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1. Full Text Skin nerve α-synuclein deposits: A biomarker for idiopathic Parkinson disease
by Donadio, Vincenzo and Incensi, Alex and Leta, Valentina and Giannoccaro, Maria Pia and Scaglione, Cesa and Martinelli, Paolo and Capellari, Sabina and Avoni, Patrizia and Baruzzi, Agostino and Liguori, Rocco
Neurology, ISSN 0028-3878, 04/2014, Volume 82, Issue 15, pp. 1362 - 1369
OBJECTIVE:To investigate (1) whether phosphorylated α-synuclein deposits in skin nerve fibers might represent a useful biomarker for idiopathic Parkinson... 
LEWY BODY PATHOLOGY | CRITERIA | SYSTEM | DIAGNOSIS | NEUROPATHY | BIOPSY | DENERVATION | CLINICAL NEUROLOGY | INSIGHTS | LEVODOPA | Biomarkers - metabolism | Nerve Fibers - pathology | Peripheral Nervous System Diseases - diagnosis | Peripheral Nervous System Diseases - etiology | Nerve Fibers - metabolism | Parkinson Disease - complications | Parkinson Disease - pathology | Phosphorylation | Skin - metabolism | Humans | Middle Aged | Peripheral Nervous System Diseases - metabolism | Aged, 80 and over | Parkinson Disease - diagnosis | Skin - innervation | Aged | Parkinson Disease - metabolism | Peripheral Nervous System Diseases - pathology | alpha-Synuclein - metabolism | Skin - pathology
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2. Full Text Targeting the endocannabinoid system: to enhance or reduce?
by Di Marzo, Vincenzo
Nature Reviews Drug Discovery, ISSN 1474-1776, 05/2008, Volume 7, Issue 5, pp. 438 - 455
As our understanding of the endocannabinoids improves, so does the awareness of their complexity. During pathological states, the levels of these mediators in... 
ALLERGIC CONTACT-DERMATITIS | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ENDOGENOUS LIGAND 2-ARACHIDONOYLGLYCEROL | ACID AMIDE HYDROLASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CB1 RECEPTOR ANTAGONIST | PERIPHERAL CANNABINOID RECEPTOR | PHARMACOLOGY & PHARMACY | AMYOTROPHIC-LATERAL-SCLEROSIS | VANILLOID TRPV1 RECEPTORS | TRANSPORT INHIBITOR AM404 | ANANDAMIDE CELLULAR UPTAKE | Cannabinoid Receptor Modulators - metabolism | Central Nervous System Diseases - pathology | Metabolic Diseases - pathology | Neurodegenerative Diseases - pathology | Humans | Metabolic Diseases - drug therapy | Neurodegenerative Diseases - metabolism | Neurodegenerative Diseases - drug therapy | Central Nervous System Diseases - metabolism | Cannabinoids - therapeutic use | Animals | Gastrointestinal Diseases - metabolism | Metabolic Diseases - metabolism | Models, Biological | Gastrointestinal Diseases - drug therapy | Central Nervous System Diseases - drug therapy | Gastrointestinal Diseases - pathology | Endocannabinoids | Drug targeting | Cannabinoids | Dosage and administration | Enzyme inhibitors | Research
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3. Full Text Neuropathic pain: A maladaptive response of the nervous system to damage
by Costigan, Michael and Scholz, Joachim and Woolf, Clifford J
Annual Review of Neuroscience, ISSN 0147-006X, 06/2009, Volume 32, Issue 1, pp. 1 - 32
Neuropathic pain is triggered by lesions to the somatosensory, nervous system that alter its structure and function so that pain occurs spontaneously and... 
