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Journal Article
Journal Article
Journal Article
Molecular Genetics and Genomics, ISSN 1617-4615, 8/2017, Volume 292, Issue 4, pp. 699 - 727
Increasing organismal complexity during the evolution of life has been attributed to the duplication of genes and entire genomes. More recently, theoretical... 
Life Sciences | Human Genetics | Biochemistry, general | Duplicated genes | Fatty acid- and retinoid-binding proteins | Peroxisome proliferator-activated receptor | Plant Genetics and Genomics | Teleost fishes | Microbial Genetics and Genomics | Subfunctionalization and neofunctionalization | Whole genome duplication | Animal Genetics and Genomics | ZEBRAFISH DANIO-RERIO | MESSENGER-RNA EXPRESSION | PEROXISOME PROLIFERATOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TISSUE-SPECIFIC EXPRESSION | RAY-FINNED FISHES | DIETARY FATTY-ACIDS | WHOLE-GENOME DUPLICATION | RETINOIC ACID | PROLIFERATOR RESPONSE ELEMENTS | GENETICS & HEREDITY | L-FABP GENE | Multigene Family - genetics | Genes, Duplicate - genetics | Transcriptional Activation - genetics | Gene Expression Regulation - genetics | PPAR alpha - genetics | Fatty Acid-Binding Proteins - genetics | Promoter Regions, Genetic - genetics | Zebrafish - genetics | Biological Evolution | Tetraodontiformes - genetics | Animals | PPAR gamma - agonists | Gene Duplication - genetics | Retinol-Binding Proteins - genetics | PPAR alpha - agonists | Oryzias - genetics | Smegmamorpha - genetics | Clofibrate - pharmacology | Evolution, Molecular | PPAR gamma - genetics | Transcription | Lipid-binding protein | Gene regulation | Genes | Zebrafish | Evolutionary genetics | Genomes | Regulatory sequences | Retention | Promoters | Proteins | Fatty acid-binding protein | Isoforms | Evolution | Fish | Gene duplication | Degeneration | Complementation | Peroxisome proliferator-activated receptors | Intracellular
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 12/2013, Volume 115, Issue 11, pp. 1618 - 1625
Prolonged immobilization (IM) results in skeletal muscle atrophy accompanied by increased reactive oxygen species (ROS) generation, inflammation, and protein... 
Atrophy | Mitochondria | Remobilization | Immobilization | Inflammation | Proliferator-activated receptor-γ coactivator-1α | Skeletal muscle | DISUSE ATROPHY | SPORT SCIENCES | OXIDATIVE STRESS | ACTIVATION | PHYSIOLOGY | immobilization | mitochondria | SOLEUS MUSCLE | MECHANICAL VENTILATION | proliferator-activated receptor-gamma coactivator-1 alpha | FACTOR-KAPPA-B | remobilization | SKELETAL-MUSCLE | inflammation | atrophy | DYSFUNCTION | skeletal muscle | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | MafB Transcription Factor - metabolism | Reactive Oxygen Species - metabolism | Tumor Necrosis Factor-alpha - genetics | Muscle, Skeletal - metabolism | NF-kappa B - metabolism | Mitochondrial Proteins - genetics | Dinoprost - metabolism | Electron Transport Complex IV - metabolism | Tripartite Motif Proteins | DNA-Binding Proteins - metabolism | Inflammation - metabolism | DNA, Mitochondrial - genetics | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Muscle Proteins - metabolism | Female | Dinoprost - analogs & derivatives | Mitochondrial Turnover - genetics | Interleukin-6 - metabolism | Interleukin-6 - genetics | Oxidation-Reduction | MafB Transcription Factor - genetics | Ubiquitin-Protein Ligases - metabolism | Up-Regulation - genetics | Mitochondria - metabolism | Signal Transduction - genetics | Electron Transport Complex IV - genetics | Muscle, Skeletal - physiology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Hindlimb Suspension | Down-Regulation - genetics | Hydrogen Peroxide - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Dinoprost - genetics | Animals | NF-kappa B - genetics | Inflammation - genetics | Mice | Ubiquitin-Protein Ligases - genetics
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e108578
Background: Pre-term birth (PTB) remains the leading cause of infant mortality and morbidity. Its etiology is multifactorial, with a strong genetic component.... 
