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Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2008, Volume 118, Issue 12, pp. 3917 - 3929
The role of autophagy in oncogenesis remains ambiguous, and mechanisms that induce autophagy and regulate its outcome in human cancers are poorly understood.... 
BREAST-CANCER | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | THERAPY | RELEVANCE | MECHANISMS | OPPORTUNITIES | TUMORIGENESIS | EXPRESSION | PROGRESSION | Protein Kinases - metabolism | Neoplasm Transplantation | Protein Kinases - genetics | Antibiotics, Antineoplastic - pharmacology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Ovarian Neoplasms - pathology | Cell Survival - genetics | Transplantation, Heterologous | Phosphatidylinositol 3-Kinases - metabolism | Autophagy - drug effects | Ovarian Neoplasms - genetics | Chloroquine - pharmacology | Cysteine Endopeptidases - metabolism | Tumor Suppressor Proteins - genetics | Female | Ovarian Neoplasms - metabolism | Antirheumatic Agents - pharmacology | Autophagy - genetics | Cell Survival - drug effects | Tumor Suppressor Proteins - metabolism | rho GTP-Binding Proteins - genetics | Phagosomes - metabolism | Sirolimus - pharmacology | Genomic Imprinting - drug effects | Genomic Imprinting - genetics | Phosphatidylinositol 3-Kinases - genetics | Animals | Intercellular Signaling Peptides and Proteins - pharmacology | Mice, Nude | Cysteine Endopeptidases - genetics | rho GTP-Binding Proteins - metabolism | Cell Line, Tumor | Mice | Mice, Inbred BALB C | TOR Serine-Threonine Kinases | Phagosomes - genetics | Care and treatment | Causes of | Physiological aspects | Tumor suppressor genes | Genetic aspects | Research | Health aspects | Apoptosis | Ovarian cancer | Index Medicus | Abridged Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 11/2014, Volume 16, Issue 12, pp. 1215 - 1226
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 47, pp. 33654 - 33666
Autophagy and apoptosis regulate cancer cell viability in response to cytotoxic stress; however, their functional relationship remains unclear.... 
INDUCED CELL-DEATH | ACTIVATION | PROTEIN | INDUCED APOPTOSIS | BH3 Mimetic | BIOCHEMISTRY & MOLECULAR BIOLOGY | TARGETING AUTOPHAGY | MIMETIC ABT-737 | Caspase | TUMOR-CELLS | Autophagy | p62 | Sequestosome 1 | Cancer Therapy | INHIBITION | DEGRADATION | Apoptosis | Bcl-2 Family Proteins | PANCREATIC-CANCER CELLS | Neoplasms - metabolism | Phagosomes - enzymology | Microtubule-Associated Proteins - genetics | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Gene Expression Regulation, Neoplastic | Apoptosis - genetics | Caspase 8 - biosynthesis | Neoplasm Proteins - metabolism | Autophagy - drug effects | Gene Knockdown Techniques | Caspase 8 - genetics | Neoplasms - genetics | Enzyme Induction - drug effects | Antineoplastic Agents - pharmacology | Autophagy - genetics | Neoplasm Proteins - genetics | bcl-2-Associated X Protein - genetics | Aniline Compounds - pharmacology | Jurkat Cells | bcl-2-Associated X Protein - metabolism | Up-Regulation - genetics | Enzyme Activation - drug effects | Sulfonamides - pharmacology | TNF-Related Apoptosis-Inducing Ligand - metabolism | Up-Regulation - drug effects | Enzyme Induction - genetics | Adaptor Proteins, Signal Transducing - genetics | Adaptor Proteins, Signal Transducing - biosynthesis | Mutation | Enzyme Activation - genetics | Neoplasms - pathology | TNF-Related Apoptosis-Inducing Ligand - genetics | Phagosomes - genetics | Index Medicus | Cell Biology
Journal Article
Cancer Science, ISSN 1347-9032, 07/2013, Volume 104, Issue 7, pp. 865 - 870
CUB (C1r/C1s, urchin embryonic growth factor, BMP 1) domain‐containing protein 1 ( CDCP 1) has been implicated in promoting metastasis of cancer cells through... 