Disinhibition | Neural plasticity | Pain phenotype | Neuroimmune interaction | Synaptic facilitation | CENTRAL SENSITIZATION | neural plasticity | ROOT GANGLION NEURONS | neuroimmune interaction | GATED SODIUM-CHANNELS | NEUROSCIENCES | PERIPHERAL-NERVE | SPINAL DORSAL-HORN | SUBSTANTIA-GELATINOSA NEURONS | SCIATIC-NERVE | CHRONIC CONSTRICTION INJURY | synaptic facilitation | pain phenotype | PRIMARY SENSORY NEURONS | UP-REGULATION | disinhibition | Afferent Pathways - metabolism | Pain Threshold - physiology | Neuralgia - genetics | Humans | Nervous System - metabolism | Neuralgia - metabolism | Adaptation, Physiological - physiology | Afferent Pathways - physiopathology | Nociceptors - physiology | Spinal Nerve Roots - metabolism | Peripheral Nervous System Diseases - physiopathology | Nervous System - physiopathology | Peripheral Nervous System Diseases - metabolism | Animals | Neuronal Plasticity - physiology | Spinal Nerve Roots - physiopathology | Sensory Receptor Cells - physiology | Signal Transduction - physiology | Nociceptors - metabolism | Neuralgia - physiopathology | Peripheral Nervous System Diseases - genetics | Neuroplasticity | Nervous system | Research | Analysis | Abnormalities | Genetic polymorphisms
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4. Full Text Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
by Schumacher, Michael and Rammes, Gerhard and Baghai, Thomas C and Groyer, Ghislaine and Papadopoulos, Vassilios and Rupprecht, Rainer and Akula, Nagaraju and Adams, David and Fan, Jinjiang
Nature Reviews Drug Discovery, ISSN 1474-1776, 12/2010, Volume 9, Issue 12, pp. 971 - 988
The translocator protein (18 kDa) (TSPO) is localized primarily in the outer mitochondrial membrane of steroid-synthesizing cells, including those in the... 
POSITRON-EMISSION-TOMOGRAPHY | EXTRASYNAPTIC GABA(A) RECEPTORS | ADULT SEPARATION ANXIETY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HUMAN GLIOBLASTOMA CELLS | PERIPHERAL BENZODIAZEPINE-RECEPTOR | MITOCHONDRIAL CHOLESTEROL TRANSPORT | DIAZEPAM-BINDING INHIBITOR | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | ADENINE-NUCLEOTIDE CARRIER | AMYOTROPHIC-LATERAL-SCLEROSIS | Biomarkers - metabolism | Animals | Mental Disorders - drug therapy | Humans | Mental Disorders - metabolism | Nervous System Diseases - drug therapy | Receptors, GABA - metabolism | Ligands | Nervous System Diseases - metabolism | Drug Delivery Systems - methods | Disease Models, Animal | Nervous system diseases | Neuropsychopharmacology | Physiological aspects | Development and progression | Research | Drug therapy | Health aspects | Mental illness | Natural history | Membrane proteins
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5. Full Text Microtubule-based transport -basic mechanisms, traffic rules and role in neurological pathogenesis
by Franker, Mariella and Hoogenraad, Casper
Journal of Cell Science, ISSN 0021-9533, 06/2013, Volume 126, Issue 11, pp. 2319 - 2329
textabstractMicrotubule-based transport is essential for neuronal function because of the large distances that must be traveled by various building blocks and... 
Adaptor proteins | Brain | Neuron | Dynein | Microtubule | Neurological disease | Transport | Kinesin | CYTOPLASMIC DYNEIN | HAND-OVER-HAND | MARIE-TOOTH-DISEASE | TUG-OF-WAR | HEREDITARY SPASTIC PARAPLEGIA | SQUID GIANT-AXON | CELL BIOLOGY | MUSCLES TYPE-1 CFEOM1 | FAST AXONAL-TRANSPORT | PROGRESSIVE MOTOR NEURONOPATHY | NEURONAL MIGRATION DEFECTS | Central Nervous System Diseases - genetics | Central Nervous System Diseases - pathology | Neurons - pathology | Humans | Biological Transport, Active - genetics | Central Nervous System Diseases - metabolism | Peripheral Nervous System Diseases - metabolism | Microtubules - metabolism | Animals | Microtubules - genetics | Neurons - metabolism | Peripheral Nervous System Diseases - pathology | Peripheral Nervous System Diseases - genetics
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6. Full Text Denture cream: An unusual source of excess zinc, leading to hypocupremia and neurologic disease
by Nations, S.P and Boyer, P.J and Love, L.A and Burritt, M.F and Butz, J.A and Wolfe, G.I and Hynan, L.S and Reisch, J and Trivedi, J.R
Neurology, ISSN 0028-3878, 08/2008, Volume 71, Issue 9, pp. 639 - 643
Chronic, excess zinc intake can result in copper deficiency and profound neurologic disease. However, when hyperzincemia is identified, the source often... 