ETHNIC-DIFFERENCES | INTERLEUKIN-6 IL-6 | PREMATURE RUPTURE | TUMOR-NECROSIS-FACTOR | INCREASED RISK | MULTIDISCIPLINARY SCIENCES | RACIAL DISPARITY | FACTOR-ALPHA GENE | FAMILIAL PATTERNS | FETAL MEMBRANES | TNF-ALPHA | Genetic Predisposition to Disease | Premature Birth - genetics | Receptors, Estrogen - genetics | Infant Mortality | Humans | Autoimmunity - genetics | Infant | Fetal Membranes, Premature Rupture - epidemiology | Premature Birth - epidemiology | STAT1 Transcription Factor - genetics | Interferon Regulatory Factor-3 - genetics | Polymorphism, Genetic | Pregnancy | Fetal Membranes, Premature Rupture - genetics | NF-kappa B - genetics | Pregnancy Complications - genetics | Receptors, Glucocorticoid - genetics | Female | Infant, Newborn | Pregnancy Complications - epidemiology | PPAR gamma - genetics | Membranes | Regulators | Transcription factors | Racial differences | Glucocorticoids | Identification methods | Pathogenesis | Genes | Premature birth | Genomics | Estrogens | Childrens health | Inflammatory response | Genomes | Single-nucleotide polymorphism | Birth | Pathways | Etiology | Genetic factors | Stat1 protein | Cytokines | Infant mortality | Inflammation | Metabolism | Morbidity | Children & youth | Medicine | Studies | Interferon regulatory factor 3 | Womens health | Collagen | Interferon | Peroxisome proliferator-activated receptors
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, p. e51238
Important insights concerning the molecular basis of skeletal muscle disuse-atrophy and aging related muscle loss have been obtained in cell culture and animal... 
PROLONGED BED REST | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GENE-EXPRESSION | HUMAN QUADRICEPS MUSCLE | LIMB IMMOBILIZATION | NF-KAPPA-B | PROTEIN-SYNTHESIS | DENERVATION ATROPHY | UBIQUITIN-PROTEASOME PATHWAY | Muscle Strength - genetics | Muscle Contraction - genetics | Humans | Middle Aged | Transcriptome | Apoptosis - genetics | Male | Muscle, Skeletal - metabolism | Muscular Disorders, Atrophic - physiopathology | NF-kappa B - metabolism | Muscle Fibers, Skeletal - metabolism | Tripartite Motif Proteins | Young Adult | Heat-Shock Proteins - genetics | Aging - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Adult | Muscular Disorders, Atrophic - pathology | Autophagy - genetics | Proto-Oncogene Proteins c-akt - metabolism | Muscular Disorders, Atrophic - metabolism | Cytokines - metabolism | Muscular Disorders, Atrophic - genetics | Organ Size | Signal Transduction - genetics | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Aging - pathology | Muscle Proteins - genetics | Aging - physiology | Muscle, Skeletal - physiopathology | Muscle Fibers, Skeletal - pathology | Aged | Muscle, Skeletal - pathology | Transcription, Genetic - genetics | Ubiquitin-Protein Ligases - genetics | Insulin-Like Growth Factor I - metabolism | Aging - metabolism | Muscles | Genetic transcription | RNA | Analysis | Cell culture | Health sciences | Phosphorylation | Animal models | Transcription factors | Transcription | Gene regulation | Immobilization | AKT protein | Insulin-like growth factors | Autophagy | Sports medicine | Proteins | Atrophy | Rodents | Aging | Tumor necrosis factor-TNF | Age | Inflammation | Gene expression | Skeletal muscle | Medicine | Studies | Biomechanics | Musculoskeletal system | Signaling | Exercise physiology | Microscopy | Protein synthesis | Phagocytosis | Apoptosis
Journal Article
Cancer Epidemiology Biomarkers and Prevention, ISSN 1055-9965, 06/2011, Volume 20, Issue 6, pp. 1131 - 1145
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 13, pp. 10355 - 10367
Hepatic stellate cells (HSCs) undergo myofibroblastic activation in liver fibrosis and regeneration. This phenotypic switch is mechanistically similar to... 
