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Benzodiazepine prescription patterns of psychiatry and non-psychiatry residents and specialists, 03/2005
Objective: The aim of this study was to evaluate the thoughts aboutusing benzodiazepines in the treatment and the prescription patterns ofpsychiatry and... 
benzodiazepine, pharmacokinetic, pharmacodynamic,psychiatrist, prescription | Psychiatry
Journal
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, ISSN 0946-1965, 09/2019, Volume 57, Issue 9, pp. 450 - 457
Objective: Letermovir is an inhibitor of the terminase complex of cytomegalovirus (CMV) used as prophylactic therapy in CMV-seropositive allogeneic... 
pharmacokinetic/pharmacodynamic | WOMEN | drug interactions | PHARMACOLOGY & PHARMACY | phase I | clinical trials | INHIBITORS | CYTOMEGALOVIRUS | COMBINATION | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2018, Volume 366, Issue 1, pp. 96 - 104
Xenograft mice are largely used to evaluate the efficacy of oncological drugs during preclinical phases of drug discovery and development. Mathematical models... 
GROWTH INHIBITION | ONCOLOGY | EFFICACY | ANTICANCER AGENTS | KINETICS | PHARMACOKINETIC-PHARMACODYNAMIC MODEL | DRUG DEVELOPMENT | PHARMACOLOGY & PHARMACY | MICE | ANTITUMOR-ACTIVITY | COMBINATION
Journal Article
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 12/2019, Volume 74, Issue 12, pp. 3530 - 3536
Abstract Objectives To demonstrate how phenotypic cell viability data can provide insight into antimycobacterial effects for the isoniazid/rifampicin treatment... 
MYCOBACTERIUM-TUBERCULOSIS | PHARMACOKINETIC/PHARMACODYNAMIC MODEL | INFECTIOUS DISEASES | MULTISTATE TUBERCULOSIS | BACTERICIDAL ACTIVITY | TUBERCULOSIS PHARMACOMETRIC MODEL | TOLERANCE | RESISTANCE | COLISTIN | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | EMERGENCE | Original Research
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 05/2018, Volume 62, Issue 5
Resistance to antibiotics among bacterial pathogens is rapidly spreading, and therapeutic options against multidrug-resistant bacteria are limited. There is an... 
SYSTEM | pharmacokinetic/pharmacodynamic | relebactam | BETA-LACTAMASE INHIBITORS | PHARMACOKINETICS | antibiotic resistance | hollow-fiber model | beta-lactamase inhibitor | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | PHARMACODYNAMICS
Journal Article
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 06/2019, Volume 108, Issue 6, pp. 2162 - 2172
Excessive fluid intake, that is, hyperhydration, may be adopted by athletes as a masking method during antidoping sample collection to influence the excretion... 
pharmacokinetics | absorption, distribution, metabolism, and excretion (ADME) | pharmacokinetic/pharmacodynamic (PK/PD) modeling | renal excretion | electrophoresis | CHEMISTRY, MEDICINAL | PERFORMANCE | PHARMACOLOGY & PHARMACY | PHARMACODYNAMICS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Japanese Journal of Infectious Diseases, ISSN 1344-6304, 2017
The pharmacokinetic-pharmacodynamic (PK-PD) breakpoints (BPs) of garenoxacin (GRNX) and other oral quinolones were calculated using the Monte Carlo simulation... 
Garenoxacin | Pharmacokinetic-pharmacodynamic breakpoint | Community-acquired pneumonia | Monte Carlo simulation
Journal Article
Clinical Microbiology Reviews, ISSN 0893-8512, 07/2007, Volume 20, Issue 3, pp. 391 - 408
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 10/2018, Volume 104, Issue 4, pp. 644 - 654
Balancing antitumor efficacy with toxicity is a significant challenge, and drug‐induced myelosuppression is a common dose‐limiting toxicity of cancer... 
PHARMACOKINETIC/PHARMACODYNAMIC MODEL | STEM-CELLS | PHARMACODYNAMIC MODEL | SYSTEMS PHARMACOLOGY | NEUTROPHIL DYNAMICS | BONE-MARROW | DRUG DISCOVERY | SELF-RENEWAL | PHARMACOLOGY & PHARMACY | TIME-COURSE | CHEMOTHERAPY | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2019, Volume 108, Issue 1, pp. 18 - 20
Model-based analyses have been applied to influence various drug development and regulatory decisions in the last 2 decades. Applied models range from... 
pharmacokinetic/pharmacodynamic (PK/PD) modeling | regulatory science | physiologically based pharmacokinetic (PBPK) modeling | clinical trial simulation(s) | ADME | computational | CHEMISTRY, MEDICINAL | PHARMACOLOGY & PHARMACY | SCIENCE | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, ISSN 0271-0749, 11/2019, Volume 39, Issue 6, pp. 567 - 574
Background Pharmacokinetic-pharmacodynamic (PK/PD) models were developed to describe the relationship between the time course of paliperidone plasma... 
PLACEBO | EFFICACY | relapse | EXTENDED-RELEASE TABLETS | PSYCHIATRY | PREVENTION | pharmacokinetic-pharmacodynamic modeling | RISPERIDONE | schizophrenia | SIMULATION | paliperidone palmitate | POPULATION PHARMACOKINETICS | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | SWITCHING STRATEGIES
Journal Article
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, ISSN 1198-743X, 12/2017
Deriving suitable dosing regimens for antibiotic combination therapy poses several challenges as the drug interaction can be highly complex, the traditional... 
Simulations | Semi-mechanistic pharmacokinetic–pharmacodynamic modelling | Medical and Health Sciences | Antibiotics | Medicin och hälsovetenskap | Interaction | Drug combinations
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 11/2018, Volume 104, Issue 5, pp. 957 - 965
Therapeutic concentrations of voriconazole in invasive fungal infections (IFIs) are ensured using a drug monitoring approach, which relies on attainment of... 
ASPERGILLOSIS | CYP2C19 GENOTYPE | PHARMACOKINETIC/PHARMACODYNAMIC ANALYSIS | PRACTICE GUIDELINES | PHARMACOKINETICS | EFFICACY | SAFETY | PHARMACOLOGY & PHARMACY | MONTE-CARLO-SIMULATION | IDENTIFICATION | DISEASES SOCIETY | Dose optimization | CYP2C19 polymorphisms | Monte Carlo Simulations | Invasive fungal infections | Voriconazole
Journal Article