Peripheral Nervous System Diseases - chemically induced | Central Nervous System - metabolism | Spinal Cord Diseases - physiopathology | Zinc - metabolism | Humans | Middle Aged | Peripheral Nervous System - physiopathology | Zinc - poisoning | Male | Peripheral Nervous System Diseases - physiopathology | Peripheral Nervous System Diseases - metabolism | Spinal Cord Diseases - chemically induced | Peripheral Nervous System - metabolism | Spinal Cord Diseases - metabolism | Central Nervous System - drug effects | Adult | Female | Tissue Adhesives - poisoning | Central Nervous System - physiopathology | Copper - deficiency | Peripheral Nervous System - drug effects | Index Medicus | Abridged Index Medicus
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7. Full Text Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
by Han, Xiaoning and Takano, Takahiro and Wang, Fushun and Bekar, Lane and Xu, Qiwu and Schnermann, Jurgen and Peng, Weiguo and Jensen, Tina K and Fujita, Takumi and Pei, Yong and Chen, Jiang-Fan and Chen, Michael and Goldman, Nanna and Tieu, Kim and Nedergaard, Maiken and Liu, Wei
Nature Neuroscience, ISSN 1097-6256, 07/2010, Volume 13, Issue 7, pp. 883 - 888
Acupuncture is an invasive procedure commonly used to relieve pain. Acupuncture is practiced worldwide, despite difficulties in reconciling its principles with... 
RAT | ELECTROACUPUNCTURE | ADENOSINE A RECEPTOR | CINGULATE CORTEX | TUBULOGLOMERULAR FEEDBACK | SPINAL-CORD | INFLAMMATORY PAIN | MICE | PROSTATIC ACID-PHOSPHATASE | NEUROSCIENCES | DORSAL-HORN | Afferent Pathways - metabolism | Pain Management | Acupuncture Analgesia | Sciatica - therapy | Peripheral Nervous System Diseases - therapy | Sciatica - complications | Sciatica - metabolism | Pain - metabolism | Peripheral Nervous System Diseases - metabolism | Nucleotidases - metabolism | Animals | Analysis of Variance | Pain - complications | Statistics, Nonparametric | Adenosine - metabolism | Mice | Receptors, Purinergic P1 - metabolism | Peripheral Nervous System Diseases - complications | Disease Models, Animal | Adenosine | Care and treatment | Pain | Physiological aspects | Genetic aspects | Acupuncture | Research | Methods
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8. Full Text Autonomic and inflammatory consequences of posttraumatic stress disorder and the link to cardiovascular disease
by Brudey, Chevelle and Park, Jeanie and Wiaderkiewicz, Jan and Kobayashi, Ihori and Mellman, Thomas and Marvar, Paul J
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 08/2015, Volume 309, Issue 4, pp. R315 - R321
Stress- and anxiety-related disorders are on the rise in both military and general populations. Over the next decade, it is predicted that treatment of these... 
Renin-angiotensin system | Cardiovascular disease | Posttraumatic stress disorder | C-REACTIVE PROTEIN | cardiovascular disease | PHYSIOLOGY | SERUM INTERLEUKIN-6 | ANGIOTENSIN RECEPTOR BLOCKERS | ADULT AFRICAN-AMERICANS | WAR VETERANS | BLOOD-PRESSURE | posttraumatic stress disorder | DIABETES-MELLITUS | VIETNAM VETERANS | SYMPATHETIC-NERVE ACTIVITY | CORONARY-HEART-DISEASE | renin-angiotensin system | Autonomic Nervous System Diseases - etiology | Prognosis | Stress Disorders, Post-Traumatic - metabolism | Humans | Stress Disorders, Post-Traumatic - physiopathology | Autonomic Nervous System - physiopathology | Stress Disorders, Post-Traumatic - immunology | Inflammation - metabolism | Renin-Angiotensin System | Inflammation Mediators - metabolism | Autonomic Nervous System - metabolism | Autonomic Nervous System Diseases - immunology | Inflammation Mediators - immunology | Cardiovascular Diseases - etiology | Cardiovascular Diseases - physiopathology | Autonomic Nervous System Diseases - metabolism | Cardiovascular Diseases - metabolism | Risk Factors | Inflammation - immunology | Inflammation - etiology | Stress Disorders, Post-Traumatic - complications | Cardiovascular Diseases - immunology | Animals | Autonomic Nervous System Diseases - physiopathology | Autonomic Nervous System - immunology | Inflammation - physiopathology | PTSD | Immunological Symptoms | Cardiovascular Diseases | Neuroendocrinology | Etiology | Cardiovascular Symptoms | Peripheral Nervous System | Review
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