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Genes and Development, ISSN 0890-9369, 07/2004, Volume 18, Issue 13, pp. 1533 - 1538
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 2006, Volume 75, Issue 1, pp. 137 - 163
This review focuses on remarkable recent findings concerning the mechanism by which the LKB1 protein kinase that is mutated in Peutz-Jeghers cancer syndrome... 
Cell growth | mTOR | Tuberous sclerosis | AMPK | Polarity | Tumor suppressor | Peutz-Jeghers syndrome | Cancer | MOLECULAR CHARACTERIZATION | ACTIVATED PROTEIN-KINASE | SERINE-THREONINE KINASE | PEUTZ-JEGHERS-SYNDROME | CYTOPLASMIC LOCALIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | cell growth | tumor suppressor | tuberous sclerosis | TUBEROUS SCLEROSIS COMPLEX | SALT-INDUCIBLE KINASE | C-ELEGANS EMBRYOS | cancer | CANCER SYNDROME | polarity | LKB1 TUMOR-SUPPRESSOR | Cell Polarity | Humans | Peutz-Jeghers Syndrome - therapy | Protein-Serine-Threonine Kinases - classification | Adaptor Proteins, Vesicular Transport - genetics | Molecular Sequence Data | Multienzyme Complexes - metabolism | Phylogeny | Adaptor Proteins, Vesicular Transport - metabolism | AMP-Activated Protein Kinases | Isoenzymes - classification | Isoenzymes - metabolism | Genes, Tumor Suppressor | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Sequence | Multienzyme Complexes - classification | Isoenzymes - genetics | Protein-Serine-Threonine Kinases - genetics | Multienzyme Complexes - genetics | Peutz-Jeghers Syndrome - genetics | Sequence Alignment | Animals | Peutz-Jeghers Syndrome - metabolism | Signal Transduction - physiology | Protein Processing, Post-Translational | Enzyme Activation | Mutation | Care and treatment | Physiological aspects | Genetic aspects | Research | Protein kinases
Journal Article
Human Pathology, ISSN 0046-8177, 2015, Volume 49, pp. 39 - 48
Journal Article
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 04/2008, Volume 40, Issue 4, pp. 455 - 459
Germline mutations in STK11 (also known as LKB1) are found in individuals with Peutz-Jeghers syndrome (PJS) manifesting with gastrointestinal polyps that... 
LUNG | SMOOTH-MUSCLE | TGF-BETA | PEUTZ-JEGHERS-SYNDROME | GROWTH-FACTORS | GENETICS & HEREDITY | MYOFIBROBLASTS | DIFFERENTIATION | CANCER | FIBROBLASTS | Protein Kinases - metabolism | Cell Proliferation | Epithelial Cells - metabolism | Peutz-Jeghers Syndrome - pathology | Stromal Cells - pathology | Humans | Microfilament Proteins - physiology | Male | RNA, Messenger - metabolism | Tamoxifen - administration & dosage | Gastrointestinal Tract - pathology | Polymerase Chain Reaction | Female | Integrases - metabolism | Microfilament Proteins - genetics | Muscle Proteins - physiology | Fibroblasts - metabolism | Cells, Cultured - drug effects | Protein-Serine-Threonine Kinases - physiology | Mice, Inbred C57BL | RNA, Messenger - genetics | Stromal Cells - metabolism | Injections, Intraperitoneal | Epithelial Cells - pathology | Selective Estrogen Receptor Modulators - administration & dosage | Longevity | Muscle, Smooth - metabolism | Blotting, Western | Gastrointestinal Tract - metabolism | Mice, Knockout | Muscle Proteins - genetics | Animals | Peutz-Jeghers Syndrome - prevention & control | Fibroblasts - drug effects | Peutz-Jeghers Syndrome - metabolism | Intestinal Polyps - pathology | Cells, Cultured - metabolism | Fibroblasts - cytology | Mesoderm - metabolism | Mice | TOR Serine-Threonine Kinases | Intestinal Polyps - metabolism | Muscle, Smooth - pathology | Transforming Growth Factor beta - metabolism | Smad2 Protein | Gene mutations | Gastrointestinal cancer | Genetic aspects | Research | Drug therapy | Health aspects | Risk factors | Signal transduction | Genetics | Mutation | Cellular biology | Rodents | Gastroenterology
Journal Article
Journal of Cell Science, ISSN 0021-9533, 12/2004, Volume 117, Issue 26, pp. 6365 - 6375
Journal Article
Journal Article