CDCP1 | BECLIN-1 | ANOIKIS | GENE | ONCOLOGY | SRC | DEATH | INDUCTION | IDENTIFICATION | TUMORIGENESIS | RNA, Small Interfering - genetics | Cell Adhesion Molecules - genetics | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Lung Neoplasms - metabolism | Caspase 3 - metabolism | Cell Adhesion Molecules - antagonists & inhibitors | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Antigens, CD - genetics | Autophagy - drug effects | Antigens, CD - metabolism | Proto-Oncogene Proteins c-fyn - genetics | Phosphorylation - genetics | Adenocarcinoma - metabolism | Cell Death - genetics | Caspase 3 - genetics | src-Family Kinases - metabolism | Adenocarcinoma - genetics | Autophagy - genetics | Cell Death - drug effects | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Phagosomes - drug effects | Lung Neoplasms - genetics | Adenine - analogs & derivatives | Anoikis - genetics | Phagosomes - metabolism | Adenine - pharmacology | Signal Transduction - genetics | Cell Adhesion Molecules - metabolism | Phagosomes - pathology | Protein Kinase C-delta - metabolism | Proto-Oncogene Proteins c-fyn - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Anoikis - drug effects | RNA, Small Interfering - administration & dosage | src-Family Kinases - genetics | Protein Kinase C-delta - genetics | Phagosomes - genetics | Bone morphogenetic proteins | Lung cancer | Cancer cells | Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 07/2013, Volume 32, Issue 13, pp. 1903 - 1916
The Wnt/β‐catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify... 
cancer | autophagy | LC3 | p62 | Wnt/β‐catenin | Autophagy | Wnt/β-catenin | Cancer | CELLS | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | P62/SQSTM1 | CASPASE CLEAVAGE | SELECTIVE AUTOPHAGY | CELL BIOLOGY | TRANSCRIPTION FACTOR NRF2 | STRUCTURAL BASIS | COLORECTAL-CANCER | Wnt/beta-catenin | RNA, Small Interfering - genetics | Colonic Neoplasms - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Wnt Proteins - metabolism | Antigens, CD - genetics | Colonic Neoplasms - metabolism | Immunoenzyme Techniques | Antigens, CD - metabolism | Lysosomes - metabolism | Wnt Proteins - genetics | Chromatin Immunoprecipitation | Proteolysis | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Recombinant Proteins - metabolism | Transcription Factor 4 | Leukocyte Immunoglobulin-like Receptor B1 | Phagosomes - metabolism | RNA, Messenger - genetics | Recombinant Proteins - genetics | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | beta Catenin - metabolism | Blotting, Western | beta Catenin - genetics | Mice, Knockout | Transcription Factors - metabolism | Animals | beta Catenin - antagonists & inhibitors | Colonic Neoplasms - pathology | Adaptor Proteins, Signal Transducing - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Fluorescent Antibody Technique | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Index Medicus | β-catenin | Wnt
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14564 - 14569
A conserved insulin-like pathway modulates both aging and pathogen resistance in Caenorhabditis elegans. However, the specific innate effector functions that... 
Salmonella | Pathogens | Phagocytes | Epithelial cells | Salmonella infections | Genes | Nematodes | Bacteria | Infections | Genetic mutation | BACTERIAL PATHOGENS | LIFE-SPAN | IMMUNITY | LEGIONELLA-PNEUMOPHILA | CAENORHABDITIS-ELEGANS | CROHNS-DISEASE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | C-ELEGANS | DICTYOSTELIUM-DISCOIDEUM | CELL-DEATH | Caenorhabditis elegans - microbiology | Dictyostelium - microbiology | Immunity, Innate - genetics | Autophagy - physiology | Green Fluorescent Proteins - genetics | Intestinal Mucosa - cytology | RNA Interference | Receptor, Insulin - genetics | Phagosomes - ultrastructure | Autophagy - genetics | Vesicular Transport Proteins | Green Fluorescent Proteins - metabolism | Microscopy, Electron, Transmission | Salmonella typhimurium - physiology | Transcription Factors - physiology | Intestinal Mucosa - ultrastructure | Salmonella typhimurium - genetics | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Epithelial Cells - ultrastructure | Intestinal Mucosa - microbiology | Longevity - genetics | Receptor, Insulin - physiology | Transcription Factors - genetics | Host-Pathogen Interactions | Caenorhabditis elegans - ultrastructure | Animals | Epithelial Cells - microbiology | Survival Analysis | Dictyostelium - genetics | Caenorhabditis elegans Proteins - physiology | Mutation | Caenorhabditis elegans Proteins - genetics | Forkhead Transcription Factors | Microscopy, Fluorescence | Prevention | Pathogenic microorganisms | Genetic aspects | Salmonellosis | Research | Bacterial genetics | Salmonella typhimurium | Cell culture | Resistance to control | Effects | Infection | Overexpression | Life span | Aging | Lysosomes | Forkhead protein | Protein-tyrosine kinase receptors | Replication | Insulin | Phagocytosis | Index Medicus | Biological Sciences
Journal Article
PLoS Pathogens, ISSN 1553-7366, 11/2012, Volume 8, Issue 11, pp. e1002988 - e1002988
Journal Article
Journal of Virology, ISSN 0022-538X, 2015, Volume 89, Issue 17, pp. 8880 - 8896
Zika virus (ZIKV) is an emerging arbovirus of the Flaviviridae family, which includes dengue, West Nile, yellow fever, and Japanese encephalitis viruses, that... 
