord | Genes | Clinical trials | Recovery of function | Insulin-like growth factors | Kinases | Recovery | Proteins | Paraplegia | Dorsal root ganglia | Rodents | Transcription activation | Supplementation | Medical research | Myelin | Schwann cells | Gene expression | Trauma | Ganglia | Regeneration | Axons | Myelination | Breathing | Index Medicus | Life Sciences | Pharmacology | Neurons and Cognition | Pharmaceutical sciences | Neurobiology
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 04/2015, Volume 22, Issue 5, pp. 731 - 742
NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm and axon survival. Axons depend on the activity of the central enzyme... 
IN-VITRO | DEATH PATHWAY | PROTECTION | SELF-DESTRUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | WALLERIAN DEGENERATION | SUBCELLULAR COMPARTMENTATION | ENZYMATIC-ACTIVITY | WLD(S) | NEUROMUSCULAR-JUNCTIONS | TRANSGENIC MICE | CELL BIOLOGY | Index Medicus | Original Paper
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 01/2017, Volume 8, Issue 1, pp. 14272 - 14272
The peripheral nervous system (PNS) regenerates after injury. However, regeneration is often compromised in the case of large lesions, and the speed of axon... 
SYSTEM | PERIPHERAL-NERVES | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION FACTOR SCIP | GENE-EXPRESSION | DIFFERENTIATION | C-JUN | NF-KAPPA-B | MYELIN MAINTENANCE | SUMOYLATION | REVEALS | Luciferases - metabolism | Recovery of Function - drug effects | Early Growth Response Protein 2 - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | Luciferases - genetics | SOXB1 Transcription Factors - metabolism | SOXB1 Transcription Factors - genetics | Peripheral Nerve Injuries - metabolism | PAX3 Transcription Factor - genetics | Histone Deacetylase 1 - antagonists & inhibitors | Benzamides - pharmacology | JNK Mitogen-Activated Protein Kinases - genetics | Peripheral Nerve Injuries - drug therapy | Histone Deacetylase 1 - genetics | Genes, Reporter | Schwann Cells - drug effects | Nerve Regeneration - genetics | Histone Deacetylase 2 - genetics | Signal Transduction | Histone Deacetylase 2 - antagonists & inhibitors | Gene Expression Regulation | Peripheral Nerve Injuries - pathology | Axons - drug effects | Axons - metabolism | PAX3 Transcription Factor - metabolism | Schwann Cells - metabolism | Pyrimidines - pharmacology | Transcription Factors - genetics | Mice, Knockout | Transcription Factors - metabolism | Animals | Histone Deacetylase 2 - deficiency | Histone Deacetylase 1 - deficiency | Nerve Regeneration - drug effects | Early Growth Response Protein 2 - metabolism | Histone Deacetylase Inhibitors - pharmacology | Mice | Peripheral Nerve Injuries - genetics | Index Medicus
Journal Article