PREF-1 | HETEROGENEITY | ACTIVATION | RAT HEPATOCYTES | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXPERIMENTAL MELANOMA METASTASIS | ADIPOCYTE DIFFERENTIATION | RECEPTOR | ADIPOGENESIS | EXPRESSION | Liver - pathology | Rats, Wistar | Coculture Techniques | Cyclin-Dependent Kinase 4 - genetics | Hepatic Stellate Cells - metabolism | Epithelial-Mesenchymal Transition - drug effects | Hepatocytes - pathology | Male | Cyclin A - genetics | Hepatocytes - metabolism | Epithelial-Mesenchymal Transition - genetics | Wnt Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Wnt Proteins - genetics | Liver Cirrhosis - metabolism | Epigenesis, Genetic - drug effects | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Liver Cirrhosis - genetics | Hepatic Stellate Cells - pathology | PPAR gamma - genetics | Cell Line | Liver Regeneration | Mitogen-Activated Protein Kinase 3 - genetics | Membrane Proteins - genetics | Cyclin A - metabolism | Liver - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Rats | Nuclear Proteins - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Chick Embryo | Nerve Tissue Proteins - genetics | PPAR gamma - biosynthesis | Antibodies - pharmacology | Nerve Tissue Proteins - metabolism | Proto-Oncogene Proteins c-akt | Animals | Wnt Signaling Pathway - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Wnt Signaling Pathway - genetics | Epigenesis, Genetic - genetics | Chickens | Liver Cirrhosis - pathology | Cell Proliferation - drug effects | Mice | Cyclin D - genetics | Cyclin D - metabolism | Wnt Signaling | Regeneration | Partial Hepatectomy | Epigenetics | Pparγ | Peroxisome Proliferator-activated Receptor (PPAR) | Pref-1 | Cell Biology | Adipogenesis | Wnt10b
Journal Article
Journal of Molecular Evolution, ISSN 0022-2844, 12/2018, Volume 86, Issue 9, pp. 618 - 634
Low oxygen and fluctuant ambient temperature pose serious challenges to mammalian survival. Physiological adaptations in mammals to hypoxia and low... 
Adaptive evolution | Hypoxia | Differential expression | HIF pathway | NST | Low temperature | INDUCIBLE FACTOR | ECHOLOCATING BATS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOLE-RAT | HEAT-EXCHANGE | BOTTLE-NOSED DOLPHINS | EVOLUTIONARY BIOLOGY | AMINO-ACID-SEQUENCE | POSITIVE SELECTION | MITOCHONDRIAL UNCOUPLING PROTEIN | GENETICS & HEREDITY | HETEROCEPHALUS-GLABER | ADIPOSE-TISSUE | Mammals - genetics | Mammals - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | Thermogenesis - genetics | Uncoupling Protein 1 - genetics | Cold-Shock Response - physiology | Uncoupling Protein 1 - metabolism | Acclimatization | Phylogeny | Cold-Shock Response - genetics | Lagomorpha - genetics | Cold Temperature - adverse effects | Hypoxia - metabolism | Selection, Genetic - genetics | Biological Evolution | Hypoxia - genetics | Animals | Adaptation, Physiological - genetics | Ecosystem | Rodentia - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Evolution, Molecular | Anopheles | Genes | Zoology | Genetic research | Amino acids | Evolution | Genetic aspects | Cetacea | Identification and classification | Adaptations | High altitude | Biological evolution | Burrows | Positive selection | Variations | Evolutionary genetics | Shivering | Marine mammals | Proteins | Connective tissues | Marine environment | Taxa | Non-shivering | Cold tolerance | Ambient temperature | Uncoupling protein 1 | Rodents | Diving | Genetics | Species | Invasions | Plateaus | Exploration | Mammals | Gene expression | Natural selection | Molecular modelling | Thermogenesis | Peroxisome proliferator-activated receptors | Blubber | Temperature tolerance | Aquatic ecosystems
Journal Article