HUMAN DENDRITIC CELLS | DENGUE-VIRUS | REPLICATION | VIROLOGY | AEDES-ALBOPICTUS | ENCEPHALITIS-VIRUS | IMMUNE-RESPONSES | WEST-NILE-VIRUS | HEPARAN-SULFATE | AUTOPHAGY | I INTERFERON | Keratinocytes - virology | Membrane Glycoproteins - metabolism | Dendritic Cells - immunology | Humans | Flaviviridae - physiology | Virus Internalization | Interferon-Induced Helicase, IFIH1 | Lectins, C-Type - metabolism | Phagosomes - immunology | RNA Interference | Vero Cells | Myxovirus Resistance Proteins - biosynthesis | DEAD Box Protein 58 | Toll-Like Receptor 3 - immunology | Receptor Protein-Tyrosine Kinases - metabolism | Toll-Like Receptor 3 - metabolism | Cell Adhesion Molecules - metabolism | RNA, Small Interfering | Receptors, Cell Surface - genetics | Cell Adhesion Molecules - genetics | Ubiquitins - biosynthesis | Interferon-beta - immunology | Receptors, Virus - metabolism | Cercopithecus aethiops | Receptors, Virus - genetics | Lectins, C-Type - genetics | Insect Vectors - virology | Autophagy - immunology | Aedes - virology | Flaviviridae - immunology | Toll-Like Receptor 7 - immunology | HEK293 Cells | Toll-Like Receptor 3 - genetics | DEAD-box RNA Helicases - metabolism | Dendritic Cells - virology | Skin - virology | Flaviviridae Infections - immunology | Skin - immunology | Fibroblasts - virology | Proto-Oncogene Proteins - metabolism | Cells, Cultured | Interferon-beta - biosynthesis | Receptors, Cell Surface - metabolism | Proto-Oncogene Proteins - genetics | Hepatitis A Virus Cellular Receptor 1 | Flaviviridae Infections - virology | Membrane Glycoproteins - genetics | DEAD-box RNA Helicases - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Virus Replication | Cytokines - biosynthesis | Index Medicus | Life Sciences | Microbiology and Parasitology | Virology
Journal Article
Neuron, ISSN 0896-6273, 12/2010, Volume 68, Issue 5, pp. 857 - 864
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 4/2009, Volume 185, Issue 2, pp. 305 - 321
Autophagy, an intracellular degradative pathway, maintains cell homeostasis under normal and stress conditions. Nascent double-membrane autophagosomes... 
Starvation | Transferrins | 3T3 cells | Small interfering RNA | HeLa cells | Antibodies | CHO cells | Endosomes | Golgi apparatus | P branes | CORE MACHINERY | TRANSPORT | UNFOLDED PROTEIN RESPONSE | MULTIVESICULAR BODIES | MEMBRANE | EPSILON-COP | ENDOCYTIC PATHWAYS | BETA-COP | CELL MUTANT | GOLGI-COMPLEX | CELL BIOLOGY | Mannose-Binding Lectins - metabolism | RNA, Small Interfering - genetics | Membrane Glycoproteins - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Ubiquitin - metabolism | Autophagy - physiology | Coat Protein Complex I - metabolism | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Protein Subunits - metabolism | Lysosomal-Associated Membrane Protein 1 - genetics | Membrane Proteins - metabolism | Protein Subunits - genetics | Biomarkers - metabolism | Cell Line | Membrane Proteins - genetics | Lysosomal-Associated Membrane Protein 2 - genetics | Phagosomes - metabolism | Ubiquitin - genetics | Coat Protein Complex I - genetics | Membrane Glycoproteins - genetics | Animals | Mannose-Binding Lectins - genetics | Adaptor Proteins, Signal Transducing - genetics | Recombinant Fusion Proteins - genetics | Golgi Apparatus - metabolism | Lysosomal-Associated Membrane Protein 1 - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Transferrin - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | RNA, Small Interfering - metabolism | Ubiquitin | Gas vesicles | Physiological aspects | Research | Phagocytosis | Proteins | Studies | Membranes | Biochemistry | Cells | Index Medicus
Journal Article