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Molecular Biology of the Cell, ISSN 1059-1524, 12/2008, Volume 20, Issue 3, pp. 870 - 881
Journal Article
ACS Nano, ISSN 1936-0851, 08/2013, Volume 7, Issue 8, pp. 6605 - 6618
Journal Article
Biomaterials, ISSN 0142-9612, 2015, Volume 73, pp. 160 - 174
Abstract Accelerating the clearance of intracellular protein aggregates through elevation of autophagy represents a viable approach for the treatment of... 
Advanced Basic Science | Dentistry | Europium hydroxide nanorods [EHNs: EuIII(OH)3] | mTOR | Huntingtin protein aggregates | p-ERK1/2 | Trehalose | Autophagy | Europium hydroxide nanorods [EHNs: Eu | P-ERK1/2 | OH | ] | MTOR | REGULATE AUTOPHAGY | MATERIALS SCIENCE, BIOMATERIALS | GENUINE AUTOPHAGY | ENGINEERING, BIOMEDICAL | ALZHEIMERS-DISEASE | MUTANT HUNTINGTIN | DRUG-RESISTANCE | ALPHA-SYNUCLEIN | WALLED CARBON NANOTUBES | MAMMALIAN-CELLS | LYSOSOME IMPAIRMENT | Europium hydroxide nanorods [EHNs: Eulli(OH)] | POLYGLUTAMINE EXPANSIONS | Phagosomes - chemistry | Phosphorylation | Europium - chemistry | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Adenine - chemistry | Neurodegenerative Diseases - embryology | Nanotubes - chemistry | Trehalose - chemistry | Nerve Tissue Proteins - chemistry | Lysosomes - metabolism | Macrolides - chemistry | Green Fluorescent Proteins - metabolism | Adenine - analogs & derivatives | Hydroxides - chemistry | Signal Transduction | Cell Survival | Neurodegenerative Diseases - metabolism | Huntingtin Protein | Androstadienes - chemistry | Animals | Autophagy-Related Protein 5 | Butadienes - chemistry | Chloroquine - chemistry | Nitriles - chemistry | Cell Line, Tumor | Mice | HeLa Cells | Microscopy, Fluorescence | RNA, Small Interfering - metabolism | Rare earth metals | Chronic diseases | Nervous system diseases | Biological products | Hydroxides | Proteins | Pathways | Aggregates | Medical services | Activation | Clearances | Nanorods
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2005, Volume 280, Issue 46, pp. 38133 - 38145
Studies involving Toll-like receptor 3 (TLR3)-deficient mice suggest that this receptor binds double-stranded RNA. In the present study, we analyzed... 
FC-RECEPTOR | ACTIVATION | HUMAN DENDRITIC CELLS | IMMUNE-RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CPG-DNA | APOPTOTIC CELLS | SUBCELLULAR-LOCALIZATION | ENDOPLASMIC-RETICULUM | NF-KAPPA-B | ESSENTIAL COMPONENTS | Leukocytes, Mononuclear - metabolism | Calcium - metabolism | Humans | NF-kappa B - metabolism | Endosomes - metabolism | Time Factors | U937 Cells | Base Sequence | Cell Membrane - metabolism | Cysteine - metabolism | Binding Sites | Dimerization | Tyrosine - chemistry | Amino Acid Sequence | Signal Transduction | Cell Separation | Enzyme Inhibitors - pharmacology | Glycosylation | DNA - metabolism | Recombinant Fusion Proteins - chemistry | Toll-Like Receptor 3 - metabolism | Blotting, Western | Chloroquine - chemistry | Ligands | Mutation | Hydrogen-Ion Concentration | Phagosomes - chemistry | Luciferases - metabolism | Lysosomes - chemistry | Cross-Linking Reagents - pharmacology | Receptors, IgG - chemistry | Molecular Sequence Data | Receptors, IgG - biosynthesis | Recombinant Fusion Proteins - metabolism | Dose-Response Relationship, Drug | Flow Cytometry | Lysosomes - metabolism | Transfection | Genes, Dominant | Macrolides - pharmacology | Antigens, CD - chemistry | Antirheumatic Agents - pharmacology | Dendritic Cells - metabolism | Genes, Reporter | Protein Structure, Tertiary | Cell Line | Mutagenesis, Site-Directed | Cytokines - metabolism | Cysteine - chemistry | Leucine - chemistry | Sequence Homology, Amino Acid | Protein Binding | Toll-Like Receptor 3 - chemistry
Journal Article
Nature Communications, ISSN 2041-1723, 05/2017, Volume 8, Issue 1
Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control the production of phosphatidylinositol 3-phosphate (PtdIns3P), a... 
TSC1-TSC2 COMPLEX | PROTEIN CONJUGATION SYSTEM | PHOSPHATIDYLINOSITOL 3-PHOSPHATE | PHOSPHORYLATION | MEMBRANE | MULTIDISCIPLINARY SCIENCES | KINASE | LC3 LIPIDATION | BINDING-SITES | IDENTIFICATION | REPEAT PROTEIN
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177987
New treatments and novel drugs are required to counter the growing problem of drug-resistant strains of Mycobacterium tuberculosis (M.tb). Our approach against... 
TARGET | ARREST | 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL | CELLS | GALECTIN-3 | METABOLISM | RAB5 | MULTIDISCIPLINARY SCIENCES | IRON ACQUISITION | INFECTION | Gallium - metabolism | Phagosomes - microbiology | Virulence - drug effects | Antitubercular Agents - chemistry | Rifampin - chemistry | Humans | Galectin 3 - metabolism | Mycobacterium tuberculosis - drug effects | Gallium - analysis | Mycobacterium tuberculosis - physiology | Macrophages - microbiology | Mannose - chemistry | Cell Survival - drug effects | Metal Nanoparticles - chemistry | Phagosomes - metabolism | Antitubercular Agents - pharmacology | Cells, Cultured | Folic Acid - chemistry | Macrophages - cytology | Cathepsin D - metabolism | Galectin 3 - genetics | Particle Size | Gallium - pharmacology | Macrophages - metabolism | Cathepsin D - genetics | Dendrimers - chemistry | Macrophages - drug effects | Polymers - chemistry | Rifampin - pharmacology | Drug resistance in microorganisms | Care and treatment | Tuberculosis | Mycobacterium tuberculosis | Analysis | Dosage and administration | Research | Macrophages | Health aspects | Antibacterial agents | Drugs | Gallium | Drug delivery systems | Phagosomes | Infections | Mannose | Iron | Drug delivery | Drug resistance | Drug development | Folic acid | Nanoparticles | Hydrogenase | Proteins | Copolymers | Bacteria | Cathepsin D | Drug therapy | Antimicrobial agents | Metabolism | Medicine | Pathology | Monocytes | Rifampin | Viral infections
Journal Article
Journal Article