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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 06/2018, Volume 62, Issue 6
For an increasing number of antimalarial agents identified in high-throughput phenotypic screens, there is evidence that they target PfATP4, a putative Na+... 
Transporters | PfATP4 | Antimalarial agents | KAE609 | TARGET | INTRAERYTHROCYTIC MALARIA PARASITE | antimalarial agents | ACID | transporters | MEMBRANE-PERMEABILITY | MICROBIOLOGY | SPIROINDOLONE ANTIMALARIALS | PLASMODIUM-FALCIPARUM | PHARMACOLOGY & PHARMACY | RED-BLOOD-CELLS | ERYTHROCYTE | CATION ATPASE PFATP4 | EXTRUSION
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 8795 - 15
Four hundred structurally diverse drug-like compounds comprising the Medicines for Malaria Venture's 'Pathogen Box' were screened for their effect on a range... 
TARGET | ACID | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | CANDIDATE | CATION ATPASE PFATP4 | EXTRUSION
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 12/2014, Volume 111, Issue 50, pp. E5455 - E5462
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 11/2019, Volume 9, Issue 1, pp. 17785 - 17
Natural products offer an abundant source of diverse novel scaffolds that inspires development of next generation anti-malarials. With this vision, a library... 
PROPRANOLOL | ACTIVATION | ASYMMETRIC-SYNTHESIS | ERYTHROCYTES | BICYCLIC LACTAMS | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | DRUG-RESISTANCE | CATION ATPASE PFATP4 | INTRACELLULAR NA+ | OPTICAL ISOMERS
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 12/2019, Volume 62, Issue 23, pp. 10526 - 10562
Malaria is a devastating disease caused by Plasmodium parasites, resulting in approximately 435000 deaths in 2018. The impact of malaria is compounded by the... 
FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | SINGLE-DOSE CURE | CHEMISTRY, MEDICINAL | MALARIA BOX REVEALS | ARTEMISININ RESISTANCE | DOUBLE-BLIND | ORIENTED SYNTHESIS YIELDS | CATION ATPASE PFATP4 | UNCOMPLICATED PLASMODIUM-FALCIPARUM | MALEATE-PIPERAQUINE PHOSPHATE | KAE609 CIPARGAMIN
Journal Article
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5521
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 04/2019, Volume 294, Issue 14, pp. 5720 - 5734
The Plasmodium falciparum ATPase PfATP4 is the target of a diverse range of antimalarial compounds, including the clinical drug candidate cipargamin. PfATP4... 
Na+ pump | SURVIVAL | INTRAERYTHROCYTIC MALARIA PARASITE | protozoan parasite | PROTEIN | ATPase | BIOCHEMISTRY & MOLECULAR BIOLOGY | cipargamin | sodium transporter | TgATP4 | malaria | SPIROINDOLONE | PFATP4 | Toxoplasma gondii | drug action | PLASMODIUM-FALCIPARUM | CATION ATPASE | membrane transport | NA+ | X-RAY-MICROANALYSIS | EXTRUSION
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 10292 - 15
We developed a novel series of antimalarial compounds based on a 4-cyano-3-methylisoquinoline. Our lead compound MB14 achieved modest inhibition of the growth... 
INVASION | TRANSPORTER | MULTIDISCIPLINARY SCIENCES | MUTATION | RESISTANCE | DEPENDENT PROTEIN-KINASE | MALARIA PARASITE | CANDIDATE | CATION ATPASE PFATP4 | IDENTIFICATION | SPIROINDOLONE KAE609 | Malaria | Sodium | Antimalarial agents | Erythrocytes | Membrane permeability | Lysis | Genomes | Parasites | Permeability
Journal Article
Drugs, ISSN 0012-6667, 06/2018, Volume 78, Issue 9, pp. 861 - 879
Journal Article
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 05/2019, Volume 93, Issue 5, pp. 737 - 759
Journal Article
Journal Article